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Sci."},{"key":"10.1016\/j.biopha.2016.08.060_bib0355","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.toxlet.2013.04.022","article-title":"Protein binding modulates the cellular uptake of silver nanoparticles into human cells: implications for in vitro to in vivo extrapolations?","volume":"220","author":"Monteiro-Riviere","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2016.08.060_bib0360","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1021\/nn404481f","article-title":"Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines","volume":"7","author":"Yan","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.biopha.2016.08.060_bib0365","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1021\/mp800032f","article-title":"Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution","volume":"5","author":"Dobrovolskaia","year":"2008","journal-title":"Mol. 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Biopharm."},{"key":"10.1016\/j.biopha.2016.08.060_bib0380","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/ja2084338","article-title":"Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake","volume":"134","author":"Walkey","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2016.08.060_bib0385","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1021\/ja300537u","article-title":"A chemical approach for cell-specific targeting of nanomaterials: small-molecule-initiated misfolding of nanoparticle corona proteins","volume":"134","author":"Prapainop","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2016.08.060_bib0390","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2217\/nnm.15.188","article-title":"The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery","volume":"11","author":"Corbo","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2016.08.060_bib0395","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jconrel.2010.08.012","article-title":"Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems","volume":"147","author":"Mohanan","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2016.08.060_bib0400","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.addr.2009.03.009","article-title":"Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy","volume":"61","author":"Aggarwal","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biopha.2016.08.060_bib0405","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1039\/c3cs60064e","article-title":"Cytokines as biomarkers of nanoparticle immunotoxicity","volume":"42","author":"Elsabahy","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biopha.2016.08.060_bib0410","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1166\/jnn.2010.2420","article-title":"Small-sized titanium dioxide nanoparticles mediate immune toxicity in rat pulmonary alveolar macrophages in vivo","volume":"10","author":"Liu","year":"2010","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0415","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.3390\/ijms15046961","article-title":"Systemic immune effects of titanium dioxide nanoparticles after repeated intratracheal instillation in rat","volume":"15","author":"Fu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2016.08.060_bib0420","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1134\/S1995078014050061","article-title":"Silver-nanoparticle exposure on immune system of mice depending on the route of administration","volume":"9","author":"Kalmantaeva","year":"2014","journal-title":"Nanotechnol. Russ."},{"key":"10.1016\/j.biopha.2016.08.060_bib0425","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1556-276X-8-102","article-title":"Liposome: classification, preparation, and applications","volume":"8","author":"Akbarzadeh","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biopha.2016.08.060_bib0430","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/annonc\/mdg374","article-title":"Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil\u00ae): possible role in hypersensitivity reactions","volume":"14","author":"Chanan-Khan","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0435","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1016\/j.biomaterials.2010.05.027","article-title":"The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation","volume":"31","author":"Kedmi","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2016.08.060_bib0440","first-page":"2729","article-title":"Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity","volume":"7","author":"Shen","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2016.08.060_bib0445","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/17435390.2011.648225","article-title":"Surface functionalities of gold nanoparticles impact embryonic gene expression responses","volume":"7","author":"Truong","year":"2013","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.biopha.2016.08.060_bib0450","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/intimm\/dxt053","article-title":"Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb\/c mice","volume":"26","author":"Roy","year":"2014","journal-title":"Int. Immunol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0455","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cellimm.2013.04.003","article-title":"Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles","volume":"282","author":"Potnis","year":"2013","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0460","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.biomaterials.2014.10.043","article-title":"Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: in vivo tracking and evaluation of antigen-specific CD8+ T cell immune response","volume":"37","author":"Rahimian","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2016.08.060_bib0465","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2014.11.033","article-title":"In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model","volume":"198","author":"Silva","year":"2015","journal-title":"J. Control. 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Med."},{"key":"10.1016\/j.biopha.2016.08.060_bib0520","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s13346-013-0161-z","article-title":"Lipid nanoparticle delivery systems for siRNA-based therapeutics","volume":"4","author":"Wan","year":"2014","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.biopha.2016.08.060_bib0525","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biopha.2016.01.026","article-title":"The role of oncomirs in the pathogenesis and treatment of breast cancer","volume":"78","author":"Hemmatzadeh","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2016.08.060_bib0530","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.biopha.2016.05.009","article-title":"Differential role of microRNAs in the pathogenesis and treatment of Esophageal cancer","volume":"82","author":"Hemmatzadeh","year":"2016","journal-title":"Biomed. 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Med."},{"key":"10.1016\/j.biopha.2016.08.060_bib0550","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/09687860600790537","article-title":"Immunostimulation of dendritic cells by cationic liposomes","volume":"23","author":"Vangasseri","year":"2006","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0555","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nano.2013.12.003","article-title":"Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways","volume":"10","author":"Lonez","year":"2014","journal-title":"Nanomed. Nanotechnol. Biol. 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Mol. 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Control. Release"},{"key":"10.1016\/j.biopha.2016.08.060_bib0770","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.it.2007.07.011","article-title":"Immunogenicity of protein therapeutics","volume":"28","author":"De Groot","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0775","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/iub.297","article-title":"Cell\u2010penetrating peptides: nanocarrier for macromolecule delivery in living cells","volume":"62","author":"Chugh","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2016.08.060_bib0780","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/nn204530r","article-title":"Modulating adaptive immune responses to peptide self-assemblies","volume":"6","author":"Rudra","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.biopha.2016.08.060_bib0785","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1021\/bc200293d","article-title":"Cell-penetrating peptides PepFects, show no evidence of toxicity and immunogenicity in vitro and in vivo","volume":"22","author":"Suhorutsenko","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biopha.2016.08.060_bib0790","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejpb.2013.03.024","article-title":"Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: implications for continued therapeutic use","volume":"85","author":"Carter","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biopha.2016.08.060_bib0795","first-page":"419","article-title":"Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants, Nanomedicine: nanotechnology","volume":"9","author":"Bartlett","year":"2013","journal-title":"Biol. Med."},{"key":"10.1016\/j.biopha.2016.08.060_bib0800","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.vaccine.2012.02.042","article-title":"Transfer of the ability of HIV-1 Tat to raise an adjuvant-free humoral immune response to unrelated antigens","volume":"30","author":"Gadzinski","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.biopha.2016.08.060_bib0805","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s11095-008-9802-1","article-title":"Targeted delivery with peptidomimetic conjugated self-assembled nanoparticles","volume":"26","author":"Jabbari","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2016.08.060_bib0810","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1021\/cr300367d","article-title":"Nanocarbons for the development of advanced catalysts","volume":"113","author":"Su","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biopha.2016.08.060_bib0815","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ejso.2012.02.001","article-title":"Sentinel lymph node biopsy using carbon nanoparticles for Chinese patients with papillary thyroid microcarcinoma","volume":"38","author":"Hao","year":"2012","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"10.1016\/j.biopha.2016.08.060_bib0820","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/adma.200501576","article-title":"Recent progress in the synthesis of porous carbon materials","volume":"18","author":"Lee","year":"2006","journal-title":"Adv. Mater."},{"key":"10.1016\/j.biopha.2016.08.060_bib0825","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1021\/nl801976m","article-title":"Structurally ordered mesoporous carbon nanoparticles as transmembrane delivery vehicle in human cancer cells","volume":"8","author":"Kim","year":"2008","journal-title":"Nano Lett."},{"key":"10.1016\/j.biopha.2016.08.060_bib0830","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nnano.2009.151","article-title":"Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice","volume":"4","author":"Mitchell","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0835","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1126\/science.1222453","article-title":"Carbon nanotubes: present and future commercial applications","volume":"339","author":"De Volder","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.biopha.2016.08.060_bib0840","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/426028","article-title":"Immunomodulation of nanoparticles in nanomedicine applications","volume":"2014","author":"Jiao","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biopha.2016.08.060_bib0845","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-12-138","article-title":"Impact of carbon nanotubes and graphene on immune cells","volume":"12","author":"Orecchioni","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2016.08.060_bib0850","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11671-008-9153-1","article-title":"Exploring the immunotoxicity of carbon nanotubes","volume":"3","author":"Yu","year":"2008","journal-title":"Nanoscale Res. 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Rev."},{"key":"10.1016\/j.biopha.2016.08.060_bib0875","series-title":"Biological Effects of Fibrous and Particulate Substances","first-page":"103","article-title":"Fibrogenic and immunotoxic responses to carbon nanotubes","author":"Bonner","year":"2016"},{"key":"10.1016\/j.biopha.2016.08.060_bib0880","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/17435390.2010.523483","article-title":"Immune responses of BALB\/c mice to subcutaneously injected multi-walled carbon nanotubes","volume":"5","author":"Meng","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.biopha.2016.08.060_bib0885","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.addr.2013.09.005","article-title":"When carbon nanotubes encounter the immune system: desirable and undesirable effects","volume":"65","author":"Dumortier","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biopha.2016.08.060_bib0890","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1002\/smll.201200873","article-title":"A carbon nanotube toxicity paradigm driven by mast cells and the IL-33\/ST2 axis","volume":"8","author":"Katwa","year":"2012","journal-title":"Small"},{"key":"10.1016\/j.biopha.2016.08.060_bib0895","article-title":"Current understanding of interactions between nanoparticles and the immune system","author":"Dobrovolskaia","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2016.08.060_bib0900","article-title":"Immunotoxicological impact of occupational and environmental nanoparticles exposure: the influence of physical, chemical, and combined characteristics of the particles","volume":"0394632015608933","author":"Pedata","year":"2015","journal-title":"Int. J. Immunopathol. 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