{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:53:27Z","timestamp":1773888807106,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Nephrology and Kidney Transplant Research Center"},{"name":"Urmia University of Medical Sciences, Urmia, Iran"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biopha.2016.09.097","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T18:02:18Z","timestamp":1475517738000},"page":"698-704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Ginger extract protects rat\u2019s kidneys against oxidative damage after chronic ethanol administration"],"prefix":"10.1016","volume":"84","author":[{"given":"Aireza","family":"Shirpoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin Abdollahzade","family":"Fard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Taghizadeh","family":"Afshari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-2066","authenticated-orcid":false,"given":"Farzaneh Hosseini","family":"Gharalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Rasmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2016.09.097_bib0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0741-8329(00)00110-5","article-title":"Effects of ethanol on the changes in renal fluid and electrolyte handling and kidney morphology induced by long-term chloroquine administration to rats","volume":"22","author":"Musabayane","year":"2000","journal-title":"Alcohol"},{"issue":"12","key":"10.1016\/j.biopha.2016.09.097_bib0010","doi-asserted-by":"crossref","first-page":"e0145691","DOI":"10.1371\/journal.pone.0145691","article-title":"Inflammatory PAF receptor signaling initiates hedgehog signaling and kidney fibrogenesis during ethanol consumption","volume":"10","author":"Latchoumycandane","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2016.09.097_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.05.020","article-title":"Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption","volume":"86","author":"Latchoumycandane","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0005-2736(91)90150-7","article-title":"In vitro effect of ethanol on sodium and glucose transport in rabbit renal brush border membrane vesicles","volume":"1070","author":"Parenti","year":"1991","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Biomembr."},{"key":"10.1016\/j.biopha.2016.09.097_bib0025","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.freeradbiomed.2014.01.001","article-title":"Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation","volume":"69","author":"Latchoumycandane","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2016.09.097_bib0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.redox.2015.06.021","article-title":"Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney","volume":"6","author":"Harris","year":"2015","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.biopha.2016.09.097_bib0035","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1093\/ndt\/gfp114","article-title":"Alcohol consumption and 5-year onset of chronic kidney disease: the AusDiab study","volume":"24","author":"White","year":"2009","journal-title":"Nephrol. Dialysis Transplant."},{"issue":"12","key":"10.1016\/j.biopha.2016.09.097_bib0040","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/oxfordjournals.aje.a009958","article-title":"Risk of end-stage renal disease associated with alcohol consumption","volume":"150","author":"Perneger","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.biopha.2016.09.097_bib0045","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.toxrep.2014.09.004","article-title":"Xanthohumol a prenylated flavonoid from hops (Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration","volume":"1","author":"Pinto","year":"2014","journal-title":"Toxicol. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.097_bib0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.intimp.2013.04.024","article-title":"Vasoprotective effect of vitamin E: Rescue of ethanol-induced atherosclerosis and inflammatory stress in rat vascular wall","volume":"16","author":"Shirpoor","year":"2013","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2016.09.097_bib0055","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0741-8329(92)90088-R","article-title":"Ultrastructural changes in the rat kidney following fetal exposure to ethanol","volume":"9","author":"Assadi","year":"1992","journal-title":"Alcohol"},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2016.09.097_bib0060","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/hep.20957","article-title":"Alcohol and oxidative liver injury","volume":"43","author":"Dey","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phymed.2014.10.002","article-title":"Protective role of ellagitannins from Eucalyptus citriodora against ethanol-induced gastric ulcer in rats: impact on oxidative stress, inflammation and calcitonin-gene related peptide","volume":"22","author":"Al-Sayed","year":"2015","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.biopha.2016.09.097_bib0070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2012.09.044","article-title":"Herbal medicines for the prevention of alcoholic liver disease: a review","volume":"144","author":"Ding","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.09.097_bib0075","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.indcrop.2015.03.033","article-title":"Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds","volume":"70","author":"Nile","year":"2015","journal-title":"Ind. Crops Prod."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.intimp.2015.03.008","article-title":"The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: a 3-month follow-up study","volume":"26","author":"Shirpoor","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0085","first-page":"307","article-title":"Practice guideline committee of the american association for the study of liver, G. practice parameters committee of the American College of, Alcoholic Liver Disease","volume":"51","author":"O\u2019Shea","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.biopha.2016.09.097_bib0090","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2016.09.097_bib0095","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopha.2016.01.015","article-title":"Protective effect of vitamin E against ethanol-induced small intestine damage in rats","volume":"78","author":"Shirpoor","year":"2016","journal-title":"Biomed. Pharmacother.=Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0928-4680(99)00034-6","article-title":"Dose response of ethanol on antioxidant defense system of liver, lung, and kidney in rat","volume":"7","author":"Scott","year":"2000","journal-title":"Pathophysiology"},{"issue":"9","key":"10.1016\/j.biopha.2016.09.097_bib0105","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/carcin\/11.9.1447","article-title":"The role of 8-hydroxyguanine in carcinogenesis","volume":"11","author":"Floyd","year":"1990","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0110","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1136\/gut.51.1.132","article-title":"Cocarcinogenic effects of alcohol in hepatocarcinogenesis","volume":"51","author":"Stickel","year":"2002","journal-title":"Gut"},{"issue":"3\u20134","key":"10.1016\/j.biopha.2016.09.097_bib0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0891-5849(91)90080-M","article-title":"Chemical determination of free radical-induced damage to DNA","volume":"10","author":"Dizdaroglu","year":"1991","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2016.09.097_bib0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1179\/135100007X200290","article-title":"Impact of Hemidesmus indicus R.Br. extract on ethanol-mediated oxidative damage in rat kidney","volume":"12","author":"Saravanan","year":"2007","journal-title":"Redox Rep."},{"issue":"6","key":"10.1016\/j.biopha.2016.09.097_bib0125","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/ki.2008.638","article-title":"Factors other than glomerular filtration rate affect serum cystatin C levels","volume":"75","author":"Stevens","year":"2009","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.097_bib0130","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ki.2010.431","article-title":"Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate","volume":"79","author":"Tangri","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2016.09.097_bib0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00365513.2015.1025427","article-title":"Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: \u2018Shrunken pore syndrome\u2019","volume":"75","author":"Grubb","year":"2015","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"6","key":"10.1016\/j.biopha.2016.09.097_bib0140","doi-asserted-by":"crossref","first-page":"F1226","DOI":"10.1152\/ajprenal.00316.2002","article-title":"Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys","volume":"284","author":"Lund","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"9","key":"10.1016\/j.biopha.2016.09.097_bib0145","first-page":"1719","article-title":"Methodology for assessment of renal function","volume":"66","author":"Hayashi","year":"2008","journal-title":"Nihon Rinsho. Jap. J. Clin. Med."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.097_bib0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000105499","article-title":"Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells","volume":"7","author":"Hu","year":"2007","journal-title":"Pancreatology"},{"issue":"8","key":"10.1016\/j.biopha.2016.09.097_bib0155","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/acer.12111","article-title":"Activation of cardiac fibroblasts by ethanol is blocked by TGF-\u03b2 inhibition","volume":"37","author":"Law","year":"2013","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"6","key":"10.1016\/j.biopha.2016.09.097_bib0160","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.patbio.2015.10.001","article-title":"Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol","volume":"63","author":"Dhouib","year":"2015","journal-title":"Pathol. Biol. (Paris)"},{"issue":"6","key":"10.1016\/j.biopha.2016.09.097_bib0165","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1080\/15548627.2016.1166317","article-title":"Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction","volume":"12","author":"Livingston","year":"2016","journal-title":"Autophagy"},{"issue":"2\u20133","key":"10.1016\/j.biopha.2016.09.097_bib0170","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-4274(01)00401-5","article-title":"Mitochondrial oxidative damage and myocardial fibrosis in rats chronically intoxicated with moderate doses of ethanol","volume":"123","author":"Vendemiale","year":"2001","journal-title":"Toxicol. Lett."},{"issue":"7","key":"10.1016\/j.biopha.2016.09.097_bib0175","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ki.2011.180","article-title":"TWEAK, a multifunctional cytokine in kidney injury","volume":"80","author":"Sanz","year":"2011","journal-title":"Kidney Int."},{"issue":"6824","key":"10.1016\/j.biopha.2016.09.097_bib0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0185","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.immuni.2014.12.017","article-title":"Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis","volume":"42","author":"Kwak","year":"2015","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.biopha.2016.09.097_bib0190","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.foodchem.2012.04.145","article-title":"In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin","volume":"135","author":"Li","year":"2012","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.biopha.2016.09.097_bib0195","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/mc.22163","article-title":"Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer","volume":"54","author":"Zick","year":"2015","journal-title":"Mol. Carcinog."},{"issue":"1","key":"10.1016\/j.biopha.2016.09.097_bib0200","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/cvr\/cvq288","article-title":"Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice","volume":"89","author":"McGaffin","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.biopha.2016.09.097_bib0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.etp.2010.09.004","article-title":"Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale)","volume":"64","author":"Oboh","year":"2012","journal-title":"Exp. Toxicol. Pathol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216310411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216310411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:39:22Z","timestamp":1773873562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216310411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":41,"alternative-id":["S0753332216310411"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.09.097","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginger extract protects rat\u2019s kidneys against oxidative damage after chronic ethanol administration","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.09.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}