{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:52:02Z","timestamp":1773888722337,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":778,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Government of India"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biopha.2016.10.059","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T21:36:20Z","timestamp":1477604180000},"page":"1256-1265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effect of L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 against in-vitro and in-vivo models of cerebral ischemia and associated neurological disorders"],"prefix":"10.1016","volume":"84","author":[{"given":"Satyendra K.","family":"Rajput","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chhuttan L.","family":"Meena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya B.","family":"Pant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam S.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.10.059_bib0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuropharm.2008.05.031","article-title":"The cost of cerebral ischaemia","volume":"55","author":"Flynn","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11910-007-0019-1","article-title":"Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials","volume":"7","author":"Fisher","year":"2007","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.biopha.2016.10.059_bib0015","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1161\/01.STR.31.8.1889","article-title":"Oxidative stress in the context of acute cerebrovascular stroke","volume":"31","author":"El Kossi","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2016.10.059_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1179\/016164107X229894","article-title":"Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury","volume":"30","author":"Wang","year":"2008","journal-title":"Neurol. Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pathophys.2009.12.001","article-title":"Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis","volume":"17","author":"Deb","year":"2010","journal-title":"Pathophysiology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mad.2015.04.001","article-title":"PARP-1 involvement in neurodegeneration: a focus on Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"146\u2013148","author":"Martire","year":"2015","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.biopha.2016.10.059_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14581\/jer.15001","article-title":"Pharmacoresistant epilepsy: a current update on non-conventional pharmacological and non-pharmacological interventions","volume":"5","author":"Sharma","year":"2015","journal-title":"J. Epilepsy Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-2999(91)90084-4","article-title":"Effects of YM-14673 a new thyroid-releasing hormone analogue, on neurological deficits in stroke-prone spontaneously hypertensive rats","volume":"192","author":"Yamamoto","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0045","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0091-3057(95)00134-I","article-title":"Effects of RGH-2202 on behavioral deficits after focal cerebral ischemia in rats","volume":"52","author":"Noda","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2016.10.059_bib0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00004647-200001000-00011","article-title":"Effect of JTP-2942 a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats","volume":"20","author":"Yonemori","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.biopha.2016.10.059_bib0055","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1440-1681.2001.03395.x","article-title":"Delayed administration of JTP-2942 a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain","volume":"28","author":"Katsumata","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0060","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0024-3205(02)02268-3","article-title":"Neuroprotective effect and brain receptor binding of taltirelin a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL\/6J mice","volume":"72","author":"Urayama","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2016.10.059_bib0065","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1210\/endo-106-5-1416","article-title":"Binding sites for thyrotropin-releasing hormone in sheep nucleus accumbens resemble pituitary receptors","volume":"106","author":"Burt","year":"1980","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0006-8993(81)90728-9","article-title":"Discrete regional distributions of thyrotropin releasing hormone (TRH) receptor binding in monkey central nervous system","volume":"205","author":"Ogawa","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1152\/physrev.1996.76.1.175","article-title":"Molecular and cellular biology of thyrotropinreleasing hormone receptors","volume":"76","author":"Gershengorn","year":"1996","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2016.10.059_bib0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/jme.0.0300087","article-title":"Thyrotropin-releasing hormone receptors \u2013 similarities and differences","volume":"30","author":"Sun","year":"2003","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0085","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1021\/jm0505462","article-title":"Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2","volume":"48","author":"Kaur","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0090","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1016\/j.bmc.2006.05.031","article-title":"Synthesis, receptor binding, and activation studies of N(1)-alkyl-L-histidine containing thyrotropin-releasing hormone (TRH) analogues","volume":"14","author":"Kaur","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0095","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1124\/jpet.102.044040","article-title":"The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics","volume":"305","author":"Gary","year":"2003","journal-title":"J. Pharmacol. Exper. Ther."},{"key":"10.1016\/j.biopha.2016.10.059_bib0100","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/jhet.5570450608","article-title":"Facile synthesis of N-(-boc-1, 2-dialkyl-l-histidines: utility in the synthesis of thyrotropin-releasing hormone (trh) analogs and evaluation of the cns activity","volume":"45","author":"Monga","year":"2008","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0105","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/npp.2012.256","article-title":"Thyrotropin-releasing hormone receptor type 1 (TRH-R1) not TRH-R2, primarily mediates taltirelin actions in the CNS of mice","volume":"38","author":"Thirunarayanan","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0110","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/cmdc.201000481","article-title":"Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues","volume":"6","author":"Monga","year":"2011","journal-title":"ChemMedChem"},{"key":"10.1016\/j.biopha.2016.10.059_bib0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.eplepsyres.2009.09.007","article-title":"Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters","volume":"87","author":"Rajput","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0120","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.yebeh.2008.10.006","article-title":"Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog","volume":"14","author":"Rajput","year":"2009","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.biopha.2016.10.059_bib0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuroscience.2011.10.008","article-title":"L-pGlu-(2-propyl)-l-His-l-ProNH2 attenuates 4-aminopyridine-induced epileptiform activity and sodium current: a possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential","volume":"199","author":"Sah","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2016.10.059_bib0130","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.peptides.2011.04.006","article-title":"Protective effects of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer Thyrotropin Releasing Hormone analog in in vitro and in vivo models of cerebral ischemia","volume":"32","author":"Rajput","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2016.10.059_bib0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0960327110371696","article-title":"Influence of cytotoxic doses of 4-hydroxynonenal on selected expression of neurotransmitter receptors in PC-12 cells","volume":"30","author":"Siddiqui","year":"2011","journal-title":"Hum. Exp Toxicol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0140","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0169-328X(98)00181-8","article-title":"Glutamate-induced cytotoxicity in PC12 pheochromocytoma cells: role of oxidation of phospholipids, glutathione and protein sulfhydryls revealed by bcl-2 transfection","volume":"60","author":"Tyurin","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0145","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/15376510802355216","article-title":"Oxygen glucose deprivation model of cerebral stroke in PC-12 cells: glucose as a limiting factor","volume":"19","author":"Singh","year":"2009","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biopha.2016.10.059_bib0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(90)90586-U","article-title":"Norvaline2-TRH: binding to TRH receptors in rat brain homogenates","volume":"180","author":"Vonhof","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0160","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/1096-9861(20001211)428:2<319::AID-CNE10>3.0.CO;2-9","article-title":"Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats","volume":"428","author":"Heuer","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1212\/WNL.0000000000000610","article-title":"The global burden of neurologic diseases","volume":"83","author":"Chin","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0170","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1212\/WNL.0000000000001251","article-title":"The global burden of neurologic diseases","volume":"84","author":"Shubhakaran","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0175","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1096\/fasebj.6.15.1464368","article-title":"Mechanisms of excitotoxicity in neurologic diseases","volume":"6","author":"Beal","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2016.10.059_bib0180","first-page":"133","article-title":"Thyrotropin-releasing hormone: basis and potential for its therapeutic use","volume":"30","author":"Kelly","year":"1995","journal-title":"Essays Biochem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(97)00155-6","article-title":"Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells","volume":"326","author":"Froissard","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0190","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.npep.2009.07.002","article-title":"Effects of TRH and its analogues on primary cortical neuronal celldamageinduced by various excitotoxic, necrotic and apoptotic agents","volume":"43","author":"Jantas","year":"2009","journal-title":"Neuropeptides"},{"key":"10.1016\/j.biopha.2016.10.059_bib0195","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.npep.2010.08.004","article-title":"Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells","volume":"44","author":"Jaworska-Feil","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.biopha.2016.10.059_bib0200","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1210\/en.2002-221074","article-title":"Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor?","volume":"144","author":"Lu","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0205","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bmc.2006.09.045","article-title":"Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1","volume":"15","author":"Kaur","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biopha.2016.10.059_bib0210","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.neuropharm.2007.02.003","article-title":"Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone","volume":"52","author":"Scalabrino","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/ars.2009.2668","article-title":"Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities","volume":"12","author":"Adibhatla","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2016.10.059_bib0220","first-page":"12","article-title":"Selective neuronal vulnerability to oxidative stress in the brain","volume":"2","author":"Wang","year":"2010","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.biopha.2016.10.059_bib0225","doi-asserted-by":"crossref","first-page":"57267","DOI":"10.1039\/C5RA07927F","article-title":"Reactive oxygen species: friend or foe","volume":"5","author":"Sharma","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2016.10.059_bib0230","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbrc.2008.11.036","article-title":"The phosphatase inhibitor, okadaic acid, strongly protects primary rat cortical neurons from lethal oxygen-glucose deprivation","volume":"378","author":"Atkinson","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2016.10.059_bib0235","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijdevneu.2012.08.008","article-title":"N(1)-(quinolin-2-ylmethyl)butane-1,4-diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia","volume":"30","author":"Cen","year":"2012","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.biopha.2016.10.059_bib0240","series-title":"Memory: From Mind to Molecules (Scientific American Library)","first-page":"358","author":"Squire","year":"1999"},{"key":"10.1016\/j.biopha.2016.10.059_bib0245","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00690397","article-title":"The density and distribution of ischemic brain injury in the rat following 2\u201310min of forebrain ischemia","volume":"64","author":"Smith","year":"1984","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0250","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/endo-126-1-317","article-title":"The paraventricular nucleus of the hypothalamus has a major role in thyroid hormone feedback regulation of thyrotropin synthesis and secretion","volume":"126","author":"Taylor","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2016.10.059_bib0255","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1248\/bpb.b12-00463","article-title":"Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation","volume":"35","author":"Fan","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2016.10.059_bib0260","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2016.10.059_bib0265","first-page":"4699","article-title":"Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells","volume":"367","author":"Lelekov-Boissard","year":"2009","journal-title":"Philos. Transact. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.biopha.2016.10.059_bib0270","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/j.1460-9568.2008.06478.x","article-title":"Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia","volume":"28","author":"Patzer","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.biopha.2016.10.059_bib0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2011.08.047","article-title":"Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke","volume":"1420","author":"Raza","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2016.10.059_bib0280","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/1874609811205030005","article-title":"Cancer-related fatigue, inflammation and thyrotropin-releasing hormone","volume":"5","author":"Kamath","year":"2012","journal-title":"Curr. Aging Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216308113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216308113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:36:19Z","timestamp":1773873379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216308113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":56,"alternative-id":["S0753332216308113"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.10.059","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of L-pGlu-(1-benzyl)-l-His-l-Pro-NH2 against in-vitro and in-vivo models of cerebral ischemia and associated neurological disorders","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.10.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}