{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:11:14Z","timestamp":1781349074526,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/05732-4"],"award-info":[{"award-number":["2011\/05732-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/00715-7"],"award-info":[{"award-number":["2012\/00715-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/07946-4"],"award-info":[{"award-number":["2012\/07946-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.biopha.2016.08.027","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T17:36:22Z","timestamp":1471714582000},"page":"1111-1115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Protective effects of Solanum cernuum extract against chromosomal and genomic damage induced by methyl methanesulfonate in Swiss mice"],"prefix":"10.1016","volume":"83","author":[{"given":"Jaqueline L.","family":"Damasceno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollyanna F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza A.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia O.","family":"Ac\u00e9sio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo D.","family":"Ozelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo K.","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-5914","authenticated-orcid":false,"given":"Denise C.","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.08.027_bib0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1590\/S0001-37652013000200007","article-title":"Protective effects of steroidal alkaloids isolated from Solanum paniculatum L. against mitomycin cytotoxic and genotoxic actions","volume":"85","author":"Vieira","year":"2013","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.biopha.2016.08.027_bib0010","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00709-012-0391-9","article-title":"Plastid genetic engineering in Solanaceae","volume":"249","author":"Venkatesh","year":"2012","journal-title":"Protoplasma"},{"key":"10.1016\/j.biopha.2016.08.027_bib0015","first-page":"283","article-title":"Preliminar analysis of anti-ulcerative activity of Solanum cernuum Vell. hydroalcoholic extract","volume":"21","author":"Araujo","year":"2002","journal-title":"Acta. Farm Bonaerense"},{"key":"10.1016\/j.biopha.2016.08.027_bib0020","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jep.2011.09.045","article-title":"Toxicological evaluation of acute and sub-chronic ingestion of hydroalcoholic extract of Solanum cernuum Vell. in mice","volume":"138","author":"Alman\u00e7a","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0025","first-page":"179","article-title":"Pharmacological caracterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties","volume":"22","author":"Lopes","year":"2014","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.biopha.2016.08.027_bib0030","first-page":"37","article-title":"Evaluation of cytological parameters induced by aqueous extracts of seven plants used as antihypertensive agents in argentine folk medicine","volume":"21","author":"Amat","year":"2002","journal-title":"Acta Farm. Bonaerense"},{"key":"10.1016\/j.biopha.2016.08.027_bib0035","first-page":"13","article-title":"Toxicology of solanine\u2014an overview","volume":"25","author":"Dalvi","year":"1983","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0040","first-page":"291","article-title":"In vivo rodent micronucleus assay","volume":"312","author":"Hayashi","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0045","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.toxicon.2007.02.006","article-title":"Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells","volume":"49","author":"Cao","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.biopha.2016.08.027_bib0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/em.2860020408","article-title":"Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test","volume":"2","author":"MacGregor","year":"1980","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.biopha.2016.08.027_bib0055","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1383-5718(96)00133-7","article-title":"Detection of chemically induced DNA lesions in multiple mouse organs (liver lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay","volume":"388","author":"Sasaki","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0065","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.biopha.2016.08.027_bib0070","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.tiv.2007.06.020","article-title":"Genotoxic, mutagenic and cytotoxic effects of the commercial dye CI Disperse Blue 291 in the human hepatic cell line HepG2","volume":"8","author":"Tsuboy","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.biopha.2016.08.027_bib0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0165-1110(90)90039-E","article-title":"Antimutagenicity profiles for some model compounds","volume":"238","author":"Waters","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0080","unstructured":"OECD, OECD Guideline for the Testing of Chemicals: Mammalian Erythrocyte Micronucleus Test, 474 (1997) 1\u201310."},{"key":"10.1016\/j.biopha.2016.08.027_bib0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1098-2280(2000)36:3<195::AID-EM2>3.0.CO;2-B","article-title":"Interference of tannic acid on the genotoxicity of mitomycin C methyl methanesulfonate, and nitrogen mustard in somatic cells of Drosophila melanogaster","volume":"36","author":"Lehmann","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.biopha.2016.08.027_bib0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0165-1110(93)90005-8","article-title":"A review of the genotoxicity of 1-ethyl-1-nitrosourea","volume":"297","author":"Shibuya","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0095","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ncponc0319","article-title":"Cancer chemoprevention: scientific promise clinical uncertainty","volume":"2","author":"Sporn","year":"2005","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrgentox.2009.10.009","article-title":"Evaluation of the genotoxic and antigenotoxic effects after acute and subacute treatments with a\u00e7ai pulp (Euterpe oleracea Mart.) on mice using the erythrocytes micronucleus test and the comet assay","volume":"695","author":"Ribeiro","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2016.08.027_bib0105","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1016\/j.tetlet.2011.09.060","article-title":"Cernumidine and isocernumidine, new type of cyclic guanidine alkaloids from Solanum cernuum","volume":"52","author":"Lopes","year":"2011","journal-title":"Tetrahedron. Lett."},{"key":"10.1016\/j.biopha.2016.08.027_bib0110","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1248\/bpb.26.1198","article-title":"Cytotoxic activity of steroidal glycosides from Solanum plants","volume":"26","author":"Ikeda","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2016.08.027_bib0115","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1021\/jf030324h","article-title":"Tetrahydro-\u03b2-carboline alkaloids occur in fruits and fruit juices. Activity as antioxidants and radical scavengers","volume":"51","author":"Herraiz","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2016.08.027_bib0120","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.3390\/nu5072564","article-title":"Chemopreventive potential of flavonoids in oral squamous cell carcinoma in human studies","volume":"5","author":"Iriti","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2016.08.027_bib0125","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/tx060164e","article-title":"Methylating agents and DNA repair responses: methylated bases and sources of strand breaks","volume":"19","author":"Wyatt","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0130","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1074\/jbc.271.9.4805","article-title":"Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols","volume":"271","author":"Liu","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.08.027_bib0135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ejphar.2012.06.027","article-title":"Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice","volume":"691","author":"Shanthakumar","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0140","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1271\/bbb.120562","article-title":"Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells","volume":"77","author":"Hong","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.biopha.2016.08.027_bib0145","first-page":"1","article-title":"Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2016.08.027_bib0150","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1508\/cytologia.67.417","article-title":"Absence of genotoxic and antigenotoxic effects of a standardized extract of the medicinal plant Solanum melongena on peripheral blood and bone marrow cells of Wistar rats","volume":"67","author":"Chacon","year":"2002","journal-title":"Cytologia"},{"key":"10.1016\/j.biopha.2016.08.027_bib0155","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.fct.2006.11.004","article-title":"Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo","volume":"45","author":"Azevedo","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0160","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/S1519-69842010000300017","article-title":"Assessment of mutagenicity and cytotoxicity of Solanum paniculatum L. extracts using in vivo micronucleus test in mice","volume":"70","author":"Vieira","year":"2010","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.biopha.2016.08.027_bib0165","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1055\/s-0030-1270886","article-title":"Antimutagenic potential of Solanum lycocarpum against induction of chromosomal aberrations in V79 cells and micronuclei in mice by doxorubicin","volume":"77","author":"Tavares","year":"2011","journal-title":"Plant. Med."},{"key":"10.1016\/j.biopha.2016.08.027_bib0170","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3923\/jpt.2007.160.167","article-title":"Antioxidant activity of two steroidal alkaloids extracted from Solanum aculeastrum","volume":"2","author":"Koduru","year":"2007","journal-title":"J. Pharmacol. Toxicol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216302037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216302037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:41:39Z","timestamp":1776944499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216302037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":34,"alternative-id":["S0753332216302037"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.027","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of Solanum cernuum extract against chromosomal and genomic damage induced by methyl methanesulfonate in Swiss mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}