{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:13:28Z","timestamp":1788884008095,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Supeior","award":["CAPES"],"award-info":[{"award-number":["CAPES"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.biopha.2017.04.058","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T10:32:28Z","timestamp":1492684348000},"page":"813-820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Sesquiterpenes evaluation on Schistosoma mansoni : Survival, excretory system and membrane integrity"],"prefix":"10.1016","volume":"90","author":[{"given":"Rosimeire Nunes","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Rodrigues","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Manuel Fernandes","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L\u00facia","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Silva","family":"Santos Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"de Lourdes Sierpe Jeraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silmara Marques","family":"Allegretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.04.058_bib0005","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4155\/fmc.15.22","article-title":"Toward organometallic antischistosomal drug candidates","volume":"7","author":"Hess","year":"2015","journal-title":"Schistosomiasis. Future Med. Chem."},{"key":"10.1016\/j.biopha.2017.04.058_bib0010","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"9936","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2017.04.058_bib0015","first-page":"667","article-title":"Praziquantel: mechanisms of action, Resistance and new derivatives for schistosomiasis","volume":"659","author":"Doenhoff","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.biopha.2017.04.058_bib0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.4155\/fmc.15.27","article-title":"Schistosomiasis and its treatment","volume":"7","author":"Caffrey","year":"2015","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.biopha.2017.04.058_bib0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00436-012-3172-7","article-title":"Anthelmintic activity of carvacryl acetate against Schistosoma mansoni","volume":"112","author":"Moraes","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biopha.2017.04.058_bib0030","first-page":"e139","article-title":"Structural parameters, molecular properties, and biological evaluation of some terpenes targeting Schistosoma mansoni parasite","volume":"129","author":"Mafud","year":"2016","journal-title":"Chemico-Biolo Interact."},{"key":"10.1016\/j.biopha.2017.04.058_bib0035","first-page":"1","article-title":"Computer-Aided drug design using sesquiterpene lactones as sources of new structures with potential activity against infectious neglected diseases","volume":"22","author":"Acevedo","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.04.058_bib0040","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejphar.2007.04.059","article-title":"Anti-inflammatory effects of compounds alpha-humulene and (\u2227)-trans-caryophyllene isolated from the essential oil of Cordia verben\u00e1cea","volume":"569","author":"Fernandes","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0045","doi-asserted-by":"crossref","first-page":"11965","DOI":"10.3390\/molecules171011965","article-title":"Trans-Caryophyllene, a natural sesquiterpene, causes tracheal smooth muscle relaxation through blockade of voltage-Dependent Ca2+ channels","volume":"17","author":"Pinho-da-Silva","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.04.058_bib0050","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological effects of essential oils\u2022a review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0055","first-page":"343","article-title":"Cytotoxic activity of \u03b1-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells","volume":"76","author":"Hadri","year":"2010","journal-title":"Ann. R. Acad. Nac. Farm."},{"key":"10.1016\/j.biopha.2017.04.058_bib0060","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.pt.2005.08.004","article-title":"Plant active components\u2022a resource for antiparasitic agents?","volume":"21","author":"Anthony","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0065","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0169-4758(00)01787-7","article-title":"Molecular crosstalk in host-parasite relationships: schistosome- and leech-host interactions","volume":"16","author":"Salzet","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.biopha.2017.04.058_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S0031182003004177","article-title":"Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system","volume":"128","author":"Sato","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.biopha.2017.04.058_bib0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pt.2009.05.003","article-title":"The schistosome excretory system: a key to regulation of metabolism, drug excretion and host interaction","volume":"25","author":"Kusel","year":"2009","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4172\/2161-0444.1000269","article-title":"Novel upconversion fluorescent probe for Schistosoma japonicum cercariae imaging","volume":"5","author":"Fan","year":"2015","journal-title":"Med. Chem."},{"issue":"185","key":"10.1016\/j.biopha.2017.04.058_bib0085","first-page":"284","article-title":"Making sense of the schistosome surface","volume":"65","author":"Skelly","year":"2014","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0090","doi-asserted-by":"crossref","first-page":"e10451","DOI":"10.1371\/journal.pone.0010451","article-title":"The tegument of the human parasitic worm schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter","volume":"5","author":"Faghiri","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.04.058_bib0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exppara.2012.06.005","article-title":"Schistosoma mansoni: in vitro schistosomicidal activity of essential oil of Baccharis trimera (Less) DC","volume":"132","author":"de Oliveira","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0100","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1017\/S003118201000065X","article-title":"Use of fluorescent probes as a useful tool to identify resistant Schistosoma mansoni isolates to praziquantel","volume":"13","author":"Couto","year":"2010","journal-title":"Parasitol"},{"key":"10.1016\/j.biopha.2017.04.058_bib0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0001-706X(00)00067-X","article-title":"Tegumental changes in 21-day-old Schistosoma mansoni harboured in mice treated with artemether","volume":"75","author":"Xiao","year":"2000","journal-title":"Acta Trop."},{"key":"10.1016\/j.biopha.2017.04.058_bib0110","doi-asserted-by":"crossref","first-page":"15058","DOI":"10.3390\/molecules190915058","article-title":"New uses for old drugs: the tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China","volume":"19","author":"Liu","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.04.058_bib0115","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1039\/C4OB00426D","article-title":"Structurally modified natural sesquiterpene lactones constitute effective and less toxic schistosomicidal compounds","volume":"12","author":"Sass","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.biopha.2017.04.058_bib0120","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.3390\/molecules19033793","article-title":"Antischistosomal activity of the terpene nerolidol","volume":"19","author":"Silva","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.04.058_bib0125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molbiopara.2009.04.007","article-title":"Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel Susceptibility","volume":"167","author":"Messerli","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijpddr.2014.09.007","article-title":"Schistosome ABC multidrug transporters: from pharmacology to physiology","volume":"4","author":"Greenberg","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resistance"},{"key":"10.1016\/j.biopha.2017.04.058_bib0135","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1017\/S0031182002002536","article-title":"Functional visualization of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin","volume":"125","author":"Sato","year":"2002","journal-title":"Parasitol"},{"key":"10.1016\/j.biopha.2017.04.058_bib0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1590\/S0074-02762006000900046","article-title":"The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni","volume":"101","author":"Kusel","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.biopha.2017.04.058_bib0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S0022149X08070235","article-title":"In vitro effects of artesunate on the survival of worm pairs and egg production of Schistosoma mansoni","volume":"83","author":"Mitsui","year":"2009","journal-title":"J. Helminthol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0150","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00436-011-2267-x","article-title":"Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice","volume":"109","author":"Mostafa","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biopha.2017.04.058_bib0155","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S0022149X0999054X","article-title":"Susceptibility to praziquantel of male and female cercariae of praziquantel-resistant and susceptible isolates of Schistosoma mansoni","volume":"84","author":"Liang","year":"2010","journal-title":"J. Helminthol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2004.09.004","article-title":"Are Ca2+ channels targets of praziquantel action?","volume":"35","author":"Greenberg","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0165","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijpara.2006.01.007","article-title":"Functions of the tegument of schistosomes: clues from the proteome and lipidome","volume":"36","author":"Van Hellemond","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182005009169","article-title":"The response of the excretory system of adult Schistosoma mansoni to praziquantel and biomolecules","volume":"132","author":"Oliveira","year":"2006","journal-title":"Parasitol"},{"key":"10.1016\/j.biopha.2017.04.058_bib0175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijpharm.2007.01.009","article-title":"Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions","volume":"337","author":"Araujo","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2017.04.058_bib0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0014-4894(88)90104-X","article-title":"Schistosoma mansoni: praziquantel-induced changes to the female reproductive system","volume":"65","author":"Shaw","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0065-308X(01)50032-9","article-title":"Antiparasitic properties of medicinal plants and other naturally occurring products","volume":"50","author":"Tagboto","year":"2011","journal-title":"Adv. In Parasitol."},{"key":"10.1016\/j.biopha.2017.04.058_bib0190","first-page":"724","article-title":"Artemether, an effective new agent for chemoprophylaxis against schistosomiasis in China: its in vivo effect on the biochemical metabolism of the asian schistosome","volume":"31","author":"Xiao","year":"2000","journal-title":"Asian J.. Trop. Med. Public Health."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217306236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217306236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T11:03:13Z","timestamp":1569063793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217306236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":38,"alternative-id":["S0753332217306236"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.058","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sesquiterpenes evaluation on Schistosoma mansoni: Survival, excretory system and membrane integrity","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}