{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:15:09Z","timestamp":1762431309019,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.biopha.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T07:21:46Z","timestamp":1489908106000},"page":"1378-1386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice"],"prefix":"10.1016","volume":"89","author":[{"given":"Nageh Ahmed","family":"Elmahdy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia Salem","family":"Sokar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Labib","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa Ibrahim","family":"Sarhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin Hamed","family":"Abou-Elela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.03.007_bib0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.biopha.2017.03.007_bib0010","article-title":"Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell","volume":"8","author":"G\u00e4bele","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biopha.2017.03.007_bib0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0016-5085(99)70135-6","article-title":"Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: a dynamic view. The Multivirc Group","volume":"116","author":"Sobesky","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2017.03.007_bib0020","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJM200102083440604","article-title":"Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct","volume":"344","author":"Hammel","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2017.03.007_bib0025","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1159\/000445269","article-title":"Liver and biliary system new developments on the treatment of liver fibrosis","volume":"34","author":"Koyama","year":"2016","journal-title":"Dig. Dis."},{"key":"10.1016\/j.biopha.2017.03.007_bib0030","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00004836-200310000-00013","article-title":"Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons","volume":"37","author":"Lieber","year":"2003","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0035","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1742-7843.2007.00069.x","article-title":"Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes","volume":"100","author":"Kiruthiga","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0040","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.3748\/wjg.v11.i8.1141","article-title":"Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis","volume":"11","author":"Jeong","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0045","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3748\/wjg.v21.i3.742","article-title":"Use of mesenchymal stem cells to treat liver fibrosis: current situation and future prospects","volume":"21","author":"Berardis","year":"2015","journal-title":"World J Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbadis.2007.12.004","article-title":"Stem cells, cell transplantation and liver repopulation","volume":"1782","author":"Oertel","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.03.007_bib0055","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/35018642","article-title":"Hepatocytes from non-hepatic adult stem cells","volume":"406","author":"Alison","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2017.03.007_bib0060","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3727\/096368913X675746","article-title":"The structural basis of functional improvement in response to human umbilical cord blood stem cell transplantation in hearts with postinfarct LV remodeling","volume":"24","author":"Chen","year":"2015","journal-title":"Cell Transplant"},{"key":"10.1016\/j.biopha.2017.03.007_bib0065","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bbrc.2004.09.115","article-title":"Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion","volume":"324","author":"Tanabe","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.03.007_bib0070","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/j.1476-5381.2011.01599.x","article-title":"Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence","volume":"165","author":"Ohyama","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0075","first-page":"1","article-title":"Non-invasive index of liver fibrosis induced by alcohol, thioacetamide and schistosomal infection in mice","author":"Hessien","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.03.007_bib0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta\u2014Gen. Subj."},{"key":"10.1016\/j.biopha.2017.03.007_bib0095","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3748\/wjg.v12.i12.1918","article-title":"Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver","volume":"12","author":"Zhang","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0100","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10495-005-1055-4","article-title":"The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis","volume":"10","author":"Elsharkawy","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.biopha.2017.03.007_bib0105","first-page":"1","article-title":"Protective Effect of grape seed extract and\/or silymarin against thioacetamide-induced hepatic fibrosis in rats","volume":"4","author":"Nada","year":"2015","journal-title":"Liver"},{"key":"10.1016\/j.biopha.2017.03.007_bib0110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3164\/jcbn.10-35","article-title":"Protective effects of vitamin e analogs against carbon tetrachloride-induced fatty liver in rats","volume":"47","author":"Yachi","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.biopha.2017.03.007_bib0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S2221-1691(12)60073-2","article-title":"Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study","volume":"2","author":"Prahalathan","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2017.03.007_bib0120","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3892\/etm.2015.2232","article-title":"Effects of bone marrow-derived mesenchymal stem cells transplanted via the portal vein or tail vein on liver injury in rats with liver cirrhosis","author":"Song","year":"2015","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.biopha.2017.03.007_bib0125","article-title":"Effect of human umbilical cord blood stem cells on hepatic regeneration and immune response in liver fibrosis in rats","volume":"5","author":"Ismail","year":"2015","journal-title":"J. Physiol. Pharmacol. Adv."},{"key":"10.1016\/j.biopha.2017.03.007_bib0130","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/01480545.2011.648329","article-title":"Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats","volume":"36","author":"Sancheti","year":"2013","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0135","first-page":"692","article-title":"Modulation of AP-endonuclease1 levels associated with hepatic cirrhosis in rat model treated with human umbilical cord blood mononuclear stem cells","volume":"4","author":"Bassiouny","year":"2011","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-61779-445-2_23","article-title":"Multiple reaction monitoring for the accurate quantification of amino acids: using hydroxyproline to estimate collagen content","volume":"828","author":"Colgrave","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0145","doi-asserted-by":"crossref","first-page":"E416","DOI":"10.1002\/ijc.26443","article-title":"Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma","volume":"131","author":"Prakobwong","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2017.03.007_bib0150","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.clinbiochem.2007.04.017","article-title":"Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis","volume":"40","author":"Abdel Aziz","year":"2007","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.biopha.2017.03.007_bib0155","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-230X-11-91","article-title":"Non-invasive markers for hepatic fibrosis","volume":"11","author":"Baranova","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0160","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1478-3231.2009.02031.x","article-title":"Effect of human umbilical cord blood-derived mesenchymal stem cells in a cirrhotic rat model","volume":"29","author":"Jung","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.biopha.2017.03.007_bib0165","doi-asserted-by":"crossref","first-page":"738","DOI":"10.12980\/JCLM.2.2014APJTB-2014-0111","article-title":"Plant derived antioxidants and antifibrotic drugs: past, present and future","volume":"2","author":"Ezhilarasan","year":"2014","journal-title":"J. Coast. Life Med."},{"key":"10.1016\/j.biopha.2017.03.007_bib0170","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/hep.22862","article-title":"Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model","volume":"49","author":"Zhou","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2017.03.007_bib0175","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3350\/cmh.2015.21.2.141","article-title":"Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis","volume":"21","author":"Jang","year":"2015","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0180","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3748\/wjg.v18.i10.1048","article-title":"Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis","volume":"18","author":"Zhao","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.03.007_bib0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2007.05.150","article-title":"Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells","volume":"363","author":"Parekkadan","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.03.007_bib0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/cmi.2010.57","article-title":"Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases","volume":"8","author":"Lin","year":"2011","journal-title":"Cell. Mol. Immunol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216330037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216330037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:20:58Z","timestamp":1760095258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216330037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":38,"alternative-id":["S0753332216330037"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.03.007","relation":{},"ISSN":["0753-3322"],"issn-type":[{"type":"print","value":"0753-3322"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}