{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:13:11Z","timestamp":1762161191569,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"crossref","award":["502-14-02229373-10079"],"award-info":[{"award-number":["502-14-02229373-10079"]}],"id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.biopha.2015.07.001","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T21:32:06Z","timestamp":1438378326000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines"],"prefix":"10.1016","volume":"74","author":[{"given":"Karolina","family":"Wojtowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rados\u0142aw","family":"Januchowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Zabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9916","key":"10.1016\/j.biopha.2015.07.001_bib0175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0140-6736(13)62224-2","article-title":"Global cancer patterns: causes and prevention","volume":"383","author":"Vineis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2015.07.001_bib0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-60761-416-6_4","article-title":"Mechanisms of multidrug resistance in cancer","volume":"596","author":"Gillet","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fonc.2014.00041","article-title":"Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein function","volume":"4","author":"Sharom","year":"2014","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2015.07.001_bib0190","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2174\/1389203023380413","article-title":"Subcellular detection and localization of the drug transporter P-glycoprotein in cultured tumor cells","volume":"3","author":"Molinari","year":"2002","journal-title":"Curr. Protein Pept. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2015.07.001_bib0195","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.biopha.2013.03.011","article-title":"Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line","volume":"67","author":"Szaflarski","year":"2013","journal-title":"Biomed. Pharmacother."},{"year":"2009","series-title":"Essentials of Glycobiology","author":"Varki","key":"10.1016\/j.biopha.2015.07.001_bib0200"},{"key":"10.1016\/j.biopha.2015.07.001_bib0205","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/jnci\/80.7.506","article-title":"Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells","volume":"80","author":"Greenberger","year":"1988","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.biopha.2015.07.001_bib0210","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00280-005-1004-5","article-title":"Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP\/ABCG2)","volume":"56","author":"Mohrmann","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0215","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1111\/j.1742-4658.2009.07423.x","article-title":"Disruption of N-linked glycosylation enhances ubiquitin-mediates proteasomal degradation of the human ATP-binding cassette transporter ABCG2","volume":"276","author":"Nakagawa","year":"2009","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.biopha.2015.07.001_bib0220","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/aja.2013.24","article-title":"Breast cancer resistance protein (BCRP) and the testis\u2014an unexpected turn of events","volume":"15","author":"Qian","year":"2013","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.biopha.2015.07.001_bib0225","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1021\/bi0479858","article-title":"N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane","volume":"44","author":"Diop","year":"2005","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.biopha.2015.07.001_bib0230","doi-asserted-by":"crossref","first-page":"445","DOI":"10.18388\/abp.2012_2076","article-title":"Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P","volume":"59","author":"Wojtowicz","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0235","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1521-1878(199905)21:5<412::AID-BIES8>3.0.CO;2-5","article-title":"Protein glycosylation in development and disease","volume":"21","author":"Dennis","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.biopha.2015.07.001_bib0240","doi-asserted-by":"crossref","first-page":"7772","DOI":"10.3390\/ijms12117772","article-title":"Tunicamycin depresses P-glycoprotein glycosylation without an effect on its membrane localization and drug efflux activity in L1210 cells","volume":"12","author":"\u0160ere\u0161","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2015.07.001_bib0245","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1096\/fasebj.13.13.1724","article-title":"The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy","volume":"13","author":"Loo","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2015.07.001_bib0250","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/1471-2407-11-525","article-title":"Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines","volume":"11","author":"Grosso","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2015.07.001_bib0255","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s002320001020","article-title":"Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system","volume":"173","author":"Gribar","year":"2000","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0260","doi-asserted-by":"crossref","first-page":"241763","DOI":"10.1155\/2013\/241763","article-title":"MDR gene expression analysis of six drug-resistant ovarian cancer cell lines","volume":"2013","author":"Januchowski","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.biopha.2015.07.001_bib0265","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1126\/science.286.5446.1882","article-title":"Setting the standards: quality control in the secretory pathway","volume":"286","author":"Ellgaard","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.biopha.2015.07.001_bib0270","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1146\/annurev.biochem.73.011303.073752","article-title":"Roles of N-linked glycans in the endoplasmic reticulum","volume":"73","author":"Helenius","year":"2004","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.biopha.2015.07.001_bib0275","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2174\/138955706778195162","article-title":"Glycosylation pathways as drug targets for cancer: glycosidase inhibitors","volume":"6","author":"Gerber-Lemaire","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2015.07.001_bib0280","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0959-440X(95)80051-4","article-title":"Glycosylation inhibitors in biology and medicine","volume":"5","author":"Jacob","year":"1995","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2015.07.001_bib0285","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<279::AID-IJC18>3.0.CO;2-N","article-title":"Inhibition of N-linked glycosylation by tunicamycin enhances sensitivity to cisplatin in human head-and neck carcinoma cells","volume":"80","author":"Noda","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2015.07.001_bib0290","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1475-2867-7-5","article-title":"Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian cystadenocarcinoma cells","volume":"7","author":"Hiss","year":"2007","journal-title":"Cancer Cell Int."},{"issue":"47","key":"10.1016\/j.biopha.2015.07.001_bib0295","doi-asserted-by":"crossref","first-page":"44701","DOI":"10.1074\/jbc.M206047200","article-title":"Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation","volume":"277","author":"Song","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2015.07.001_bib0300","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jcp.1041140204","article-title":"The biochemical and ultrastructural effects of tunicamycin and d-glucosamine in L1210 leukemic cells","volume":"114","author":"Morin","year":"1983","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0305","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/bjc.1995.133","article-title":"Inhibition of N-linked glycosylation of P-glycoprotein by tunicamycin results in a reduced multidrug resistance phenotype","volume":"71","author":"Kramer","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biopha.2015.07.001_bib0310","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00280-010-1477-8","article-title":"Inhibition of N-linked glycosylation by tunicamycin induces E-cadherin-mediated cell-cell adhesion and inhibits cell proliferation in undifferentiated human colon cancer cells","volume":"68","author":"Madureira","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2015.07.001_bib0315","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1016\/S0021-9258(18)53199-9","article-title":"N-Glycosylation and deletion mutants of the human MDR1 P-glycoprotein","volume":"268","author":"Schinkel","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2015.07.001_bib0320","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/bjc.1993.177","article-title":"Constitutive expression of multidrug resistance in human colorectal tumors and cell lines","volume":"67","author":"Kramer","year":"1993","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biopha.2015.07.001_bib0325","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1042\/bj3530493","article-title":"Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells","volume":"353","author":"Liao","year":"2001","journal-title":"Biochem. J"},{"issue":"5","key":"10.1016\/j.biopha.2015.07.001_bib0330","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/iub.1133","article-title":"Functional roles of glycogene and N-glycan in multidrug resistance of human breast cancer cells","volume":"65","author":"Ma","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2015.07.001_bib0335","first-page":"205","article-title":"Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flip recombinase system","volume":"5","author":"Wakabayashi","year":"2006","journal-title":"J. Exp. Ther. Oncol."},{"key":"10.1016\/j.biopha.2015.07.001_bib0340","doi-asserted-by":"crossref","first-page":"36926","DOI":"10.1074\/jbc.M502937200","article-title":"Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2","volume":"280","author":"Henriksen","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215001444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215001444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:56:30Z","timestamp":1760093790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215001444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":34,"alternative-id":["S0753332215001444"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2015.07.001","relation":{},"ISSN":["0753-3322"],"issn-type":[{"type":"print","value":"0753-3322"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2015.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}