{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:11:59Z","timestamp":1787976719745,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.biopha.2017.04.042","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T06:18:06Z","timestamp":1492841886000},"page":"906-913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Noscapinoids bearing silver nanocrystals augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in B16F1, mouse melanoma skin cancer cells"],"prefix":"10.1016","volume":"90","author":[{"given":"Naina","family":"Soni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Jyoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upendra Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Katyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitender","family":"Madan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.04.042_bib0005","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1055-9965.EPI-12-0327","article-title":"Time to get serious about skin cancer prevention","volume":"21","author":"Lazovich","year":"2012","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.biopha.2017.04.042_bib0010","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of non-melanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2004.09.012","article-title":"Ultraviolet radiation-mediated damage to cellular DNA","volume":"571","author":"Cadet","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2017.04.042_bib0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/ije\/dyn017","article-title":"Estimating the global disease burden due to ultraviolet radiation exposure","volume":"37","author":"Lucas","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0025","first-page":"2163","article-title":"TNM classification of malignant melanoma and non-melanoma skin cancer","volume":"24","author":"Suzuki","year":"1997","journal-title":"Gan To Kagaku Ryoho"},{"key":"10.1016\/j.biopha.2017.04.042_bib0030","first-page":"1","article-title":"A retrospective analysis of the role of adjuvant radiotherapy in the treatment of cutaneous melanoma","volume":"15","author":"Baker","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.biopha.2017.04.042_bib0035","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1200\/JCO.1999.17.9.2745","article-title":"Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma","volume":"17","author":"Chapman","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0040","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1200\/JCO.1999.17.7.2105","article-title":"High-dose recombinant Interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993","volume":"17","author":"Atkins","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0045","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with Ipilimumab in patients with metastatic melanoma","volume":"363","author":"Hodi","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2017.04.042_bib0050","first-page":"4109","article-title":"Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma","volume":"62","author":"Landen","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2017.04.042_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ijc.24765","article-title":"Non-toxic melanoma therapy by a novel tubulin-binding agent","volume":"126","author":"Aneja","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2017.04.042_bib0060","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00280-009-1060-3","article-title":"Inclusion complexes of noscapine in \u03b2-cyclodextrin offer better solubility and improved pharmacokinetics","volume":"65","author":"Madan","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0065","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1124\/mol.63.4.799","article-title":"Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation","volume":"63","author":"Zhou","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0070","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00280-004-0903-1","article-title":"EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice","volume":"55","author":"Zhou","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0075","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1021\/mp500408n","article-title":"Cyclodextrin complexes of reduced bromonoscapine in guar gum microspheres enhance colonic drug delivery","volume":"11","author":"Madan","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biopha.2017.04.042_bib0080","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijpharm.2005.04.004","article-title":"Effects of ionization and penetration enhancers on the transdermal delivery of 5-fluorouracil through excised human stratum corneum","volume":"298","author":"Singh","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2017.04.042_bib0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpharm.2006.08.021","article-title":"Doxorubicin skin penetration from monoolein-containing propylene glycol formulations","volume":"329","author":"Herai","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2017.04.042_bib0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejpb.2009.04.016","article-title":"Assessment of the percutaneous penetration of cisplatin: the effect of monoolein and the drug skin penetration pathway","volume":"73","author":"Simonetti","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biopha.2017.04.042_bib0095","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/CAD.0b013e328346c7d6","article-title":"Comparative study of transfersomes, liposomes, and niosomes for topical delivery of 5-fluorouracil to skin cancer cells: preparation, characterization, in-vitro release, and cytotoxicity analysis","volume":"22","author":"Alvi","year":"2011","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.biopha.2017.04.042_bib0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijpharm.2011.03.068","article-title":"Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin","volume":"412","author":"Manconi","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2017.04.042_bib0105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0168-3659(99)00213-8","article-title":"A vehicle for photodynamic therapy of skin cancer: influence of dimethyl sulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy","volume":"65","author":"De Rosa","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2017.04.042_bib0110","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1021\/ic8002228","article-title":"Biomolecule assisted synthesis of water soluble silver nanoparticles and their biomedical applications","volume":"47","author":"Wu","year":"2008","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.biopha.2017.04.042_bib0115","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.2147\/IJN.S111279","article-title":"Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy","volume":"11","author":"Zhang","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2017.04.042_bib0120","first-page":"1","article-title":"Silver nanoparticles protect human keratinocytes against UV-B radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis","volume":"2","author":"Arora","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2017.04.042_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-9-459","article-title":"Oxidative stress mediated cytotoxicity of biologically synthesized silver nanoparticles in human lung epithelial adenocarcinoma cell line","volume":"9","author":"Han","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biopha.2017.04.042_bib0130","first-page":"298","article-title":"Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives","volume":"5","author":"De Wit","year":"1983","journal-title":"Pharm. Weekblad. Sci. Ed."},{"key":"10.1016\/j.biopha.2017.04.042_bib0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Immunol. J. Methods"},{"key":"10.1016\/j.biopha.2017.04.042_bib0140","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.colsurfb.2013.02.010","article-title":"Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells","volume":"107","author":"Madan","year":"2013","journal-title":"Colloids Surf. B: Biointerface"},{"key":"10.1016\/j.biopha.2017.04.042_bib0145","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1166\/jbn.2016.2182","article-title":"In vitro effect of 30nm silver nanoparticles on adipogenic differentiation of human mesenchymal stem cells","volume":"12","author":"He","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0150","doi-asserted-by":"crossref","first-page":"e76232","DOI":"10.1371\/journal.pone.0076232","article-title":"Lumican-derived peptides inhibit melanoma cell growth and migration","volume":"8","author":"Pietraszek","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.biopha.2017.04.042_bib0155","first-page":"98","article-title":"Nachrichten von der Gesellschaft der Wissenschaften zu Gottingen","author":"Scherrer","year":"1918","journal-title":"Mathematisch-Physikalische Klasse"},{"key":"10.1016\/j.biopha.2017.04.042_bib0160","doi-asserted-by":"crossref","first-page":"316","DOI":"10.7150\/thno.7819","article-title":"Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 System)","volume":"4","author":"Mukherjee","year":"2014","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2017.04.042_bib0165","first-page":"599","article-title":"Formulation and in-vitro evaluation of tretinoin microemulsion as a potential carrier for dermal drug delivery","volume":"12","author":"Mortazavi","year":"2013","journal-title":"Iran J. Pharm. Res."},{"key":"10.1016\/j.biopha.2017.04.042_bib0170","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10529-010-0208-x","article-title":"In vitro release behavior and cytotoxicity of doxorubicin-loaded gold nanoparticles in cancerous cells","volume":"32","author":"Asadishad","year":"2010","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.biopha.2017.04.042_bib0175","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.04.042_bib0180","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/jid.1960.129","article-title":"Skin penetration","volume":"35","author":"Stoughton","year":"1960","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0185","first-page":"48","article-title":"Silver nanoparticles in cosmetics","volume":"6","author":"Gajbhiye","year":"2016","journal-title":"J. Cosmet. Dermatol. Sci. Appl."},{"key":"10.1016\/j.biopha.2017.04.042_bib0190","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1166\/jbn.2010.1143","article-title":"Engineered inorganic nanoparticles and cosmetics: facts, issues, knowledge gaps and challenge","volume":"6","author":"Wiechers","year":"2010","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0195","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3390\/molecules21121719","article-title":"Nanoparticle-enabled transdermal drug delivery systems for enhanced dose control and tissue targeting","volume":"21","author":"Palmer","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.04.042_bib0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/derm.1.4.9501","article-title":"Nanoparticles and their interactions with the dermal barrier","volume":"1","author":"Schneider","year":"2009","journal-title":"Derm. Endocrinol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.toxlet.2007.02.009","article-title":"In vitro percutaneous absorption of metal compounds","volume":"170","author":"Larese","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2017.04.042_bib0210","doi-asserted-by":"crossref","first-page":"16908","DOI":"10.1038\/srep16908","article-title":"Shape-dependent skin penetration of silver nanoparticles: does it really matter?","volume":"5","author":"Tak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2017.04.042_bib0215","doi-asserted-by":"crossref","first-page":"117","DOI":"10.32725\/jab.2008.015","article-title":"Silver or silver nanoparticles: a hazardous threat to the environment and human health?","volume":"6","author":"Panyala","year":"2008","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.biopha.2017.04.042_bib0220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1743-8977-7-20","article-title":"Subchronic oral toxicity of silver nanoparticles","volume":"7","author":"Kim","year":"2010","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0225","first-page":"652","article-title":"Szycher's Handbook of Polyurethanes","year":"2012"},{"key":"10.1016\/j.biopha.2017.04.042_bib0230","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00204-010-0545-5","article-title":"Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549","volume":"85","author":"Foldbjerg","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2017.04.042_bib0235","first-page":"1194","article-title":"Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer","volume":"56","author":"Gerweck","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2017.04.042_bib0240","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s13238-014-0089-1","article-title":"Mitochondria-mediated apoptosis in mammals","volume":"5","author":"Xiong","year":"2014","journal-title":"Protein Cell."},{"key":"10.1016\/j.biopha.2017.04.042_bib0245","doi-asserted-by":"crossref","first-page":"27902","DOI":"10.1038\/srep27902","article-title":"Silver nanoparticles defeat p53positive and p53negative osteosarcoma cells by triggering mitochondrial stress and apoptosis","volume":"6","author":"Kovacs","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2017.04.042_bib0250","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1289\/ehp.0901398","article-title":"Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro","volume":"118","author":"Samberg","year":"2010","journal-title":"Environ. Health Perspect."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2018.05.153","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000}}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216316183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332216316183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T23:08:35Z","timestamp":1719875315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332216316183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":50,"alternative-id":["S0753332216316183"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.042","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.biopha.2018.05.153","asserted-by":"object"}]},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noscapinoids bearing silver nanocrystals augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in B16F1, mouse melanoma skin cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}