{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:08:54Z","timestamp":1788880134083,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.biopha.2016.04.036","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T22:32:45Z","timestamp":1461882765000},"page":"402-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid"],"prefix":"10.1016","volume":"81","author":[{"given":"Sakshi","family":"Piplani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.04.036_bib0005","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.med.45.1.379","article-title":"Mechanisms of epilepsy","volume":"45","author":"McNamara","year":"1994","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biopha.2016.04.036_bib0010","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.seizure.2010.10.026","article-title":"Advances in understanding basic mechanisms of epilepsy and seizures","volume":"19","author":"Jefferys","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.biopha.2016.04.036_bib0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1054\/jocn.2002.1133","article-title":"Valproate and neuroprotection","volume":"9","author":"Vajda","year":"2002","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.biopha.2016.04.036_bib0020","first-page":"1","article-title":"A scientific review: mechanisms of valproate-mediated teratogenesis","volume":"6","author":"Llyod","year":"2013","journal-title":"Biosci. Horiz."},{"key":"10.1016\/j.biopha.2016.04.036_bib0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0773.1991.tb01303.x","article-title":"Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms","volume":"69","author":"Nau","year":"1991","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1528-1157.1984.tb05632.x","article-title":"Valproic acid and metabolites: pharmacological and toxicological studies","volume":"25","author":"Nau","year":"1984","journal-title":"Epilepsia"},{"key":"10.1016\/j.biopha.2016.04.036_bib0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1527-3458.2003.tb00249.x","article-title":"Valproate: past, present and future","volume":"9","author":"Johannesen","year":"2003","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.biopha.2016.04.036_bib0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0301-0082(98)00075-6","article-title":"Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action","volume":"58","author":"L\u00f6scher","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1874467210902010095","article-title":"Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection","volume":"2","author":"Monti","year":"2009","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0301-0082(82)90010-7","article-title":"Mechanism of anticonvulsant action of valproate","volume":"19","author":"Chapman","year":"1982","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0055","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/0006-2952(81)90323-3","article-title":"Valproate induced changes in GABA metabolism at the subcellular level","volume":"30","author":"L\u00f6scher","year":"1981","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.nurt.2006.11.007","article-title":"Valproic acid: second generation","volume":"4","author":"Bialer","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.biopha.2016.04.036_bib0065","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/j.1471-4159.1978.tb06572.x","article-title":"Effects of the anticonvulsant sodium valproate on gamma-aminobutyrate and aldehyde metabolism in ox brain","volume":"31","author":"Whittle","year":"1978","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2016.04.036_bib0070","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1471-4159.1981.tb00595.x","article-title":"Effect of inhibitors of GABA aminotransferase on the metabolism of GABA in brain tissue and synaptosomal fractions","volume":"36","author":"L\u00f6scher","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2016.04.036_bib0075","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0006-2952(82)90471-3","article-title":"Anticonvulsant and biochemical effects of inhibitors of GABA aminotransferase and valproic acid during subchronic treatment in mice","volume":"31","author":"L\u00f6scher","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0080","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0006-8993(89)91044-5","article-title":"Valproate enhances GABA turnover in the substantia nigra","volume":"501","author":"L\u00f6scher","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2016.04.036_bib0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00967253","article-title":"Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain","volume":"18","author":"L\u00f6scher","year":"1993","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2016.04.036_bib0090","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00964170","article-title":"Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities","volume":"9","author":"Battistin","year":"1984","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2016.04.036_bib0095","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI114877","article-title":"Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites-possible mechanism of anticonvulsant and toxic actions","volume":"86","author":"Luder","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2016.04.036_bib0100","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nrd1549","article-title":"Docking and scoring in virtual screening for drug discovery: methods and applications","volume":"3","author":"Kitchen","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2016.04.036_bib0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Comput.-Aided Drug Des."},{"key":"10.1016\/j.biopha.2016.04.036_bib0110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12551-013-0130-2","article-title":"Receptor\u2fffligand molecular docking","volume":"6","author":"Guedes","year":"2014","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.biopha.2016.04.036_bib0115","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2174\/187152712800269669","article-title":"Molecular interaction of the antineoplastic drug, methotrexate with human brain acetylcholinesterase: a docking study","volume":"11","author":"Shakil","year":"2012","journal-title":"CNS Neurol. Disord.\u2fffDrug."},{"key":"10.1016\/j.biopha.2016.04.036_bib0120","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2fffa visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.biopha.2016.04.036_bib0125","first-page":"27","article-title":"Force fields for protein simulations","volume":"66","author":"Ponder","year":"2003","journal-title":"Adv. Prot. Chem."},{"key":"10.1016\/j.biopha.2016.04.036_bib0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0076-6879(03)74020-8","article-title":"Modeller: generation and refinement of homology-based protein structure models","volume":"374","author":"Fiser","year":"2003","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biopha.2016.04.036_bib0140","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/prot.21715","article-title":"QMEAN: a comprehensive scoring function for model quality assessment","volume":"71","author":"Benkert","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.biopha.2016.04.036_bib0145","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1006\/jmbi.1998.1665","article-title":"Assessing protein structures with a non-local atomic interaction energy","volume":"277","author":"Melo","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biopha.2016.04.036_bib0150","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1110\/ps.0217002","article-title":"Distance-scaled, finite ideal-gas reference state improves structure-derived potentials of mean force for structure selection and stability prediction","volume":"11","author":"Zhou","year":"2002","journal-title":"Protein Sci."},{"key":"10.1016\/j.biopha.2016.04.036_bib0155","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"key":"10.1016\/j.biopha.2016.04.036_bib0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","article-title":"Assessment of protein models with three-dimensional profiles","volume":"356","author":"Luthy","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.04.036_bib0165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.biopha.2016.04.036_bib0170","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.biopha.2016.04.036_bib0175","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"Ligplot+: multiple ligand protein interaction diagram for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.biopha.2016.04.036_bib0180","article-title":"Goodman & Gilman\u2fffs the pharmacological basis of therapeutics","volume":"vol. 12e","author":"Brunton","year":"2011"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215303474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215303474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:30:06Z","timestamp":1788877806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215303474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":36,"alternative-id":["S0753332215303474"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.04.036","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.04.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}