{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:24:12Z","timestamp":1791822252420,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["S1411037"],"award-info":[{"award-number":["S1411037"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.biopha.2014.09.009","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:39Z","timestamp":1412035239000},"page":"999-1005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-\u03baB nuclear translocation and down-regulation of Bcl-xL and XIAP"],"prefix":"10.1016","volume":"68","author":[{"given":"Masanobu","family":"Tsubaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shimaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Imano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Satou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2014.09.009_bib0005","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrc780","article-title":"NF-kappaB in cancer: from innocent bystander to major culprit","volume":"2","author":"Karin","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.biopha.2014.09.009_bib0015","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-kappaB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2014.09.009_bib0020","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0025","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1038\/sj.onc.1203221","article-title":"Aberrant rel\/nfkb genes and activity in human cancer","volume":"18","author":"Rayet","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2014.09.009_bib0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1046\/j.1365-2141.2001.03102.x","article-title":"Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis","volume":"115","author":"Ni","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0035","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1172\/JCI119849","article-title":"Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells","volume":"100","author":"Bargou","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.biopha.2014.09.009_bib0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1074-7613(01)00258-8","article-title":"A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B-cell lymphomas","volume":"16","author":"Pham","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2014.09.009_bib0045","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B-cell-like diffuse large B-cell lymphoma cells","volume":"194","author":"Davis","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.biopha.2014.09.009_bib0050","first-page":"4342","article-title":"Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor","volume":"58","author":"Orlowski","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0055","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/cncr.20182","article-title":"Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies","volume":"100","author":"Panwalkar","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2014.09.009_bib0060","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1610-0387.2007.06346.x","article-title":"Treatment of psoriasis with fumaric acid esters (Fumaderm)","volume":"5","author":"Mrowietz","year":"2007","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.biopha.2014.09.009_bib0065","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.cellbi.2009.06.027","article-title":"Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells","volume":"33","author":"Yamazoe","year":"2009","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.biopha.2014.09.009_bib0070","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1756-9966-32-62","article-title":"Activation of NF-\u03baB by the RANKL\/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines","volume":"32","author":"Tsubaki","year":"2013","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12272-011-0316-8","article-title":"Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-\u03baB in HL-60 cells","volume":"34","author":"Shoji","year":"2011","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0080","doi-asserted-by":"crossref","first-page":"11888","DOI":"10.1158\/0008-5472.CAN-06-2397","article-title":"Dimethylfumarate impairs melanoma growth and metastasis","volume":"66","author":"Loewe","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0085","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.168.9.4781","article-title":"Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B\/p65 in human endothelial cells","volume":"168","author":"Loewe","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0090","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/jid.2011.46","article-title":"Suppression of VEGFR2 expression in human endothelial cells by dimethylfumarate treatment: evidence for anti-angiogenic action","volume":"131","author":"Meissner","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0095","doi-asserted-by":"crossref","first-page":"L326","DOI":"10.1152\/ajplung.90624.2008","article-title":"Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion","volume":"297","author":"Seidel","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2014.02.062","article-title":"Dimethyl fumarate inhibits the expression and function of hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1)","volume":"448","author":"Zhao","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2014.09.009_bib0105","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00018-013-1545-4","article-title":"NF-\u03baB pathways in hematological malignancies","volume":"71","author":"Gasparini","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.biopha.2014.09.009_bib0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.leukres.2012.11.009","article-title":"Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro","volume":"37","author":"Han","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0115","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.leukres.2011.11.014","article-title":"Cardamonin exerts potent activity against multiple myeloma through blockade of NF-\u03baB pathway in vitro","volume":"36","author":"Qin","year":"2012","journal-title":"Leuk Res"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2014.09.009_bib0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-010-0709-x","article-title":"Role of Bcl-2 family proteins and caspases in the regulation of apoptosis","volume":"351","author":"Ola","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.biopha.2014.09.009_bib0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcb.23335","article-title":"Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?","volume":"113","author":"Beverly","year":"2012","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.biopha.2014.09.009_bib0130","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.ejca.2013.07.010","article-title":"Inhibition of the tumour necrosis factor-alpha autocrine loop enhances the sensitivity of multiple myeloma cells to anticancer drugs","volume":"49","author":"Tsubaki","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.biopha.2014.09.009_bib0135","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bcp.2007.12.013","article-title":"Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations","volume":"75","author":"Mackenzie","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/excr.2001.5381","article-title":"Curcumin induces apoptosis in human melanoma cells through a Fas receptor\/caspase-8 pathway independent of p53","volume":"271","author":"Bush","year":"2001","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0145","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1541-7786.MCR-07-2088","article-title":"Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis","volume":"6","author":"Sethi","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.biopha.2014.09.009_bib0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.yadr.2008.09.010","article-title":"Application of angiogenesis to clinical dermatology","volume":"24","author":"Fried","year":"2008","journal-title":"Adv Dermatol"},{"key":"10.1016\/j.biopha.2014.09.009_bib0155","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/jid.2010.416","article-title":"Dimethylfumarate inhibits angiogenesis in vitro and in vivo: a possible role for its antipsoriatic effect?","volume":"131","author":"Garc\u00eda-Caballero","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.biopha.2014.09.009_bib0160","doi-asserted-by":"crossref","DOI":"10.1042\/AN20100033","article-title":"The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1","volume":"3","author":"Lin","year":"2011","journal-title":"ASN Neuro"},{"key":"10.1016\/j.biopha.2014.09.009_bib0165","doi-asserted-by":"crossref","first-page":"9921","DOI":"10.1073\/pnas.1005138107","article-title":"Vinpocetine as a potent antiinflammatory agent","volume":"107","author":"Medina","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopha.2014.09.009_bib0170","first-page":"79","article-title":"Antiproliferative and cytotoxic profiles of antipsoriatic fumaric acid derivatives in keratinocyte cultures","volume":"270","author":"Seb\u00f6k","year":"1994","journal-title":"Eur J Pharmacol"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221400122X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221400122X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:56:44Z","timestamp":1760093804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221400122X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S075333221400122X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2014.09.009","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-\u03baB nuclear translocation and down-regulation of Bcl-xL and XIAP","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2014.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}