{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:31Z","timestamp":1792790611485,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.biopha.2016.11.025","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T16:46:35Z","timestamp":1479573995000},"page":"1558-1567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Beneficial effect of carvone, a dietary monoterpene ameliorates hyperglycemia by regulating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats"],"prefix":"10.1016","volume":"84","author":[{"given":"Udaiyar","family":"Muruganathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramani","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.11.025_bib0005","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ijbiomac.2016.01.062","article-title":"Mcy protein, a potential antidiabetic agent: evaluation of carbohydrate metabolic enzymes and antioxidant status","volume":"86","author":"Marella","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2016.11.025_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2016.02.006","article-title":"Effect of glucose variability on pathways associated with glucotoxicity in diabetes: evaluation of a novel in vitro experimental approach","volume":"114","author":"Kuricova","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2016.11.025_bib0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.diabres.2015.05.037","article-title":"Update of mortality attributable to diabetes for the IDF Diabetes Atlas: estimates for the year 2013","volume":"109","author":"IDF Diabetes Atlas Group","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2016.11.025_bib0020","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4239\/wjd.v7.i6.134","article-title":"Infantile onset diabetes mellitus in developing countries\u2014India","volume":"7","author":"Varadarajan","year":"2016","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.biopha.2016.11.025_bib0025","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1389557514666140722082713","article-title":"Recent updates on glucokinase activators for the treatment of type 2 diabetes mellitus","volume":"14","author":"Grewal","year":"2014","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0030","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1039\/c2np00074a","article-title":"Recent discovery of plant-derived anti-diabetic natural products","volume":"29","author":"Hung","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.biopha.2016.11.025_bib0035","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.2174\/1568026616666160414123602","article-title":"Exploring natural products as a source for antidiabetic lead compounds and possible lead optimization","volume":"16","author":"Khalaf","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.foodchem.2005.01.003","article-title":"Carvone: why and how should one bother to produce this terpene","volume":"95","author":"Carvalho","year":"2006","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2621.1989.tb08571.x","article-title":"Influence of some spice essential oils on Aspergilrus pamsiticus growth and production of aflatoxin in a synthetic medium","volume":"54","author":"Farag","year":"1989","journal-title":"J. Food Sci."},{"key":"10.1016\/j.biopha.2016.11.025_bib0050","first-page":"150","article-title":"Nematitidal activity of some essential oils against Meloidogyne incognita","volume":"31","author":"Saxena","year":"1987","journal-title":"Indian Perfumer"},{"key":"10.1016\/j.biopha.2016.11.025_bib0055","first-page":"148","article-title":"Planta Med Serum carotenoids and atherosclerosis: the Rotterdam study","volume":"338","author":"Zheng","year":"1992","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2016.11.025_bib0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/0973-7847.79101","article-title":"Cuminumcyminum and Carumcarvi: an update","volume":"5","author":"Johri","year":"2011","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.biopha.2016.11.025_bib0065","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/000456326900600108","article-title":"Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor","volume":"6","author":"Trinder","year":"1969","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0070","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0009-9120(88)80087-0","article-title":"One-steps and wich enzyme immunoassay for insulin using monoclonal antibodies","volume":"21","author":"Burgi","year":"1998","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-4347(00)82009-5","article-title":"New less temperature sensitive, micro chromatographic method for the separation and quantitation of glycosylated haemoglobin using a non-cyanide buffer system","volume":"344","author":"Bisse","year":"1999","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.biopha.2016.11.025_bib0080","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/geronj\/12.2.166","article-title":"The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery tissue in individuals of various ages","volume":"12","author":"Brandstrup","year":"1957","journal-title":"J. Gerontol."},{"key":"10.1016\/j.biopha.2016.11.025_bib0085","first-page":"222","volume":"vol. 2","author":"Bergmeyer","year":"1984"},{"key":"10.1016\/j.biopha.2016.11.025_bib0090","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0009-8981(59)90165-2","article-title":"Pathological occurrence of glucose-6-phosphatase in serum in liver diseases","volume":"4","author":"Koide","year":"1959","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2016.11.025_bib0095","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0300-9629(97)00013-3","article-title":"Rana esculenta L. liver Fru-1,6-P2ase and G-6-pase activity and Fru-2,6-P2 concentration after acclimation at 5 and 25 degrees C","volume":"118","author":"Dziewulska-Szwajkowska","year":"1997","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.biopha.2016.11.025_bib0100","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0024-3205(00)00758-X","article-title":"Effects of myricetin on glycemia and glycogen metabolism in diabetic rats","volume":"67","author":"Ong","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2016.11.025_bib0105","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0110","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1172\/JCI104075","article-title":"Hypocatalasemia: a new genetic carrier state","volume":"39","author":"Takahara","year":"1960","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2016.11.025_bib0115","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.biopha.2016.11.025_bib0120","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2307\/2527799","article-title":"Multiple ranges tests for correlated and heteroscedastic means","volume":"13","author":"Duncan","year":"1957","journal-title":"Biometrics"},{"key":"10.1016\/j.biopha.2016.11.025_bib0135","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.2337\/db14-0059","article-title":"Glycemic goals in diabetes: trade-off between glycemic control and iatrogenic hypoglycemia","volume":"63","author":"Cryer","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2016.11.025_bib0140","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2221-6189(13)60150-X","article-title":"Antihyperglycemic effect of carvone: effect on the levels of glycoprotein components in streptozotocin-induced diabetic rats","volume":"2","author":"Muruganathan","year":"2013","journal-title":"JAD"},{"key":"10.1016\/j.biopha.2016.11.025_bib0145","first-page":"70034","article-title":"Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases","volume":"14","author":"Kalyani","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biopha.2016.11.025_bib0150","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1373\/clinchem.2013.210781","article-title":"Diagnosing diabetes mellitus: performance of hemoglobin A1c point-of-care instruments in general practice offices","volume":"59","author":"Solvik","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0155","doi-asserted-by":"crossref","first-page":"88431","DOI":"10.1371\/journal.pone.0088431","article-title":"Characterization of a novel glucokinase activator in rat and mouse models","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2016.11.025_bib0160","first-page":"35","article-title":"Glucose-6-phosphate dehydrogenase deficiency and type 2 diabetes","volume":"8","author":"Heymann","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2016.11.025_bib0165","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nutres.2015.10.001","article-title":"Gallic acid ameliorates hyperglycemia and improves hepatic carbohydrate metabolism in rats fed a high-fructose diet","volume":"36","author":"Huang","year":"2016","journal-title":"Nutr. Res."},{"key":"10.1016\/j.biopha.2016.11.025_bib0170","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/iub.1017","article-title":"Glucose-6-phosphate dehydrogenase, NADPH, and cell survival","volume":"64","author":"Stanton","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2016.11.025_bib0175","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/sj.gt.3301306","article-title":"Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells","volume":"7","author":"Chen","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.biopha.2016.11.025_bib0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cbi.2016.03.033","article-title":"Russelioside B a pregnane glycoside ameliorates hyperglycemia in streptozotocin induced diabetic rats by regulating key enzymes of glucose metabolism","volume":"252","author":"Abdel-Sattar","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2016.11.025_bib0185","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1210\/en.2009-1185","article-title":"Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells","volume":"151","author":"Zhang","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2016.11.025_bib0190","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12576-014-0335-6","article-title":"High dose of aspirin moderates diabetes-induced changes of heart glycogen\/glucose metabolism in rats","volume":"64","author":"Dervisevik","year":"2014","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.biopha.2016.11.025_bib0195","doi-asserted-by":"crossref","first-page":"4513871","DOI":"10.1155\/2016\/4513871","article-title":"Gmelina arborea Roxb. (Family: Verbenaceae) extract upregulates the \u03b2-cell regeneration in STZ induced diabetic rats","volume":"2016","author":"Attanayake","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2016.11.025_bib0200","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.acthis.2012.12.007","article-title":"The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats","volume":"115","author":"Kaya-Dagistanli","year":"2013","journal-title":"Acta Histochem."},{"key":"10.1016\/j.biopha.2016.11.025_bib0205","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.phymed.2014.04.005","article-title":"Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats","volume":"21","author":"Kalailingam","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2016.11.025_bib0210","doi-asserted-by":"crossref","first-page":"90","DOI":"10.14336\/AD.2015.0702","article-title":"Hyperglycemic stress and carbon stress in diabetic glucotoxicity","volume":"7","author":"Luo","year":"2016","journal-title":"Aging Dis."},{"key":"10.1016\/j.biopha.2016.11.025_bib0215","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/cpr.12062","article-title":"Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis","volume":"46","author":"Vinothkumar","year":"2013","journal-title":"Cell Prolif."},{"key":"10.1016\/j.biopha.2016.11.025_bib0220","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jep.2013.12.007","article-title":"Trapa natans L. root extract suppresses hyperglycemic and hepatotoxic effects in STZ-induced diabetic rat mode","volume":"151","author":"Kharbanda","year":"2014","journal-title":"J. Ethnopharmacol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216312380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216312380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:38:01Z","timestamp":1773873481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216312380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":44,"alternative-id":["S0753332216312380"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.025","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial effect of carvone, a dietary monoterpene ameliorates hyperglycemia by regulating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}