{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:05:45Z","timestamp":1783710345965,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.biopha.2016.11.119","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T21:19:57Z","timestamp":1481318397000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Synthesis and evaluation of analgesic, behavioral effects and chronic toxicity of the new 3,5-diaminopyrazole and its precursor the thiocyanoacetamide"],"prefix":"10.1016","volume":"86","author":[{"given":"Ridha","family":"Ben Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Ben Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khouloud","family":"Bokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Maghraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Hajri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azaiez","family":"Ben Akacha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadli","family":"Dziri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le V\u00e9ronique","family":"El May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.11.119_bib0005","first-page":"123","article-title":"Synth\u00e8se et caract\u00e9risation de quelques diaminopyrazoles","volume":"12","author":"Manai","year":"2010","journal-title":"J. Soc. Chim. Tunisie"},{"key":"10.1016\/j.biopha.2016.11.119_bib0010","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.bmc.2007.12.033","article-title":"Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems","volume":"6","author":"Benaamane","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.119_bib0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.lfs.2013.12.005","article-title":"Antinociceptive anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3 carbohydrazide, a new heterocyclic pyrazole derivative","volume":"95","author":"Malvar","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2016.11.119_bib0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0223-5234(01)01252-1","article-title":"Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity","volume":"36","author":"Turan-Zitouni","year":"2001","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.119_bib0025","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.3390\/molecules18044669","article-title":"Synthesis and antimicrobial activity of some new thieno[2,3-b]thiophene derivatives","volume":"18","author":"Mabkhot","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2016.11.119_bib0030","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jhet.5570440528","article-title":"Pyridazine and phthalazine derivatives with potential antimicrobial activity","volume":"44","author":"Butnariu","year":"2007","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.biopha.2016.11.119_bib0035","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3987\/COM-05-10428","article-title":"Synthesis and antimicrobial activity of some new pyridazine derivatives","volume":"65","author":"Caprosu","year":"2005","journal-title":"Heterocycles"},{"key":"10.1016\/j.biopha.2016.11.119_bib0040","first-page":"415","article-title":"New derivatives of 1-methylphthalazine with antimicrobial and fungistatic action","volume":"5","author":"Dima","year":"1999","journal-title":"Ann. Pharm. Fr."},{"key":"10.1016\/j.biopha.2016.11.119_bib0045","first-page":"155","article-title":"The breakdown of plant biostructure followed by amino acids determination","volume":"6","author":"Drochioiu","year":"2001","journal-title":"Rom. Biotechnol. Lett."},{"key":"10.1016\/j.biopha.2016.11.119_bib0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0014-827X(01)01037-0","article-title":"Synthesis and antinociceptive activity of 6-substituted-3- pyridazinone derivatives","volume":"56","author":"Gok\u00e7e","year":"2001","journal-title":"Il Farmaco"},{"key":"10.1016\/j.biopha.2016.11.119_bib0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-4274(01)00539-2","article-title":"Extrathyroidal actions of antithyroid thionamides","volume":"128","author":"Bandyopadhyay","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2016.11.119_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0117498","article-title":"Tempol treatment reduces anxiety like behaviors induced by multiple anxiogenic drugs in rats","volume":"10","author":"Patki","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2016.11.119_bib0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.rvsc.2016.01.023","article-title":"Effects of oral administration of caffeine on some physiological parameters and maternal behaviour of sows at farrowing","volume":"105","author":"Superchi","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.biopha.2016.11.119_bib0070","first-page":"1473","article-title":"Pyrazoles: synthetic strategies and their pharmaceutical applications-an overview","volume":"5","author":"Kumar","year":"2013","journal-title":"Int. J. Pharm. Tech. Res."},{"key":"10.1016\/j.biopha.2016.11.119_bib0075","first-page":"356","article-title":"Recent advances on the synthesis of pyrazole-containing compounds of potent biological activities and study their chemical applications","volume":"3","author":"Eldebss Taha","year":"2014","journal-title":"Asian J. Biochem. Pharmace. Res."},{"key":"10.1016\/j.biopha.2016.11.119_bib0080","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1016\/j.ejmech.2011.08.010","article-title":"Synthesis and antioxidant activity of oxazolyl\/thiazolylsulfonylmethyl pyrazoles and isoxazoles","volume":"46","author":"Padmaja","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.119_bib0085","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: insights from spatial processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.biopha.2016.11.119_bib0090","first-page":"54","article-title":"Cognitive neuroscience of emotional memory","volume":"7","author":"LaBar","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.11.119_bib0095","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cub.2007.08.005","article-title":"The amygdale","volume":"17","author":"LeDoux","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.biopha.2016.11.119_bib0100","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1038\/npp.2010.71","article-title":"Effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption","volume":"35","author":"Rogers","year":"2010","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.biopha.2016.11.119_bib0105","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3109\/02699052.2012.750753","article-title":"Effects of combined ferrous sulphate administration and exposure to static magnetic field on spatial learning and motor abilities in rats","volume":"27","author":"Maaroufi","year":"2013","journal-title":"Brain Inj."},{"key":"10.1016\/j.biopha.2016.11.119_bib0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.119_bib0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1037\/h0071444","article-title":"Emotional behavior in the rat. I: Defecation and urination as measures of individual differences in emotionality","volume":"18","author":"Hall","year":"1934","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.biopha.2016.11.119_bib0120","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.3390\/molecules20022668","article-title":"Synthesis and evaluation of new 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives as potential antidepressant agents","volume":"20","author":"\u00d6zdemir","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2016.11.119_bib0125","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1590\/S0100-879X2004001000013","article-title":"Antinociceptive effect of novel pyrazolines in mice","volume":"37","author":"Tabarelli","year":"2004","journal-title":"Braz. Med. Boil. Res."},{"key":"10.1016\/j.biopha.2016.11.119_bib0130","volume":"vol. 1","author":"Olfert","year":"1993"},{"key":"10.1016\/j.biopha.2016.11.119_bib0135","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","article-title":"Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)","volume":"58","author":"Hedenmalm","year":"2002","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.119_bib0140","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"26","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2016.11.119_bib0145","first-page":"55","article-title":"Evaluation of the analgesic activity of the methanolic stem bark extract of Dialium Guineense (Wild)","volume":"1","author":"Ezeja","year":"2011","journal-title":"Ann. Med. Health Sci. Res."},{"key":"10.1016\/j.biopha.2016.11.119_bib0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1037\/h0061626","article-title":"Cognitive maps in rats and men","volume":"55","author":"Tolman","year":"1948","journal-title":"Psychol. Rev"},{"key":"10.1016\/j.biopha.2016.11.119_bib0155","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsych.2011.07.009","article-title":"Early-life forebrain glucocorticoid receptor overexpression increases anxiety behavior and cocaine sensitization","volume":"71","author":"Wei","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2016.11.119_bib0160","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.physbeh.2008.10.019","article-title":"Impairment of emotional behavior and spatial learning in adult Wistar rats by ferrous sulfate","volume":"96","author":"Maaroufi","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.biopha.2016.11.119_bib0165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","article-title":"Tests for emotionality in rats and mice: a review","volume":"21","author":"Archer","year":"1973","journal-title":"Anim. Behav."},{"key":"10.1016\/j.biopha.2016.11.119_bib0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0168-0102(03)00224-4","article-title":"Effects of ventrolateral-ventromedial thalamic lesions on motor coordination and spatial orientation in rats","volume":"47","author":"Jeljeli","year":"2003","journal-title":"Neurosci. Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216313695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216313695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:25:44Z","timestamp":1782865544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216313695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":34,"alternative-id":["S0753332216313695"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.119","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and evaluation of analgesic, behavioral effects and chronic toxicity of the new 3,5-diaminopyrazole and its precursor the thiocyanoacetamide","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.119","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}