{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:54:49Z","timestamp":1780059289223,"version":"3.54.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574005"],"award-info":[{"award-number":["81574005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2015JJ6083"],"award-info":[{"award-number":["2015JJ6083"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.biopha.2017.03.084","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T10:32:47Z","timestamp":1492684367000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis"],"prefix":"10.1016","volume":"90","author":[{"given":"Biao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2017.03.084_bib0005","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1574888X1130800062","article-title":"The potential of stem cell therapy for osteoarthritis and rheumatoid arthritis","volume":"8","author":"Keerthi","year":"2013","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"11","key":"10.1016\/j.biopha.2017.03.084_bib0010","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1002\/art.38778","article-title":"Structural associations of symptomatic knee osteoarthritis","volume":"66","author":"Stoppiello","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.biopha.2017.03.084_bib0015","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-015-0664-5","article-title":"Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis","volume":"16","author":"Prieto-Potin","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.biopha.2017.03.084_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"6937","key":"10.1016\/j.biopha.2017.03.084_bib0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biopha.2017.03.084_bib0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.biopha.2017.03.084_bib0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/1756-185X.12115","article-title":"Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients","volume":"17","author":"Iwadate","year":"2014","journal-title":"Int. J. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2017.03.084_bib0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm.3028","article-title":"The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine","volume":"19","author":"Bianco","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2017.03.084_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1908365","article-title":"The modulatory effects of mesenchymal stem cells on osteoclastogenesis","author":"Sharaf-Eldin","year":"2016","journal-title":"Stem Cells Int."},{"issue":"6","key":"10.1016\/j.biopha.2017.03.084_bib0050","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/art.30309","article-title":"Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production","volume":"63","author":"Oshita","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.biopha.2017.03.084_bib0055","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.4049\/jimmunol.181.6.4389","article-title":"Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator","volume":"181","author":"Jarvinen","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2017.03.084_bib0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10456-005-2892-z","article-title":"The anti-angiogenic effect of sinomenine","volume":"8","author":"Kok","year":"2005","journal-title":"Angiogenesis"},{"issue":"2","key":"10.1016\/j.biopha.2017.03.084_bib0065","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.intimp.2015.10.030","article-title":"Anti-inflammatory effects of novel sinomenine derivatives","volume":"29","author":"Zhao","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2017.03.084_bib0070","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0192-0561(96)00025-2","article-title":"Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine","volume":"18","author":"Liu","year":"1996","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.biopha.2017.03.084_bib0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.sjpain.2014.12.003","article-title":"Sinomenine alleviates mechanical hypersensitivity in mice with experimentally induced rheumatoid arthritis","volume":"7","author":"Gao","year":"2015","journal-title":"Scandinavian J. Pain"},{"issue":"11","key":"10.1016\/j.biopha.2017.03.084_bib0080","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00296-010-1506-2","article-title":"Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147","volume":"31","author":"Ou","year":"2011","journal-title":"Rheumatol. Int."},{"issue":"11","key":"10.1016\/j.biopha.2017.03.084_bib0085","first-page":"1223","article-title":"Impairment of macrophage eicosanoid and nitric-oxide production by an alkaloid from sinomenium-acutum","volume":"44-2","author":"Liu","year":"1994","journal-title":"Arzneimittel-Forschung\/Drug Res."},{"issue":"2","key":"10.1016\/j.biopha.2017.03.084_bib0090","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.intimp.2015.04.029","article-title":"Sinomenine potentiates degranulation of RBL-2H3 basophils via up-regulation of phospholipase A2 phosphorylation by Annexin A1 cleavage and ERK phosphorylation without influencing on calcium mobilization","volume":"28","author":"Huang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2017.03.084_bib0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-60761-999-4_2","article-title":"Isolation and expansion of mesenchymal stem cells\/multipotential stromal cells from human bone marrow","volume":"698","author":"Penfornis","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2017.03.084_bib0100","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9742034","article-title":"Umbilical cord-derived mesenchymal stem cells relieve hindlimb ischemia through enhancing angiogenesis in tree shrews","author":"Yin","year":"2016","journal-title":"Stem Cells Int."},{"issue":"27","key":"10.1016\/j.biopha.2017.03.084_bib0105","doi-asserted-by":"crossref","first-page":"24458","DOI":"10.1074\/jbc.M111.223297","article-title":"Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone","volume":"286","author":"Ghayor","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biopha.2017.03.084_bib0110","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.biopha.2017.03.084_bib0115","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00002281-200005000-00006","article-title":"Pathogenesis of bone erosions in rheumatoid arthritis","volume":"12","author":"Goldring","year":"2000","journal-title":"Curr. Opin. Rheumatol."},{"issue":"10","key":"10.1016\/j.biopha.2017.03.084_bib0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrrheum.2009.175","article-title":"Promising bone-related therapeutic targets for rheumatoid arthritis","volume":"5","author":"Choi","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.biopha.2017.03.084_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/annrheumdis-2012-201319","article-title":"Impact of tumour necrosis factor inhibitor treatment on radiographic progression in rheumatoid arthritis patients in clinical practice: results from the nationwide Danish DANBIO registry","volume":"72","author":"Ornbjerg","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.biopha.2017.03.084_bib0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrrheum.2009.82","article-title":"Tyrosine kinases as targets for the treatment of rheumatoid arthritis","volume":"5","author":"Swanson","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.biopha.2017.03.084_bib0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3899\/jrheum.120447","article-title":"Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results","volume":"40","author":"Fleischmann","year":"2013","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.biopha.2017.03.084_bib0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/08916934.2010.517815","article-title":"Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis","volume":"44","author":"Chao","year":"2011","journal-title":"Autoimmunity"},{"issue":"3","key":"10.1016\/j.biopha.2017.03.084_bib0145","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcp.2011.09.018","article-title":"Subchondral bone as a key target for osteoarthritis treatment","volume":"83","author":"Castaneda","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2017.03.084_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074274","article-title":"Sinomenine suppresses osteoclast formation and mycobacterium tuberculosis H37Ra-Induced bone loss by modulating RANKL signaling pathways","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2017.03.084_bib0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.intimp.2013.11.014","article-title":"A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines","volume":"18","author":"Sun","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2017.03.084_bib0160","doi-asserted-by":"crossref","DOI":"10.1186\/scrt2","article-title":"Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications","volume":"1","author":"Ghannam","year":"2010","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.biopha.2017.03.084_bib0165","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1089\/scd.2009.0021","article-title":"Tumor necrosis factor-alpha alters the modulatory effects of mesenchymal stem cells on osteoclast formation and function","volume":"18","author":"Zhu","year":"2009","journal-title":"Stem Cells Dev."},{"issue":"4","key":"10.1016\/j.biopha.2017.03.084_bib0170","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J. Biol. Chem."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216324702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216324702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T23:13:17Z","timestamp":1719875597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216324702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":34,"alternative-id":["S0753332216324702"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.03.084","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.03.084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}