{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:10:59Z","timestamp":1785337859685,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.biopha.2016.12.112","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T04:09:03Z","timestamp":1483762143000},"page":"381-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Thiosemicarbazones and Phthalyl-Thiazoles compounds exert antiviral activity against yellow fever virus and Saint Louis encephalitis virus"],"prefix":"10.1016","volume":"87","author":[{"given":"Carolina Colombelli","family":"Pacca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Elias","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Wanderlan P.","family":"Espindola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gev\u00e2nio B.O.Oliveira","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina Lima","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio L.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2016.12.112_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coviro.2012.12.001","article-title":"Flaviviruses: braking the entering","volume":"3","author":"Pierson","year":"2013","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0010","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/1871524911106040296","article-title":"Arboviral encephalitis and RNAi treatment","volume":"11","author":"Nogueira","year":"2011","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0015","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1016\/j.vaccine.2011.09.114","article-title":"Flaviviruses and flavivirus vaccines","volume":"30","author":"Heinz","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.biopha.2016.12.112_bib0020","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1517\/14712598.8.11.1787","article-title":"Yellow fever vaccine: past, present and future","volume":"8","author":"Roukens","year":"2008","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.biopha.2016.12.112_bib0025","first-page":"37","article-title":"The etiology of yellow fever-A preliminary note","volume":"26","author":"Reed","year":"1900","journal-title":"Public Health Papers Rep."},{"key":"10.1016\/j.biopha.2016.12.112_bib0030","first-page":"113","article-title":"The prevention of yellow fever","volume":"27","author":"Reed","year":"1901","journal-title":"Public Health Papers Rep."},{"key":"10.1016\/j.biopha.2016.12.112_bib0035","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S1286-4579(00)01320-4","article-title":"The brazilian flaviviruses","volume":"2","author":"Figueiredo","year":"2000","journal-title":"Microbes Infect."},{"key":"10.1016\/j.biopha.2016.12.112_bib0040","series-title":"Febre Amarela: a doen\u00e7a e a vacina, uma hist\u00f3ria inacabada","author":"Benchimol","year":"2001"},{"key":"10.1016\/j.biopha.2016.12.112_bib0045","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jmv.2078","article-title":"Epidemic of jungle yellow fever in Brazil, 2000: implications of climatic alterations in disease spread","volume":"65","author":"Vasconcelos","year":"2001","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0050","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1099\/vir.0.019117-0","article-title":"Molecular epidemiology of Saint Louis encephalitis virus in the Brazilian Amazon: genetic divergence and dispersal","volume":"91","author":"Rodrigues","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0055","doi-asserted-by":"crossref","first-page":"e2537","DOI":"10.1371\/journal.pntd.0002537","article-title":"Isolation of saint louis encephalitis virus from a horse with neurological disease in Brazil","volume":"7","author":"Rosa","year":"2013","journal-title":"PLoS Negl.Trop. Dis."},{"key":"10.1016\/j.biopha.2016.12.112_bib0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-3527(03)61004-3","article-title":"Epidemiology of St. louis encephalitis virus","volume":"61","author":"Reisen","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.biopha.2016.12.112_bib0065","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1128\/JCM.37.6.1935-1940.1999","article-title":"Use of base excision sequence scanning for detection of genetic variations in St. Louis encephalitis virus isolates","volume":"37","author":"Charrel","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0070","first-page":"566","article-title":"Duplex microsphere-based immunoassay for detection of anti-West Nile virus and anti-St. Louis encephalitis virus immunoglobulin m antibodies","volume":"12","author":"Johnson","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4269\/ajtmh.1980.29.667","article-title":"Epidemiological investigation for arboviruses in Jamaica, west indies","volume":"29","author":"Belle","year":"1980","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2016.12.112_bib0080","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4269\/ajtmh.1959.8.557","article-title":"St. Louis encephalitis in Panama. I. Isolation of the virus from forest mosquitoes and human blood","volume":"8","author":"Galindo","year":"1959","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2016.12.112_bib0085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4269\/ajtmh.1966.15.385","article-title":"An ecological survey for arboviruses in Almirante, Panama 1959\u20131962","volume":"15","author":"Galindo","year":"1966","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2016.12.112_bib0090","first-page":"247","article-title":"Saint Louis encephalitis virus in Buenos Aires city during the outbreak of dengue in 2009","volume":"71","author":"Lopez","year":"2011","journal-title":"Medicina (B Aires)."},{"key":"10.1016\/j.biopha.2016.12.112_bib0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcv.2007.11.022","article-title":"Human outbreak of St. louis encephalitis detected in Argentina, 2005","volume":"42","author":"Spinsanti","year":"2008","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3201\/eid1301.060905","article-title":"Saint louis encephalitis virus, Brazil","volume":"13","author":"Mondini","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.biopha.2016.12.112_bib0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/vbz.2009.0200","article-title":"Detection of Saint Louis encephalitis virus in Dengue-suspected cases during a dengue 3 outbreak","volume":"11","author":"Terzian","year":"2011","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.biopha.2016.12.112_bib0110","first-page":"2689","article-title":"Review on flavivirus vaccine development","volume":"23","author":"Hombach","year":"2005"},{"key":"10.1016\/j.biopha.2016.12.112_bib0115","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0166-3542(94)90077-9","article-title":"Inhibition of human immunodeficiency virus by N-methylisatin-beta 4':4'-diethylthiosemicarbazone and N-allylisatin-beta-4':4'-diallythiosemicarbazone","volume":"24","author":"Teitz","year":"1994","journal-title":"Antiviral Res."},{"key":"10.1016\/j.biopha.2016.12.112_bib0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.taap.2004.02.006","article-title":"Toxic effects of bis(thiosemicarbazone) compounds and its palladium(II) complexes on herpes simplex virus growth","volume":"197","author":"Genova","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00280-002-0480-0","article-title":"Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule","volume":"50","author":"Feun","year":"2002","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0130","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0162-0134(03)00156-9","article-title":"Synthesis, structural characterization and antimicrobial activities of 12 zinc(II) complexes with four thiosemicarbazone and two semicarbazone ligands","volume":"96","author":"Kasuga","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0135","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1021\/tx800182k","article-title":"Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity","volume":"21","author":"Opletalova","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0140","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/S0960-894X(02)00703-5","article-title":"Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives","volume":"12","author":"Bharti","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2016.12.112_bib0145","first-page":"109","article-title":"ynthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro \u22122-indolinone derivatives","author":"Nalan Terzio\u011flu","year":"2006","journal-title":"Arkivoc"},{"key":"10.1016\/j.biopha.2016.12.112_bib0150","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1021\/jm800412d","article-title":"Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins","volume":"51","author":"Li","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0155","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00705-015-2378-2","article-title":"First genome sequence of St. Louis encephalitis virus (SLEV) isolated from a human in Brazil","volume":"160","author":"Vedovello","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0160","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1021\/jm301518v","article-title":"Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice","volume":"55","author":"Moreira","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0165","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/cmdc.200900525","article-title":"Discovery of phthalimides as immunomodulatory and antitumor drug prototypes","volume":"5","author":"Pessoa","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.biopha.2016.12.112_bib0170","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ejmech.2015.04.041","article-title":"Design, synthesis and structure-activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities","volume":"96","author":"Cardoso","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0175","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ejmech.2015.06.048","article-title":"Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain","volume":"101","author":"Espindola","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2016.12.112_bib0180","series-title":"Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections","author":"Lennette","year":"1995"},{"key":"10.1016\/j.biopha.2016.12.112_bib0185","doi-asserted-by":"crossref","first-page":"14175","DOI":"10.1073\/pnas.0807163105","article-title":"C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity","volume":"105","author":"Fradinger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2016.12.112_bib0190","first-page":"419","article-title":"The pathology of experimental yellow fever in the macacus rhesus: III. comparison with the pathology of yellow fever in man","volume":"4","author":"Hudson","year":"1928","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2016.12.112_bib0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/rmv.483","article-title":"Mechanisms of action of ribavirin against distinct viruses","volume":"16","author":"Graci","year":"2006","journal-title":"Rev. Med. Virol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216316122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216316122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:44:10Z","timestamp":1785336250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216316122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":39,"alternative-id":["S0753332216316122"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2016.12.112","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiosemicarbazones and Phthalyl-Thiazoles compounds exert antiviral activity against yellow fever virus and Saint Louis encephalitis virus","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2016.12.112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}