{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:10:26Z","timestamp":1772799026982,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.biopha.2014.12.042","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T18:01:12Z","timestamp":1420826472000},"page":"24-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Expression of 17\u03b2-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer"],"prefix":"10.1016","volume":"70","author":[{"given":"Bartosz Adam","family":"Frycz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawid","family":"Murawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Borejsza-Wysocki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"Marciniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Murawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Drews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142 Piotr","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2014.12.042_bib0005","series-title":"GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No.\u00a011","author":"Ferlay","year":"2013"},{"key":"10.1016\/j.biopha.2014.12.042_bib0010","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4251\/wjgo.v4.i7.156","article-title":"Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention","volume":"4","author":"Nagini","year":"2012","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0015","first-page":"358","article-title":"Environmental and lifestyle risk factors of gastric cancer","volume":"16","author":"Lee","year":"2013","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.biopha.2014.12.042_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/frne.2001.0216","article-title":"DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology","volume":"22","author":"Labrie","year":"2001","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0025","doi-asserted-by":"crossref","first-page":"C113","DOI":"10.1016\/0303-7207(91)90116-A","article-title":"Intracrinology","volume":"78","author":"Labrie","year":"1991","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.urolonc.2008.07.036","article-title":"The Coffey lecture: steroidogenic enzyme inhibitors and hormone dependent cancer","volume":"27","author":"Brodie","year":"2009","journal-title":"Urol Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0960-0760(00)00155-2","article-title":"Analysis and characteristics of multiple types of human 17-hydroxysteroid dehydrogenase","volume":"76","author":"Luu-The","year":"2001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0040","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0039-128X(96)00174-2","article-title":"The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology","volume":"62","author":"Labrie","year":"1997","journal-title":"Steroids"},{"key":"10.1016\/j.biopha.2014.12.042_bib0045","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biopha.2013.06.012","article-title":"Expression of 17\u03b2-hydroxysteroid dehydrogenase type 1 in gastric cancer","volume":"67","author":"Frycz","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.biopha.2014.12.042_bib0050","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1043-2760(00)00342-8","article-title":"Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues","volume":"11","author":"Labrie","year":"2000","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.biopha.2014.12.042_bib0055","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/1471-2407-12-566","article-title":"Expression profile and prognostic role of sex hormone receptors in gastric cancer","volume":"2","author":"Gan","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2014.12.042_bib0060","first-page":"3889","article-title":"Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues","volume":"23","author":"Oduwole","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.biopha.2014.12.042_bib0065","first-page":"1935","article-title":"In situ androgen production in human gastric carcinoma \u2013 androgen synthesizing and metabolizing enzymes","volume":"26","author":"Nakamura","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.biopha.2014.12.042_bib0070","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.biopha.2014.12.042_bib0075","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbrc.2003.11.177","article-title":"Guideline to reference gene selection for quantitative real-time PCR","volume":"313","author":"Radoni\u0107","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2014.12.042_bib0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10120-008-0463-x","article-title":"Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer","volume":"11","author":"Izawa","year":"2008","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.biopha.2014.12.042_bib0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/1055-9965.EPI-11-0834","article-title":"Sex hormones, hormonal interventions, and gastric cancer risk: a meta-analysis","volume":"21","author":"Camargo","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.biopha.2014.12.042_bib0090","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.ejca.2008.07.031","article-title":"Oestrogen and the enigmatic male predominance of gastric cancer","volume":"44","author":"Chandanos","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.biopha.2014.12.042_bib0095","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1158\/1055-9965.2203.13.12","article-title":"Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden","volume":"13","author":"Lindblad","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.biopha.2014.12.042_bib0100","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/aje\/kwq321","article-title":"Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition","volume":"172","author":"Duell","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0105","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ejca.2008.02.049","article-title":"Tamoxifen exposure in relation to gastric adenocarcinoma development","volume":"44","author":"Chandanos","year":"2008","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.biopha.2014.12.042_bib0110","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1093\/oxfordjournals.annonc.a010406","article-title":"Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan","volume":"11","author":"Matsuyama","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0115","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1158\/1940-6207.CAPR-11-0219","article-title":"17\u03b2-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice","volume":"4","author":"Sheh","year":"2011","journal-title":"Cancer Prev Res"},{"key":"10.1016\/j.biopha.2014.12.042_bib0120","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/carcin\/bgr072","article-title":"17\u03b2-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice","volume":"32","author":"Ohtani","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biopha.2014.12.042_bib0125","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/carcin\/bgm150","article-title":"Protective role of 17beta-estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice","volume":"28","author":"Ohtani","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biopha.2014.12.042_bib0130","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1210\/endo.140.10.7030","article-title":"17beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N\u2032-nitro-nitrosoguanidine","volume":"140","author":"Campbell-Thompson","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2014.12.042_bib0135","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jss.2006.12.002","article-title":"The effect of nitric oxide, growth factors, and estrogen on gastric cell migration","volume":"143","author":"Nylander-Koski","year":"2007","journal-title":"J Surg Res"},{"key":"10.1016\/j.biopha.2014.12.042_bib0140","first-page":"3215","article-title":"Effects of 17beta-estradiol administration on apoptosis and polyamine content in AGS cell line","volume":"21","author":"Pricci","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/j.biopha.2014.12.042_bib0145","first-page":"116","article-title":"A study on the effects of estradiol and estramustine on gastrointestinal cell lines","volume":"16","author":"Harrison","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0150","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1002\/1097-0142(19890601)63:11<2148::AID-CNCR2820631113>3.0.CO;2-C","article-title":"The effect of sex hormones and tamoxifen on the growth of human gastric and colorectal cancer cell lines","volume":"63","author":"Harrison","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2014.12.042_bib0155","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/1008-682X.122361","article-title":"Androgens and prostate disease","volume":"16","author":"Cooper","year":"2014","journal-title":"Asian J Androl"},{"key":"10.1016\/j.biopha.2014.12.042_bib0160","first-page":"157","article-title":"Androgens and ovarian cancers","volume":"25","author":"Wang","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0344-0338(11)81156-8","article-title":"De novo expression of aromatase in gastric carcinoma. Light and electron microscopic immunohistochemical and immunoblot study","volume":"188","author":"Saitoh","year":"1992","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.biopha.2014.12.042_bib0170","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.mehy.2013.01.023","article-title":"Androgen receptor may be responsible for gender disparity in gastric cancer","volume":"80","author":"Tian","year":"2013","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.biopha.2014.12.042_bib0175","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00432-003-0531-x","article-title":"Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer","volume":"130","author":"Kominea","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.biopha.2014.12.042_bib0180","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/oxfordjournals.epirev.a000795","article-title":"Hormones and prostate cancer: what's next?","volume":"23","author":"Hsing","year":"2001","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.biopha.2014.12.042_bib0185","first-page":"73","article-title":"Expressions of genes encoding steroidogenic enzymes and their role in prostate carcinogenesis","volume":"83","author":"Frycz","year":"2014","journal-title":"Nowiny Lekarskie"},{"key":"10.1016\/j.biopha.2014.12.042_bib0190","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/pros.10108","article-title":"Hormones and prostate cancer: current perspectives and future directions","volume":"52","author":"Hsing","year":"2002","journal-title":"Prostate"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215000098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215000098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:54:50Z","timestamp":1760093690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215000098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":38,"alternative-id":["S0753332215000098"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2014.12.042","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of 17\u03b2-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2014.12.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}