{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:09:54Z","timestamp":1790464194601,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.biopha.2008.04.008","type":"journal-article","created":{"date-parts":[[2008,6,14]],"date-time":"2008-06-14T05:08:56Z","timestamp":1213420136000},"page":"267-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Redistribution of intracellular calcium and its effect on apoptosis in macrophages: Induction by oxidized LDL"],"prefix":"10.1016","volume":"63","author":[{"given":"Tongle","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2008.04.008_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis \u2014 an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopha.2008.04.008_bib2","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.ATV.0000184783.04864.9f","article-title":"Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis the importance of lesion stage and phagocytic efficiency","volume":"25","author":"Tabas","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.biopha.2008.04.008_bib3","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.ATV.0000210279.97308.9a","article-title":"Minimally oxidized ldl offsets the apoptotic effects of extensively oxidized ldl and free cholesterol in macrophages","volume":"26","author":"Boullier","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.biopha.2008.04.008_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0887-2333(98)00032-0","article-title":"Calcium signalling and the regulation of apoptosis","volume":"12","author":"Porn-Ares","year":"1998","journal-title":"Toxicol in Vitro"},{"key":"10.1016\/j.biopha.2008.04.008_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0143-4160(98)90116-6","article-title":"The role of calcium in apoptosis","volume":"23","author":"Pierluigi","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1016\/j.biopha.2008.04.008_bib6","doi-asserted-by":"crossref","first-page":"19794","DOI":"10.1073\/pnas.0609671104","article-title":"Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages","volume":"103","author":"Seimon","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopha.2008.04.008_bib7","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bbrc.2005.10.010","article-title":"Intracellular-free calcium dynamics and F-actin alteration in the formation of macrophage foam cells","volume":"338","author":"Deng","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2008.04.008_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signaling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2008.04.008_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.biopha.2008.04.008_bib10","doi-asserted-by":"crossref","first-page":"37030","DOI":"10.1074\/jbc.M405195200","article-title":"Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic\u2013endoplasmic reticulum calcium atpase-2b activity in parallel with increased order of membrane lipids","volume":"279","author":"Li","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2008.04.008_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.cardiores.2005.11.023","article-title":"Endoplasmic reticulum Ca2+ depletion induces endothelial cell apoptosis independently of caspase-12","volume":"69","author":"Nakano","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.biopha.2008.04.008_bib12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/sj.onc.1210638","article-title":"Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis","volume":"27","author":"Deniaud","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2008.04.008_bib13","doi-asserted-by":"crossref","first-page":"27510","DOI":"10.1074\/jbc.270.46.27510","article-title":"Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode","volume":"270","author":"Sparagna","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2008.04.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:MCBI.0000038228.85494.3b","article-title":"Mitochondrial signaling pathways: a receiver\/integrator organelle","volume":"262","author":"Goldenthal","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.biopha.2008.04.008_bib15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1083\/jcb.200608073","article-title":"Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels","volume":"175","author":"Szabadkai","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.biopha.2008.04.008_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4157(95)00003-A","article-title":"The mitochondrial permeability transition","volume":"1241","author":"Zoratti","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopha.2008.04.008_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0014-5793(02)02972-1","article-title":"Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells","volume":"523","author":"Giovanninia","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biopha.2008.04.008_bib18","doi-asserted-by":"crossref","first-page":"H2298","DOI":"10.1152\/ajpheart.00508.2003","article-title":"Oxidized low-density lipoprotein and 15-deoxy-\u039412, 14-PGJ2 increase mitochondrial complex I activity in endothelial cells","volume":"285","author":"Ceaser","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.biopha.2008.04.008_bib19","doi-asserted-by":"crossref","first-page":"9893","DOI":"10.1073\/pnas.93.18.9893","article-title":"Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria","volume":"93","author":"Murphy","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopha.2008.04.008_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0092-8674(00)80450-X","article-title":"Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria","volume":"91","author":"Vander Heiden","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2008.04.008_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0014-5793(96)00371-7","article-title":"Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells","volume":"385","author":"Deigner","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.biopha.2008.04.008_bib22","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1006\/bbrc.1997.7042","article-title":"Selective loading of rhod 2 into mitochondria shows mitochondrial Ca2+ transients during the contractile cycle in adult rabbit cardiac myocytes","volume":"236","author":"Trollinger","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2008.04.008_bib23","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-3495(99)77239-5","article-title":"Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence","volume":"76","author":"Petronilli","year":"1999","journal-title":"Biophys J"},{"key":"10.1016\/j.biopha.2008.04.008_bib24","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","article-title":"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential","volume":"30","author":"Reers","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2008.04.008_bib25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.87.7.2466","article-title":"Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase","volume":"87","author":"Thastrup","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopha.2008.04.008_bib26","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0092-8674(00)80301-3","article-title":"Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals","volume":"89","author":"Ichas","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2008.04.008_bib27","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0006-291X(03)00616-8","article-title":"Calcium signaling and apoptosis","volume":"304","author":"Hajnoczky","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2008.04.008_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1388-1981(02)00343-8","article-title":"Oxidized low-density lipoprotein-induced apoptosis","volume":"1585","author":"Salvayre","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopha.2008.04.008_bib29","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1099320","article-title":"The pathophysiology of mitochondrial cell death","volume":"305","author":"Green","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biopha.2008.04.008_bib30","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biopha.2008.04.008_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1005475802350","article-title":"Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs","volume":"31","author":"Fontaine","year":"1999","journal-title":"J Bioenerg Biomembr"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208001169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208001169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:42:46Z","timestamp":1760092966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332208001169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0753332208001169"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2008.04.008","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redistribution of intracellular calcium and its effect on apoptosis in macrophages: Induction by oxidized LDL","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2008.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}