{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:39:11Z","timestamp":1776947951653,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biopha.2016.07.052","type":"journal-article","created":{"date-parts":[[2016,8,7]],"date-time":"2016-08-07T08:15:09Z","timestamp":1470557709000},"page":"865-875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["Antidiabetic assessment; in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats"],"prefix":"10.1016","volume":"83","author":[{"given":"Th. I.","family":"Shaheen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrez E.","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihan S.","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"El-Bana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enayat","family":"Emara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"El-Khayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa M.G.","family":"Fouda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam","family":"Ebaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hebeish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.07.052_bib0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ypmed.2015.12.012","article-title":"A community based primary prevention programme for type 2 diabetes integrating identification and lifestyle intervention for prevention: the Let's prevent diabetes cluster randomised controlled trial","volume":"84","author":"Davies","year":"2016","journal-title":"Prev. Med."},{"key":"10.1016\/j.biopha.2016.07.052_bib0010","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev-biochem-072909-095555","article-title":"Endoplasmic reticulum stress and type 2 diabetes","volume":"81","author":"Back","year":"2012","journal-title":"Annu. Rev. Biochem."},{"issue":"9","key":"10.1016\/j.biopha.2016.07.052_bib0015","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.2337\/diabetes.54.9.2787","article-title":"Rosiglitazone improves myocardial glucose uptake in patients with type 2 diabetes and coronary artery disease: a 16-week randomized, double-blind, placebo-controlled study","volume":"54","author":"Lautam\u00e4ki","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2016.07.052_bib0020","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.colsurfb.2012.07.005","article-title":"Development of stevioside pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine","volume":"101","author":"Barwal","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"8","key":"10.1016\/j.biopha.2016.07.052_bib0025","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2337\/diacare.12.8.553","article-title":"Traditional plant medicines as treatments for diabetes","volume":"12","author":"Bailey","year":"1989","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2016.07.052_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.colsurfb.2011.05.016","article-title":"Facile green synthesis of gold nanoparticles using leaf extract of antidiabetic potent Cassia auriculata","volume":"87","author":"Ganesh Kumar","year":"2011","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.biopha.2016.07.052_bib0035","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.colsurfb.2014.07.022","article-title":"Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats\u2014an in vivo approach","volume":"122","author":"Karthick","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.biopha.2016.07.052_bib0040","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.saa.2013.07.038","article-title":"Functionalization of gold nanoparticles as antidiabetic nanomaterial","volume":"116","author":"Venkatachalam","year":"2013","journal-title":"Spectrochim. Acta Part A"},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0045","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.carbpol.2011.05.048","article-title":"Highly effective antibacterial textiles containing green synthesized silver nanoparticles","volume":"86","author":"Hebeish","year":"2011","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0050","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.carbpol.2011.04.088","article-title":"Environmental synthesis of silver nanoparticles using hydroxypropyl starch and their characterization","volume":"86","author":"El-Rafie","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2016.07.052_bib0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.carbpol.2013.10.054","article-title":"Thermal responsive hydrogels based on semi interpenetrating network of poly (NIPAm) and cellulose nanowhiskers","volume":"102","author":"Hebeish","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2016.07.052_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/201057","article-title":"Nanostructural features of silver nanoparticles powder synthesized through concurrent formation of the nanosized particles of both starch and silver","volume":"2013","author":"Hebeish","year":"2013","journal-title":"J. Nanotechnol."},{"key":"10.1016\/j.biopha.2016.07.052_bib0065","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.carbpol.2016.03.029","article-title":"Antibacterial activity of silver nanoparticles synthesized in-situ by solution spraying onto cellulose","volume":"147","author":"Yan Jinhua","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2016.07.052_bib0070","series-title":"Chapter 1\u2014Nanotechnology and the Future of Dentistry, Emerging Nanotechnologies in Dentistry","first-page":"1","author":"Subramani","year":"2012"},{"key":"10.1016\/j.biopha.2016.07.052_bib0075","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.carbpol.2015.10.003","article-title":"Eco-friendly microwave-assisted green and rapid synthesis of well-stabilized gold and core\u2013shell silver\u2013gold nanoparticles","volume":"136","author":"El-Naggar","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"12","key":"10.1016\/j.biopha.2016.07.052_bib0080","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/nar\/22.12.2183","article-title":"Summary: the modified nucleosides of RNA","volume":"22","author":"Limbach","year":"1994","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0085","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/jnnp.74.2.268","article-title":"Colonic transit time and rectoanal videomanometry in Parkinson's disease","volume":"74","author":"Sakakibara","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<136::AID-PTR607>3.0.CO;2-K","article-title":"Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats","volume":"14","author":"Pari","year":"2000","journal-title":"Phytother. Res.: PTR"},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jcp.22.2.158","article-title":"Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen","volume":"22","author":"Trinder","year":"1969","journal-title":"J. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.biopha.2016.07.052_bib0100","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4269\/ajtmh.1983.32.565","article-title":"Comparison of the enzyme-linked immunosorbent assay (ELISA) with standard tests used to detect yellow fever virus antibodies","volume":"32","author":"Deubel","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"12","key":"10.1016\/j.biopha.2016.07.052_bib0105","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/clinchem\/19.12.1350","article-title":"Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum","volume":"19","author":"Richmond","year":"1973","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2016.07.052_bib0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/000456329703400601","article-title":"Effects of drugs on clinical laboratory tests","volume":"34","author":"Young","year":"1997","journal-title":"Ann. Clin. Biochem.: Int. J. Biochem. Med."},{"issue":"5","key":"10.1016\/j.biopha.2016.07.052_bib0115","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/clinchem\/23.5.882","article-title":"Cholesterol determination in high-density lipoproteins separated by three different methods","volume":"23","author":"Lopes-Virella","year":"1977","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2016.07.052_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00325481.1984.11698776","article-title":"Hyperlipidemia. What is \u2018normal,\u2019 who should be treated and how","volume":"76","author":"Glatter","year":"1984","journal-title":"Postgrad. Med."},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2016.07.052_bib0130","first-page":"414","article-title":"The determination of nitrite in water","volume":"86","author":"M. H.A.C","year":"1961","journal-title":"Analyst"},{"issue":"5","key":"10.1016\/j.biopha.2016.07.052_bib0135","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.theriogenology.2004.07.005","article-title":"Activity of glutathione peroxidase, superoxide dismutase and catalase and lipid peroxidation intensity in stallion semen during storage at 5\u00b0C","volume":"63","author":"Kankofer","year":"2005","journal-title":"Theriogenology"},{"issue":"8","key":"10.1016\/j.biopha.2016.07.052_bib0140","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood.V77.8.1627.1627","article-title":"Interleukin-1 and interleukin-1 antagonism","volume":"77","author":"Dinarello","year":"1991","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.biopha.2016.07.052_bib0145","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1152\/jn.1990.63.3.592","article-title":"Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements","volume":"63","author":"Romo","year":"1990","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.biopha.2016.07.052_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-7075-10-20","article-title":"Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats","volume":"10","author":"Ebaid","year":"2013","journal-title":"Nutr. Metab."},{"issue":"1","key":"10.1016\/j.biopha.2016.07.052_bib0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1743-7075-10-20","article-title":"Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats","volume":"10","author":"Ebaid","year":"2013","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biopha.2016.07.052_bib0160","doi-asserted-by":"crossref","unstructured":"H. Yamamoto, Y., Uchigata, H. Okamoto, Streptozotocin and alloxan induce DNA strand breaks and poly (ADP\u2013ribose) synthetase in pancreatic islets, (1981).","DOI":"10.1038\/294284a0"},{"issue":"2","key":"10.1016\/j.biopha.2016.07.052_bib0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12263-007-0051-4","article-title":"Characterization of intestinal inflammation and identification of related gene expression changes in mdr1a(\u2212\/\u2212) mice","volume":"2","author":"Dommels","year":"2007","journal-title":"Genes Nutr."},{"issue":"5838","key":"10.1016\/j.biopha.2016.07.052_bib0170","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/294284a0","article-title":"Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets","volume":"294","author":"Yamamoto","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.07.052_bib0175","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ijbiomac.2015.09.005","article-title":"Synthesis, characterization, release kinetics and toxicity profile of drug-loaded starch nanoparticles","volume":"81","author":"El-Naggar","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.biopha.2016.07.052_bib0180","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1161\/01.CIR.96.12.4226","article-title":"Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol","volume":"96","author":"Gylling","year":"1997","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biopha.2016.07.052_bib0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.2040-1124.2010.00013.x","article-title":"Oxidative stress: a cause and therapeutic target of diabetic complications","volume":"1","author":"Araki","year":"2010","journal-title":"J. Diabetes Invest."},{"key":"10.1016\/j.biopha.2016.07.052_bib0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2012\/281068","article-title":"Assessment of DNA damage after photodynamic therapy using a metallophthalocyanine photosensitizer","volume":"2012","author":"El-Hussein","year":"2012","journal-title":"Int. J. Photoenergy"},{"issue":"4","key":"10.1016\/j.biopha.2016.07.052_bib0195","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00418-004-0678-9","article-title":"Hyperglycemia-induced oxidative stress in diabetic complications","volume":"122","author":"King","year":"2004","journal-title":"Histochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2016.07.052_bib0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.7150\/ijbs.5220","article-title":"Akt activation protects liver cells from apoptosis in rats during acute cold exposure","volume":"9","author":"Wang","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2016.07.052_bib0205","article-title":"Registration of a drought-resistant chickpea germplasm","volume":"33","author":"Germplasm","year":"1993","journal-title":"Crop Sci."},{"issue":"10","key":"10.1016\/j.biopha.2016.07.052_bib0210","article-title":"Early degenerative effects of diabetes mellitus on pancreas, liver, and kidney in rats: an immunohistochemical study","volume":"2012","author":"Haligur","year":"2012","journal-title":"Exp. Diabetes Res."},{"issue":"3","key":"10.1016\/j.biopha.2016.07.052_bib0215","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s11172-008-0080-1","article-title":"Antioxidant properties of gold nanoparticles studied by ESR spectroscopy","volume":"57","author":"Yakimovich","year":"2008","journal-title":"Russ. Chem. Bull."},{"issue":"19","key":"10.1016\/j.biopha.2016.07.052_bib0220","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1093\/nar\/gki954","article-title":"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery","volume":"33","author":"Yang","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.biopha.2016.07.052_bib0225","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s11671-009-9334-6","article-title":"Assessment of the in vivo toxicity of gold nanoparticles","volume":"4","author":"Chen","year":"2009","journal-title":"Nanoscale Res. Lett."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216306898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216306898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:38:22Z","timestamp":1776944302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216306898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":45,"alternative-id":["S0753332216306898"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.07.052","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidiabetic assessment; in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.07.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}