{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:39:29Z","timestamp":1790505569691,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.biopha.2014.10.011","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T01:33:20Z","timestamp":1414632800000},"page":"1065-1069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Enhancement of the antibiotic activity of aminoglycosides by alpha-tocopherol and other cholesterol derivates"],"prefix":"10.1016","volume":"68","author":[{"given":"Jacqueline C.","family":"Andrade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Flaviana B.","family":"Morais-Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia M.M.","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo R.","family":"Tintino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin R.A.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2014.10.011_bib0005","first-page":"247","article-title":"Avalia\u00e7\u00e3o da atividade antimicrobiana de riparinas sobre cepas de Staphylococcus aureus et Escherichia coli multirresistentes","volume":"37","author":"Cat\u00e3o","year":"2005","journal-title":"RBAC"},{"key":"10.1016\/j.biopha.2014.10.011_bib0010","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps? Not just for resistance","volume":"4","author":"Piddoc","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.biopha.2014.10.011_bib0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000151267","article-title":"Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine","volume":"54","author":"Coutinho","year":"2008","journal-title":"Chemotherapy"},{"key":"10.1016\/j.biopha.2014.10.011_bib0020","first-page":"1","article-title":"Antibi\u00f3ticos e Resist\u00eancia Bacteriana, Velhas Quest\u00f5es, Novos Desafios","volume":"1","author":"Dias","year":"2010","journal-title":"Cad Otorrino"},{"key":"10.1016\/j.biopha.2014.10.011_bib0025","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.biopha.2014.10.011_bib0030","series-title":"Microbiologia","author":"Tortora","year":"2008"},{"key":"10.1016\/j.biopha.2014.10.011_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-9-35","article-title":"Termite usage associated with antibiotic therapy: enhancement of aminoglycoside antibiotic activity by natural products of Nasutitermes corniger (Motschulsky 1855)","volume":"9","author":"Coutinho","year":"2009","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.biopha.2014.10.011_bib0040","series-title":"Microbiologia M\u00e9dica","first-page":"2004","author":"Murray","year":"2004"},{"key":"10.1016\/j.biopha.2014.10.011_bib0045","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1515\/znc-2004-9-1009","article-title":"Antimicrobial activity of fractions and compounds from Calophyllum brasiliense (clusiaceae\/guttiferae)","volume":"59","author":"Pretto","year":"2004","journal-title":"Naturforsch"},{"key":"10.1016\/j.biopha.2014.10.011_bib0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1039\/b212695h","article-title":"Anti-staphylococcal plant natural products","volume":"126","author":"Gibbons","year":"2004","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.biopha.2014.10.011_bib0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1574-6968.1999.tb08733.x","article-title":"Potentiation of methicillin, activity against methicillin-resistant Staphylococcus aureus by diterpenes","volume":"179","author":"Nicolson","year":"1999","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.biopha.2014.10.011_bib0060","first-page":"191","article-title":"Aspectos b\u00e1sicos y determinaci\u00f3n de las vitaminas antioxidantes E y A","volume":"43","author":"M\u00e1rquez","year":"2002","journal-title":"Invest Cl\u00edn"},{"key":"10.1016\/j.biopha.2014.10.011_bib0065","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1590\/S0004-27302009000500008","article-title":"Vitaminas e minerais com propriedades antioxidantes e risco cardiometab\u00f3lico: controv\u00e9rsias e perspectivas","volume":"53","author":"Catania","year":"2009","journal-title":"Arq Bras Endocrinol Metab"},{"key":"10.1016\/j.biopha.2014.10.011_bib0070","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1590\/S1415-52732007000500008","article-title":"Adi\u00e7\u00e3o da vitamina E aos alimentos: implica\u00e7\u00f5es para os alimentos e para a sa\u00fade humana","volume":"20","author":"Batista","year":"2007","journal-title":"Rev Nutr"},{"key":"10.1016\/j.biopha.2014.10.011_bib0075","first-page":"391","article-title":"Vitamina E: un tema siempre presente, nunca conclu\u00eddo","volume":"78","author":"Berg","year":"2010","journal-title":"Rev Arg Cardiolog\u00eda"},{"key":"10.1016\/j.biopha.2014.10.011_bib0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.32635\/2176-9745.RBC.2009v55n3.1622","article-title":"Vitaminas Antioxidantes na Preven\u00e7\u00e3o do C\u00e2ncer do Colo Uterino","volume":"55","author":"Sampaio","year":"2009","journal-title":"Rev Bras Cancerol"},{"key":"10.1016\/j.biopha.2014.10.011_bib0085","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1590\/S0103-84781999000100033","article-title":"Colesterol e composi\u00e7\u00e3o dos \u00e1cidos graxos nas dietas para humanos e na carca\u00e7a su\u00edna","volume":"29","author":"Ludke","year":"1999","journal-title":"Ci Rural"},{"key":"10.1016\/j.biopha.2014.10.011_bib0090","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1590\/S0004-27302010000900002","article-title":"HDL: the yin-yang of cardiovascular disease","volume":"54","author":"Lean\u00e7a","year":"2010","journal-title":"Arq Bras Endocrinol Metab"},{"key":"10.1016\/j.biopha.2014.10.011_bib0095","series-title":"A C\u00e9lula 2001","article-title":"Biomembranas","author":"Santos","year":"2001"},{"key":"10.1016\/j.biopha.2014.10.011_bib0100","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.peptides.2003.09.014","article-title":"Interactions of antifungal plant defensins with fungal membrane components","volume":"24","author":"Thevissen","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2014.10.011_bib0105","first-page":"17","article-title":"A particularidade de ser um fungo \u2013 I. Constituintes celulares","volume":"19","author":"Loguercio-leite","year":"2006","journal-title":"Biotemas"},{"key":"10.1016\/j.biopha.2014.10.011_bib0110","series-title":"Mecanismo das doen\u00e7as infecciosas","author":"Schaechter","year":"2002"},{"key":"10.1016\/j.biopha.2014.10.011_bib0115","series-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"NCCLS\u00a0\u2013\u00a0National Comittee for Clinical Laboratory Standards","year":"2005"},{"key":"10.1016\/j.biopha.2014.10.011_bib0120","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1021\/jm9509410","article-title":"De novo antimicrobial peptides with low mammalian cell toxicity","volume":"39","author":"Javadpour","year":"1996","journal-title":"J Med Chem"},{"key":"10.1016\/j.biopha.2014.10.011_bib0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0102-695X2006000100014","article-title":"Estudo da interfer\u00eancia de \u00f3leos essenciais sobre a atividade de alguns antibi\u00f3ticos usados na cl\u00ednica","volume":"16","author":"Oliveira","year":"2006","journal-title":"Rev Bras Farmacogn"},{"key":"10.1016\/j.biopha.2014.10.011_bib0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S0102-695X2008000200019","article-title":"Composi\u00e7\u00e3o qu\u00edmica e modula\u00e7\u00e3o da resist\u00eancia bacteriana a drogas do \u00f3leo essencial das folhas de Rollinia leptopetala R.E. Fries","volume":"18","author":"Costa","year":"2008","journal-title":"Rev Bras Farmacogn"},{"key":"10.1016\/j.biopha.2014.10.011_bib0135","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1590\/S0102-695X2010000300010","article-title":"Interfer\u00eancia de extratos da Baccharis dracunculifolia DC., Asteraceae, sobre a atividade de antibi\u00f3ticos usados na cl\u00ednica","volume":"20","author":"Canton","year":"2010","journal-title":"Rev Bras Farmacogn"},{"key":"10.1016\/j.biopha.2014.10.011_bib0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0103-84782004000100024","article-title":"Atividade antimicrobiana \u201cin vitro\u201d de extrato alco\u00f3lico de pr\u00f3polis","volume":"34","author":"Vargas","year":"2004","journal-title":"Ci Rural"},{"key":"10.1016\/j.biopha.2014.10.011_bib0145","series-title":"Atividade antimicrobiana de fra\u00e7\u00f5es e extratos e compostos puros obtidos das flores da Acmela brasilensis Spreng (Wedelia paludosa) (Asteraceae)","author":"Sartori","year":"2005"},{"key":"10.1016\/j.biopha.2014.10.011_bib0150","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1016\/S0021-9258(17)37154-5","article-title":"Interaction of cyclic hydrocarbons with biological membranes","volume":"269","author":"Sikkema","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.biopha.2014.10.011_bib0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bpc.2006.02.007","article-title":"Natural terpenes: self-assembly and membrane partitioning","volume":"122","author":"Turina","year":"2006","journal-title":"Biophys Chem"},{"key":"10.1016\/j.biopha.2014.10.011_bib0160","first-page":"1","article-title":"\u00c1cidos graxos poliinsaturados de cadeia longa","volume":"10","author":"Hirayama","year":"2006","journal-title":"Elect J Ped Gastroenterol Nutr Liver Dis"},{"key":"10.1016\/j.biopha.2014.10.011_bib0165","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s000180050024","article-title":"Bacterial antibiotic efflux systems of medical importance","volume":"56","author":"K\u00f6hler","year":"1999","journal-title":"Cell Assoc Mol Life Sci"},{"key":"10.1016\/j.biopha.2014.10.011_bib0170","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential oils: their antibacterial properties. potential applicationsin foods\u00a0\u2013\u00a0a review","volume":"94","author":"Burt","year":"2004","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.biopha.2014.10.011_bib0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-1097(03)00890-5","article-title":"Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol","volume":"230","author":"Nostro","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.biopha.2014.10.011_bib0180","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AEM.71.2.797-803.2005","article-title":"Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica Serovar Typhimurium","volume":"71","author":"Knowles","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.biopha.2014.10.011_bib0185","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bjp.0706556","article-title":"Mitochondria: a target for c\u00e2ncer therapy","volume":"147","author":"Armstrong","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.biopha.2014.10.011_bib0190","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1590\/S0100-40422005000300025","article-title":"Lipossomas: propriedades f\u00edsico-qu\u00edmicas e farmacol\u00f3gicas, aplica\u00e7\u00f5es na Quimioterapia \u00e0 base de antim\u00f4nio","volume":"28","author":"Fr\u00e9zard","year":"2005","journal-title":"Quim Nova"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332214001401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332214001401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:55:09Z","timestamp":1760093709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332214001401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0753332214001401"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2014.10.011","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancement of the antibiotic activity of aminoglycosides by alpha-tocopherol and other cholesterol derivates","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2014.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}