{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:50:42Z","timestamp":1790095842640,"version":"4.0.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"DST-SERB in the form of Start-Up grant for Young Scientists","award":["YSS\/2015\/001267"],"award-info":[{"award-number":["YSS\/2015\/001267"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.biopha.2016.11.130","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T11:15:23Z","timestamp":1480936523000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer"],"prefix":"10.1016","volume":"85","author":[{"given":"Shabir Ahmad","family":"Ganai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0005","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4161\/epi.3.6.7273","article-title":"The role of histone deacetylases in prostate cancer","volume":"3","author":"Abbas","year":"2008","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0010","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrc1779","article-title":"Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer","volume":"6","author":"Minucci","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0015","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1073\/pnas.052410099","article-title":"Comprehensive analysis of CpG islands in human chromosomes 21 and 22","volume":"99","author":"Takai","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2016.11.130_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.pharmthera.2016.07.001","article-title":"Modulating epigenetic HAT activity for reinstating acetylation homeostasis: a promising therapeutic strategy for neurological disorders","volume":"166","author":"Ganai","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"37","key":"10.1016\/j.biopha.2016.11.130_bib0025","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","article-title":"HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"issue":"36","key":"10.1016\/j.biopha.2016.11.130_bib0030","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1039\/c2sm25662b","article-title":"The polyelectrolyte properties of chromatin","volume":"8","author":"Korolev","year":"2012","journal-title":"Soft Matter"},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0035","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/07391102.2014.938247","article-title":"HDAC inhibition through valproic acid modulates the methylation profiles in human embryonic kidney cells","volume":"33","author":"Ganai","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.biopha.2016.11.130_bib0040","first-page":"1","article-title":"Histone deacetylase inhibitor pracinostat in doublet therapy: a unique strategy to improve therapeutic efficacy and to tackle herculean cancer chemoresistance","author":"Ganai","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2016.11.130_bib0045","article-title":"Histone deacetylase inhibitors modulating non-epigenetic players: the novel molecular targets for therapeutic intervention","author":"Ganai","year":"2016","journal-title":"Curr. Drug Targets"},{"issue":"5","key":"10.1016\/j.biopha.2016.11.130_bib0050","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1073\/pnas.0307708100","article-title":"Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1","volume":"101","author":"Gui","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"19","key":"10.1016\/j.biopha.2016.11.130_bib0055","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1074\/jbc.M510023200","article-title":"Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer","volume":"281","author":"Wilson","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6887","key":"10.1016\/j.biopha.2016.11.130_bib0060","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.tcb.2008.04.003","article-title":"HDAC6: a key regulator of cytoskeleton, cell migration and cell\u2013cell interactions","volume":"18","author":"Valenzuela-Fernandez","year":"2008","journal-title":"Trends Cell Biol."},{"issue":"39","key":"10.1016\/j.biopha.2016.11.130_bib0070","doi-asserted-by":"crossref","first-page":"16663","DOI":"10.1073\/pnas.0908908106","article-title":"Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6","volume":"106","author":"Gibbs","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0075","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbrc.2008.01.056","article-title":"Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors","volume":"368","author":"Park","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0080","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4161\/epi.3.6.7273","article-title":"The role of histone deacetylases in prostate cancer","volume":"3","author":"Abbas","year":"2008","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1570159X13666151021111609","article-title":"Histone Deacetylase (HDAC) Inhibitors \u2212 emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration","volume":"14","author":"Ganai","year":"2016","journal-title":"Current Neuropharmacol."},{"key":"10.1016\/j.biopha.2016.11.130_bib0090","article-title":"Plant derived inhibitor Sulforaphane in combinatorial therapy against therapeutically challenging Pancreatic Cancer","author":"Ganai","year":"2016","journal-title":"Anti-cancer Agents Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.130_bib0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biopha.2016.04.022","article-title":"Histone deacetylase inhibitor sulforaphane: the phytochemical with vibrant activity against prostate cancer","volume":"81","author":"Ganai","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2016.11.130_bib0100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2407-12-180","article-title":"Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells","volume":"12","author":"Pal-Bhadra","year":"2012","journal-title":"BMC Cancer"},{"issue":"12","key":"10.1016\/j.biopha.2016.11.130_bib0105","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/mc.20866","article-title":"Plant flavone Apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study","volume":"51","author":"Pandey","year":"2012","journal-title":"Mol. Carcinog."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0110","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1074\/jbc.M305529200","article-title":"Apigenin induces apoptosis through proteasomal degradation of HER2\/neu in HER2\/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase\/Akt-dependent pathway","volume":"279","author":"Way","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2016.11.130_bib0115","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3164\/jcbn.08-230","article-title":"Apigenin induces apoptosis through a mitochondria\/caspase-pathway in human breast cancer MDA-MB-453Cells","volume":"44","author":"Choi","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0120","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3892\/or_00000598","article-title":"5-Fluorouracil combined with Apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells","volume":"22","author":"Choi","year":"2009","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0125","first-page":"945","article-title":"The dietary flavonoid Apigenin sensitizes malignant tumor cells to tumor necrosis factor?related apoptosis-inducing ligand","volume":"5","author":"Horinaka","year":"2006","journal-title":"Am. Assoc. Cancer Res."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0130","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbamcr.2011.12.008","article-title":"Evidence for activation of mutated p53 by Apigenin in human pancreatic cancer","volume":"1823","author":"King","year":"2012","journal-title":"BiochimicaetBiophysicaActa (BBA) \u2212 Mol. Cell Res."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0135","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/bcr1797","article-title":"Inhibition of proteasome activity by the dietary flavonoid Apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts","volume":"9","author":"Chen","year":"2007","journal-title":"Breast Cancer Res. BCR"},{"issue":"3","key":"10.1016\/j.biopha.2016.11.130_bib0140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrm2346","article-title":"The Rpd3\/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men","volume":"9","author":"Yang","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0145","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/07391102.2013.879073","article-title":"Energy-optimised pharmacophore approach to identify potential hotspots during inhibition of Class II HDAC isoforms","volume":"33","author":"Ganai","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"3","key":"10.1016\/j.biopha.2016.11.130_bib0150","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/molecules20033898","article-title":"Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents","volume":"20","author":"Mottamal","year":"2015","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.biopha.2016.11.130_bib0155","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2174\/1568026616666160212122609","article-title":"Novel approaches towards designing of isoform-Selective inhibitors against class II histone deacetylases: the acute requirement for targetted anticancer therapy","volume":"16","author":"Ganai","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/bbrc.1999.0897","article-title":"Characterization of five human cDNAs with homology to the yeast SIR2 gene: sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity","volume":"260","author":"Frye","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0165","doi-asserted-by":"crossref","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"6749","key":"10.1016\/j.biopha.2016.11.130_bib0170","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/43710","article-title":"Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors","volume":"401","author":"Finnin","year":"1999","journal-title":"Nature"},{"issue":"Pt 1","key":"10.1016\/j.biopha.2016.11.130_bib0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj3500199","article-title":"Cloning and characterization of a novel human histone deacetylase. HDAC8","volume":"350","author":"Buggy","year":"2000","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molonc.2007.01.001","article-title":"The role of histone deacetylases (HDACs) in human cancer","volume":"1","author":"Ropero","year":"2007","journal-title":"Mol. Oncol."},{"issue":"16","key":"10.1016\/j.biopha.2016.11.130_bib0185","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1093\/emboj\/19.16.4342","article-title":"Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3","volume":"19","author":"Li","year":"2000","journal-title":"EMBO J."},{"issue":"35","key":"10.1016\/j.biopha.2016.11.130_bib0190","doi-asserted-by":"crossref","first-page":"31826","DOI":"10.1074\/jbc.M204149200","article-title":"Regulation of histone deacetylase 2 by protein kinase CK2","volume":"277","author":"Tsai","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"41","key":"10.1016\/j.biopha.2016.11.130_bib0195","doi-asserted-by":"crossref","first-page":"9544","DOI":"10.1523\/JNEUROSCI.1826-05.2005","article-title":"Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death","volume":"25","author":"Bolger","year":"2005","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0200","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2217\/epi.15.106","article-title":"Regulation of class IIa HDAC activities: it is not only matter of subcellular localization","volume":"8","author":"Di Giorgio","year":"2016","journal-title":"Epigenomics"},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jcb.20179","article-title":"Regulation of histone deacetylase activities","volume":"93","author":"Sengupta","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0210","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1091\/mbc.e05-08-0775","article-title":"Regulation of histone deacetylase 4 expression by the SP family of transcription factors","volume":"17","author":"Liu","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0215","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1091\/mbc.e03-08-0624","article-title":"Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis","volume":"15","author":"Paroni","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"28","key":"10.1016\/j.biopha.2016.11.130_bib0220","doi-asserted-by":"crossref","first-page":"19499","DOI":"10.1074\/jbc.M800331200","article-title":"Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function","volume":"283","author":"Scott","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0225","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.canlet.2014.08.031","article-title":"MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer","volume":"354","author":"Wu","year":"2014","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.biopha.2016.11.130_bib0230","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/sj.bjc.6605895","article-title":"microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity","volume":"103","author":"Zhang","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0235","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2174\/1568026615666150813145800","article-title":"Panobinostat: the small molecule metalloenzyme inhibitor with marvelous anticancer activity","volume":"16","author":"Ganai","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.biopha.2016.11.130_bib0240","first-page":"1","article-title":"HDAC inhibitors entinostat and suberoylanilide hydroxamic acid (SAHA): the ray of hope for cancer therapy","author":"Ganai","year":"2014","journal-title":"Mol. Life Sci."},{"key":"10.1016\/j.biopha.2016.11.130_bib0245","first-page":"1","article-title":"In silico approaches towards safe targeting of class I histone deacetylases","author":"Ganai","year":"2014","journal-title":"Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0250","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/138161208783885335","article-title":"Isoform-selective histone deacetylase inhibitors","volume":"14","author":"Itoh","year":"2008","journal-title":"Curr. Pharm. Des."},{"issue":"17","key":"10.1016\/j.biopha.2016.11.130_bib0255","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1016\/j.bmcl.2007.06.060","article-title":"Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclurapomifera","volume":"17","author":"Son","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0260","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00280-010-1324-y","article-title":"Identification of type-specific anticancer histone deacetylase inhibitors: road to success","volume":"66","author":"Noureen","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0265","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/pros.20022","article-title":"Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer","volume":"59","author":"Halkidou","year":"2004","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0270","first-page":"769","article-title":"Expression profile of class I histone deacetylases in human cancer tissues","volume":"18","author":"Nakagawa","year":"2007","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2016.11.130_bib0275","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bbrc.2008.06.045","article-title":"A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells","volume":"373","author":"Kojima","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-015-0186-0","article-title":"a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis","volume":"15","author":"Shi","year":"2015","journal-title":"Cancer Cell Int."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0285","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: a promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0290","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10571-007-9175-8","article-title":"A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells","volume":"28","author":"Cheung","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0295","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2217\/fon.11.2","article-title":"Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer","volume":"7","author":"Thurn","year":"2011","journal-title":"Future Oncol."},{"key":"10.1016\/j.biopha.2016.11.130_bib0300","doi-asserted-by":"crossref","DOI":"10.1007\/s12272-015-0673-9","article-title":"Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance","author":"Ganai","year":"2015","journal-title":"Arch. Pharmacal Res."},{"issue":"1","key":"10.1016\/j.biopha.2016.11.130_bib0305","first-page":"9","article-title":"Cancer statistics. 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA : Cancer J. Clin."},{"issue":"5","key":"10.1016\/j.biopha.2016.11.130_bib0310","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10495-014-0971-6","article-title":"Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70\u2013Bax interaction in prostate cancer","volume":"19","author":"Shukla","year":"2014","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0315","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/mc.10168","article-title":"Molecular mechanisms for Apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells","volume":"39","author":"Shukla","year":"2004","journal-title":"Mol. Carcinog."},{"issue":"6","key":"10.1016\/j.biopha.2016.11.130_bib0320","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1007\/s11095-011-0625-0","article-title":"Apigenin attenuates insulin-like growth factor-I signaling in an autochthonous mouse prostate cancer model","volume":"29","author":"Shukla","year":"2012","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0325","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1006\/bbrc.2001.5672","article-title":"Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of Apigenin in normal versus human prostate carcinoma cells","volume":"287","author":"Gupta","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.biopha.2016.11.130_bib0330","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.freeradbiomed.2008.02.007","article-title":"Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation","volume":"44","author":"Shukla","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0335","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/carcin\/bgt316","article-title":"Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K\/Akt\/FoxO pathway","volume":"35","author":"Shukla","year":"2014","journal-title":"Carcinogenesis"},{"issue":"31","key":"10.1016\/j.biopha.2016.11.130_bib0340","doi-asserted-by":"crossref","first-page":"31216","DOI":"10.18632\/oncotarget.5157","article-title":"Apigenin blocks IKK(activation and suppresses prostate cancer progression","volume":"6","author":"Shukla","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.biopha.2016.11.130_bib0345","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/carcin\/bgn201","article-title":"Plant flavonoid Apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study","volume":"29","author":"Kaur","year":"2008","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.biopha.2016.11.130_bib0350","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1158\/1535-7163.MCT-05-0431","article-title":"The dietary flavonoid Apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand","volume":"5","author":"Horinaka","year":"2006","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0355","doi-asserted-by":"crossref","first-page":"e55922","DOI":"10.1371\/journal.pone.0055922","article-title":"Apigenin sensitizes prostate cancer cells to Apo2L\/TRAIL by targeting adenine nucleotide translocase-2","volume":"8","author":"Oishi","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biopha.2016.11.130_bib0360","doi-asserted-by":"crossref","first-page":"e0138710","DOI":"10.1371\/journal.pone.0138710","article-title":"Suppression of NF-\u03baB and NF-\u03baB-Regulated gene expression by apigenin through I\u03baB\u03b1 and IKK pathway in TRAMP mice","volume":"10","author":"Shukla","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2016.11.130_bib0365","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3892\/mmr.2014.2801","article-title":"Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer","volume":"11","author":"Zhu","year":"2015","journal-title":"Mol. Med. Rep."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216314986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216314986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T19:06:22Z","timestamp":1719860782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216314986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":73,"alternative-id":["S0753332216314986"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.130","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}