{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:29:07Z","timestamp":1760142547285,"version":"build-2065373602"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.biopha.2008.02.007","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T17:53:32Z","timestamp":1206467612000},"page":"264-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroprotective gene profile in the brain of magnesium-deficient mice"],"prefix":"10.1016","volume":"62","author":[{"given":"Mich\u00e8le","family":"German-Fattal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Lecerf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Maurois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Durlach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2008.02.007_bib1","first-page":"321","article-title":"Dietary magnesium intake in a French adult population","volume":"10","author":"Galan","year":"1997","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib2","first-page":"283","article-title":"Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals","volume":"14","author":"Schimatschek","year":"2001","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib3","first-page":"R734","article-title":"Pathobiology of magnesium deficiency: a cytokine\/neurogenic inflammation hypothesis","volume":"263","author":"Weglicki","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.biopha.2008.02.007_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0925-4439(00)00018-1","article-title":"Inflammatory response following acute magnesium deficiency in the rat","volume":"1501","author":"Malpuech-Brugere","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopha.2008.02.007_bib5","first-page":"259","article-title":"Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process","volume":"17","author":"Nasulewicz","year":"2004","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib6","first-page":"225","article-title":"Severe Mg-deficiency is not associated with endothelial cell activation in mouse lung","volume":"18","author":"Sabbagh","year":"2005","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib7","series-title":"New perspectives in magnesium research, nutrition and health","first-page":"338","article-title":"Magnesium in the central nervous system","author":"Turner","year":"2007"},{"key":"10.1016\/j.biopha.2008.02.007_bib8","series-title":"Magnesium\/Mg and interaction of Mg with trace elements","first-page":"11","article-title":"Aetiology and pathophysiology of central nervous hyperexcitability due to various types of magnesium deficit: magnesium deficiency and magnesium depletion","author":"Durlach","year":"1998"},{"key":"10.1016\/j.biopha.2008.02.007_bib9","first-page":"293","article-title":"Physiopathology of symptomatic\u00a0and latent forms of central nervous hyperexcitability due to magnesium deficiency: a current general scheme","volume":"13","author":"Durlach","year":"2000","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1051\/rnd:19810309","article-title":"[Audiogenic seizure in the mouse according to strain and sex: the effect of the magnesium ration and neuromediators]","volume":"21","author":"Bac","year":"1981","journal-title":"Reprod Nutr Dev"},{"key":"10.1016\/j.biopha.2008.02.007_bib11","first-page":"676","article-title":"Caract\u00e9ristiques de la crise convulsive audiog\u00e8ne chez les souris rendues sensibles par la carence magn\u00e9sique","volume":"316","author":"Bac","year":"1993","journal-title":"CR Acad Sci Paris (Life Sciences)"},{"key":"10.1016\/j.biopha.2008.02.007_bib12","first-page":"303","article-title":"Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms","volume":"5","author":"Morris","year":"1992","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/ar1002","article-title":"Neural immune pathways and their connection to inflammatory diseases","volume":"5","author":"Eskandari","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.biopha.2008.02.007_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/153537020623100301","article-title":"The immune system as a regulator of thyroid hormone activity","volume":"231","author":"Klein","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.biopha.2008.02.007_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.mp.4001643","article-title":"Brain-immune interactions and disease susceptibility","volume":"10","author":"Marques-Deak","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.biopha.2008.02.007_bib16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1189\/jlb.0303101","article-title":"The cannabinoid system and immune modulation","volume":"74","author":"Klein","year":"2003","journal-title":"J Leuk Biol"},{"key":"10.1016\/j.biopha.2008.02.007_bib17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1189\/jlb.0405216","article-title":"Cannabinoid receptors in microglia of the central nervous system: immune functional relevance","volume":"78","author":"Cabral","year":"2005","journal-title":"J Leuk Biol"},{"key":"10.1016\/j.biopha.2008.02.007_bib18","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/00007890-200211270-00020","article-title":"Endothelial cell early activation induced by allogeneic lymphocytes in isolated perfused mouse lung","volume":"74","author":"Joucher","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.biopha.2008.02.007_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0022-510X(90)90154-F","article-title":"Distribution of magnesium in central nervous system tissue, trabecular and cortical bone in rats fed with unbalanced diets of minerals","volume":"99","author":"Yasui","year":"1990","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.biopha.2008.02.007_bib20","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0008-6363(95)00196-4","article-title":"Role of free radicals and substance P in magnesium deficiency","volume":"31","author":"Weglicki","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.trim.2006.09.002","article-title":"Allogeneic activation is attenuated in a model of mouse lung perfused with magnesium-deficient blood","volume":"16","author":"Sabbagh","year":"2006","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.biopha.2008.02.007_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0925-4439(98)00081-7","article-title":"Enhanced tumor necrosis factor-alpha production following endotoxin challenge in rats is an early event during magnesium deficiency","volume":"1453","author":"Malpuech-Brugere","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopha.2008.02.007_bib23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1292\/jvms.63.467","article-title":"Enhanced production of IL-1beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency","volume":"63","author":"Nakagawa","year":"2001","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.biopha.2008.02.007_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02454195","article-title":"Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin","volume":"110","author":"Weglicki","year":"1992","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.biopha.2008.02.007_bib25","first-page":"93","article-title":"Influence of graded magnesium deficiencies on white blood cell counts and lymphocyte subpopulations in rats","volume":"19","author":"Van Orden","year":"2006","journal-title":"Magnes Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/(SICI)1097-4547(19970715)49:2<248::AID-JNR13>3.0.CO;2-X","article-title":"Proliferation of ramified microglia on an astrocyte monolayer: characterization of stimulatory and inhibitory cytokines","volume":"49","author":"Kloss","year":"1997","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1385\/CRIAI:28:3:187","article-title":"Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer","volume":"28","author":"Atreya","year":"2005","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.biopha.2008.02.007_bib28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/intimm\/dxh396","article-title":"Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25\u2212 and CD25 high regulatory T cells","volume":"18","author":"Oberg","year":"2006","journal-title":"Int Immunol"},{"key":"10.1016\/j.biopha.2008.02.007_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/sj.jcbfm.9600061","article-title":"Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)\/gp130 attenuates ischemic brain injury in rats","volume":"25","author":"Suzuki","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.biopha.2008.02.007_bib30","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.peptides.2005.03.044","article-title":"Insulin-like growth factor (IGF) induced proliferation of human lung fibroblasts is enhanced by neurotensin","volume":"26","author":"Scarpa","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2008.02.007_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(03)00159-9","article-title":"The insulin-like growth factor system and cancer","volume":"195","author":"LeRoith","year":"2003","journal-title":"Cancer Lett"},{"key":"10.1016\/j.biopha.2008.02.007_bib32","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1210\/me.2002-0214","article-title":"Local insulin-like growth factor-II mediates prolactin-induced mammary gland development","volume":"17","author":"Hovey","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.biopha.2008.02.007_bib33","doi-asserted-by":"crossref","first-page":"15446","DOI":"10.1073\/pnas.0406870101","article-title":"Development of hydrocephalus in mice lacking SOCS7","volume":"101","author":"Krebs","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopha.2008.02.007_bib34","doi-asserted-by":"crossref","first-page":"13817","DOI":"10.1074\/jbc.M411596200","article-title":"Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation","volume":"280","author":"Martens","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2008.02.007_bib35","first-page":"99","article-title":"Prolactin triggers pro-inflammatory immune responses in peripheral immune cells","volume":"15","author":"Brand","year":"2004","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.biopha.2008.02.007_bib36","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1046\/j.1460-9568.2002.01965.x","article-title":"Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses","volume":"15","author":"Torner","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopha.2008.02.007_bib37","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/j.1460-9568.2007.05416.x","article-title":"Chronic intracerebral prolactin attenuates neuronal stress circuitries in virgin rats","volume":"25","author":"Donner","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.biopha.2008.02.007_bib38","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood-2003-08-2913","article-title":"G-CSF receptor truncations found in SCN\/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact","volume":"104","author":"van de Geijn","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2008.02.007_bib39","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI23559","article-title":"The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis","volume":"115","author":"Schneider","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopha.2008.02.007_bib40","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1471-4159.2006.03727.x","article-title":"Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease","volume":"97","author":"Meuer","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.biopha.2008.02.007_bib41","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.STR.0000208205.26253.96","article-title":"A novel neuroprotectant granulocyte-colony stimulating factor","volume":"37","author":"Solaroglu","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2008.02.007_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainres.2005.11.035","article-title":"Cannabinoid CB2 receptors: immunohistochemical localization in rat brain","volume":"1071","author":"Gong","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.biopha.2008.02.007_bib43","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1523\/JNEUROSCI.23-16-06470.2003","article-title":"Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia","volume":"23","author":"Molina-Holgado","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.biopha.2008.02.007_bib44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1385\/NMM:7:1-2:037","article-title":"Cannabinoid receptors and their role in neuroprotection","volume":"7","author":"van der Stelt","year":"2005","journal-title":"Neuromolecular Med"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208000449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208000449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:40:46Z","timestamp":1760092846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332208000449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0753332208000449"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2008.02.007","relation":{},"ISSN":["0753-3322"],"issn-type":[{"type":"print","value":"0753-3322"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective gene profile in the brain of magnesium-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2008.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}