{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:29:20Z","timestamp":1792297760985,"version":"4.4.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004263","name":"\u201cFunda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Rio Grande do Sul\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"\u201cConselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"\u201cCoordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u201d","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.biopha.2017.01.121","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:01:17Z","timestamp":1486339277000},"page":"939-947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Vaccinium virgatum fruit extract as an important adjuvant in biochemical and behavioral alterations observed in animal model of metabolic syndrome"],"prefix":"10.1016","volume":"88","author":[{"given":"Pathise Souto","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Porto","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Rigon","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Clasen","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Henrique","family":"Reginatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuella Pinto","family":"Kaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane Giacomelli","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselia Maria","family":"Spanevello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claiton Leoneti","family":"Lencina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francieli Moro","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.01.121_bib0005","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.295.13.1549","article-title":"Prevalence of overweight and obesity in the United States, 1999\u20132004","volume":"295","author":"Ogden","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2017.01.121_bib0010","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1440-1819.2009.02004.x","article-title":"Total antioxidant capacity and total oxidant status in patients with major depression: impact of antidepressant treatment","volume":"63","author":"Cumurcu","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.2009.2014","article-title":"Prevalence and trends in obesity among US adults, 1999\u20132008","volume":"303","author":"Flegal","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2017.01.121_bib0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.nutres.2013.03.006","article-title":"Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome","volume":"33","author":"Ichimura","year":"2013","journal-title":"Nutr. Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.phrs.2012.11.008","article-title":"Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice","volume":"68","author":"Roopchand","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0030","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.2337\/diabetes.52.12.2882","article-title":"Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects","volume":"52","author":"Tripathy","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2017.01.121_bib0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1464-5491.2000.00259.x","article-title":"Radicals and oxidative stress in diabetes","volume":"17","author":"West","year":"2000","journal-title":"Diabet. Med."},{"key":"10.1016\/j.biopha.2017.01.121_bib0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0361-9230(01)00484-1","article-title":"Behavioral and biochemical effects of glutathione depletion in the rat brain","volume":"55","author":"Cruz-Aguado","year":"2001","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2017.01.121_bib0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbt.10058","article-title":"Diabetes, oxidative stress, and antioxidants: a review","volume":"17","author":"Maritim","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00253-012-3957-8","article-title":"Red mold, diabetes, and oxidative stress: a review","volume":"94","author":"Shi","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.phymed.2009.02.018","article-title":"Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium aiton","volume":"16","author":"Grace","year":"2009","journal-title":"Phytomed"},{"key":"10.1016\/j.biopha.2017.01.121_bib0060","first-page":"CR28","article-title":"Aroniamelanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker level in patients with metabolic syndrome","volume":"16","author":"Broneel","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.biopha.2017.01.121_bib0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11130-010-0177-1","article-title":"Berries Improving human health and healthy aging, and promoting quality life","volume":"65","author":"Paredes-Lopez","year":"2010","journal-title":"Plant Food Hum. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.12659\/MSM.881711","article-title":"Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats","volume":"17","author":"Ashour","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.biopha.2017.01.121_bib0075","doi-asserted-by":"crossref","first-page":"H254","DOI":"10.1152\/ajpheart.01023.2001","article-title":"Melatonin as an effective protector against doxorubicin induced cardiotoxicity","volume":"283","author":"Liu","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0080","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.foodchem.2008.06.066","article-title":"Comparison of polyphenolic composition and antioxidant activity of wild Italian blueberries and some cultivated varieties","volume":"112","author":"Giovanelli","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.foodchem.2010.08.063","article-title":"Comparison of anthocyanins and phenolics in organically and conventionally grown blueberries in selected cultivars","volume":"125","author":"You","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0090","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/jn\/133.7.2125","article-title":"Dietarycyanidin 3-O-\u03b2-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice","volume":"133","author":"Tsuda","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0095","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.phymed.2006.08.005","article-title":"Anti-diabetic properties of the Canadian low bush blueberry Vaccinium angustifolium","volume":"13","author":"Martineau","year":"2006","journal-title":"Phytomed"},{"key":"10.1016\/j.biopha.2017.01.121_bib0100","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bcp.2007.08.008","article-title":"Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to down regulation of retinol binding protein 4 expression in diabetic mice","volume":"74","author":"Sasaki","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0105","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0031-9422(03)00438-2","article-title":"Analysis and biological activities of anthocyanins","volume":"64","author":"Kong","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.biopha.2017.01.121_bib0110","first-page":"95","article-title":"Antiangiogenic, antioxidant, and anticarcinogenic properties of a novel anthocyanin-rich berry extract formula","volume":"69","author":"Bagchi","year":"2004","journal-title":"J. Biochem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0115","doi-asserted-by":"crossref","first-page":"277S","DOI":"10.1093\/ajcn\/81.1.277S","article-title":"Polyphenols and glutathione synthesis regulation","volume":"81","author":"Moskaug","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0120","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ptr.3584","article-title":"Vaccinium myrtillus ameliorates unpredictable chronic mild stress induced depression: possible involvement of nitric oxide pathway","volume":"26","author":"Kumar","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phrs.2005.07.003","article-title":"Effect of lyophilized Vaccinium berries on memory, anxiety and locomotion in adult rats","volume":"52","author":"Ramires","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0130","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodchem.2007.09.018","article-title":"Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity","volume":"107","author":"Molan","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0135","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1037\/a0017681","article-title":"The effects of aging on memory for sequentially presented objects in rats","volume":"123","author":"Hauser","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10284150500078117","article-title":"Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory","volume":"8","author":"Andres-Lacueva","year":"2005","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0145","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1196\/annals.1395.052","article-title":"Fruit polyphenols and their effects on neuronal signaling and behavior in senescence","volume":"1100","author":"Joseph","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0101-20612009000100028","article-title":"Influ\u00eancia do pH da solu\u00e7\u00e3o extrativa no teor de antocianinas em frutos de morango","volume":"29","author":"Bordignon","year":"2009","journal-title":"Ci\u00eanc Tecn Alim"},{"key":"10.1016\/j.biopha.2017.01.121_bib0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodchem.2003.05.007","article-title":"Screening of radical scavenging activity of some medicinal and aromatic plant extracts","volume":"85","author":"Miliauskas","year":"2004","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0160","series-title":"Methods Enzymol","first-page":"152","article-title":"Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteau reagent","author":"Singleton","year":"2017"},{"key":"10.1016\/j.biopha.2017.01.121_bib0165","series-title":"Curr Prot Food Anal Chem","first-page":"F1.2.1","article-title":"Characterization and measurement of anthocyanins by UV-visible spectroscopy","author":"Giusti","year":"2001"},{"key":"10.1016\/j.biopha.2017.01.121_bib0170","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/jaoac\/88.5.1269","article-title":"Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants and wines by the pH differential method: collaborative study","volume":"8","author":"Lee","year":"2005","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.biopha.2017.01.121_bib0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.lfs.2007.05.001","article-title":"Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior","volume":"81","author":"Souza","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0180","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00394-013-0601-z","article-title":"Red grape berry-cultured cells reduce blood pressure in rats with metabolic-like syndrome","volume":"53","author":"Leibowitz","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0185","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.pnpbp.2006.12.018","article-title":"The inhibition of different types of potassium channels underlies the antidepressant-like effect of adenosine in the mouse forced swimming test","volume":"31","author":"Kaster","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2017.01.121_bib0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2003.10.040","article-title":"Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors","volume":"55","author":"Kaster","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2017.01.121_bib0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-6147(00)88973-7","article-title":"Use of the elevated plus maze in the search for novel anxiolytic agents","volume":"16","author":"Dawson","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2017.01.121_bib0200","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0205","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3940(01)01636-6","article-title":"Changes in thiol content and expression of glutathione redox system genes on the hippocampus and cerebellum in Alzheime\u0155s disease","volume":"302","author":"Aksenov","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2017.01.121_bib0210","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0215","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0220","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0225","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.brainresbull.2016.10.008","article-title":"Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine","volume":"127","author":"Debom","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2017.01.121_bib0230","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3945\/jn.110.124701","article-title":"Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome","volume":"140","author":"Basu","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0235","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3945\/jn.114.205674","article-title":"Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients","volume":"145","author":"Li","year":"2015","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/217451","article-title":"Evaluation of the effects of vaccinium arctostaphylos L. fruit extract on serum lipids and hs-CRP levels and oxidative stress in adult patients with hyperlipidemia: a randomized double-Blind, placebo-Controlled clinical trial","volume":"2014","author":"Soltani","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2017.01.121_bib0245","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1017\/S0007114513002390","article-title":"Wild blueberry (Vaccinium angustifoliun)-encriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats","volume":"111","author":"Vendrame","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/mnfr.200700393","article-title":"Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms","volume":"52","author":"Hsu","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0255","first-page":"14","volume":"1","author":"Taesun","year":"2011","journal-title":"Antiobesity. Drug Discov. Dev."},{"key":"10.1016\/j.biopha.2017.01.121_bib0260","first-page":"53","article-title":"Phenolic compounds rutin and o-coumaric acid ameliorate obesity induced by high-fat diet in rats","volume":"5","author":"Hus","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2017.01.121_bib0265","first-page":"733","article-title":"Quercetin: potentials in the prevention and therapy of disease","volume":"11","author":"Bischof","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.biopha.2017.01.121_bib0270","series-title":"Free Radicals in Biology and Medicine","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.biopha.2017.01.121_bib0275","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1017\/S1461145711001532","article-title":"Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study","volume":"15","author":"Magalh\u00e3es","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0280","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pnpbp.2013.03.003","article-title":"Oxidative stress and therapeutic implications in psychiatric disorders","volume":"46","author":"Zhang","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2017.01.121_bib0285","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1155\/2014\/831841","article-title":"Biology of ageing and role of dietary antioxidants","volume":"2014","author":"Peng","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biopha.2017.01.121_bib0290","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuroscience.2014.03.040","article-title":"Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of wnin\/ob, a novel rat model of premature aging","volume":"269","author":"Sinha","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2017.01.121_bib0295","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.ijo.0803068","article-title":"Atherogenic inflammatory and oxidative stress markers in relation to overweight values in male former athletes","volume":"30","author":"Pihl","year":"2006","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.biopha.2017.01.121_bib0300","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijcard.2006.12.025","article-title":"Diet compounds, glycemic index and obesity-related cardiac effects","volume":"124","author":"Diniz","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2017.01.121_bib0305","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2010.10.004","article-title":"Cellular metabolic stress: considering how cells respond to nutrient excess","volume":"40","author":"Wellen","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biopha.2017.01.121_bib0310","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.nut.2012.01.001","article-title":"Dietary antioxidants: do they have a role to play in the ongoing fight against abnormal glucose metabolism","volume":"28","author":"Avignon","year":"2012","journal-title":"Nutrition"},{"key":"10.1016\/j.biopha.2017.01.121_bib0315","first-page":"188","article-title":"Protective effects of lamotrigine aripiprazole and escitalopram on depression-induced oxidative stress in rat brain","volume":"32","author":"Eren","year":"2007","journal-title":"Neuro Chem. Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0320","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuint.2009.01.001","article-title":"Effects of chronic mild stress on the oxidative parameters in the rat brain","volume":"54","author":"Lucca","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2017.01.121_bib0325","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jpsychires.2011.11.009","article-title":"Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress","volume":"46","author":"Moretti","year":"2012","journal-title":"J. Psychiatry Res."},{"key":"10.1016\/j.biopha.2017.01.121_bib0330","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pnpbp.2014.06.006","article-title":"Subjective depressive symptoms and metabolic syndrome among the general population","volume":"54","author":"Rhee","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2017.01.121_bib0335","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/dc11-2055","article-title":"Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies","volume":"35","author":"Pan","year":"2012","journal-title":"Diab. Care"},{"key":"10.1016\/j.biopha.2017.01.121_bib0340","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1017\/S1368980007000663","article-title":"Inflammation, obesity and comorbidities: the role of diet","volume":"10A","author":"Bullo","year":"2007","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.biopha.2017.01.121_bib0345","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.psychres.2014.02.016","article-title":"Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression","volume":"217","author":"Rudolf","year":"2014","journal-title":"Psychiatry Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216324611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216324611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:07:52Z","timestamp":1778242072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216324611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":69,"alternative-id":["S0753332216324611"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.01.121","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccinium virgatum fruit extract as an important adjuvant in biochemical and behavioral alterations observed in animal model of metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.01.121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}