{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:27:07Z","timestamp":1767968827419,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270514"],"award-info":[{"award-number":["81270514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31571455"],"award-info":[{"award-number":["31571455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31401210"],"award-info":[{"award-number":["31401210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Natural Science Foundation of Jiangsu Province","award":["BK20140955"],"award-info":[{"award-number":["BK20140955"]}]},{"name":"Natural Science Research General Program of Jiangsu Higher Education Institutions","award":["14KJB310011"],"award-info":[{"award-number":["14KJB310011"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["ysxk-2010"],"award-info":[{"award-number":["ysxk-2010"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.biopha.2016.01.018","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T15:59:02Z","timestamp":1454428742000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes"],"prefix":"10.1016","volume":"78","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanhuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangjuan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiafei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2016.01.018_bib0005","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1053\/j.gastro.2014.01.020","article-title":"Interactions between the intestinal microbiome and liver diseases","volume":"146","author":"Schnabl","year":"2014","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0010","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/hep.23917","article-title":"The role of intestinal endotoxin in liver injury: a long and evolving history","volume":"52","author":"Nolan","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2016.01.018_bib0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.5217\/ir.2014.12.2.90","article-title":"Lipopolysaccharide: basic biochemistry, intracellular signaling, and physiological impacts in the gut","volume":"12","author":"Rhee","year":"2014","journal-title":"Intest. Res."},{"key":"10.1016\/j.biopha.2016.01.018_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"2","key":"10.1016\/j.biopha.2016.01.018_bib0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0030","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s10875-010-9440-3","article-title":"Molecular mechanism of NLRP3 inflammasome activation","volume":"30","author":"Jin","year":"2010","journal-title":"J. Clin. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2016.01.018_bib0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2016.01.018_bib0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.24341","article-title":"Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.biopha.2016.01.018_bib0045","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.biopha.2016.01.018_bib0050","first-page":"305","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.biopha.2016.01.018_bib0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.taap.2012.09.016","article-title":"Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-beta receptor-mediated ERK and p38 pathways","volume":"265","author":"Zhang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2016.01.018_bib0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mce.2013.09.020","article-title":"Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K\/AKT and ERK pathways","volume":"382","author":"Zhang","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"12","key":"10.1016\/j.biopha.2016.01.018_bib0065","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1111\/febs.12818","article-title":"Tetramethylpyrazine inhibits angiotensin II-induced activation of hepatic stellate cells associated with interference of platelet-derived growth factor beta receptor pathways","volume":"281","author":"Zhang","year":"2014","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.biopha.2016.01.018_bib0070","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1055\/s-2002-32569","article-title":"Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury","volume":"68","author":"Liu","year":"2002","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.biopha.2016.01.018_bib0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1124\/mol.110.068064","article-title":"TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules","volume":"79","author":"Matsunaga","year":"2011","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0080","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jhep.2012.11.023","article-title":"The gut microbiota and the liver: pathophysiological and clinical implications","volume":"58","author":"Quigley","year":"2013","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.biopha.2016.01.018_bib0085","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0168-8278(91)90933-3","article-title":"Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay","volume":"12","author":"Fukui","year":"1991","journal-title":"J. Hepatol."},{"issue":"6 Pt 1","key":"10.1016\/j.biopha.2016.01.018_bib0090","first-page":"G1252","article-title":"Role of endotoxin in the hypermetabolic state after acute ethanol exposure","volume":"275","author":"Rivera","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"7","key":"10.1016\/j.biopha.2016.01.018_bib0095","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1872-034X.2012.00972.x","article-title":"Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats","volume":"42","author":"Fan","year":"2012","journal-title":"Hepatol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2016.01.018_bib0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jhep.2009.02.032","article-title":"Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model","volume":"51","author":"Kudo","year":"2009","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0105","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2004.05.004","article-title":"Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases","volume":"117","author":"Martinon","year":"2004","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.biopha.2016.01.018_bib0110","first-page":"29","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0115","first-page":"19","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2016.01.018_bib0120","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1073\/pnas.94.6.2557","article-title":"Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis","volume":"94","author":"Yang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1-2","key":"10.1016\/j.biopha.2016.01.018_bib0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0378-5173(01)00572-5","article-title":"Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis","volume":"216","author":"Tsai","year":"2001","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.biopha.2016.01.018_bib0130","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/BF02256534","article-title":"Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity","volume":"9","author":"So","year":"2002","journal-title":"J. Biomed. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2016.01.018_bib0135","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1440-1746.2011.06661.x","article-title":"Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum","volume":"26","author":"Chen","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.biopha.2016.01.018_bib0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.burns.2015.02.010","article-title":"Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats","volume":"41","author":"Wang","year":"2015","journal-title":"Burns"},{"issue":"8","key":"10.1016\/j.biopha.2016.01.018_bib0145","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nri3713","article-title":"Assembly and localization of Toll-like receptor signalling complexes","volume":"14","author":"Gay","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2016.01.018_bib0150","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.it.2012.03.001","article-title":"Toll-like receptor (TLR) and inflammasome actions in the central nervous system","volume":"33","author":"Hanamsagar","year":"2012","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2016.01.018_bib0155","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbrc.2015.05.088","article-title":"Tetramethylpyrazine inhibits neutrophil activation following permanent cerebral ischemia in rats","volume":"463","author":"Chang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215301293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215301293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:02:07Z","timestamp":1760094127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215301293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":31,"alternative-id":["S0753332215301293"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.01.018","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligustrazine disrupts lipopolysaccharide-activated NLRP3 inflammasome pathway associated with inhibition of Toll-like receptor 4 in hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}