{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:11:49Z","timestamp":1789949509025,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360501"],"award-info":[{"award-number":["81360501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670006"],"award-info":[{"award-number":["81670006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guizhou Province Technology Bureau Union Fund","award":["UnionLH-2015-7386"],"award-info":[{"award-number":["UnionLH-2015-7386"]}]},{"name":"Guizhou Province Technology Bureau Union Fund","award":["2015GZ38396"],"award-info":[{"award-number":["2015GZ38396"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.biopha.2017.04.076","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T01:15:42Z","timestamp":1492910142000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Overexpression of heme oxygenase-1 in bone marrow stromal cells promotes microenvironment-mediated imatinib resistance in chronic myeloid leukemia"],"prefix":"10.1016","volume":"91","author":[{"given":"Ping","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Zhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meisheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5411","key":"10.1016\/j.biopha.2017.04.076_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2017.04.076_bib0010","doi-asserted-by":"crossref","first-page":"354","DOI":"10.55782\/ane-2013-1942","article-title":"Bone marrow stromal cell transplantation enhances recovery of motor function after lacunar stroke in rats","volume":"73","author":"Shichinohe","year":"2013","journal-title":"Acta Neurobiol. Exp."},{"issue":"4","key":"10.1016\/j.biopha.2017.04.076_bib0015","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2141.2009.07868.x","article-title":"Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression","volume":"147","author":"Ding","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"9","key":"10.1016\/j.biopha.2017.04.076_bib0020","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1182\/blood-2009-09-242719","article-title":"Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression","volume":"115","author":"Ghosh","year":"2010","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.biopha.2017.04.076_bib0025","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3324\/haematol.2010.031377","article-title":"Inflammatory cytokines and signaling pathways are associated with survival of primary chronic lymphocytic leukemia cells in vitro: a dominant role of CCL2","volume":"96","author":"Angela Schulz","year":"2011","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.biopha.2017.04.076_bib0030","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.canlet.2015.07.044","article-title":"Tumor microenvironment and cancer therapy resistance","volume":"380","author":"Sun","year":"2015","journal-title":"Cancer Lett."},{"issue":"9","key":"10.1016\/j.biopha.2017.04.076_bib0035","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1182\/blood-2002-01-0102","article-title":"In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6\/gp130\/STAT3 pathway","volume":"100","author":"C","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.biopha.2017.04.076_bib0040","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ni.2017","article-title":"CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions","volume":"12","author":"Schajnovitz","year":"2011","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2017.04.076_bib0045","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.thromres.2012.12.009","article-title":"Bisoprolol reverses epinephrine-mediated inhibition of cell emigration through increases in the expression of \u03b2-arrestin 2 and CCR7 and PI3K phosphorylation, in dendritic cells loaded with cholesterol","volume":"131","author":"Yang","year":"2013","journal-title":"Thromb. Res."},{"issue":"3","key":"10.1016\/j.biopha.2017.04.076_bib0050","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.V96.3.1039","article-title":"The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells","volume":"96","author":"Ardeshna","year":"2000","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.biopha.2017.04.076_bib0055","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1093\/nar\/gkt243","article-title":"Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter","volume":"41","author":"Maruyama","year":"2013","journal-title":"Nucl. Acids Res."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.076_bib0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/path.2855","article-title":"PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome","volume":"224","author":"Li","year":"2011","journal-title":"J. Pathol."},{"issue":"38","key":"10.1016\/j.biopha.2017.04.076_bib0065","doi-asserted-by":"crossref","first-page":"32113","DOI":"10.1074\/jbc.M112.393140","article-title":"Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules","volume":"287","author":"Banerjee","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.biopha.2017.04.076_bib0070","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/ijc.29933","article-title":"Targeting of Heme Oxygenase-1 as a novel immune regulator of neuroblastoma","volume":"138","author":"Fest","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"20","key":"10.1016\/j.biopha.2017.04.076_bib0075","first-page":"1","article-title":"The Nrf2\/HO-1 Axis in Cancer Cell Growth and Chemoresistance","volume":"2016","author":"Furfaro","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.076_bib0080","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.leukres.2015.02.009","article-title":"Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK\/c-JUN signaling pathway","volume":"39","author":"Lin","year":"2015","journal-title":"Leuk. Res."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.076_bib0085","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/febs.13633","article-title":"Potential crosstalk of Interleukin-6-heme oxygenase-1 dependent mechanism involved in resistance to lenalidomide in multiple myeloma cells","volume":"283","author":"Wu","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.biopha.2017.04.076_bib0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biopha.2015.12.029","article-title":"Heme oxygenase-1 contributes to imatinib resistance by promoting autophagy in chronic myeloid leukemia through disrupting the mTOR signaling pathway","volume":"78","author":"Cao","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2017.04.076_bib0095","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1634\/stemcells.2004-0331","article-title":"Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells","volume":"24","author":"Sotiropoulou","year":"2006","journal-title":"Stem Cells"},{"issue":"11","key":"10.1016\/j.biopha.2017.04.076_bib0100","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Concise Review Mesenchymal Stem\/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair-Current Views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.biopha.2017.04.076_bib0105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/joa.12032","article-title":"Isolation, characterization and the multi-lineage differentiation potential of rabbit bone marrow\u2010derived mesenchymal stem cells","volume":"222","author":"Tan","year":"2013","journal-title":"J. Anat."},{"issue":"5","key":"10.1016\/j.biopha.2017.04.076_bib0110","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2165\/00019053-200523050-00010","article-title":"Cost effectiveness of imatinib compared with interferon-\u03b1 or hydroxycarbamide for first-line treatment of chronic myeloid leukaemia","volume":"23","author":"Dalziel","year":"2005","journal-title":"PharmacoEconomics"},{"issue":"5","key":"10.1016\/j.biopha.2017.04.076_bib0115","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc2126","article-title":"Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia","volume":"7","author":"Weisberg","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.biopha.2017.04.076_bib0120","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1158\/0008-5472.CAN-03-1200","article-title":"Identification of heme oxygenase-1 as a novel BCR\/ABL-dependent survival factor in chronic myeloid leukemia","volume":"64","author":"Mayerhofer","year":"2004","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.biopha.2017.04.076_bib0125","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood-2005-12-040972","article-title":"Bcr-Abl signaling through the PI-3\/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1","volume":"109","author":"Yoshida","year":"2007","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.biopha.2017.04.076_bib0130","doi-asserted-by":"crossref","first-page":"12558","DOI":"10.1074\/jbc.M114.626960","article-title":"Induction of heme oxygenase-1 by Na+-H+ exchanger 1 protein plays a crucial role in imatinib-resistant chronic myeloid leukemia cells","volume":"290","author":"Ma","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2017.04.076_bib0135","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.2042-3306.2010.00098.x","article-title":"Isolation of equine bone marrow-derived mesenchymal stem cells: a comparison between three protocols","volume":"42","author":"Bourzac","year":"2010","journal-title":"Equine Vet. J."},{"issue":"1","key":"10.1016\/j.biopha.2017.04.076_bib0140","first-page":"44","article-title":"Small interfering RNA silencing of interleukin-6 in mesenchymal stromal cells inhibits multiple myeloma cell growth","volume":"40","author":"Teoh","year":"2015","journal-title":"Leuk. Res."},{"issue":"22","key":"10.1016\/j.biopha.2017.04.076_bib0145","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1182\/blood-2009-09-245811","article-title":"The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment","volume":"116","author":"Steele","year":"2010","journal-title":"Blood"},{"issue":"20","key":"10.1016\/j.biopha.2017.04.076_bib0150","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1158\/1078-0432.CCR-12-3676","article-title":"Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance","volume":"19","author":"de Haart","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"16","key":"10.1016\/j.biopha.2017.04.076_bib0155","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1182\/blood-2011-02-334136","article-title":"p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1\u03b1-mediated down-regulation of CXCL12","volume":"118","author":"Kojima","year":"2011","journal-title":"Blood"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221731329X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221731329X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:06:49Z","timestamp":1760094409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221731329X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":31,"alternative-id":["S075333221731329X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.076","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of heme oxygenase-1 in bone marrow stromal cells promotes microenvironment-mediated imatinib resistance in chronic myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.04.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}