{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:26:01Z","timestamp":1787509561333,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biopha.2016.06.034","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T07:15:30Z","timestamp":1468048530000},"page":"330-339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-\u03b1, IL-1\u03b2 and NF-\u03baB inflammatory cytokine networks in elderly spontaneously hypertensive rats"],"prefix":"10.1016","volume":"83","author":[{"given":"Jingchao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2016.06.034_bib0005","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1161\/HYPERTENSIONAHA.107.087890","article-title":"Left ventricular hypertrophy, subclinical atherosclerosis, and inflammation","volume":"49","author":"Mehta","year":"2007","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.biopha.2016.06.034_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.coph.2004.01.004","article-title":"Inflammation in the cardiovascular system: here, there and everywhere","volume":"4","author":"Badr","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2016.06.034_bib0015","first-page":"802","article-title":"Increased levels of inflammatory markers in hypertensives with target organ damage","volume":"64","author":"Jastrzebski","year":"2006","journal-title":"Kardiol. Pol."},{"issue":"2","key":"10.1016\/j.biopha.2016.06.034_bib0020","first-page":"286","article-title":"Colocalization of myocardial fibrosis and inflammatory cells in rats","volume":"70","author":"Hinglais","year":"1994","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.biopha.2016.06.034_bib0025","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0008-6363(96)00158-7","article-title":"Inflammatory cells and myocardial fibrosis: spatial and temporal distribution in renovascular hypertensive rats","volume":"32","author":"Nicoletti","year":"1996","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.biopha.2016.06.034_bib0030","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1097\/00004872-200310000-00022","article-title":"A role for cardiac mast cells in the pathogenesis of hypertensive heart disease","volume":"21","author":"Shiota","year":"2003","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.biopha.2016.06.034_bib0035","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.81.5.664","article-title":"Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload","volume":"81","author":"Shioi","year":"1997","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2016.06.034_bib0040","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/01.HYP.0000118584.33350.7d","article-title":"Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation?","volume":"43","author":"Kuwahara","year":"2004","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.biopha.2016.06.034_bib0045","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.106.643585","article-title":"Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state","volume":"115","author":"Sun","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biopha.2016.06.034_bib0050","doi-asserted-by":"crossref","first-page":"H1712","DOI":"10.1152\/ajpheart.00124.2004","article-title":"NF-kappaB activation is required for the development of cardiac hypertrophy in vivo","volume":"287","author":"Li","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2016.06.034_bib0055","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.yjmcc.2006.07.006","article-title":"Regulating the regulator: NF-kappaB signaling in heart","volume":"41","author":"Hall","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.biopha.2016.06.034_bib0060","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.biopha.2016.06.034_bib0065","doi-asserted-by":"crossref","first-page":"16304","DOI":"10.1074\/jbc.M212321200","article-title":"JAK2\/STAT3, not ERK1\/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes","volume":"278","author":"Yu","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2016.06.034_bib0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1254\/jjp.89.157","article-title":"Amlodipine inhibits pro-inflammatory cytokines and free radical production and inducible nitric oxide synthase expression in lipopolysaccharide\/interferon-gamma-stimulated cultured vascular smooth muscle cells","volume":"89","author":"Chou","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2016.06.034_bib0075","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1291\/hypres.29.457","article-title":"Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions","volume":"29","author":"Yoshii","year":"2006","journal-title":"Hypertens. Res."},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2016.06.034_bib0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00003495-200464002-00006","article-title":"Statins in hypertensive patients: potential explanations for the ASCOT-LLA study results","volume":"64","author":"Blanco-Colio","year":"2004","journal-title":"Drugs"},{"issue":"8","key":"10.1016\/j.biopha.2016.06.034_bib0085","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0022-2828(03)00180-9","article-title":"3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats","volume":"35","author":"Hasegawa","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"7","key":"10.1016\/j.biopha.2016.06.034_bib0090","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1161\/hc3401.093154","article-title":"Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor","volume":"104","author":"Sivasubramanian","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biopha.2016.06.034_bib0095","doi-asserted-by":"crossref","first-page":"H960","DOI":"10.1152\/ajpheart.0718.2001","article-title":"Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-alpha","volume":"284","author":"Janczewski","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2016.06.034_bib0100","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI118095","article-title":"Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes","volume":"96","author":"Thaik","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.biopha.2016.06.034_bib0105","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.yjmcc.2004.12.015","article-title":"IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart","volume":"38","author":"Gurantz","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"38","key":"10.1016\/j.biopha.2016.06.034_bib0110","doi-asserted-by":"crossref","first-page":"39513","DOI":"10.1074\/jbc.M405844200","article-title":"Differential regulation of matrix metalloproteinase-2 and \u22129 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1beta","volume":"279","author":"Xie","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2016.06.034_bib0115","first-page":"318","article-title":"Inflammation of different tissues in spontaneously hypertensive rats","volume":"58","author":"Sun","year":"2006","journal-title":"Sheng li xue bao: [Acta physiologica Sinica]"},{"issue":"3\u20134","key":"10.1016\/j.biopha.2016.06.034_bib0120","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.phrs.2008.06.009","article-title":"Local RAS. and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats","volume":"58","author":"Li","year":"2008","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2016.06.034_bib0125","doi-asserted-by":"crossref","first-page":"H768","DOI":"10.1152\/ajpheart.00937.2002","article-title":"Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis","volume":"286","author":"Kataoka","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"9","key":"10.1016\/j.biopha.2016.06.034_bib0130","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.intimp.2009.04.010","article-title":"Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3\u2009K\/Akt pathway","volume":"9","author":"Li","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2016.06.034_bib0135","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbrc.2011.06.137","article-title":"Anti-oxidant and anti-inflammatory mechanisms of amlodipine action to improve endothelial cell dysfunction induced by irreversibly glycated LDL","volume":"411","author":"Toma","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.biopha.2016.06.034_bib0140","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.CIR.104.3.317","article-title":"Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy","volume":"104","author":"Patel","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2016.06.034_bib0145","first-page":"1392","article-title":"The influence of atorvastatin on the expression of NF-\u03baB\/I\u03baB and inflammation factors in rabbit atherosclerosis","volume":"21","author":"Du","year":"2005","journal-title":"Chin. Pharmacol. Bull."},{"issue":"6","key":"10.1016\/j.biopha.2016.06.034_bib0150","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/FJC.0b013e31804a5e34","article-title":"Rosuvastatin suppresses the inflammatory responses through inhibition of c-jun N-terminal kinase and nuclear factor-kappaB in endothelial cells","volume":"49","author":"Kim","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215305096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332215305096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:46:51Z","timestamp":1776944811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332215305096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":30,"alternative-id":["S0753332215305096"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.06.034","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-\u03b1, IL-1\u03b2 and NF-\u03baB inflammatory cytokine networks in elderly spontaneously hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}