{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:53:50Z","timestamp":1775858030387,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.biopha.2017.04.035","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T04:17:36Z","timestamp":1492748256000},"page":"842-849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Protective effects of tranilast on experimental colitis in rats"],"prefix":"10.1016","volume":"90","author":[{"given":"Yoshiki","family":"Seto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Tsukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuki","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Kojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Onoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9573","key":"10.1016\/j.biopha.2017.04.035_bib0005","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0010","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"issue":"9573","key":"10.1016\/j.biopha.2017.04.035_bib0015","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","article-title":"Inflammatory bowel disease: cause and immunobiology","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"issue":"27","key":"10.1016\/j.biopha.2017.04.035_bib0020","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.4254\/wjh.v7.i27.2716","article-title":"Hepatic manifestations of non-steroidal inflammatory bowel disease therapy","volume":"7","author":"Hirten","year":"2015","journal-title":"World J. Hepatol."},{"issue":"Suppl. 5","key":"10.1016\/j.biopha.2017.04.035_bib0025","doi-asserted-by":"crossref","first-page":"V1","DOI":"10.1136\/gut.2004.043372","article-title":"Guidelines for the management of inflammatory bowel disease in adults","volume":"53","author":"Carter","year":"2004","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.biopha.2017.04.035_bib0030","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1053\/j.gastro.2006.01.048","article-title":"American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease","volume":"130","author":"Lichtenstein","year":"2006","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.biopha.2017.04.035_bib0035","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1046\/j.1365-2036.2003.01534.x","article-title":"Rescue therapy with tacrolimus is effective in patients with severe and refractory inflammatory bowel disease","volume":"17","author":"Baumgart","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/1756283X14558193","article-title":"Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases","volume":"8","author":"Amiot","year":"2015","journal-title":"Therap. Adv. Gastroenterol."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.035_bib0045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0091-6749(76)90054-3","article-title":"Inhibition of hypersensitivity reactions by a new drug, N(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5')","volume":"57","author":"Koda","year":"1976","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1254\/jjp.60.85","article-title":"Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages","volume":"60","author":"Suzawa","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.04.035_bib0055","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1476-5381.1976.tb08614.x","article-title":"Pharmacological properties of N-(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5'), a new anti-atopic agent","volume":"58","author":"Azuma","year":"1976","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.04.035_bib0060","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0006-2952(87)90353-4","article-title":"Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl)anthranilic acid (N-5') in granulation tissue","volume":"36","author":"Isaji","year":"1987","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0021-9150(95)05607-6","article-title":"Inhibition of PDGF- and TGF-beta 1-induced collagen synthesis, migration and proliferation by tranilast in vascular smooth muscle cells from spontaneously hypertensive rats","volume":"118","author":"Miyazawa","year":"1995","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1254\/jjp.60.91","article-title":"The mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblasts","volume":"60","author":"Suzawa","year":"1992","journal-title":"Jpn. J. Pharmacol."},{"issue":"5749","key":"10.1016\/j.biopha.2017.04.035_bib0075","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1117634","article-title":"Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite","volume":"310","author":"Platten","year":"2005","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2017.04.035_bib0080","first-page":"195","article-title":"A case of colonic Crohn's disease possibly managed with tranilast","volume":"94","author":"Kikuchi","year":"1997","journal-title":"Nihon Shokakibyo Gakkai zasshi"},{"issue":"4","key":"10.1016\/j.biopha.2017.04.035_bib0085","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/gut.2006.115469","article-title":"Long-term prospective pilot study with tranilast for the prevention of stricture progression in patients with Crohn's disease","volume":"56","author":"Oshitani","year":"2007","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.biopha.2017.04.035_bib0090","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.CIR.0000028335.31300.DA","article-title":"Results of prevention of REStenosis with tranilast and its outcomes (PRESTO) trial","volume":"106","author":"Holmes","year":"2002","journal-title":"Circulation"},{"issue":"5 Pt 1","key":"10.1016\/j.biopha.2017.04.035_bib0095","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0002-8703(99)70025-6","article-title":"Impact of tranilast on restenosis after coronary angioplasty: tranilast restenosis following angioplasty trial (TREAT)","volume":"138","author":"Tamai","year":"1999","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0100","first-page":"141","article-title":"Tranilast kissei pharmaceutical","volume":"1","author":"Konneh","year":"1998","journal-title":"IDrugs"},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pharep.2013.08.013","article-title":"Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: possible morphological and biochemical alterations","volume":"66","author":"Dodda","year":"2014","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0110","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.taap.2013.04.026","article-title":"Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats","volume":"271","author":"Nagib","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.035_bib0115","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10787-011-0114-4","article-title":"Protective effect of aqueous extract of Spinacia oleracea leaves in experimental paradigms of inflammatory bowel disease","volume":"20","author":"Otari","year":"2012","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0120","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jss.2014.08.064","article-title":"Effectiveness of sildenafil and U-74389G in a rat model of colitis","volume":"193","author":"Margonis","year":"2015","journal-title":"J. Surg. Res."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0125","first-page":"92","article-title":"Validation of a modified model of TNBS-induced colitis in rats. How to induce a chemical colitis in rats","volume":"86","author":"Tomasello","year":"2015","journal-title":"Acta Biomed."},{"issue":"1-3","key":"10.1016\/j.biopha.2017.04.035_bib0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2012.06.044","article-title":"N-methyl-D-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats","volume":"691","author":"Erces","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.04.035_bib0135","first-page":"19","article-title":"Induction of TNBS colitis in mice","author":"Scheiffele","year":"2002","journal-title":"Curr. Protoc. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.035_bib0140","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.157.5.2174","article-title":"Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance","volume":"157","author":"Elson","year":"1996","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00062752-200001000-00010","article-title":"Myeloperoxidase","volume":"7","author":"Winterbourn","year":"2000","journal-title":"Curr. Opin. Hematol."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0150","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.atherosclerosis.2014.05.948","article-title":"Niacin decreases leukocyte myeloperoxidase: mechanistic role of redox agents and Src\/p38MAP kinase","volume":"235","author":"Ganji","year":"2014","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.dld.2015.09.002","article-title":"Protective effects of tranilast on oxazolone-induced rat colitis through a mast cell-dependent pathway","volume":"48","author":"Chu","year":"2016","journal-title":"Dig. Liver Dis."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.035_bib0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1211\/jpp.58.1.0011","article-title":"Effect of tranilast on matrix metalloproteinase production from neutrophils in-vitro","volume":"58","author":"Shimizu","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2017.04.035_bib0165","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s10620-011-1628-8","article-title":"Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12\/23p40 in a TNBS-induced Crohn's disease model","volume":"56","author":"Radi","year":"2011","journal-title":"Dig. Dis. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2017.04.035_bib0170","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/rheumatology\/kem160","article-title":"The anti-allergic drug, N-(3' 4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis","volume":"46","author":"Inglis","year":"2007","journal-title":"Rheumatology"},{"issue":"6","key":"10.1016\/j.biopha.2017.04.035_bib0175","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bcp.2011.06.013","article-title":"Suppression of human CD4+ T cell activation by 3,4-dimethoxycinnamonyl-anthranilic acid (tranilast) is mediated by CXCL9 and CXCL10","volume":"82","author":"Hertenstein","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.035_bib0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1440-1827.2009.02490.x","article-title":"Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1","volume":"60","author":"Sun","year":"2010","journal-title":"Pathol. Int."},{"issue":"7","key":"10.1016\/j.biopha.2017.04.035_bib0185","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-2362.2007.01809.x","article-title":"A clinical trial on absorption and N-acetylation of oral and rectal mesalazine","volume":"37","author":"Dilger","year":"2007","journal-title":"Eur. J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.035_bib0190","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2036.1990.tb00496.x","article-title":"Pharmacokinetics of a 5-aminosalicylic acid enteric-coated tablet in patients with Crohn's disease or ulcerative colitis and in healthy volunteers","volume":"4","author":"Norlander","year":"1990","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2017.04.035_bib0195","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ejps.2009.12.009","article-title":"Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability","volume":"39","author":"Kawabata","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.04.035_bib0200","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2133\/dmpk.DMPK-11-RG-101","article-title":"Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability","volume":"27","author":"Onoue","year":"2012","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.035_bib0205","first-page":"291","article-title":"Formulation approaches for orally administered poorly soluble drugs","volume":"57","author":"Pinnamaneni","year":"2002","journal-title":"Pharmazie"},{"key":"10.1016\/j.biopha.2017.04.035_bib0210","series-title":"Japanese Orange Books No. 12 (Approved Drug Products with Therapeutic Equivalence Evaluations)","author":"The Society of Japanese Pharmacopedia, Tranilast","year":"2002"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2017.04.035_bib0215","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijpharm.2013.05.022","article-title":"Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability","volume":"452","author":"Onoue","year":"2013","journal-title":"Int. J. Pharm."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217310922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217310922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:42:28Z","timestamp":1692758548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217310922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":43,"alternative-id":["S0753332217310922"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.035","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of tranilast on experimental colitis in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}