{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:00Z","timestamp":1790614320515,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.biopha.2016.11.074","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T05:15:18Z","timestamp":1480050918000},"page":"635-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: Future applications in Parkinson\u2019s disease"],"prefix":"10.1016","volume":"85","author":[{"given":"Abdelrahman Ibrahim","family":"Abushouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Negida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussien","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Abdel-Daim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.11.074_bib0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of parkinson\u2019s disease","volume":"5","author":"De Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0010","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.11.074_bib0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF03159935","article-title":"Pathology of parkinson\u2019s disease","volume":"14","author":"Jellinger","year":"1991","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0020","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1172\/JCI29178","article-title":"Diagnosis and treatment of Parkinson disease: molecules to medicine","volume":"116","author":"Savitt","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2016.11.074_bib0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1212\/WNL.44.3_Part_1.499","article-title":"A clinical genetic study of Parkinson\u2019s disease Evidence for dominant transmission","volume":"44","author":"Lazzarini","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1086\/496902","article-title":"High-resolution whole-genome association study of Parkinson disease","volume":"77","author":"Maraganore","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.biopha.2016.11.074_bib0035","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the \u03b1-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biopha.2016.11.074_bib0040","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1021\/bi961799n","article-title":"NACP, a protein implicated in Alzheimer\u2019s disease and learning, is natively unfolded","volume":"35","author":"Weinreb","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2016.11.074_bib0045","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"\u03b1-Synuclein in filamentous inclusions of Lewy bodies from Parkinson\u2019s disease and dementia with Lewy bodies","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0050","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"\u03b1-Synuclein impairs macroautophagy: implications for Parkinson\u2019s disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0055","first-page":"87","article-title":"Alpha\u2013synuclein, nigral degeneration and parkinsonism","author":"Mizuno","year":"2005","journal-title":"Sci. Basis Treat. Parkinson\u2019s Dis."},{"key":"10.1016\/j.biopha.2016.11.074_bib0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","article-title":"Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.11.074_bib0065","doi-asserted-by":"crossref","first-page":"13354","DOI":"10.1073\/pnas.240347797","article-title":"Parkin functions as an E2-dependent ubiquitin\u2013protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0070","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1002\/mds.22798","article-title":"The role of parkin in familial and sporadic Parkinson\u2019s disease","volume":"25","author":"Dawson","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.biopha.2016.11.074_bib0075","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.biopha.2016.11.074_bib0080","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular pathways of neurodegeneration in Parkinson\u2019s disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biopha.2016.11.074_bib0085","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s007020100004","article-title":"Neurochemical findings in the MPTP model of Parkinson\u2019s disease","volume":"108","author":"Schmidt","year":"2001","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.biopha.2016.11.074_bib0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0304-3940(86)90282-X","article-title":"Histochemistry of MPTP oxidation in the rat brain: sites of synthesis of the parkinsonism-inducing toxin MPP+","volume":"65","author":"Nakamura","year":"1986","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2016.11.074_bib0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/00002826-198612000-00001","article-title":"MPTP: current concepts and controversies","volume":"9","author":"Langston","year":"1986","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0100","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1096\/fj.03-0109fje","article-title":"Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson\u2019s disease","volume":"17","author":"Gao","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2016.11.074_bib0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson\u2019s disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0110","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.80.14.4546","article-title":"A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine","volume":"80","author":"Burns","year":"1983","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0115","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/bies.10067","article-title":"Animal models of Parkinson\u2019s disease","volume":"24","author":"Betarbet","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.biopha.2016.11.074_bib0120","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1177\/1091581810383705","article-title":"Rosmarinic acid antagonized 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in MES23. 5 dopaminergic cells","volume":"29","author":"Du","year":"2010","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0125","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2010.05.006","article-title":"Protective effects of Gastrodia elata Blume on MPP+-induced cytotoxicity in human dopaminergic SH-SY5Y cells","volume":"130","author":"An","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/exnr.2002.8049","article-title":"Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons","volume":"179","author":"Li","year":"2003","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0135","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jep.2010.06.009","article-title":"Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway","volume":"131","author":"Cao","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0140","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.3390\/molecules16075349","article-title":"Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells","volume":"16","author":"Kim","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2016.11.074_bib0145","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pbb.2008.03.014","article-title":"Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract","volume":"90","author":"Zhao","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2016.11.074_bib0150","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1055\/s-2002-35667","article-title":"Tubuloside B from Cistanche salsa rescues the PC12 neuronal cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis and oxidative stress","volume":"68","author":"Sheng","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0155","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1007\/s11064-009-9978-8","article-title":"Cruciferous nutraceutical 3H-1, 2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by MPTP, MPP(+), 6-OHDA, HNE and acrolein","volume":"34","author":"Jia","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0160","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.fct.2011.01.002","article-title":"Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson\u2019s disease","volume":"49","author":"Kim","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0165","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jep.2009.09.017","article-title":"Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity","volume":"126","author":"Kim","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0170","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1023\/A:1013971524150","article-title":"EGb761 blocks MPP+-induced lipid peroxidation in mouse corpus striatum","volume":"26","author":"Rojas","year":"2001","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0175","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jnutbio.2010.08.005","article-title":"S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice","volume":"22","author":"Rojas","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2016.11.074_bib0180","first-page":"2021","article-title":"Protective effect of effective part of Acanthopanacis senticosus on damage of PC12 cells induced by MPP+","volume":"35","author":"An","year":"2010","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.biopha.2016.11.074_bib0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuint.2014.06.003","article-title":"Gastrodin protects against MPP(+)-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK\/Nrf2 pathway in human dopaminergic cells","volume":"75","author":"Jiang","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2016.11.074_bib0190","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","article-title":"Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury","volume":"96","author":"Dor\u00e9","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0195","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fct.2005.08.017","article-title":"Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells","volume":"44","author":"An","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neulet.2010.03.053","article-title":"dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson\u2019s disease","volume":"475","author":"Huang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2016.11.074_bib0205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(02)02240-9","article-title":"Protective effect of verbascoside on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells","volume":"451","author":"Sheng","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0210","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1021\/jf302792t","article-title":"Neuroprotective effects of longan (Dimocarpus longan Lour.) flower water extract on MPP+-induced neurotoxicity in rat brain","volume":"60","author":"Lin","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2016.11.074_bib0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1472-6882-12-82","article-title":"Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1\/PGC-1alpha signaling pathway","volume":"12","author":"Ye","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0220","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1248\/bpb.b13-00743","article-title":"Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson\u2019s disease in vitro and in vivo","volume":"37","author":"Guo","year":"2014","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2016.11.074_bib0225","first-page":"1241","article-title":"[Protective effects of Lycium barbarum extract against MPP(+) \u2212induced neurotoxicity in Caenorhabditis elegans and PC12 cells]","volume":"34","author":"Yao","year":"2011","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2016.11.074_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J"},{"key":"10.1016\/j.biopha.2016.11.074_bib0235","first-page":"176","article-title":"[Ginsenoside Rg1 may protect SHSY5Y cells from apoptosis induced by MPP+ through JNK way]","volume":"38","author":"Fang","year":"2003","journal-title":"Yao Xue Bao"},{"key":"10.1016\/j.biopha.2016.11.074_bib0240","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.fct.2006.05.004","article-title":"Protocatechuic acid suppresses MPP+ \u2212induced mitochondrial dysfunction and apoptotic cell death in PC12 cells","volume":"44","author":"Guan","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0245","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neures.2005.06.014","article-title":"Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation","volume":"53","author":"Bo","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0250","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijbiomac.2014.05.049","article-title":"Protective effects of Gynostemma pentaphyllum polysaccharides on PC12 cells impaired by MPP(+)","volume":"69","author":"Deng","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0255","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2307\/3579638","article-title":"Proteolysis of poly (ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono (ADP-ribosyl) ated and DNA-bound substrates","volume":"150","author":"D\u2019Amours","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0260","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejphar.2007.10.052","article-title":"Pedicularioside A from Buddleia lindleyana inhibits cell death induced by 1-methyl-4-phenylpyridinium ions (MPP+) in primary cultures of rat mesencephalic neurons","volume":"579","author":"Li","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-2003-37029","article-title":"Acteoside from Cistanche salsa inhibits apoptosis by 1-methyl-4-phenylpyridinium ion in cerebellar granule neurons","volume":"69","author":"Pu","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0270","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jep.2004.10.014","article-title":"Phenylethanoid glycosides from Cistanches salsa inhibit apoptosis induced by 1-methyl-4-phenylpyridinium ion in neurons","volume":"97","author":"Tian","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0275","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.cellbi.2009.06.006","article-title":"Neuroprotective effect of methanol extract of Phellodendri Cortex against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells","volume":"33","author":"Jung","year":"2009","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.biopha.2016.11.074_bib0280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diabetes.50.1.77","article-title":"Cell-permeable peptide inhibitors of JNK novel blockers of \u03b2-cell death","volume":"50","author":"Bonny","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2016.11.074_bib0285","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jep.2009.10.023","article-title":"Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity","volume":"127","author":"Luo","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0290","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","article-title":"Mammalian thioredoxin is a direct inhibitor of apoptosis signal regulating kinase (ASK) 1","volume":"17","author":"Saitoh","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.biopha.2016.11.074_bib0295","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jep.2010.07.008","article-title":"Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+\/MPTP-induced cytotoxicity in vitro and in vivo","volume":"131","author":"Doo","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0300","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/toxsci\/kfr255","article-title":"Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways","volume":"125","author":"Singh","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0305","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1038\/sj.onc.1207115","article-title":"PI3K\/Akt and apoptosis: size matters","volume":"22","author":"Franke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2016.11.074_bib0310","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/cdd.2013.153","article-title":"The rheostat in the membrane: BCL-2 family proteins and apoptosis","volume":"21","author":"Volkmann","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2016.11.074_bib0315","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3892\/ijmm.2014.2056","article-title":"Protective effects of apigenin against 1-methyl-4-phenylpyridinium ioninduced neurotoxicity in PC12 cells","volume":"35","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jep.2014.11.007","article-title":"Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson\u2019s disease","volume":"159","author":"Bae","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0325","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1590\/S0100-879X2012007500039","article-title":"Protection against neurotoxicity by an autophagic mechanism","volume":"45","author":"Liu","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0330","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3109\/14756366.2011.616946","article-title":"Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents","volume":"27","author":"Herraiz","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.074_bib0335","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1023\/B:NERE.0000026406.64547.93","article-title":"EGb761 pretreatment reduces monoamine oxidase activity in mouse corpus striatum during 1-methyl-4-phenylpyridinium neurotoxicity","volume":"29","author":"Rojas","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0340","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s00018-009-9030-9","article-title":"In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.)","volume":"66","author":"Zhao","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0345","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0024-3205(02)02347-0","article-title":"Effects of green tea polyphenols on dopamine uptake and on MPP+ \u2212induced dopamine neuron injury","volume":"72","author":"Pan","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0350","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1212\/WNL.55.9.1358","article-title":"Parkinson\u2019s disease and parkinsonism in a longitudinal study Two-fold higher incidence in men","volume":"55","author":"Baldereschi","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0355","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwg068","article-title":"Incidence of Parkinson\u2019s disease: variation by age, gender, and race\/ethnicity","volume":"157","author":"Van Den Eeden","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0360","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/mds.1170","article-title":"Hysterectomy, menopause, and estrogen use preceding Parkinson\u2019s disease: an exploratory case control study","volume":"16","author":"Benedetti","year":"2001","journal-title":"Mov. Disord."},{"key":"10.1016\/j.biopha.2016.11.074_bib0365","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jnr.10833","article-title":"Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxdopamine lesions","volume":"75","author":"Quesada","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0370","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/jnr.10315","article-title":"Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells","volume":"70","author":"Gelinas","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0375","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12035-009-8077-9","article-title":"The multifaceted profile of activated microglia","volume":"40","author":"Lynch","year":"2009","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0380","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/toxsci\/kfi055","article-title":"Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B\u2014dependent mechanism","volume":"84","author":"Filipov","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2016.11.074_bib0385","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1093\/hmg\/ddt192","article-title":"Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of \u03b1-synuclein in Parkinson\u2019s disease models","volume":"22","author":"Hebron","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biopha.2016.11.074_bib0390","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuro.2014.07.006","article-title":"Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson\u2019s disease mouse model","volume":"44","author":"Sarkar","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0395","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2217\/nnm.14.165","article-title":"Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly (lactide) nanoparticles in MPTP-induced Parkinsonism","volume":"10","author":"Da Rocha Lindner","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2016.11.074_bib0400","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1753425913488429","article-title":"Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson\u2019s-like disease: possible role of SOCS-1 in reducing pro-inflammatory responses","volume":"20","author":"Lofrumento","year":"2014","journal-title":"Innate immun."},{"key":"10.1016\/j.biopha.2016.11.074_bib0405","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2015.05.024","article-title":"Neuroprotective effect of lycopene against MPTP induced experimental Parkinson\u2019s disease in mice","volume":"599","author":"Prema","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2016.11.074_bib0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/jbcpp-2015-0021","article-title":"Neuroprotective effect of hydroxy safflor yellow A against cerebral ischemia-reperfusion injury in rats: putative role of mPTP","volume":"27","author":"Ramagiri","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0415","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.neuro.2015.10.012","article-title":"Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL\/6 mice","volume":"51","author":"Sridharan","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0420","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3109\/13880209.2014.991835","article-title":"Neuroprotective effects of alkaloids from Piper longum in a MPTP-induced mouse model of Parkinson\u2019s disease","volume":"53","author":"Bi","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0425","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.intimp.2015.10.032","article-title":"Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine)-induced mouse model of Parkinson\u2019s disease","volume":"29","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0430","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1142\/S0192415X16500506","article-title":"Neuroprotective effect of coptis chinensis in MPP+ and MPTP-induced parkinson\u2019s disease models","volume":"44","author":"Friedemann","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0435","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3109\/10715762.2015.1032958","article-title":"Neuroprotective effects of ginkgetin against neuroinjury in Parkinson\u2019s disease model induced by MPTP via chelating iron","volume":"49","author":"Wang","year":"2015","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2016.11.074_bib0440","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.phymed.2012.04.002","article-title":"Effects of cannabinoids Delta(9)-tetrahydrocannabinol, Delta(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures","volume":"19","author":"Moldzio","year":"2012","journal-title":"Phytomedicine"},{"issue":"151","key":"10.1016\/j.biopha.2016.11.074_bib0445","article-title":"Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system","volume":"15","author":"Guo","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0450","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jep.2010.12.016","article-title":"The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson\u2019s disease","volume":"134","author":"Bae","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0455","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.fitote.2011.04.012","article-title":"Neuroprotective bakkenolides from the roots of Valeriana jatamansi","volume":"82","author":"Xu","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2016.11.074_bib0460","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nut.2008.10.013","article-title":"Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson\u2019s disease","volume":"25","author":"Rojas","year":"2009","journal-title":"Nutrition"},{"key":"10.1016\/j.biopha.2016.11.074_bib0465","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuropharm.2014.07.012","article-title":"Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice","volume":"86","author":"Patil","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0470","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijbiomac.2015.12.025","article-title":"Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice","volume":"86","author":"Meenakshi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2013.12.001","article-title":"Comparison of the neuroprotective potential of Mucuna pruriens seed extract with estrogen in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice model","volume":"65","author":"Yadav","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2016.11.074_bib0480","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tox.2014.02.009","article-title":"Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson\u2019s disease","volume":"319","author":"P\u00e9rez-H","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0485","first-page":"2494","article-title":"[Neuroprotective effects and mechanisms of Chuanxiong Chatiao pulvis against MPTP-induced dopaminergic neurotoxicity in mice model of Parkinson\u2019s disease]","volume":"34","author":"Shu","year":"2009","journal-title":"Zhongguo Zhong yao za zhi=Zhongguo zhongyao zazhi=China J. Chin. Materia Medica"},{"key":"10.1016\/j.biopha.2016.11.074_bib0490","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2015.09.029","article-title":"Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson\u2019s disease","volume":"768","author":"Chen","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0495","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/542383","article-title":"Neuroprotective effects of Jitai tablet, a traditional Chinese medicine, on the MPTP-induced acute model of Parkinson\u2019s disease: involvement of the dopamine system","volume":"2014","author":"Liu","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0500","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.fitote.2011.07.010","article-title":"neo-Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities","volume":"82","author":"Guo","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2016.11.074_bib0505","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1271\/bbb.120097","article-title":"Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi","volume":"76","author":"Xu","year":"2012","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.biopha.2016.11.074_bib0510","first-page":"554","article-title":"[Isolation and identification of Suavissimoside R1 from roots of Rubus parvifollus used for protecting dopaminergic neurons against MPP+ toxicity]","volume":"31","author":"Yu","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2016.11.074_bib0515","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/jamaneurol.2014.131","article-title":"A randomized clinical trial of high-dosage coenzyme q10 in early Parkinson disease: no evidence of benefit","volume":"71","author":"Beal","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0520","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1871527314666150821103306","article-title":"Coenzyme Q10 for patients with parkinson\u2019s disease: a systematic review and meta-analysis, CNS &","volume":"15","author":"Negida","year":"2016","journal-title":"Neurol. Disord. Drug Targ."},{"key":"10.1016\/j.biopha.2016.11.074_bib0525","doi-asserted-by":"crossref","unstructured":"(1996) Impact of deprenyl and tocopherol treatment on Parkinson\u2019s disease in DATATOP patients requiring levodopa. Parkinson Study Group. Annals of neurology 39:37\u201345. 10.1002\/ana.410390107.","DOI":"10.1002\/ana.410390107"},{"key":"10.1016\/j.biopha.2016.11.074_bib0530","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S1474-4422(06)70602-0","article-title":"TCH346 as a neuroprotective drug in Parkinson\u2019s disease: a double-blind, randomised, controlled trial","volume":"5","author":"Olanow","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.biopha.2016.11.074_bib0535","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1212\/01.wnl.0000277648.63931.c0","article-title":"Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease","volume":"69","author":"Parkinson Study Group","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2016.11.074_bib0540","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1056\/NEJM199301213280305","article-title":"Effects of tocopherol and deprenyl on the progression of disability in early Parkinson\u2019s disease","volume":"328","author":"Parkinson Study Group","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2016.11.074_bib0545","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson\u2019s disease, Movement disorders","volume":"25","author":"Snow","year":"2010","journal-title":"Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.biopha.2016.11.074_bib0550","doi-asserted-by":"crossref","first-page":"32476","DOI":"10.3402\/meo.v21.32476","article-title":"Curing neurophobia in medical schools: evidence-based strategies","volume":"21","author":"Abushouk","year":"2016","journal-title":"Med. Educ. Online"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216317668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216317668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T23:31:41Z","timestamp":1672443101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216317668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":110,"alternative-id":["S0753332216317668"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.074","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective mechanisms of plant extracts against MPTP induced neurotoxicity: Future applications in Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}