{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:11:15Z","timestamp":1790766675436,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.biopha.2016.11.133","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:18:47Z","timestamp":1482538727000},"page":"562-569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Modulation of the lipid profile and insulin levels of streptozotocin induced diabetic rats by ethanol extract of Cnidoscolus aconitifolius leaves and some fractions: Effect on the oral glucose tolerance of normoglycemic rats"],"prefix":"10.1016","volume":"86","author":[{"given":"N.K.","family":"Achi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.C.","family":"Ohaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.I.","family":"Ijeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Eleazu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.11.133_bib0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S2221-1691(12)60067-7","article-title":"Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity","volume":"2","author":"Patel","year":"2012","journal-title":"Asia. Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2016.11.133_bib0010","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0140-6736(14)60886-2","article-title":"The global implications of diabetes and cancer","volume":"383","author":"Yuankai","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2016.11.133_bib0015","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.toxrep.2014.08.013","article-title":"Effect of livingstonepotato (Plectranthus esculentus N.E.Br) on hyperglycemia, antioxidant activity and lipid metabolism of streptozotocin induced diabetic rats","volume":"1","author":"Eleazu","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.biopha.2016.11.133_bib0020","unstructured":"S.S. Vasudevan, S.K.V. Seekumari, Textbook of Biochemistry for Medical Students. 7th Ed. (2013) 335\u2013338."},{"key":"10.1016\/j.biopha.2016.11.133_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jep.2013.06.009","article-title":"Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions","volume":"149","author":"Ejike","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2016.11.133_bib0030","unstructured":"World Health Organization (WHO). WHO experts committee on diabetic mellitus: Second report. WHO, Geneva (1980), Pg. 646, Technical Report Series."},{"key":"10.1016\/j.biopha.2016.11.133_bib0035","first-page":"164","article-title":"Antidiabetic potential of the aqueous leaf extract of Cnidoscolus aconitifolius on streptozotocin Induced Diabetes in Wistar rat hepatocytes","volume":"4","author":"Mordi","year":"2012","journal-title":"Curr. Res. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2016.11.133_bib0040","first-page":"283","article-title":"Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats","volume":"10","author":"Azeez","year":"2010","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.biopha.2016.11.133_bib0045","first-page":"201","article-title":"Effect of Cnidoscolus aconitifolius (Family Euphorbiaceae) aqueous leaf extract on some antioxidant enzymes and haematological parameters of high fat diet and streptozotocin induced diabetic Wistar albino rats","volume":"19","author":"Obichi","year":"2015","journal-title":"J. Appl. Sci. Environ. Managt."},{"key":"10.1016\/j.biopha.2016.11.133_bib0050","series-title":"Progress in New Crops","first-page":"516","article-title":"Potential nutritional and health benefits of the spinach","author":"Kuti","year":"1996"},{"key":"10.1016\/j.biopha.2016.11.133_bib0055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0377-8401(98)00231-4","article-title":"The nutritive values of chaya leaf meal (Cnidoscolus aconitifolius) studies with broilers chickens","volume":"77","author":"Atuahene","year":"1999","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.biopha.2016.11.133_bib0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.9734\/BJPR\/2015\/13893","article-title":"GC\u2013MS determination of bioactive constituents of the methanol fractions of Cnidoscolus aconitifolius","volume":"5","author":"Achi","year":"2015","journal-title":"Brit. J. Pharm. Res."},{"key":"10.1016\/j.biopha.2016.11.133_bib0065","series-title":"Guide for the Care and Use of Laboratory Animals","first-page":"8523","author":"National Research Council (NRC)","year":"1985"},{"key":"10.1016\/j.biopha.2016.11.133_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01234480","article-title":"A new approach to practical acute toxicity testing","volume":"54","author":"Lorke","year":"1983","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2016.11.133_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1010425932561","article-title":"Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin induced diabetic rats","volume":"2","author":"Ohaeri","year":"2001","journal-title":"Bio. Sci. Rep."},{"key":"10.1016\/j.biopha.2016.11.133_bib0080","first-page":"625","article-title":"Acute and sub-acute toxicity of Amalakyyadi churna","volume":"1","author":"Uma","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2016.11.133_bib0085","first-page":"057","article-title":"Chemical composition of mistletoe extract (Loranthus micranthus) and its effect on protein: lipid metabolism and the antioxidant status of alloxan induced diabetic rats","volume":"1","author":"Ononogbu","year":"2012","journal-title":"J. Med. Res."},{"key":"10.1016\/j.biopha.2016.11.133_bib0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/152091502760306562","article-title":"Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats","volume":"4","author":"King","year":"2002","journal-title":"Diab. Technol. Ther."},{"key":"10.1016\/j.biopha.2016.11.133_bib0095","series-title":"Clinical Guide to Laboratory Tests","first-page":"518","author":"Tietz","year":"1995"},{"key":"10.1016\/j.biopha.2016.11.133_bib0100","first-page":"2486","volume":"285","author":"NCEP","year":"2001"},{"key":"10.1016\/j.biopha.2016.11.133_bib0105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low density lipoprotein cholesterol in plasma: with-out use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2016.11.133_bib0110","series-title":"Handbook of Histopathological and Histochemical Techniques","author":"Dunn","year":"1974"},{"key":"10.1016\/j.biopha.2016.11.133_bib0115","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.biopha.2016.08.064","article-title":"Effect of kolaviron: a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats","volume":"83","author":"Kalu","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2016.11.133_bib0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/gm334","article-title":"Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)","volume":"4","author":"Ugarte","year":"2012","journal-title":"Genome Med."},{"key":"10.1016\/j.biopha.2016.11.133_bib0125","first-page":"368","article-title":"Effect of Telfairia occidentalis on oral glucose tolerance in rats","volume":"4","author":"Olorunfemi","year":"2010","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2016.11.133_bib0130","series-title":"Maniple Manuel of Clinical Biochemistry","author":"Shivananda","year":"2007"},{"key":"10.1016\/j.biopha.2016.11.133_bib0135","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/2394-2002.139616","article-title":"Effect of aqueous and alcoholic extract of Sesbania sesban (Linn) Merr root on glycemic control in streptozotocin-induced diabetic mice","volume":"5","author":"Choudhary","year":"2014","journal-title":"Drug Dev Ther."},{"key":"10.1016\/j.biopha.2016.11.133_bib0140","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pathophys.2010.10.002","article-title":"Anti-hyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats","volume":"18","author":"Ramesh","year":"2011","journal-title":"Pathophysiology"},{"key":"10.1016\/j.biopha.2016.11.133_bib0145","doi-asserted-by":"crossref","first-page":"S705","DOI":"10.1016\/S2222-1808(14)60711-8","article-title":"Biochemical basis of the use of cocoyam (Colocassia esculenta L.) in the dietary management of diabetes and its complications in streptozotocin induced diabetes in rats","volume":"4","author":"Eleazu","year":"2014","journal-title":"Asia. Pac. J. Trop. Dis."},{"key":"10.1016\/j.biopha.2016.11.133_bib0150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2251-6581-12-39","article-title":"Efficacy of Evolvulus alsinoides (L.) on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats","volume":"12","author":"Gomathi","year":"2013","journal-title":"J. Diab. Metab. Dis."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216320649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216320649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:36:12Z","timestamp":1782866172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216320649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":30,"alternative-id":["S0753332216320649"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.133","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of the lipid profile and insulin levels of streptozotocin induced diabetic rats by ethanol extract of Cnidoscolus aconitifolius leaves and some fractions: Effect on the oral glucose tolerance of normoglycemic rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.11.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}