{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:08:36Z","timestamp":1788880116637,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.biopha.2016.03.052","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T09:03:48Z","timestamp":1460192628000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Embryonic develop-associated gene 1 is overexpressed and acts as a tumor promoter in thyroid carcinoma"],"prefix":"10.1016","volume":"81","author":[{"given":"Jinkai","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.03.052_bib0005","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1001\/jama.295.18.2164","article-title":"Increasing incidence of thyroid cancer in the United States, 1973\u20132002","volume":"295","author":"Louise","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2016.03.052_bib0010","first-page":"277","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.biopha.2016.03.052_bib0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13046-015-0132-y","article-title":"Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis","volume":"34","author":"Zhang","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2016.03.052_bib0020","article-title":"Screening of RET gene mutations in Chinese patients with medullary thyroid carcinoma and their relatives","author":"Wang","year":"2015","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.biopha.2016.03.052_bib0025","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3892\/ijmm.2015.2305","article-title":"The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma","volume":"36","author":"Zhao","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2016.03.052_bib0030","doi-asserted-by":"crossref","first-page":"571480","DOI":"10.1155\/2015\/571480","article-title":"The benefits and risks of prophylactic central neck dissection for papillary thyroid carcinoma: prospective cohort study","volume":"2015","author":"Lee","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.biopha.2016.03.052_bib0035","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/1471-2407-13-462","article-title":"Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K\/Akt signaling pathway","volume":"13","author":"Fu","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2016.03.052_bib0040","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.prp.2012.06.011","article-title":"Evaluation of MMP2 and Caspase-3 expression in 107 cases of papillary thyroid carcinoma and its association with prognostic factors","volume":"209","author":"Saffar","year":"2013","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biopha.2016.03.052_bib0045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/cgt.2010.18","article-title":"MicroRNA and drug resistance","volume":"17","author":"Ma","year":"2010","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.biopha.2016.03.052_bib0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0925-4773(01)00376-8","article-title":"Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms","volume":"104","author":"Yang","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.biopha.2016.03.052_bib0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.leu.2404105","article-title":"The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells","volume":"20","author":"Yang","year":"2006","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.biopha.2016.03.052_bib0060","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bbagrm.2008.06.004","article-title":"Suppression of EDAG gene expression by phorbol 12-myristate 13-acetate is mediated through down-regulation of GATA-1","volume":"1779","author":"Li","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2016.03.052_bib0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ecl.2007.06.001","article-title":"Thyroid cancer molecular signaling pathways and use of targeted therapy","volume":"36","author":"Kundra","year":"2007","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.biopha.2016.03.052_bib0070","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood.V82.8.2517.2517","article-title":"Constitutive expression of interleukin-8 and its receptor in human myeloid and lymphoid leukemia","volume":"82","author":"Tobler","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2016.03.052_bib0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1358\/dnp.2006.19.4.985934","article-title":"NF-kappaB as a potential strategy to treat adult T-cell leukemia\/lymphoma","volume":"19","author":"Horie","year":"2006","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.biopha.2016.03.052_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/384213","article-title":"Recent advances in molecular diagnosis of thyroid cancer","volume":"2011","author":"Legakis","year":"2011","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.biopha.2016.03.052_bib0085","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2265.2007.03008.x","article-title":"Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake","volume":"68","author":"Mian","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.biopha.2016.03.052_bib0090","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1091\/mbc.e04-02-0089","article-title":"Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2","volume":"16","author":"Adamson","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biopha.2016.03.052_bib0095","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2013.09.048","article-title":"Growth inhibitory effects of three miR-129 family members on gastric cancer","volume":"532","author":"Yu","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2016.03.052_bib0100","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.leu.2404105","article-title":"The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells","volume":"20","author":"Yang","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.biopha.2016.03.052_bib0105","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/stem.1723","article-title":"EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300","volume":"32","author":"Zheng","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.biopha.2016.03.052_bib0110","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/sj.leu.2404901","article-title":"Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice","volume":"21","author":"Li","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.biopha.2016.03.052_bib0115","first-page":"2070","article-title":"Glial cell line-derived neurotrophic factor promotes proliferation of neuroglioma cells by up-regulation of cyclins PCNA and Ki-67","volume":"19","author":"Qu","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2016.03.052_bib0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10238-009-0031-7","article-title":"Significance of survivin, caspase-3, and VEGF expression in thyroid carcinoma","volume":"9","author":"Zhang","year":"2009","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2016.03.052_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/002215540004800106","article-title":"Matilde todaro, fabio bucchieri, giovanni peri, giovanni zummo, and giorgio stassi: involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in farber disease","volume":"48","author":"Felicia Farina","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.biopha.2016.03.052_bib0130","doi-asserted-by":"crossref","first-page":"279ra40","DOI":"10.1126\/scitranslmed.aaa4642","article-title":"Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy","volume":"7","author":"Leverson","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2016.03.052_bib0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3892\/etm.2015.2501","article-title":"Paeoniflorin inhibits nucleus pulposus cell apoptosis by regulating the expression of Bcl-2 family proteins and caspase-9 in a rabbit model of intervertebral disc degeneration","volume":"10","author":"Shi","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2016.03.052_bib0140","first-page":"95","article-title":"Overexpression of EDAG-1 in NIH3T3 cells leads to malignant transformation","volume":"34","author":"L\u00fc","year":"2002","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.biopha.2016.03.052_bib0145","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/sj.cdd.4401490","article-title":"EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-\u03baB","volume":"11","author":"Li","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2016.03.052_bib0150","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2016.03.052_bib0155","doi-asserted-by":"crossref","first-page":"E577","DOI":"10.1210\/jc.2010-2644","article-title":"The Akt-specific inhibitor MK2206 selectively inhibits thyroid cancer cells harboring mutations that can activate the PI3K\/Akt pathway","volume":"96","author":"Ruixin","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2016.03.052_bib0160","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2741\/3696","article-title":"A minireview: the role of MAPK\/ERK and PI3K\/Akt pathways in thyroid follicular cell-derived neoplasm","volume":"16","author":"Brzezianska","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biopha.2016.03.052_bib0165","first-page":"126","article-title":"Targeting the PI3K\/AKT pathway for the treatment of gastric cancer","volume":"3","author":"Liu","year":"2014","journal-title":"Chemotherapy"},{"key":"10.1016\/j.biopha.2016.03.052_bib0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00432-003-0505-z","article-title":"Inhibition of the PI3K-akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45","volume":"130","author":"Osaki","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biopha.2016.03.052_bib0175","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10620-010-1294-2","article-title":"Targeting PI3K\/Akt\/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis","volume":"56","author":"Redlak","year":"2011","journal-title":"Digest. Dis. Sci."},{"key":"10.1016\/j.biopha.2016.03.052_bib0180","first-page":"E1600","article-title":"p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer","volume":"2013","author":"McFadden","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2016.03.052_bib0185","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbrc.2013.11.010","article-title":"MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K\/Akt\/Bad pathway","volume":"441","author":"Ma","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215304364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215304364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:30:00Z","timestamp":1788877800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215304364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":37,"alternative-id":["S0753332215304364"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.03.052","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embryonic develop-associated gene 1 is overexpressed and acts as a tumor promoter in thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.03.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}