{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:01Z","timestamp":1786985221732,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2011ZYX4-005"],"award-info":[{"award-number":["2011ZYX4-005"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biopha.2016.08.017","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T11:03:19Z","timestamp":1471518199000},"page":"1048-1056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera"],"prefix":"10.1016","volume":"83","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biopha.2016.08.017_bib0005","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1248\/cpb.c14-00057","article-title":"New norclerodane diterpenoids from the tubers of Dioscorea bulbifera","volume":"62","author":"Tang","year":"2014","journal-title":"Chem. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.biopha.2016.08.017_bib0010","doi-asserted-by":"crossref","first-page":"253","DOI":"10.5582\/bst.2014.01076","article-title":"Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism","volume":"8","author":"Niu","year":"2014","journal-title":"Biosci. Trends"},{"issue":"6","key":"10.1016\/j.biopha.2016.08.017_bib0015","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1248\/cpb.57.625","article-title":"Two new furanoid norditerpenes from Dioscorea bulbifera","volume":"57","author":"Wang","year":"2009","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0020","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.fitote.2011.12.001","article-title":"Antitumor activity of Dioscorea bulbifera L. rhizome in vivo","volume":"83","author":"Wang","year":"2012","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.biopha.2016.08.017_bib0025","doi-asserted-by":"crossref","first-page":"32","DOI":"10.5582\/bst.8.32","article-title":"Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L","volume":"8","author":"Sheng","year":"2014","journal-title":"Biosci. Trends"},{"issue":"11","key":"10.1016\/j.biopha.2016.08.017_bib0030","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00204-013-1047-z","article-title":"Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3 K\/Akt and ERK and JNK signaling pathways in human lung cancer cell lines","volume":"87","author":"Hsieh","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2016.08.017_bib0035","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.bbamem.2012.12.010","article-title":"The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica","volume":"1828","author":"Cho","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.biopha.2016.08.017_bib0040","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.fct.2012.02.027","article-title":"A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats","volume":"50","author":"Xu","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.biopha.2016.08.017_bib0045","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.23937","article-title":"Drug-induced acute liver failure: results of a U.S. multicenter, prospective study","volume":"52","author":"Reuben","year":"2010","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biopha.2016.08.017_bib0050","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cld.2007.06.006","article-title":"Acetaminophen hepatotoxicity","volume":"11","author":"Larson","year":"2007","journal-title":"Clin. Liver Dis."},{"issue":"3","key":"10.1016\/j.biopha.2016.08.017_bib0055","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","article-title":"Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity","volume":"264","author":"McGill","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2016.08.017_bib0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jss.2012.11.051","article-title":"Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure","volume":"180","author":"Fisher","year":"2013","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nbt.2089","article-title":"Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure","volume":"30","author":"Patel","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2016.08.017_bib0070","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/hep.26208","article-title":"High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury","volume":"58","author":"Chen","year":"2013","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0075","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/hep.23720","article-title":"Pharmacogenetics of drug-induced liver injury","volume":"52","author":"Russmann","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.biopha.2016.08.017_bib0080","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd1750","article-title":"Idiosyncratic drug hepatotoxicity","volume":"4","author":"Kaplowitz","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"23","key":"10.1016\/j.biopha.2016.08.017_bib0085","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.2174\/092986709788803097","article-title":"Current concepts of mechanisms in drug-induced hepatotoxicity","volume":"16","author":"Russmann","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2016.08.017_bib0090","first-page":"117","article-title":"Study on the initial mechanism of liver injure induced by the decoction of airpotato yam rhizome","volume":"29","author":"Liang","year":"2013","journal-title":"Pharmacol. Clin. Chin. Mater. Med."},{"key":"10.1016\/j.biopha.2016.08.017_bib0095","first-page":"255","article-title":"Macroporous resin enrichment and purification of total saponins of Airpotato yam","volume":"9","author":"Liu","year":"2011","journal-title":"Cent. South Pharm."},{"issue":"3","key":"10.1016\/j.biopha.2016.08.017_bib0100","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jep.2014.02.001","article-title":"Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats","volume":"152","author":"Weng","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2016.08.017_bib0105","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3390\/ijms11062362","article-title":"Total phenolic contents and antioxidant capacities of selected Chinese medicinal plants","volume":"11","author":"Song","year":"2010","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2016.08.017_bib0110","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.fct.2007.06.007","article-title":"A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters","volume":"45","author":"Ramaiah","year":"2007","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.biopha.2016.08.017_bib0115","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1345\/aph.1K145","article-title":"Vandenberg, risperidone- and quetiapine-induced cholestasis","volume":"41","author":"Wright","year":"2007","journal-title":"Ann. Pharmacother."},{"issue":"9","key":"10.1016\/j.biopha.2016.08.017_bib0120","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/aps.2014.65","article-title":"Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters","volume":"35","author":"Wu","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.biopha.2016.08.017_bib0125","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1289\/ehp.98106375","article-title":"Oxidative stress in toxicology: established mammalian and emerging piscine model systems","volume":"106","author":"Kelly","year":"1998","journal-title":"Environ. Health Perspect."},{"issue":"3\u20134","key":"10.1016\/j.biopha.2016.08.017_bib0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1293\/tox.2014-0007","article-title":"Green tea extract-induced acute hepatotoxicity in rats","volume":"27","author":"Emoto","year":"2014","journal-title":"J. Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0135","doi-asserted-by":"crossref","first-page":"109","DOI":"10.17305\/bjbms.2013.2390","article-title":"Analysis of manganese superoxide dismutase (MnSOD: Ala-9Val) and glutathione peroxidase (GSH-Px: Pro 197 Leu) gene polymorphisms in mood disorders","volume":"13","author":"Cumurcu","year":"2013","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2016.08.017_bib0140","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/0006-2952(95)02107-8","article-title":"Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues","volume":"50","author":"Debri","year":"1995","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/01480547809034433","article-title":"Serum enzymes as indicators of chemically induced liver damage","volume":"1","author":"Drotman","year":"1978","journal-title":"Drug Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.biopha.2016.08.017_bib0150","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jhep.2005.03.017","article-title":"Enterohepatic transport of bile salts and genetics of cholestasis","volume":"43","author":"Pauli-Magnus","year":"2005","journal-title":"J. Hepatol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216308836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216308836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:38:27Z","timestamp":1776944307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216308836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":30,"alternative-id":["S0753332216308836"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.017","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}