{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:38:45Z","timestamp":1793907525582,"version":"4.8.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370408"],"award-info":[{"award-number":["81370408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370409"],"award-info":[{"award-number":["81370409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670405"],"award-info":[{"award-number":["81670405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation and the Health Department of Jiangsu Province","award":["BK20131246"],"award-info":[{"award-number":["BK20131246"]}]},{"name":"Natural Science Foundation and the Health Department of Jiangsu Province","award":["Q201308"],"award-info":[{"award-number":["Q201308"]}]},{"name":"Natural Science Foundation and the Health Department of Jiangsu Province","award":["QNRC2016836"],"award-info":[{"award-number":["QNRC2016836"]}]},{"name":"Projects from Social Development of Zhenjiang","award":["SH2015038"],"award-info":[{"award-number":["SH2015038"]}]},{"name":"Projects from Social Development of Zhenjiang","award":["SH2015023"],"award-info":[{"award-number":["SH2015023"]}]},{"name":"Projects from Social Development of Zhenjiang","award":["SH2014083"],"award-info":[{"award-number":["SH2014083"]}]},{"name":"Open Program of Key Laboratory of Nuclear Medicine, Ministry of Health and Jiangsu Key Laboratory of Molecular Nuclear Medicine","award":["KF201504"],"award-info":[{"award-number":["KF201504"]}]},{"name":"Projects from Jiangsu University","award":["JDLCZX001"],"award-info":[{"award-number":["JDLCZX001"]}]},{"name":"Projects from Jiangsu University","award":["jdfyRC-2013002"],"award-info":[{"award-number":["jdfyRC-2013002"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.biopha.2017.05.031","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T20:20:12Z","timestamp":1494879612000},"page":"1053-1064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Ghrelin attenuates vascular calcification in diabetic patients with amputation"],"prefix":"10.1016","volume":"91","author":[{"given":"Suining","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11154-016-9373-0","article-title":"Diabetes mellitus and the skin","volume":"7","author":"Makrantonaki","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.031_bib0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/1479164113485101","article-title":"High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells","volume":"10","author":"Sinha","year":"2013","journal-title":"Diab. Vasc. Dis. Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.031_bib0015","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00198-013-2511-6","article-title":"Neuropathy and the vascular-bone axis in diabetes: lessons from Charcot osteoarthropathy","volume":"25","author":"Petrova","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.biopha.2017.05.031_bib0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2007.08.023","article-title":"Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study","volume":"42","author":"Carr","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2017.05.031_bib0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2840-4-4","article-title":"Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate","volume":"18","author":"Hayden","year":"2005","journal-title":"Cardiovasc. Diab."},{"key":"10.1016\/j.biopha.2017.05.031_bib0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11892-003-0049-2","article-title":"Arterial calcification in diabetes","volume":"3","author":"Chen","year":"2003","journal-title":"Curr. Diab. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.031_bib0035","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/CIRCRESAHA.110.236596","article-title":"Activation of vascular bone morphogenetic protein signaling in diabetes mellitus","volume":"108","author":"Bostr\u00f6m","year":"2011","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biopha.2017.05.031_bib0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.atherosclerosis.2012.03.027","article-title":"Aortic stiffness and calcification in men in a population-based international study","volume":"222","author":"Sekikawa","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2017.05.031_bib0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-7120-10-32","article-title":"Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound","volume":"10","author":"Ishihara","year":"2012","journal-title":"Cardiovasc. Ultrasound"},{"issue":"8","key":"10.1016\/j.biopha.2017.05.031_bib0050","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/01.ATV.16.8.978","article-title":"Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus","volume":"16","author":"Lehto","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"16","key":"10.1016\/j.biopha.2017.05.031_bib0055","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.jacc.2008.07.027","article-title":"Mortality incidence and the severity of coronary atherosclerosis assessed by computed tomography angiography","volume":"52","author":"Ostrom","year":"2008","journal-title":"Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2017.05.031_bib0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/heart.85.1.13","article-title":"Vascular and valvar calcification: recent advances","volume":"85","author":"Farzaneh-Far","year":"2001","journal-title":"Heart"},{"issue":"10","key":"10.1016\/j.biopha.2017.05.031_bib0065","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.biopha.2017.05.031_bib0070","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1161\/01.ATV.15.11.2003","article-title":"Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells","volume":"5","author":"Shioi","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2017.05.031_bib0075","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/hh2401.101070","article-title":"Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers","volume":"89","author":"Steitz","year":"2001","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.031_bib0080","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1046\/j.1523-1755.2002.00625.x","article-title":"Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells","volume":"62","author":"Chen","year":"2002","journal-title":"Kidney Int."},{"issue":"6656","key":"10.1016\/j.biopha.2017.05.031_bib0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.031_bib0090","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.biopha.2017.05.031_bib0095","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"Minireview: the OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.biopha.2017.05.031_bib0100","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.0000149165.99974.12","article-title":"Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin","volume":"95","author":"Collin-Osdoby","year":"2004","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.031_bib0105","first-page":"513","article-title":"Ghrelin reduces rat myocardial calcification induced by nicotine and vitamin D3 in vivo","volume":"28","author":"Wang","year":"2011","journal-title":"Int. J. Mol. Med."},{"issue":"6762","key":"10.1016\/j.biopha.2017.05.031_bib0110","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.biopha.2017.05.031_bib0115","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1210\/en.2012-1622","article-title":"Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line","volume":"153","author":"Reichenbach","year":"2012","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.biopha.2017.05.031_bib0120","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.biocel.2007.04.020","article-title":"Ghrelin: a new peptide regulating growth hormone release and food intake","volume":"40","author":"De Vriese","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2017.05.031_bib0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.regpep.2005.02.015","article-title":"Ghrelin blunted vascular calcification in vivo and in vitro in rats","volume":"129","author":"Li","year":"2005","journal-title":"Regul. Pept."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.031_bib0130","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molmet.2015.03.005","article-title":"Ghrelin","volume":"4","author":"M\u00fcller","year":"2015","journal-title":"Mol. Metab."},{"issue":"19","key":"10.1016\/j.biopha.2017.05.031_bib0135","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1161\/CIRCULATIONAHA.105.553883","article-title":"Ghrelin improves endothelial function in patients with metabolic syndrome","volume":"112","author":"Tesauro","year":"2005","journal-title":"Circulation"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2017.05.031_bib0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2009.07.015","article-title":"A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats","volume":"618","author":"Yuan","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SHK.0b013e3181f48a37","article-title":"Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagusnerve","volume":"35","author":"Cheyuo","year":"2011","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0150","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbrc.2007.08.021","article-title":"Effect of ghrelin on human endothelial cells apoptosis induced by high glucose","volume":"362","author":"Zhao","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.biopha.2017.05.031_bib0155","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.bjp.0704815","article-title":"Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1","volume":"136","author":"Wiley","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0160","first-page":"803","article-title":"Ghrelin and Ang 1\u20137 have cumulative vasodilatory effects on pulmonary vessels","volume":"114","author":"Dinc\u0103","year":"2010","journal-title":"Rev. Med. Chir. Soc. Med. Nat. Iasi"},{"issue":"5","key":"10.1016\/j.biopha.2017.05.031_bib0165","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1359\/JBMR.041237","article-title":"Ghrelin directly regulates bone formation","volume":"20","author":"Fukushima","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.biopha.2017.05.031_bib0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1590\/1678-77572016-0196","article-title":"Microbiological, lipid and immunological profiles in children with gingivitis and type 1 diabetes mellitus","volume":"25","author":"Duque","year":"2017","journal-title":"J. Appl. Oral. Sci."},{"issue":"9352","key":"10.1016\/j.biopha.2017.05.031_bib0175","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0140-6736(03)12228-3","article-title":"Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis","volume":"361","author":"Rothwell","year":"2003","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.031_bib0180","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.atherosclerosis.2012.01.019","article-title":"Advanced glycation end-product N\u03b5-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes","volume":"221","author":"Wang","year":"2012","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0185","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jamcollsurg.2011.05.019","article-title":"Risk factors for 30-day postoperative complications and mortality after below-knee amputation: a study of 2,911 patients from the national surgical quality improvement program","volume":"213","author":"Belmont","year":"2011","journal-title":"J. Am. Coll. Surg."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.031_bib0190","doi-asserted-by":"crossref","first-page":"E686","DOI":"10.1152\/ajpendo.00552.2003","article-title":"Osteogenic regulation of vascular calcification: an early perspective","volume":"286","author":"Vattikuti","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.biopha.2017.05.031_bib0195","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00125-014-3348-z","article-title":"RANKL-OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy","volume":"57","author":"Ndip","year":"2014","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.031_bib0200","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.metabol.2006.08.012","article-title":"Lower-extremity arterial calcification as a correlate of coronary artery calcification","volume":"55","author":"Costacou","year":"2006","journal-title":"Metabolism"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.031_bib0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF00404070","article-title":"Medial arterial calcification in the feet of diabetic patients and matched non-diabetic control subjects","volume":"36","author":"Young","year":"1993","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.031_bib0210","first-page":"93","article-title":"Pathophysiology of coronary calcification","volume":"7","author":"Watson","year":"2000","journal-title":"J. Cardiovasc. Risk"},{"issue":"17","key":"10.1016\/j.biopha.2017.05.031_bib0215","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000070591.21548.69","article-title":"Human aortic valve calcification is associated with an osteoblast phenotype","volume":"107","author":"Rajamannan","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2017.05.031_bib0220","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2741\/3790","article-title":"Signalling pathways and vascular calcification","volume":"16","author":"Liu","year":"2011","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.031_bib0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S8756-3282(99)00121-0","article-title":"A novel molecular mechanism modulating osteoclast differentiation and function","volume":"25","author":"Yasuda","year":"1999","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.biopha.2017.05.031_bib0230","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.2337\/db10-1220","article-title":"The RANKL\/RANK\/OPG signaling pathway mediates medial arterial calcification in diabetic Charcot neuroarthropathy","volume":"60","author":"Ndip","year":"2011","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0235","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00198-006-0282-z","article-title":"Vascular calcification and osteoporosis-from clinical observation towards molecular understanding","volume":"18","author":"Hofbauer","year":"2007","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.biopha.2017.05.031_bib0240","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/eje.1.02049","article-title":"Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients","volume":"154","author":"Rasmussen","year":"2006","journal-title":"Eur. J. Endocrinol."},{"issue":"2A","key":"10.1016\/j.biopha.2017.05.031_bib0245","doi-asserted-by":"crossref","first-page":"20E","DOI":"10.1016\/S0002-9149(01)01718-0","article-title":"Insights into the mechanism of vascular calcification","volume":"88","author":"Bostr\u00f6m","year":"2001","journal-title":"Am. J. Cardiol."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.031_bib0250","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00041433-200110000-00012","article-title":"Recent advances in multifactorial regulation of vascular calcification","volume":"12","author":"Tintut","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.031_bib0255","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1677\/joe.0.1560543","article-title":"Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells","volume":"156","author":"Hagiwara","year":"1998","journal-title":"J. Endocrinol."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2017.05.031_bib0260","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0014-5793(02)02872-7","article-title":"PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways","volume":"521","author":"Zhang","year":"2002","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biopha.2017.05.031_bib0265","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00005344-200307000-00014","article-title":"Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells","volume":"42","author":"Huang","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.biopha.2017.05.031_bib0270","first-page":"242","article-title":"Ghrelin a novel player in the gut-brain regulation of growth hormone and energy balance","volume":"18","author":"St-Pierre","year":"2003","journal-title":"News Physiol. Sci."},{"issue":"10","key":"10.1016\/j.biopha.2017.05.031_bib0275","first-page":"3803","article-title":"Growth hormone secretagogue binding sites in peripheral human tissues","volume":"85","author":"Papotti","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.031_bib0280","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans","volume":"87","author":"Gnanapavan","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.05.031_bib0285","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/ncomms3685","article-title":"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans","volume":"4","author":"Takagi","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2017.05.031_bib0290","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1210\/jc.2004-1641","article-title":"Characterization of ghrelin-like immunoreactivity in human plasma","volume":"90","author":"Patterson","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.05.031_bib0295","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1002\/cne.23627","article-title":"Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse","volume":"522","author":"Mani","year":"2014","journal-title":"J. Comp. Neurol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217308788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217308788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:20:22Z","timestamp":1760095222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217308788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":59,"alternative-id":["S0753332217308788"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.031","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin attenuates vascular calcification in diabetic patients with amputation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}