{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:28:37Z","timestamp":1793672917148,"version":"4.5.1"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.biopha.2017.05.009","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T22:16:30Z","timestamp":1494368190000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with \u03b2-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening"],"prefix":"10.1016","volume":"91","author":[{"given":"Pollyana S.","family":"Siqueira-Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan G.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor G.","family":"Ara\u00fajo-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Lucchesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano A.S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula P.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus T.","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin R.A.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Aktumsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo R.","family":"Antoniolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucindo J.","family":"Quintans-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jullyana S.S.","family":"Quintans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.05.009_bib0005","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2014.3266","article-title":"Fibromyalgia: a clinical review","volume":"311","author":"Clauw","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2017.05.009_bib0010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1080\/13543784.2016.1197906","article-title":"Potential drug therapies for the treatment of fibromyalgia","volume":"25","author":"Lawson","year":"2016","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.biopha.2017.05.009_bib0015","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1517\/17460441.2015.1066776","article-title":"Challenges in drug discovery for overcoming \u2018dysfunctional pain\u2019: an emerging category of chronic pain","volume":"10","author":"Nagakura","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.biopha.2017.05.009_bib0020","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2017.05.009_bib0025","first-page":"585419","article-title":"Neurobiology underlying fibromyalgia symptoms","volume":"2012","author":"Ceko","year":"2012","journal-title":"Pain Res. Treat."},{"key":"10.1016\/j.biopha.2017.05.009_bib0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.semarthrit.2007.09.003","article-title":"Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness","volume":"37","author":"Yunus","year":"2008","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.biopha.2017.05.009_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.lfs.2016.02.049","article-title":"\u03b2-Caryophyllene, a dietary cannabinoid, complexed with \u03b2-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn","volume":"149","author":"Quintans-J\u00fanior","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2017.05.009_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pain.2009.07.032","article-title":"Is it possible to develop an animal model of fibromyalgia?","volume":"146","author":"Sluka","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2017.05.009_bib0045","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1124\/jpet.102.033167","article-title":"Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta- but not kappa-, opioid receptor agonists","volume":"302","author":"Sluka","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2017.05.009_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0535s25","article-title":"Models of muscle pain: carrageenan model and acidic saline model","author":"Radhakrishnan","year":"2004","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1168243","article-title":"Drug discovery and natural products: end of an era or an endless frontier?","volume":"325","author":"Li","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.biopha.2017.05.009_bib0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.rdc.2010.11.004","article-title":"Herbal medicine in the treatment of rheumatic diseases","volume":"37","author":"Ernst","year":"2011","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.biopha.2017.05.009_bib0065","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/ijms16010547","article-title":"Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia","volume":"16","author":"Nascimento","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2017.05.009_bib0070","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.3390\/molecules16032233","article-title":"Analgesic-like activity of essential oils constituents","volume":"16","author":"de Sousa","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2017.05.009_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.4686","article-title":"Monoterpenes with analgesic activity\u2014a systematic review","volume":"27","author":"Guimaraes","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.05.009_bib0080","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/13543776.2014.870154","article-title":"Terpenes and derivatives as a new perspective for pain treatment: a patent review","volume":"24","author":"Guimaraes","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.biopha.2017.05.009_bib0085","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00210-014-1007-z","article-title":"Linalool and linalool complexed in beta-cyclodextrin produce anti-hyperalgesic activity and increase Fos protein expression in animal model for fibromyalgia","volume":"387","author":"Nascimento","year":"2014","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0378-8741(01)00234-3","article-title":"Lippia: traditional uses, chemistry and pharmacology: a review","volume":"76","author":"Pascual","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/13880208109065203","article-title":"Essential oil of lippia grata: pharmacological effects and main constituents","volume":"19","author":"Viana","year":"1981","journal-title":"Q. J. Crude Drug Res."},{"key":"10.1016\/j.biopha.2017.05.009_bib0100","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.carbpol.2016.06.040","article-title":"Inclusion of terpenes in cyclodextrins: preparation, characterization and pharmacological approaches","volume":"151","author":"Lima","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2017.05.009_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2016.05.029","article-title":"Alpha-terpineol a monoterpene alcohol, complexed with beta-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study","volume":"254","author":"Oliveira","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2017.05.009_bib0110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.phymed.2012.12.009","article-title":"Improvement of p-cymene antinociceptive and anti-inflammatory effects by inclusion in beta-cyclodextrin","volume":"20","author":"Quintans","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.05.009_bib0115","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.phymed.2016.06.007","article-title":"Docking characterization and investigation of beta-cyclodextrin complexed with citronellal, a monoterpene present in the essential oil of Cymbopogon species, as an anti-hyperalgesic agent in chronic muscle pain model","volume":"23","author":"Santos","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.05.009_bib0120","series-title":"Efeito do complexo de inclus\u00e3o contendo betaciclodextrina e \u00f3leo essencial de Lippia grata (Verbenaceae) na nocicep\u00e7\u00e3o orofacial em modelos experimentais","author":"Siqueira-Lima","year":"2013"},{"key":"10.1016\/j.biopha.2017.05.009_bib0125","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/bcpt.12145","article-title":"Beta-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice\u2014evidence of possible involvement of descending inhibitory pain modulation pathway","volume":"114","author":"Siqueira-Lima","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0130","first-page":"299","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0135","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1096-9861(19960311)366:3<431::AID-CNE5>3.0.CO;2-5","article-title":"Altered c-fos expression in the parabrachial nucleus in a rodent model of CFA-induced peripheral inflammation","volume":"366","author":"Bellavance","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0140","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/328632a0","article-title":"Induction of c-fos-like protein in spinal cord neurons following sensory stimulation","volume":"328","author":"Hunt","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2017.05.009_bib0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(02)01418-8","article-title":"Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat","volume":"441","author":"Buritova","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0150","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0306-4522(94)00500-5","article-title":"c-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression","volume":"65","author":"Hunter","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2017.05.009_bib0155","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.164.3878.444","article-title":"Surgery in the rat during electrical analgesia induced by focal brain stimulation","volume":"164","author":"Reynolds","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.biopha.2017.05.009_bib0160","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s10973-013-3367-x","article-title":"Inclusion complex of (\u2212)-linalool and \u03b2-cyclodextrin","volume":"115","author":"Menezes","year":"2014","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.biopha.2017.05.009_bib0165","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8","article-title":"Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia","volume":"24","author":"Sluka","year":"2001","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.biopha.2017.05.009_bib0170","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.pain.2008.01.020","article-title":"Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice","volume":"137","author":"Ikeuchi","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2017.05.009_bib0175","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/ar4402","article-title":"Animal models of fibromyalgia","volume":"15","author":"DeSantana","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2017.05.009_bib0180","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12272-013-0093-7","article-title":"Mechanisms involved in the antinociceptive effects of orally administered oleanolic acid in the mouse","volume":"36","author":"Park","year":"2013","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2017.05.009_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2016.08.014","article-title":"Morphine-induced Straub tail reaction in mice treated with serotonergic compounds","volume":"791","author":"Belozertseva","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0190","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1476-5381.2010.00877.x","article-title":"The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action","volume":"161","author":"Micov","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/bcpt.12018","article-title":"Citronellol reduces orofacial nociceptive behaviour in mice\u2014evidence of involvement of retrosplenial cortex and periaqueductal grey areas","volume":"112","author":"Brito","year":"2013","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0200","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2012"},{"key":"10.1016\/j.biopha.2017.05.009_bib0205","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1021\/ja00467a001","article-title":"Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms","volume":"99","author":"Allinger","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2017.05.009_bib0210","series-title":"The Molecular Modeling Perspective in Drug Design, Guidebook on Molecular Modeling in Drug Design","first-page":"1","author":"Cohen","year":"1996"},{"key":"10.1016\/j.biopha.2017.05.009_bib0215","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/ja00299a024","article-title":"AM1 a new general purpose quantum mechanical molecular model","volume":"107","author":"Dewar","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biopha.2017.05.009_bib0220","series-title":"Molecular Modelling: Principles and Applications","author":"Leach","year":"2001"},{"key":"10.1016\/j.biopha.2017.05.009_bib0225","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1021\/jm051197e","article-title":"MolDock: a new technique for high-accuracy molecular docking","volume":"49","author":"Thomsen","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2017.05.009_bib0230","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1039\/C6FO00695G","article-title":"Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits","volume":"7","author":"Savran","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2017.05.009_bib0235","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1517\/17425247.2015.1046835","article-title":"Enhanced analgesic activity by cyclodextrins\u2014a systematic review and meta-analysis","volume":"12","author":"Brito","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.biopha.2017.05.009_bib0240","first-page":"243","article-title":"Tramadol and beta-cyclodextrin piroxicam: effective multimodal balanced analgesia for the intra- and postoperative period","volume":"22","author":"Lauretti","year":"1997","journal-title":"Reg. Anesth."},{"key":"10.1016\/j.biopha.2017.05.009_bib0245","doi-asserted-by":"crossref","DOI":"10.2174\/1381612823666170126121926","article-title":"Cyclodextrins as encapsulation agents to improve the anti-inflammatory drugs profile: a systematic review and meta-analysis","author":"Santos","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2017.05.009_bib0250","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/ijms16010547","article-title":"Cyclodextrin-complexed ocimum basilicum leaves essential oil increases fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia","volume":"16","author":"Nascimento","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2017.05.009_bib0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pneurobio.2011.03.001","article-title":"Pain mechanisms: a commentary on concepts and issues","volume":"94","author":"Perl","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0260","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jpain.2006.11.007","article-title":"Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats","volume":"8","author":"Yokoyama","year":"2007","journal-title":"J. Pain"},{"key":"10.1016\/j.biopha.2017.05.009_bib0265","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pain.2007.07.011","article-title":"Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult","volume":"136","author":"Tillu","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2017.05.009_bib0270","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2017.05.009_bib0275","first-page":"153","article-title":"Central nervous system mechanisms for pain modulation","volume":"48","author":"Willis","year":"1985","journal-title":"Appl. Neurophysiol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0280","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0173(02)00187-X","article-title":"Activity of medullary serotonergic neurons in freely moving animals","volume":"40","author":"Jacobs","year":"2002","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.biopha.2017.05.009_bib0285","first-page":"268","article-title":"The HPA and immune axes in stress: the involvement of the serotonergic system","volume":"13","author":"Leonard","year":"2005","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.biopha.2017.05.009_bib0290","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neulet.2008.05.092","article-title":"Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (\u2212)-linalool in mice","volume":"440","author":"Batista","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2017.05.009_bib0295","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.phymed.2013.08.006","article-title":"The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice","volume":"21","author":"Paula-Freire","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.05.009_bib0300","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2015.03.056","article-title":"(+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice","volume":"757","author":"Jiang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0305","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10787-016-0288-x","article-title":"TRP channels: potential drug target for neuropathic pain","volume":"24","author":"Marwaha","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.biopha.2017.05.009_bib0310","first-page":"1","article-title":"Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models","author":"Quintans-Junior","year":"2013","journal-title":"ISRN Toxicol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0315","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00296-010-1470-x","article-title":"Pathophysiology and antioxidant status of patients with fibromyalgia","volume":"31","author":"Iqbal","year":"2011","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.biopha.2017.05.009_bib0320","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.bjp.0707305","article-title":"In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling","volume":"152","author":"Ekins","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0325","article-title":"Host-guest inclusion complexation of \u03b2-cyclodextrin and hecogenin acetate to enhance anti-hyperalgesic effect in an animal model of musculoskeletal pain","author":"Quintans","year":"2016","journal-title":"Process Biochem."},{"key":"10.1016\/j.biopha.2017.05.009_bib0330","doi-asserted-by":"crossref","first-page":"457","DOI":"10.6026\/97320630008457","article-title":"Comparative molecular docking analysis of essential oil constituents as elastase inhibitors","volume":"8","author":"Sivamani","year":"2012","journal-title":"Bioinformation"},{"key":"10.1016\/j.biopha.2017.05.009_bib0335","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/10408398.2011.582544","article-title":"Cyclodextrins and antioxidants","volume":"54","author":"Lopez-Nicolas","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2017.05.009_bib0340","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.foodchem.2009.11.044","article-title":"Identification of cyclodextrin inclusion complex of chlorogenic acid and its antimicrobial activity","volume":"120","author":"Zhao","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.05.009_bib0345","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.3762\/bjoc.10.241","article-title":"Effect of cyclodextrin complexation on phenylpropanoids\u2019 solubility and antioxidant activity","volume":"10","author":"Kfoury","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.biopha.2017.05.009_bib0350","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.fct.2011.03.004","article-title":"Comparative study of different methods to measure antioxidant activity of resveratrol in the presence of cyclodextrins","volume":"49","author":"Lucas-Abell\u00e1n","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2016.08.014","article-title":"Morphine-induced Straub tail reaction in mice treated with serotonergic compounds","volume":"791","author":"Belozertsev","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(97)00277-3","article-title":"Using c-fos as a neural marker of pain","volume":"45","author":"Harris","year":"1998","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2017.05.009_bib0365","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbrc.2005.07.055","article-title":"c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity","volume":"335","author":"Doya","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.05.009_bib0370","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1128\/MCB.01344-08","article-title":"Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis","volume":"29","author":"Yuan","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2017.05.009_bib0375","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1038\/sj.onc.1204239","article-title":"Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis","volume":"20","author":"van Dam","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2017.05.009_bib0380","first-page":"299","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217306248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217306248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:15:55Z","timestamp":1760094955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217306248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":76,"alternative-id":["S0753332217306248"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.009","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with \u03b2-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}