{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:03:40Z","timestamp":1785211420100,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.biopha.2017.05.142","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T22:00:22Z","timestamp":1497132022000},"page":"942-951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Role of growth factor receptor-bound 2 in CCl4-induced hepatic fibrosis"],"prefix":"10.1016","volume":"92","author":[{"given":"Shanfei","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinni","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2017.05.142_bib0005","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.drudis.2015.10.015","article-title":"Emerging therapeutic targets for the treatment of hepatic fibrosis","volume":"21","author":"Fagone","year":"2016","journal-title":"Drug Discov. Today"},{"issue":"11","key":"10.1016\/j.biopha.2017.05.142_bib0010","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/jcb.25116","article-title":"MicroRNA-19b reduces hepatic stellate cell proliferation by targeting GRB2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol","volume":"116","author":"Ge","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.142_bib0015","first-page":"918","article-title":"MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4","volume":"15","author":"Ge","year":"2016","journal-title":"Ann. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.142_bib0020","doi-asserted-by":"crossref","first-page":"e92925","DOI":"10.1371\/journal.pone.0092925","article-title":"Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis","volume":"9","author":"Hayes","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biopha.2017.05.142_bib0025","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.bbadis.2014.06.017","article-title":"Involvement of the nuclear high mobility group B1 peptides released from injured hepatocytes in murine hepatic fibrogenesis","volume":"1842","author":"Kao","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.biopha.2017.05.142_bib0030","doi-asserted-by":"crossref","first-page":"e64373","DOI":"10.1371\/journal.pone.0064373","article-title":"High mobility group box-1 promotes the proliferation and migration of hepatic stellate cells via TLR4-dependent signal pathways of PI3 K\/Akt and JNK","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.142_bib0035","doi-asserted-by":"crossref","first-page":"e0129743","DOI":"10.1371\/journal.pone.0129743","article-title":"Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation","volume":"10","author":"Lan","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.142_bib0040","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.142_bib0045","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0050","doi-asserted-by":"crossref","first-page":"e92884","DOI":"10.1371\/journal.pone.0092884","article-title":"Apoptotic response through a high mobility Box 1 protein-dependent mechanism in LPS\/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition","volume":"9","author":"Kuroda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.05.142_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fimmu.2013.00068","article-title":"HMGB1. the central cytokine for all lymphoid cells","volume":"4","author":"Li","year":"2013","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2017.05.142_bib0060","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1089\/ars.2010.3356","article-title":"High-mobility group Box 1, oxidative stress, and disease","volume":"14","author":"Tang","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"5425","key":"10.1016\/j.biopha.2017.05.142_bib0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.142_bib0070","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.4049\/jimmunol.174.12.7506","article-title":"Release of high mobility group Box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products","volume":"174","author":"Dumitriu","year":"2005","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.142_bib0075","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1586\/14737159.2014.928205","article-title":"Plasma high mobility group Box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease","volume":"14","author":"Alisi","year":"2014","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.biopha.2017.05.142_bib0080","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2119\/molmed.2013.00099","article-title":"Emerging role of high-mobility group Box 1 (HMGB1) in liver diseases","volume":"19","author":"Chen","year":"2013","journal-title":"Mol. Med."},{"key":"10.1016\/j.biopha.2017.05.142_bib0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13069-016-0039-z","article-title":"Transcriptomic analysis of the effects of Toll-like receptor 4 and its ligands on the gene expression network of hepatic stellate cells","volume":"9","author":"Ouyang","year":"2016","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"6","key":"10.1016\/j.biopha.2017.05.142_bib0090","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI16290","article-title":"The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis","volume":"111","author":"Zhang","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2017.05.142_bib0095","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.2337\/diabetes.50.2007.S140","article-title":"IRS proteins and beta-cell function","volume":"50","author":"Burks","year":"2001","journal-title":"Diabetes"},{"issue":"249","key":"10.1016\/j.biopha.2017.05.142_bib0100","doi-asserted-by":"crossref","first-page":"pe49","DOI":"10.1126\/scisignal.2003576","article-title":"Grb2, a double-edged sword of receptor tyrosine kinase signaling","volume":"5","author":"Belov","year":"2012","journal-title":"Sci. Signal."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.142_bib0105","doi-asserted-by":"crossref","first-page":"E1067","DOI":"10.1152\/ajpendo.90714.2008","article-title":"Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.biopha.2017.05.142_bib0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s11626-013-9646-9","article-title":"Suppression of Grb2 expression improved hepatic steatosis, oxidative stress, and apoptosis induced by palmitic acid in vitro partly through insulin signaling alteration","volume":"49","author":"Shan","year":"2013","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.142_bib0115","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1074\/jbc.M704999200","article-title":"Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation","volume":"283","author":"Kondo","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.biopha.2017.05.142_bib0120","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1023\/B:DDAS.0000043369.88701.5b","article-title":"Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats","volume":"49","author":"Wei","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.biopha.2017.05.142_bib0125","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jep.2016.10.006","article-title":"Protective effects of seed melon extract on CCl4-induced hepatic fibrosis in mice","volume":"193","author":"Zhan","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0130","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3109\/1547691X.2015.1128022","article-title":"Rebamipide retards CCl4-induced hepatic fibrosis in rats: possible role for PGE2","volume":"13","author":"Zakaria","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.biopha.2017.05.142_bib0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2016.08.007","article-title":"Role of Herpes simplex virus 1 VP11\/12 tyrosine-based binding motifs for Src family kinases, p85 Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway","volume":"498","author":"Strunk","year":"2016","journal-title":"Virology"},{"issue":"22","key":"10.1016\/j.biopha.2017.05.142_bib0140","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1111\/febs.13502","article-title":"miR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning","volume":"282","author":"Wang","year":"2015","journal-title":"UHRF1 FEBS J."},{"key":"10.1016\/j.biopha.2017.05.142_bib0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2014.11.040","article-title":"The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0\/G1 phase cell cycle arrest: persistent p27(Kip1) induction by interfering with PI3K\/Akt\/FOXO3a signaling pathway","volume":"747","author":"Li","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2017.05.142_bib0150","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1074\/jbc.M704999200","article-title":"Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation","volume":"283","author":"Kondo","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2017.05.142_bib0155","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/excr.2002.5473","article-title":"Preferential binding of Grb2 or phosphatidylinositol 3-kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation","volume":"274","author":"Leshem","year":"2002","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0160","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbrc.2016.06.006","article-title":"miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2","volume":"476","author":"Zhang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.142_bib0165","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/labinvest.3780452","article-title":"Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis","volume":"82","author":"Kitamura","year":"2002","journal-title":"Lab. Invest."},{"issue":"10","key":"10.1016\/j.biopha.2017.05.142_bib0170","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1440-1681.2009.05194.x","article-title":"Pirfenidone inhibits carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents by preventing activation of hepatic stellate cells","volume":"36","author":"Zhao","year":"2009","journal-title":"Clini. Exp. Pharmacol. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2017.05.142_bib0175","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1006\/bbrc.2001.4545","article-title":"Apoptosis in dissociation between DNA synthesis and cellular functions of activated hepatic stellate cells\u2014a study with carbon tetrachloride-induced rat liver injury","volume":"282","author":"Osada","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.142_bib0180","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0168-8278(03)00411-2","article-title":"Apoptosis of hepatic stellate cells in carbon tetrachloride induced acute liver injury of the rat: analysis of isolated hepatic stellate cells","volume":"39","author":"Lee","year":"2003","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.142_bib0185","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","volume":"90","author":"Crespo Yanguas","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.biopha.2017.05.142_bib0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.142_bib0195","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1111\/jcmm.12419","article-title":"Emerging role of HMGB1 in fibrotic diseases","volume":"18","author":"Li","year":"2014","journal-title":"J. Cell. Mol. Med."},{"issue":"1-2","key":"10.1016\/j.biopha.2017.05.142_bib0200","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbagrm.2009.11.014","article-title":"High-mobility group box 1 and cancer","volume":"1799","author":"Tang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0205","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrrheum.2011.222","article-title":"HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease","volume":"8","author":"Harris","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.biopha.2017.05.142_bib0210","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/vim.2010.0080","article-title":"Is HMGB1 a new indirect marker for revealing fibrosis in chronic hepatitis and a new therapeutic target in treatment?","volume":"23","author":"Albayrak","year":"2010","journal-title":"Viral Immunol."},{"issue":"8","key":"10.1016\/j.biopha.2017.05.142_bib0215","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.tp.0000258646.54562.c7","article-title":"Experimental and clinical significance of antinuclear antibodies in liver transplantation","volume":"83","author":"Nakano","year":"2007","journal-title":"Transplantation"},{"issue":"36","key":"10.1016\/j.biopha.2017.05.142_bib0220","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.3748\/wjg.v17.i36.4090","article-title":"Inhibition of high-mobility group Box 1 expression by siRNA in rat hepatic stellate cells","volume":"17","author":"Ge","year":"2011","journal-title":"World J. Gastroenterol."},{"issue":"5-6","key":"10.1016\/j.biopha.2017.05.142_bib0225","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.lfs.2012.07.009","article-title":"High mobility group Box 1 activates Toll like receptor 4 signaling in hepatic stellate cells","volume":"91","author":"Zhang","year":"2012","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2017.05.142_bib0230","first-page":"143","article-title":"Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (review)","volume":"24","author":"Consolo","year":"2009","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0235","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1665-2681(19)32127-1","article-title":"Liver fibrosis and inflammation. A review","volume":"2","author":"Kershenobich Stalnikowitz","year":"2003","journal-title":"Ann. Hepatol."},{"issue":"7","key":"10.1016\/j.biopha.2017.05.142_bib0240","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20042614","article-title":"The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion","volume":"201","author":"Tsung","year":"2005","journal-title":"J. Exp. Med."},{"issue":"1-2","key":"10.1016\/j.biopha.2017.05.142_bib0245","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbagrm.2009.11.019","article-title":"Targeting HMGB1 in inflammation","volume":"1799","author":"Yang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.05.142_bib0250","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fct.2013.02.051","article-title":"Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-gamma expression and inhibition of PI3K\/Akt pathway","volume":"56","author":"Guo","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.biopha.2017.05.142_bib0255","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/hep.23186","article-title":"Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis","volume":"50","author":"Son","year":"2009","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.biopha.2017.05.142_bib0260","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/eji.201445226","article-title":"Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration","volume":"45","author":"Guittard","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2017.05.142_bib0265","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1177\/019262330002800407","article-title":"Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in Helicobacter hepaticus-infected and -noninfected A\/J mice","volume":"28","author":"Diwan","year":"2000","journal-title":"Toxicol. Pathol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217315056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217315056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:41:20Z","timestamp":1772264480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217315056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":53,"alternative-id":["S0753332217315056"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.142","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of growth factor receptor-bound 2 in CCl4-induced hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}