{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:34:17Z","timestamp":1770834857484,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.biopha.2016.02.002","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:28:14Z","timestamp":1455496094000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Protective effects of propolis on methotrexate-induced testis injury in rat"],"prefix":"10.1016","volume":"79","author":[{"given":"Mehmet Fatih","family":"S\u00f6nmez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra Tu\u011f\u00e7e","family":"\u00c7ilenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunay","family":"\u00dcnalm\u0131\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkan","family":"Delig\u00f6n\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smet","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Kaymak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.02.002_bib0005","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/humupd\/7.4.394","article-title":"Genetic and teratogenic effects of cancer treatments on gametes and embryos","volume":"7","author":"Arnon","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.biopha.2016.02.002_bib0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejphar.2014.02.010","article-title":"The effects of different doses of silibinin in combination with methotrexate on testicular tissue of mice","volume":"730","author":"Oufi","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0015","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/cncr.20255","article-title":"High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma","volume":"100","author":"Widemann","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2016.02.002_bib0020","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0049-0172(91)90032-U","article-title":"Long-term methotrexate therapy for rheumatoid arthritis","volume":"20","author":"Scully","year":"1991","journal-title":"Semin. Arthr. Rheum."},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2016.02.002_bib0025","first-page":"S5","article-title":"Mechanisms of action of methotrexate","volume":"71","author":"Chan","year":"2013","journal-title":"Bull. Hosp. Jt. Dis."},{"key":"10.1016\/j.biopha.2016.02.002_bib0030","first-page":"5511","article-title":"Protective effects of carvacrol against methotrexate-induced testicular toxicity in rats","volume":"7","author":"Daggulli","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2016.02.002_bib0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1191\/0748233706th265oa","article-title":"Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester","volume":"22","author":"Oktem","year":"2006","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.biopha.2016.02.002_bib0040","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0960327108092293","article-title":"Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat","volume":"27","author":"Armagan","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1439-0272.2008.00897.x","article-title":"Effect of growth hormone on testicular dysfunction induced by methotrexate in rats","volume":"41","author":"Nouri","year":"2009","journal-title":"Andrologia"},{"key":"10.1016\/j.biopha.2016.02.002_bib0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2014.02.031","article-title":"Propolis attenuates doxorubicin-induced testicular toxicity in rats","volume":"67","author":"Rizk","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0278-6915(97)00145-2","article-title":"Review of the biological properties and toxicity of bee propolis (propolis)","volume":"36","author":"Burdock","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0060","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1021\/jf305468f","article-title":"Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis","volume":"61","author":"Bueno-Silva","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2016.02.002_bib0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1379\/CSC-99r.1","article-title":"Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications","volume":"10","author":"Ciocca","year":"2005","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.biopha.2016.02.002_bib0070","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jbt.10086","article-title":"Heat shock response: hsp70 in environmental monitoring","volume":"17","author":"Mukhopadhyay","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0075","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.indcrop.2015.01.064","article-title":"A detailed study on the chemical and biological profiles of essential oil and methanol extract of Thymus nummularius (Anzer tea): Rosmarinic acid","volume":"67","author":"Ertas","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.biopha.2016.02.002_bib0080","first-page":"2","article-title":"Testicular biopsy score count\u2014a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"10.1016\/j.biopha.2016.02.002_bib0085","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1742-7843.2009.00469.x","article-title":"Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta","volume":"105","author":"Sonmez","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0090","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00345-013-1049-8","article-title":"The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: an experimental study","volume":"31","author":"Bayatli","year":"2013","journal-title":"World J. Urol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0095","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2016.02.002_bib0100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-5793(75)80385-1","article-title":"Malignant transformation-linked imbalance: decreased xanthine oxidase activity in hepatomas","volume":"59","author":"Prajda","year":"1975","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biopha.2016.02.002_bib0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cccn.2005.04.025","article-title":"Protective effect of lipoic acid on adriamycin-induced testicular toxicity","volume":"360","author":"Prahalathan","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2016.02.002_bib0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-079X.2006.00327.x","article-title":"Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats","volume":"41","author":"Atessahin","year":"2006","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2016.02.002_bib0115","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.fertnstert.2008.09.015","article-title":"Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury","volume":"92","author":"Vardi","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.biopha.2016.02.002_bib0120","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10585-005-5377-y","article-title":"Low-dose methotrexate inhibits lung metastasis and lengthens survival in rat osteosarcoma","volume":"22","author":"Tomoda","year":"2005","journal-title":"Clin. Exp. Metastas."},{"key":"10.1016\/j.biopha.2016.02.002_bib0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/07435800009066165","article-title":"Studies on methotrexate effects on testicular steroidogenesis in rats","volume":"26","author":"Badri","year":"2000","journal-title":"Endocr. Res."},{"key":"10.1016\/j.biopha.2016.02.002_bib0130","first-page":"230","article-title":"Effect of methotrexate (MTX) administration on spermatogenesis: an experimental on animal model","volume":"9","author":"Shrestha","year":"2007","journal-title":"Nepal Med. Coll. J."},{"key":"10.1016\/j.biopha.2016.02.002_bib0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2605.2002.00341.x","article-title":"Involvement of Fas system and active caspases in apoptotic signalling in testicular germ cells of ethanol-treated rats","volume":"25","author":"Eid","year":"2002","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.biopha.2016.02.002_bib0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mrgentox.2008.11.011","article-title":"Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid","volume":"673","author":"Padmanabhan","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.02.002_bib0145","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1021\/np000143z","article-title":"Two novel cytotoxic benzofuran derivatives from Brazilian propolis","volume":"63","author":"Banskota","year":"2000","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2016.02.002_bib0150","first-page":"22","article-title":"Biological activity of bee propolis in health and disease","volume":"7","author":"Khalil","year":"2006","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biopha.2016.02.002_bib0155","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.fct.2009.02.006","article-title":"Propolis protection from reproductive toxicity caused by aluminium chloride in male rats","volume":"47","author":"Yousef","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0160","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1021\/jf0612023","article-title":"Oxidant\/antioxidant properties of Croatian native propolis","volume":"54","author":"Sobocanec","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2016.02.002_bib0165","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jep.2006.10.023","article-title":"In vivo study of propolis supplementation effects on antioxidative status and red blood cells","volume":"110","author":"Jasprica","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10616-013-9568-0","article-title":"Assessment of anti-mutagenic, anti-histopathologic and antioxidant capacities of Egyptian bee pollen and propolis extracts","volume":"66","author":"Tohamy","year":"2014","journal-title":"Cytotechnology"},{"key":"10.1016\/j.biopha.2016.02.002_bib0175","first-page":"S2","article-title":"Testosterone plays a limited role in cocaine-induced conditioned place preference and locomotor activity in male rats","volume":"18","author":"Minerly","year":"2008","journal-title":"Ethn. Dis."},{"key":"10.1016\/j.biopha.2016.02.002_bib0180","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.3748\/wjg.v13.i13.1953","article-title":"Protective effect of curcumin against liver warm ischemia\/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes","volume":"13","author":"Shen","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0185","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1016\/j.fct.2012.07.060","article-title":"Deltamethrin-induced genotoxicity and testicular injury in rats: comparison with biopesticide","volume":"50","author":"Ismail","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.02.002_bib0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2131\/jts.30.111","article-title":"Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants","volume":"30","author":"Yamamoto","year":"2005","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.biopha.2016.02.002_bib0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/ror.0.0040023","article-title":"Role of heat shock protein HSP 70-2 in spermatogenesis","volume":"4","author":"Eddy","year":"1999","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.biopha.2016.02.002_bib0200","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10815-013-0165-0","article-title":"Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp 70-2 protein expression and ameliorated biochemical alterations","volume":"31","author":"Khosravanian","year":"2014","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215301852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215301852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:59:35Z","timestamp":1760093975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215301852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":40,"alternative-id":["S0753332215301852"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.02.002","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of propolis on methotrexate-induced testis injury in rat","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}