{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:49:18Z","timestamp":1790682558994,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biopha.2016.08.012","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T07:30:57Z","timestamp":1471073457000},"page":"1016-1021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Silencing NLRC5 inhibits extracellular matrix expression in keloid fibroblasts via inhibition of transforming growth factor-\u03b21\/Smad signaling pathway"],"prefix":"10.1016","volume":"83","author":[{"given":"Hai-Li","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Ren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.08.012_bib0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1357-4310(97)80541-2","article-title":"The molecular basis of keloid and hypertrophic scar formation","volume":"4","author":"Tuan","year":"1998","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.biopha.2016.08.012_bib0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids\u2014a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.biopha.2016.08.012_bib0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/DAD.0b013e3181d0c3ad","article-title":"Immunohistochemical expression of TGF-\u03b21 in keloids and hypertrophic scars","volume":"33","author":"Abdou","year":"2011","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0020","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jcp.20668","article-title":"Upregulation of secretory connective tissue growth factor (CTGF) in keratinocyte\u2010fibroblast coculture contributes to keloid pathogenesis","volume":"208","author":"Khoo","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0025","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0002-9440(10)65335-7","article-title":"Overexpression of insulin-like growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts","volume":"154","author":"Yoshimoto","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0030","first-page":"55","article-title":"TGF-\u03b21 antisense therapy modulates expression of matrix metalloproteinases in keloid-derived fibroblasts","volume":"22","author":"Sadick","year":"2008","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2016.08.012_bib0035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nri3339","article-title":"NLRC5: a key regulator of MHC class I-dependent immune responses","volume":"12","author":"Kobayashi","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0040","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2010.03.040","article-title":"NLRC5 negatively regulates the NF-\u03baB and type I interferon signaling pathways","volume":"141","author":"Cui","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2016.08.012_bib0045","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.4049\/jimmunol.0900557","article-title":"The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses","volume":"184","author":"Kuenzel","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2015.11.010","article-title":"NLRC5 regulates TGF-\u03b21-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis","volume":"70","author":"Xu","year":"2016","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.taap.2016.01.012","article-title":"Role of NLRC5 in progression and reversal of hepatic fibrosis","volume":"294","author":"Liu","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2165\/00128071-200304040-00003","article-title":"Hypertrophic scars and keloids","volume":"4","author":"Alster","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00006534-200101000-00014","article-title":"Abnormal balance between proliferation and apoptotic cell death in fibroblasts derived from keloid lesions","volume":"107","author":"Luo","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.biopha.2016.08.012_bib0070","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.7150\/ijbs.7273","article-title":"Asiatic acid isolated from centella asiatica inhibits TGF-\u03b21-induced collagen expression in human keloid fibroblasts via PPAR-\u03b3 activation","volume":"9","author":"Bian","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2016.08.012_bib0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/wrr.12136","article-title":"Simvastatin inhibits transforming growth factor-\u03b21-induced expression of type I collagen, CTGF, and \u03b1-SMA in keloid fibroblasts","volume":"22","author":"Mun","year":"2014","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.biopha.2016.08.012_bib0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2133.2012.11023.x","article-title":"FK506 inhibits the enhancing effects of transforming growth factor (TGF)\u2010\u03b21 on collagen expression and TGF\u2010\u03b2\/Smad signalling in keloid fibroblasts: implication for new therapeutic approach","volume":"167","author":"Wu","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0085","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1468-3083.2011.04200.x","article-title":"Extracellular matrix molecules implicated in hypertrophic and keloid scarring","volume":"26","author":"Sidgwick","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0090","first-page":"1642","article-title":"Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing","volume":"9","author":"Babu","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0095","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00006534-199610000-00012","article-title":"The effect of TGF-[beta] on keloid fibroblast proliferation and collagen synthesis","volume":"98","author":"Bettinger","year":"1996","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.biopha.2016.08.012_bib0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0074-7696(07)57004-X","article-title":"Fibroblast differentiation in wound healing and fibrosis","volume":"257","author":"Darby","year":"2007","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0105","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00403-010-1075-y","article-title":"Suppression of TGF-\u03b21\/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid","volume":"302","author":"Hsu","year":"2010","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.biopha.2016.08.012_bib0110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.burns.2013.11.010","article-title":"New molecular medicine-based scar management strategies","volume":"40","author":"Arno","year":"2014","journal-title":"Burns"},{"key":"10.1016\/j.biopha.2016.08.012_bib0115","first-page":"15262","article-title":"Overexpression of RACK1 inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-\u03b21\/Smad signaling pathway","volume":"8","author":"Zhou","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2016.08.012_bib0120","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor \u03b2 in human disease","volume":"342","author":"Epstein","year":"2000","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.biopha.2016.08.012_bib0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1523-1747.1999.00477.x","article-title":"Stimulation of type I collagen transcription in human skin fibroblasts by TGF-\u03b2: involvement of Smad 3","volume":"112","author":"Chen","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.biopha.2016.08.012_bib0130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00006534-200108000-00022","article-title":"Differential expression of transforming growth factor-beta receptors I and II and activation of Smad 3 in keloid fibroblasts","volume":"108","author":"Chin","year":"2001","journal-title":"Plast. Reconstr. Surg."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216305200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216305200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:37:17Z","timestamp":1776944237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216305200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":26,"alternative-id":["S0753332216305200"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.012","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing NLRC5 inhibits extracellular matrix expression in keloid fibroblasts via inhibition of transforming growth factor-\u03b21\/Smad signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}