{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:02:12Z","timestamp":1774947732216,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biopha.2016.09.021","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T15:49:05Z","timestamp":1474300145000},"page":"191-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes"],"prefix":"10.1016","volume":"84","author":[{"given":"Sadaf","family":"Davudian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Shajari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohid","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behzad","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shima","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariush","family":"Shanehbandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid Khaze","family":"Shahgoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Asadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behzad","family":"Baradaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2016.09.021_bib0005","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/cncr.22193","article-title":"Annual report to the nation on the status of cancer, 1975-2003, featuring cancer among US Hispanic\/Latino populations","volume":"107","author":"Howe","year":"2006","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.biopha.2016.09.021_bib0010","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/cncr.28509","article-title":"Annual Report to the Nation on the status of cancer, 1975\u20102010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer","volume":"120","author":"Edwards","year":"2014","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.surge.2011.01.011","article-title":"The molecular biology of colorectal carcinoma and its implications: a review","volume":"9","author":"Harrison","year":"2011","journal-title":"Surgeon"},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1463-1318.2010.02539.x","article-title":"Trends in incidence, treatment and survival of patients with stage IV colorectal cancer: a population\u2010based series","volume":"14","author":"Van der Pool","year":"2012","journal-title":"Colorectal Dis."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0025","first-page":"252","article-title":"Cancer treatment and survivorship statistics, 2014","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA A Cancer J. Clinicians"},{"issue":"11","key":"10.1016\/j.biopha.2016.09.021_bib0030","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/cncr.29253","article-title":"Variation in hospital treatment patterns for metastatic colorectal cancer","volume":"121","author":"Krell","year":"2015","journal-title":"Cancer"},{"issue":"22","key":"10.1016\/j.biopha.2016.09.021_bib0035","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.3748\/wjg.v20.i22.6786","article-title":"Colorectal cancer: from prevention to personalized medicine","volume":"20","author":"Binefa","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2016.09.021_bib0040","article-title":"promotes colorectal tumorigenesis, cell invasion, and metastasis","author":"Bian","year":"2015","journal-title":"Mol. Carcinogenesis"},{"issue":"37","key":"10.1016\/j.biopha.2016.09.021_bib0045","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1038\/onc.2011.109","article-title":"SPG20: a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis","volume":"30","author":"Lind","year":"2011","journal-title":"Oncogene"},{"issue":"24","key":"10.1016\/j.biopha.2016.09.021_bib0050","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1056\/NEJMc1402716","article-title":"Ibrutinib resistance in chronic lymphocytic leukemia","volume":"370","author":"Furman","year":"2014","journal-title":"New Engl. J. Med."},{"issue":"13","key":"10.1016\/j.biopha.2016.09.021_bib0055","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa1311107","article-title":"Ceritinib in ALK-rearranged non?small-cell lung cancer","volume":"370","author":"Shaw","year":"2014","journal-title":"New Engl. J. Med."},{"issue":"2","key":"10.1016\/j.biopha.2016.09.021_bib0060","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s12013-014-0237-5","article-title":"RLIP76 blockade by siRNA inhibits proliferation: enhances apoptosis, and suppresses invasion in HT29 colon cancer cells","volume":"71","author":"Zhang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0065","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3748\/wjg.v20.i4.943","article-title":"Genetic and epigenetic biomarkers for diagnosis: prognosis and treatment of colorectal cancer","volume":"20","author":"Copped\u00e8","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.biopha.2016.09.021_bib0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.gene.2013.12.019","article-title":"Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies","volume":"538","author":"Deng","year":"2014","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.biopha.2016.09.021_bib0075","first-page":"196","article-title":"siRNA preparations in gene therapy of melanoma","volume":"17","author":"Bogus\u0142awska","year":"2012","journal-title":"Medycyna wieku rozwojowego"},{"issue":"10","key":"10.1016\/j.biopha.2016.09.021_bib0080","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.bbamcr.2012.06.012","article-title":"The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives","volume":"1823","author":"Kannan","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA)"},{"issue":"13","key":"10.1016\/j.biopha.2016.09.021_bib0085","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1074\/jbc.270.13.7615","article-title":"Activity and expression of murine small Maf family protein MafK","volume":"270","author":"Igarashi","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0090","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/MCB.15.4.2180","article-title":"Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor","volume":"15","author":"Kataoka","year":"1995","journal-title":"Mol. Cel. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0095","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jmb.2007.11.074","article-title":"Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?","volume":"376","author":"Blank","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2016.09.021_bib0100","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1128\/MCB.15.6.3424","article-title":"The BTB domain of bric \u00e0 brac mediates dimerization in vitro","volume":"15","author":"Chen","year":"1995","journal-title":"Mol. Cel. Biol."},{"issue":"11","key":"10.1016\/j.biopha.2016.09.021_bib0105","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1128\/MCB.16.11.6083","article-title":"Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site","volume":"16","author":"Oyake","year":"1996","journal-title":"Mol. Cel. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/1471-2105-12-243","article-title":"RegNetB: Predicting relevant regulator-gene relationships in localized prostate tumor samples","volume":"12","author":"Alvarez","year":"2011","journal-title":"BMC Bioinf."},{"issue":"40","key":"10.1016\/j.biopha.2016.09.021_bib0115","doi-asserted-by":"crossref","first-page":"33533","DOI":"10.1074\/jbc.M112.392332","article-title":"Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis","volume":"287","author":"Liang","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.biopha.2016.09.021_bib0120","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1101\/gad.8.14.1664","article-title":"The POZ domain: a conserved protein-protein interaction motif","volume":"8","author":"Bardwell","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.biopha.2016.09.021_bib0125","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/367525a0","article-title":"ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor","author":"Tsukiyama","year":"1994","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0130","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0092-8674(95)90031-4","article-title":"A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation","volume":"82","author":"Gerasimova","year":"1995","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.biopha.2016.09.021_bib0135","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/nar\/22.12.2383","article-title":"Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression","volume":"22","author":"Caterina","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2016.09.021_bib0140","article-title":"An in vitro FluoroBlok tumor invasion assay","volume":"29","author":"Partridge","year":"2009","journal-title":"JoVE"},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tips.2013.11.004","article-title":"Molecularly targeted cancer therapy: some lessons from the past decade","volume":"35","author":"Huang","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2016.09.021_bib0150","doi-asserted-by":"crossref","unstructured":"REPORTS, B., BACH1, a novel master regulator of metastasis from breast to bone. Official journal of the International Bone and Mineral Society, 2012 Sep 5 (10.1038\/bonekey.2012.189 eCollection 2012.): p. 1:189.","DOI":"10.1038\/bonekey.2012.189"},{"issue":"21","key":"10.1016\/j.biopha.2016.09.021_bib0155","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1038\/emboj.2011.312","article-title":"Signalling pathway for RKIP and Let\u20107 regulates and predicts metastatic breast cancer","volume":"30","author":"Yun","year":"2011","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.biopha.2016.09.021_bib0160","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/modpathol.3880169","article-title":"Expression of matrix metalloproteinase-1 in human colorectal carcinoma","volume":"13","author":"Shiozawa","year":"2000","journal-title":"Mod. Pathol."},{"issue":"32","key":"10.1016\/j.biopha.2016.09.021_bib0165","doi-asserted-by":"crossref","first-page":"33168","DOI":"10.1074\/jbc.M405102200","article-title":"Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells role of braf mutation and fibroblast growth factor signaling","volume":"279","author":"Huntington","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2016.09.021_bib0170","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1200\/JCO.2005.07.078","article-title":"Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival","volume":"23","author":"Kim","year":"2005","journal-title":"J. Clinical Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2016.09.021_bib0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.canlet.2014.08.012","article-title":"SDF-1\/CXCR4 promotes epithelial?mesenchymal transition and progression of colorectal cancer by activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"354","author":"Hu","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2016.09.021_bib0180","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3233\/CBM-150531","article-title":"Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis","volume":"15","author":"Amara","year":"2015","journal-title":"Cancer Biomark."},{"key":"10.1016\/j.biopha.2016.09.021_bib0185","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.foodchem.2015.10.063","article-title":"Legume seeds and colorectal cancer revisited: protease inhibitors reduce MMP-9 activity and colon cancer cell migration","volume":"197","author":"Lima","year":"2016","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.biopha.2016.09.021_bib0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/cancers6020625","article-title":"MicroRNAs in the regulation of MMPs and metastasis","volume":"6","author":"Abba","year":"2014","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.biopha.2016.09.021_bib0195","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1158\/0008-5472.CAN-06-3087","article-title":"CXCL10 promotes invasion-related properties in human colorectal carcinoma cells","volume":"67","author":"Zipin-Roitman","year":"2007","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0200","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/cancers6010366","article-title":"The role of matrix metalloproteinases in colorectal cancer","volume":"6","author":"Said","year":"2014","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.biopha.2016.09.021_bib0205","first-page":"1241","article-title":"MMP13 is a potential prognostic marker for colorectal cancer","volume":"24","author":"Huang","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2016.09.021_bib0210","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7178\/ig.29","article-title":"Role of matrix metalloproteinases in inflammation\/colitis-associated colon cancer","volume":"2","author":"Walter","year":"2013","journal-title":"Immunogastroenterology"},{"key":"10.1016\/j.biopha.2016.09.021_bib0215","first-page":"pbgr304","article-title":"MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1","volume":"2011","author":"Wu","year":"2016","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.biopha.2016.09.021_bib0220","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbagrm.2012.06.001","article-title":"The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes","volume":"1819","author":"Hou","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA)"},{"issue":"8","key":"10.1016\/j.biopha.2016.09.021_bib0225","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1158\/1078-0432.CCR-10-2542","article-title":"Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers","volume":"17","author":"Wang","year":"2011","journal-title":"Clinical Cancer Res."},{"issue":"11","key":"10.1016\/j.biopha.2016.09.021_bib0230","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00384-009-0770-7","article-title":"Gene expressions of HMGI-C and HMGI (Y) are associated with stage and metastasis in colorectal cancer","volume":"24","author":"Huang","year":"2009","journal-title":"Int. J. Colorectal Dis."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0235","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2014.09.007","article-title":"HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression","volume":"355","author":"Li","year":"2014","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.021_bib0240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10620-005-1275-z","article-title":"The transcriptional repressor SNAIL is overexpressed in human colon cancer","volume":"50","author":"Roy","year":"2005","journal-title":"Digestive Dis. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2016.09.021_bib0245","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.humpath.2012.03.029","article-title":"Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer","volume":"44","author":"Fan","year":"2013","journal-title":"Hum. Pathol."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.021_bib0250","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/emboj.2008.294","article-title":"Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7","volume":"28","author":"Dangi-Garimella","year":"2009","journal-title":"EMBO J."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216311155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216311155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:28:16Z","timestamp":1773872896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216311155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":50,"alternative-id":["S0753332216311155"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.09.021","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}