{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:13:51Z","timestamp":1767996831247,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.biopha.2015.02.008","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T20:00:29Z","timestamp":1424289629000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Oxidative modification induced by photodynamic therapy with Photofrin\u00aeII and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells"],"prefix":"10.1016","volume":"71","author":[{"given":"Jolanta","family":"Saczko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Choroma\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Rembia\u0142kowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Dubi\u0144ska-Magiera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-2017","authenticated-orcid":false,"given":"Iwona","family":"Bednarz-Misa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Marcinkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julita","family":"Kulbacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2015.02.008_bib0265","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/sj.bjc.6601423","article-title":"C-erbB-2 or mutant Ha-ras induced malignant transformation of immortalized human ovarian surface epithelial cells in vitro","volume":"89","author":"Kusakari","year":"2003","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2015.02.008_bib0270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1572-1000(05)00033-5","article-title":"PD\/PDT for gynecological disease: a clinical review","volume":"2","author":"Allison","year":"2005","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.biopha.2015.02.008_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1572-1000(05)00030-X","article-title":"Mechanisms in photodynamic therapy: Part two \u2013 Cellular signaling, cell metabolism and modes of cell death","volume":"2","author":"Castano","year":"2005","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.biopha.2015.02.008_bib0280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2217\/14796694.2.1.53","article-title":"The future of photodynamic therapy in oncology","volume":"2","author":"Allison","year":"2006","journal-title":"Future Oncol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0285","first-page":"8126","article-title":"Photodynamic therapy: a means to enhanced drug delivery to tumors","volume":"63","author":"Synder","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2015.02.008_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/b108586g","article-title":"The role of apoptosis in response to photodynamic therapy: what, where, why, and how","volume":"1","author":"Oleinick","year":"2002","journal-title":"Photochem Photobiol Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2015.02.008_bib0295","first-page":"82","article-title":"Levels of lipid peroxidation in A549 cells after PDT in vitro","volume":"49","author":"Saczko","year":"2004","journal-title":"Rocz Akad Med Bialymst"},{"key":"10.1016\/j.biopha.2015.02.008_bib0300","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1011-1344(01)00207-X","article-title":"Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms","volume":"63","author":"Girotti","year":"2001","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0305","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1074\/jbc.M209125200","article-title":"Antitumor effects of photodynamic therapy are potentiated by 2-metoxyestradiol, a superoxide dismutase inhibitor","volume":"278","author":"Golab","year":"2003","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.biopha.2015.02.008_bib0310","first-page":"93","article-title":"Cytosolic superoxide dismutase activity after photodynamic therapy, intracellular distribution of Photofrin II and hypericin, and P-glycoprotein localization in human colon adenocarcinoma","volume":"45","author":"Saczko","year":"2007","journal-title":"Folia Histochem Cytobiol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0315","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bbrc.2005.04.141","article-title":"A role for manganese superoxide dismutase in apoptosis after photosensitization","volume":"332","author":"Dolgachev","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2015.02.008_bib0320","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.drup.2003.10.001","article-title":"Mechanism of action of 2-methoxyestradiol: new developments","volume":"6","author":"Mooberry","year":"2003","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.biopha.2015.02.008_bib0325","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1073\/pnas.95.8.4556","article-title":"Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury","volume":"95","author":"Wang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.biopha.2015.02.008_bib0330","first-page":"1538","article-title":"Novel 2 \u2013 methoxestradiol analogues with antitumor activity","volume":"63","author":"Tinley","year":"2003","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.biopha.2015.02.008_bib0335","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2005.01.018","article-title":"2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction apoptosis in prostate cancer cells","volume":"231","author":"Perez-Stable","year":"2006","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.biopha.2015.02.008_bib0340","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14712\/fb2007053010007","article-title":"Intracellular distribution of Photofrin in malignant and normal endothelial cell lines","volume":"53","author":"Saczko","year":"2007","journal-title":"Folia Biol (Praha)"},{"key":"10.1016\/j.biopha.2015.02.008_bib0345","series-title":"Proc. SPIE 7507, 2009 International Conference on Optical Instruments and Technology: Optical Trapping and Microscopic Imaging","article-title":"PDT-treated apoptotic cells induce macrophage synthesis NO","author":"Song So","year":"2009"},{"key":"10.1016\/j.biopha.2015.02.008_bib0350","first-page":"150","article-title":"Photofrin II-based photosensitization of human ovarian clear-cell carcinoma cell line (OvBH-1)","volume":"59","author":"Bar","year":"2007","journal-title":"Pharmacol Rep"},{"issue":"9","key":"10.1016\/j.biopha.2015.02.008_bib0355","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1349-7006.2002.tb02473.x","article-title":"Temperature-sensitive ovarian carcinoma cell line (OvBH-1)","volume":"93","author":"Bar","year":"2002","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.biopha.2015.02.008_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2009.04.001","article-title":"Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT","volume":"96","author":"Robertson","year":"2009","journal-title":"J Photochem Photobiol B: Biol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0365","first-page":"59","article-title":"Intracellular signaling mechanisms in photodynamic therapy","volume":"1704","author":"Almeida","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.biopha.2015.02.008_bib0370","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","volume":"90","author":"Dougherty","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.biopha.2015.02.008_bib0375","doi-asserted-by":"crossref","first-page":"339","DOI":"10.18388\/abp.2005_3447","article-title":"Direct tumor damage mechanisms of photodynamic therapy","volume":"52","author":"Nowis","year":"2005","journal-title":"Acta Biochim Pol"},{"issue":"7","key":"10.1016\/j.biopha.2015.02.008_bib0380","first-page":"677","article-title":"Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency","volume":"39","author":"Luksiene","year":"2003","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.biopha.2015.02.008_bib0385","series-title":"Proc of SPIE, vol. 7380","first-page":"73804F","article-title":"Improvement of antitumor activity of photodynamic therapy through inhibition of cytoprotective mechanism in tumor cells","author":"Nowis","year":"2009"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2015.02.008_bib0390","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0781.1997.tb00107.x","article-title":"Flow cytometry study of the role of superoxide anion and hydrogen peroxide in cellular photodestruction with 5-aminolevulinic acid-induced protoporphyrin IX","volume":"13","author":"Gilaberte","year":"1997","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.biopha.2015.02.008_bib0395","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(00)00256-4","article-title":"Role of nitric oxide for cancer therapy","volume":"3","author":"Lala","year":"2001","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0400","first-page":"1352","article-title":"Nitric oxide synthase activity in human gynecological cancer","volume":"54","author":"Thomsen","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2015.02.008_bib0405","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s003950050068","article-title":"Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infraction","volume":"93","author":"Ambrosio","year":"1998","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0410","first-page":"1551","article-title":"Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer","volume":"8","author":"Shi","year":"2013","journal-title":"Int J Nanomed"},{"issue":"6802","key":"10.1016\/j.biopha.2015.02.008_bib0415","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35030140","article-title":"Superoxide dismutase as a target for the selective killing of cancer cells","volume":"407","author":"Huang","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2015.02.008_bib0420","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0360-3016(00)00767-7","article-title":"Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wide-type p53 in non small-cell lung cancer","volume":"48","author":"Huober","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"10.1016\/j.biopha.2015.02.008_bib0425","first-page":"3443","article-title":"Photofrin and light induces microtubule depolymerization in cultured human endothelial cells","volume":"52","author":"Sporn","year":"1992","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.biopha.2015.02.008_bib0430","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbagen.2012.03.008","article-title":"Dynamics of signaling, cytoskeleton and cell cycle regulation proteins in glioblastoma cells after sub-lethal photodynamic treatment: antibody microarray study","volume":"1820","author":"Uzdensky","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2015.02.008_bib0435","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1089\/pho.2009.2561","article-title":"Cellular changes after photodynamic therapy on HEp-2 cells using the new ZnPcBr(8) phthalocyanine","author":"Machado","year":"2010","journal-title":"Photomed Laser Surg"},{"key":"10.1016\/j.biopha.2015.02.008_bib0440","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/jpp.59.1.0002","article-title":"Targeting nitric oxide for cancer therapy","volume":"59","author":"Hirst","year":"2007","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"10.1016\/j.biopha.2015.02.008_bib0445","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/med.20092","article-title":"Nitric oxide, a double-edged sword in cancer biology: searching for therapeutic opportunities","volume":"27","author":"Mocellin","year":"2007","journal-title":"Med Res Rev"},{"key":"10.1016\/j.biopha.2015.02.008_bib0450","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1054\/bjoc.2000.1157","article-title":"Nitric oxide production by tumor tissue","volume":"82","author":"Korbelik","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.biopha.2015.02.008_bib0455","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.niox.2013.01.002","article-title":"Nitric oxide-mediated activity in anti-cancer photodynamic therapy","volume":"30","author":"Rapozzi","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.biopha.2015.02.008_bib0460","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jphotobiol.2009.02.005","article-title":"It is nitric oxide important in photodynamic therapy?","volume":"95","author":"Reeves","year":"2009","journal-title":"J Photochem Photobiol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0465","first-page":"713","article-title":"Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability and leucocyte\u2013endothelial interactions","volume":"150","author":"Fukumura","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.biopha.2015.02.008_bib0470","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.freeradbiomed.2006.08.021","article-title":"Mitochondrial reactive oxygen species and nitric oxide-mediated cancer cell apoptosis in 2-butylamino-2-demethoksyhypocellin B photodynamic treatment","volume":"41","author":"Lu","year":"2006","journal-title":"Free Radic"},{"key":"10.1016\/j.biopha.2015.02.008_bib0475","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/bjc.1995.274","article-title":"Nitric oxide synthase activity in human breast cancer","volume":"72","author":"Thomsen","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.biopha.2015.02.008_bib0480","doi-asserted-by":"crossref","first-page":"e1302","DOI":"10.1038\/cddis.2014.264","article-title":"Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells","volume":"5","author":"Caneba","year":"2014","journal-title":"Cell Death Dis"},{"issue":"4","key":"10.1016\/j.biopha.2015.02.008_bib0485","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.semcancer.2005.04.004","article-title":"Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin","volume":"15","author":"Lechner","year":"2005","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"10.1016\/j.biopha.2015.02.008_bib0490","first-page":"75","article-title":"From pollutant gas to biological messenger: the diverse actions of nitric oxide in cancer","volume":"84","author":"Brennan","year":"2002","journal-title":"Ann R Coll Surg Engl"},{"issue":"12","key":"10.1016\/j.biopha.2015.02.008_bib0495","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/3957","article-title":"p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells","volume":"4","author":"Ambs","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.biopha.2015.02.008_bib0500","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2174\/156802606777811997","article-title":"Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators","volume":"6","author":"Brodsky","year":"2006","journal-title":"Curr Top Med Chem"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2015.02.008_bib0505","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1023\/A:1026036521852","article-title":"Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?","volume":"253","author":"Aliya","year":"2003","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"10.1016\/j.biopha.2015.02.008_bib0510","first-page":"1637","article-title":"Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter","volume":"60","author":"Luna","year":"2000","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.biopha.2015.02.008_bib0515","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2009.09.023","article-title":"A small molecule inhibitor of inducible heat shock protein 70","volume":"36","author":"Leu","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.biopha.2015.02.008_bib0520","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1158\/0008-5472.CAN-08-3439","article-title":"Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response","volume":"69","author":"Szokalska","year":"2009","journal-title":"Cancer Res"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215000578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215000578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:55:32Z","timestamp":1760093732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215000578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":52,"alternative-id":["S0753332215000578"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2015.02.008","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative modification induced by photodynamic therapy with Photofrin\u00aeII and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2015.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}