{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:08:43Z","timestamp":1788880123849,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.biopha.2016.03.038","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T14:45:41Z","timestamp":1460472341000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice"],"prefix":"10.1016","volume":"81","author":[{"given":"Lijuan","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangYun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.03.038_bib0005","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pharmthera.2009.11.001","article-title":"Glycaemic control in type 2 diabetes: targets and new therapies","volume":"125","author":"Tahrani","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2016.03.038_bib0010","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nature11808","article-title":"Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP","volume":"494","author":"Miller","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.03.038_bib0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijcard.2011.08.072","article-title":"Rosiglitazone induces arrhythmogenesis in diabetic hypertensive rats with calcium handling alteration","volume":"165","author":"Lee","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2016.03.038_bib0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/414821a","article-title":"New drug targets for type 2 diabetes and the metabolic syndrome","volume":"414","author":"Moller","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.03.038_bib0025","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.bbagrm.2010.06.004","article-title":"Small molecules from natural sources, targeting signaling pathways in diabetes","volume":"1799","author":"Liu","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2016.03.038_bib0030","first-page":"1257","article-title":"Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions","volume":"55","author":"Prieto","year":"2003","journal-title":"J. Pharm. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2016.03.038_bib0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11130-006-0023-7","article-title":"Hypoglycemic and hypocholesterolemic effects of Coptis chinensis franch inflorescence","volume":"61","author":"Yuan","year":"2006","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.biopha.2016.03.038_bib0040","first-page":"326","article-title":"The effect of Coptis chinensis on the signaling network in the squamous carcinoma cells","volume":"1","author":"Wang","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biopha.2016.03.038_bib0045","first-page":"548","article-title":"Effect of jatrorrhizine, berberine, huanglian decoction and compound-mimic prescription on blood glucose in mice","volume":"36","author":"Fu","year":"2005","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.biopha.2016.03.038_bib0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1142\/S0192415X11008646","article-title":"Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats","volume":"39","author":"Zheng","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2016.03.038_bib0055","first-page":"1855","article-title":"Pharmacodyamic material basis of Rhizoma Coptidis on insulin resistance","volume":"35","author":"Li","year":"2010","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.biopha.2016.03.038_bib0060","first-page":"346","article-title":"Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects","volume":"2","author":"Jung","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.biopha.2016.03.038_bib0065","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jnutbio.2012.03.004","article-title":"The role of dietary fatty acids in the pathology of metabolic syndrome","volume":"23","author":"Lottenberg","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2016.03.038_bib0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2013.00071","article-title":"Adipokines mediate inflammation and insulin resistance","volume":"4","author":"Kwon","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biopha.2016.03.038_bib0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/CS20050182","article-title":"A key adipocytokine in metabolic syndrome","volume":"110","author":"Okamoto","year":"2006","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2016.03.038_bib0080","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biopha.2016.03.038_bib0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-2001-17297","article-title":"Rodent obesity models: an overview","volume":"109","author":"Tschop","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.biopha.2016.03.038_bib0090","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.ijo.0801209","article-title":"Development of high fat diet-induced obesity and leptin resistance in C57Bl\/6J mice","volume":"24","author":"Lin","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.biopha.2016.03.038_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2012.08.036","article-title":"Functional and structural features of adipokine family","volume":"61","author":"Raucci","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.biopha.2016.03.038_bib0100","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.biopha.2016.03.038_bib0105","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/nu4101367","article-title":"Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models","volume":"4","author":"Omar","year":"2012","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2016.03.038_bib0110","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.03.038_bib0115","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Canto","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.03.038_bib0120","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/07853890.2010.547211","article-title":"Sirtuin 1 in lipid metabolism and obesity","volume":"43","author":"Schug","year":"2011","journal-title":"Ann. Med."},{"key":"10.1016\/j.biopha.2016.03.038_bib0125","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1248\/bpb.33.1494","article-title":"7-O-methylaromadendrin stimulates glucose uptake and improves insulin resistance in vitro","volume":"33","author":"Zhang","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2016.03.038_bib0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2007.03.006","article-title":"The GLUT4 glucose transporter","volume":"5","author":"Huang","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2016.03.038_bib0135","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in health and disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2016.03.038_bib0140","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: an emerging drug target for diabetes and the metabolic syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2016.03.038_bib0145","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2016.03.038_bib0150","doi-asserted-by":"crossref","first-page":"29060","DOI":"10.1074\/jbc.M503824200","article-title":"The Ca2+\/Calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases","volume":"280","author":"Hurley","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.03.038_bib0155","doi-asserted-by":"crossref","first-page":"31880","DOI":"10.1074\/jbc.273.48.31880","article-title":"Components of a calmodulin-dependent protein kinase cascade Molecular cloning, functional characterization and cellular localization of Ca2+\/calmodulin-dependent protein kinase \u03b2","volume":"273","author":"Anderson","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.03.038_bib0160","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cmet.2008.02.011","article-title":"Hypothalamic CaMKK2Contributes to the regulation of energy balance","volume":"7","author":"Anderson","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2016.03.038_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2005.11.009","article-title":"Chutes and Ladders The search for protein kinases that act on AMPK","volume":"31","author":"Witters","year":"2006","journal-title":"Trends Biochem. Sci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221530127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221530127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:31:34Z","timestamp":1788877894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221530127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":33,"alternative-id":["S075333221530127X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.03.038","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The inhibiting effect of the Coptis chinensis polysaccharide on the type II diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.03.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}