{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:34:58Z","timestamp":1775374498310,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.biopha.2008.10.002","type":"journal-article","created":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T04:56:08Z","timestamp":1225515368000},"page":"613-617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives"],"prefix":"10.1016","volume":"63","author":[{"given":"Raquel B.","family":"Giordani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro V.","family":"De Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ederson","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Fran\u00e7a da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo A.","family":"De Carli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiana","family":"Tasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.S.","family":"Zuanazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2008.10.002_bib1","series-title":"Global prevalence and incidence of selected curable sexually transmitted infections","year":"2001"},{"key":"10.1016\/j.biopha.2008.10.002_bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00007435-199707000-00008","article-title":"Trichomonas vaginalis associated with low birth weight and preterm delivery","volume":"24","author":"Cotch","year":"1997","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.biopha.2008.10.002_bib3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/oxfordjournals.aje.a116711","article-title":"Relation of tubal infertility to a history of sexually transmitted diseases","volume":"137","author":"Goldstein","year":"1993","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.biopha.2008.10.002_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/028418600431003","article-title":"Gynecological infections as risk determinants of subsequent cervical neoplasia","volume":"39","author":"Viikki","year":"2000","journal-title":"Acta Oncol"},{"key":"10.1016\/j.biopha.2008.10.002_bib5","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/1055-9965.EPI-05-0781","article-title":"Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer","volume":"15","author":"Sutcliffe","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.biopha.2008.10.002_bib6","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1086\/515366","article-title":"Cysteine proteinases of Trichomonas vaginalis degrade secretory leucocyte protease inhibitor","volume":"178","author":"Draper","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.biopha.2008.10.002_bib7","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/AAC.47.4.1407-1409.2003","article-title":"In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis","volume":"47","author":"Crowell","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biopha.2008.10.002_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.cr.7290169","article-title":"Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis","volume":"13","author":"Dunne","year":"2003","journal-title":"Cell Res"},{"key":"10.1016\/j.biopha.2008.10.002_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031327","article-title":"A perspective of polyamine metabolism","volume":"376","author":"Wallace","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.biopha.2008.10.002_bib10","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1042\/bj3440633","article-title":"Polyamine transport in bacteria and yeast","volume":"344","author":"Igarashi","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.biopha.2008.10.002_bib11","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/nar\/23.10.1800","article-title":"Polyamines after sequence-specific DNA-protein interactions","volume":"23","author":"Panagiotidis","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopha.2008.10.002_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.brainres.2004.02.036","article-title":"Polyamines reduces lipid peroxidation induced by different pro-oxidant agents","volume":"1008","author":"Bell\u00e9","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.biopha.2008.10.002_bib13","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1099\/00221287-146-10-2715","article-title":"Dependence of Trichomonas vaginalis upon polyamine backconversion","volume":"146","author":"Yarlett","year":"2000","journal-title":"Microbiology"},{"key":"10.1016\/j.biopha.2008.10.002_bib14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/bst0220875","article-title":"Parasite polyamine metabolism: targets for chemotherapy","volume":"22","author":"Yarlett","year":"1999","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.biopha.2008.10.002_bib15","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/IAI.73.5.2602-2610.2005","article-title":"Trichomonas vaginalis polyamine metabolism is linked to host cell adherence and cytotoxicity","volume":"73","author":"Garcia","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.biopha.2008.10.002_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jac\/20.3.405","article-title":"Antitrichomonal activity of alpha-difluoromethylornithine","volume":"20","author":"Bremner","year":"1987","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.biopha.2008.10.002_bib17","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/AAC.43.8.1919","article-title":"Inhibition of polyamine synthesis arrests trichomonad growth and induces destruction of hydrogenosomes","volume":"43","author":"Reis","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biopha.2008.10.002_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2008.04.023","article-title":"Polyamine depletion down-regulates expression of the Trichomonas vaginalis cytotoxic CP65, a 65-kDa cysteine proteinase involved in cellular damage","author":"Alvarez-Snachez","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.biopha.2008.10.002_bib19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0960-894X(01)00837-X","article-title":"Leishmanicidal activity of some aliphatic diamines and amino-alcohols","volume":"12","author":"Del Olmo","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.biopha.2008.10.002_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ijpara.2005.01.008","article-title":"Differential effects of polyamine derivative compounds against Leishmania infantum promastigotes and axenic amastigotes","volume":"35","author":"Tavares","year":"2005","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biopha.2008.10.002_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10156-004-0348-9","article-title":"Challenges and new discoveries in the treatment of leishmaniasis","volume":"10","author":"Singh","year":"2004","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.biopha.2008.10.002_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/bst0310415","article-title":"Polyamine biosynthetic enzymes as drug targets in parasitic protozoa","volume":"31","author":"Heby","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.biopha.2008.10.002_bib23","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bmcl.2003.11.055","article-title":"Diamine derivatives with antiparasitic activities","volume":"14","author":"Labadie","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.biopha.2008.10.002_bib24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/jm9911027","article-title":"Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts","volume":"43","author":"Calas","year":"2000","journal-title":"Med Chem"},{"key":"10.1016\/j.biopha.2008.10.002_bib25","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1128\/AAC.47.8.2584-2589.2003","article-title":"Heme binding contributes to antimalarial activity of bis-quaternary ammoniums","volume":"47","author":"Biagini","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.biopha.2008.10.002_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biopha.2007.12.013","article-title":"Preparation and antileishmanial activity of lipophilic N-alkyl diamines","volume":"63","author":"da Costa","year":"2009","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.biopha.2008.10.002_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0166-6851(82)90042-1","article-title":"Metabolism of 1-0-[1\u2032-14C]octadecyl-sn-glycerol in Leishmania donovani promastigotes. Ether lipid synthesis and degradation of the ether bond","volume":"5","author":"Herrmann","year":"1982","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.biopha.2008.10.002_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s004360050361","article-title":"Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine-resistant Leishmania","volume":"84","author":"Basselin","year":"1998","journal-title":"Parasitol Res"},{"key":"10.1016\/j.biopha.2008.10.002_bib29","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1016\/j.bmcl.2007.07.073","article-title":"Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives","volume":"17","author":"Almeida","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.biopha.2008.10.002_bib30","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2307\/3274682","article-title":"The establishment of various Trichomonas of animals and man in axenic cultures","volume":"43","author":"Diamond","year":"1957","journal-title":"J Parasitol"},{"key":"10.1016\/j.biopha.2008.10.002_bib31","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0002-9378(12)90730-9","article-title":"Trichomoniasis: trends in diagnosis and management","volume":"165","author":"Lossick","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.biopha.2008.10.002_bib32","first-page":"545","article-title":"Prevalence of metronidazole resistant Trichomonas vaginalis in a gynecology clinic","volume":"46","author":"Schmid","year":"2001","journal-title":"J Reprod Med"},{"key":"10.1016\/j.biopha.2008.10.002_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199907223410417","article-title":"Metronidazole resistant vaginal trichomoniasis an emerging problem","volume":"341","author":"Sobel","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopha.2008.10.002_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01937754","article-title":"Cross-resistance of Trichomonads to 5-nitroimidazole derivatives","volume":"32","author":"Meingassner","year":"1976","journal-title":"Experientia"},{"key":"10.1016\/j.biopha.2008.10.002_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0020-7519(98)00155-6","article-title":"Trichomonads, hydrogenosomes and drug resistance","volume":"29","author":"Kulda","year":"1999","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.biopha.2008.10.002_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001432-200002000-00007","article-title":"Biology of trichomonosis","volume":"13","author":"Lehker","year":"2000","journal-title":"Curr Opin Infect Dis"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208003612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332208003612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:43:41Z","timestamp":1760093021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332208003612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0753332208003612"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2008.10.002","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2008.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}