{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:13:21Z","timestamp":1791000801716,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.biopha.2017.05.148","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:46:47Z","timestamp":1500511607000},"page":"1175-1189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice"],"prefix":"10.1016","volume":"93","author":[{"given":"Yonggang","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0010","doi-asserted-by":"crossref","first-page":"e000099","DOI":"10.1136\/bmjdrc-2015-000099","article-title":"Early treatment revisions by addition or switch for type 2 diabetes: impact on glycemic control, diabetic complications, and healthcare costs","volume":"4","author":"Schwab","year":"2016","journal-title":"BMJ Open Diabetes Research and Care"},{"issue":"11","key":"10.1016\/j.biopha.2017.05.148_bib0015","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/CIRCRESAHA.116.306923","article-title":"Molecular and cellular mechanisms of cardiovascular disorders in diabetes","volume":"118","author":"Shah","year":"2016","journal-title":"Circulation Research"},{"key":"10.1016\/j.biopha.2017.05.148_bib0020","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbrep.2016.01.003","article-title":"A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca 2+ transients and prevents cardiac cell death through restoration of mitochondrial function","volume":"5","author":"Kain","year":"2016","journal-title":"Biochemistry and Biophysics Reports"},{"issue":"14","key":"10.1016\/j.biopha.2017.05.148_bib0025","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa1307684","article-title":"Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus","volume":"369","author":"Scirica","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.biopha.2017.05.148_bib0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.freeradbiomed.2015.06.025","article-title":"Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy","volume":"87","author":"Umbarkar","year":"2015","journal-title":"Free Radical Biology and Medicine"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0035","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.148_bib0040","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1080\/15548627.2015.1051295","article-title":"Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes","volume":"11","author":"Kanamori","year":"2015","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.148_bib0045","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/jcmm.12530","article-title":"FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation","volume":"19","author":"Yan","year":"2015","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.148_bib0050","first-page":"2029","article-title":"Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor \u03b1","volume":"1861","author":"Bednarski","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/13880209.2016.1226369","article-title":"Fruit vinegars attenuate cardiac injury via anti-inflammatory and anti-adiposity actions in high-fat diet-induced obese rats","volume":"55","author":"Bounihi","year":"2017","journal-title":"Pharmaceutical Biology"},{"issue":"9933","key":"10.1016\/j.biopha.2017.05.148_bib0060","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(14)60613-9","article-title":"Prevention and management of type 2 diabetes: dietary components and nutritional strategies","volume":"383","author":"Ley","year":"2014","journal-title":"The Lancet"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-012-0418-1","article-title":"The relationship between high-fat dairy consumption and obesity: cardiovascular, and metabolic disease","volume":"52","author":"Kratz","year":"2013","journal-title":"European Journal of Nutrition"},{"key":"10.1016\/j.biopha.2017.05.148_bib0070","article-title":"MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1\/AMPK pathway","author":"Kuwabara","year":"2014","journal-title":"Circulation Research"},{"issue":"6","key":"10.1016\/j.biopha.2017.05.148_bib0075","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3945\/ajcn.115.116046","article-title":"Dietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease","volume":"102","author":"Guasch-Ferr\u00e9","year":"2015","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.biopha.2017.05.148_bib0080","article-title":"The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs\u2014the role of ER stress and oxidative stress","author":"Li","year":"2016","journal-title":"Clinical Nutrition"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.148_bib0085","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1139\/cjpp-2015-0073","article-title":"Mangiferin suppressed advanced glycation end products (AGEs) through NF-\u03baB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats","volume":"94","author":"Hou","year":"2015","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.18632\/oncotarget.6384","article-title":"Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy","volume":"7","author":"Dong","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biopha.2017.05.148_bib0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12263-015-0495-x","article-title":"Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice","volume":"10","author":"Ann","year":"2015","journal-title":"Genes & Nutrition"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0100","doi-asserted-by":"crossref","first-page":"e60931","DOI":"10.1371\/journal.pone.0060931","article-title":"Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy","volume":"8","author":"Calligaris","year":"2013","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1016\/j.biopha.2017.05.148_bib0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-015-2483-2","article-title":"Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats","volume":"408","author":"Gupta","year":"2015","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.148_bib0110","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress\u2013induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0115","doi-asserted-by":"crossref","first-page":"H567","DOI":"10.1152\/ajpheart.00650.2012","article-title":"Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-\u03baB","volume":"304","author":"Wang","year":"2013","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.biopha.2017.05.148_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2014.10.002","article-title":"Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-\u03baB both in vitro and in vivo","volume":"79","author":"Zeng","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.148_bib0125","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1016\/j.cellsig.2013.08.007","article-title":"Redox activation of Nrf2 & NF-\u03baB: a double end sword?","volume":"25","author":"Buelna-Chontal","year":"2013","journal-title":"Cellular Signalling"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.148_bib0130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-079X.2010.00821.x","article-title":"Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-\u03baB and Nrf2 cascades","volume":"50","author":"Negi","year":"2011","journal-title":"Journal of Pineal Research"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.148_bib0135","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/tox.21801","article-title":"Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential","volume":"29","author":"Ni","year":"2014","journal-title":"Environmental Toxicology"},{"issue":"5","key":"10.1016\/j.biopha.2017.05.148_bib0140","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s12272-012-0514-z","article-title":"Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells","volume":"35","author":"Ni","year":"2012","journal-title":"Archives of Pharmacal Research"},{"issue":"6","key":"10.1016\/j.biopha.2017.05.148_bib0145","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1096\/fj.14-268037","article-title":"CHRFAM7A: a human-specific \u03b17-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS","volume":"29","author":"Dang","year":"2015","journal-title":"The FASEB Journal"},{"issue":"10","key":"10.1016\/j.biopha.2017.05.148_bib0150","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1074\/jbc.M113.543769","article-title":"Transcriptional repression of the transforming growth factor \u03b2 (TGF-\u03b2) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor \u03baB (NF-\u03baB) p50 enhances TGF-\u03b2 signaling in hepatic stellate cells","volume":"289","author":"Liu","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.biopha.2017.05.148_bib0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.peptides.2013.05.010","article-title":"Oral angiotensin-(1-7) prevented obesity and hepatic inflammation by inhibition of resistin\/TLR4\/MAPK\/NF-\u03baB in rats fed with high-fat diet","volume":"46","author":"Santos","year":"2013","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0160","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1042\/CS20090395","article-title":"Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats","volume":"118","author":"Elmarakby","year":"2010","journal-title":"Clinical Science"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12885-016-2191-7","article-title":"The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-\u03b21 mediated growth inhibition of pancreatic ductal epithelial cells-Nrf2 as determinant of pro-tumorigenic functions of TGF-\u03b21","volume":"16","author":"Genrich","year":"2016","journal-title":"BMC Cancer"},{"issue":"8","key":"10.1016\/j.biopha.2017.05.148_bib0170","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1681\/ASN.2010121308","article-title":"TGF-\u03b2\/Smad3 signaling promotes renal fibrosis by inhibiting miR-29","volume":"22","author":"Qin","year":"2011","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10557-013-6498-1","article-title":"Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model","volume":"28","author":"Luo","year":"2014","journal-title":"Cardiovascular Drugs and Therapy"},{"issue":"5","key":"10.1016\/j.biopha.2017.05.148_bib0180","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1053\/j.ajkd.2011.05.020","article-title":"Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD","volume":"58","author":"Desai","year":"2011","journal-title":"American Journal of Kidney Diseases"},{"issue":"7","key":"10.1016\/j.biopha.2017.05.148_bib0185","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/mnfr.200900265","article-title":"Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells","volume":"54","author":"Lu","year":"2010","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.biopha.2017.05.148_bib0190","first-page":"2011","article-title":"Protective effects of emodin and chrysophanol isolated from marine fungus Aspergillus sp. on ethanol-induced toxicity in HepG2\/CYP2E1 cells","author":"Qian","year":"2011","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.148_bib0195","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2337\/db11-0477","article-title":"Cannabinoid 1 receptor promotes cardiac dysfunction: oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy","volume":"61","author":"Rajesh","year":"2012","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0200","doi-asserted-by":"crossref","first-page":"H567","DOI":"10.1152\/ajpheart.00650.2012","article-title":"Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-\u03baB","volume":"304","author":"Wang","year":"2013","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"12","key":"10.1016\/j.biopha.2017.05.148_bib0205","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/tx200351d","article-title":"Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-\u03baB signaling, and promoting fibroblast-to-myofibroblast transformation","volume":"24","author":"He","year":"2011","journal-title":"Chemical Research in Toxicology"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.148_bib0210","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1038\/nutd.2016.2","article-title":"A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or \u03b2-cell mass in NZO mice","volume":"6","author":"Lamont","year":"2016","journal-title":"Nutrition & Diabetes"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.148_bib0215","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/jpet.116.232934","article-title":"Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic \u03b2-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-fat Diet","volume":"357","author":"Abderrazak","year":"2016","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"32","key":"10.1016\/j.biopha.2017.05.148_bib0220","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases","volume":"19","author":"Vanessa Fiorentino","year":"2013","journal-title":"Current Pharmaceutical Design"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.148_bib0225","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biocel.2012.09.017","article-title":"The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins","volume":"45","author":"Lakshmanan","year":"2013","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/j.biopha.2017.05.148_bib0230","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2013.02.021","article-title":"Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice","volume":"60","author":"Huynh","year":"2013","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.biopha.2017.05.148_bib0235","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejphar.2015.05.034","article-title":"Role of thymol on hyperglycemia and hyperlipidemia in high fat diet-induced type 2 diabetic C57BL\/6J mice","volume":"761","author":"Saravanan","year":"2015","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.biopha.2017.05.148_bib0240","first-page":"60","article-title":"Effects of spinach nitrate on insulin resistance, endothelial dysfunction markers and inflammation in mice with high-fat and high-fructose consumption","author":"Li","year":"2016","journal-title":"Food & Nutrition Research"},{"issue":"6","key":"10.1016\/j.biopha.2017.05.148_bib0245","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.freeradbiomed.2011.12.012","article-title":"4-Ketopinoresinol: a novel naturally occurring ARE activator, induces the Nrf2\/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K\/AKT signaling","volume":"52","author":"Chen","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.biopha.2017.05.148_bib0250","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2013.02.021","article-title":"Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice","volume":"60","author":"Huynh","year":"2013","journal-title":"Free Radical Biology and Medicine"},{"issue":"3","key":"10.1016\/j.biopha.2017.05.148_bib0255","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbrc.2012.09.058","article-title":"Recent advances in understanding the biochemical and molecular mechanism of diabetic cardiomyopathy","volume":"427","author":"Liu","year":"2012","journal-title":"Biochemical and biophysical research communications"},{"issue":"9","key":"10.1016\/j.biopha.2017.05.148_bib0260","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.cellsig.2011.05.013","article-title":"An I\u03baB\u03b1 phosphorylation inhibitor induces heme oxygenase-1 (HO-1) expression through the activation of reactive oxygen species (ROS)\u2013Nrf2\u2013ARE signaling and ROS\u2013PI3K\/Akt signaling in an NF-\u03baB-independent mechanism","volume":"23","author":"Min","year":"2011","journal-title":"Cellular Signalling"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0265","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jnutbio.2012.05.003","article-title":"Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2\/heme oxygenase 1 and IKK\/NF-\u03baB pathways","volume":"24","author":"Yang","year":"2013","journal-title":"The Journal of Nutritional Biochemistry"},{"issue":"11","key":"10.1016\/j.biopha.2017.05.148_bib0270","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3109\/10715762.2015.1075016","article-title":"Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2\/NF-\u03baB and SAPK\/JNK pathway","volume":"49","author":"Choudhury","year":"2015","journal-title":"Free Radical Research"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0275","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mc.21950","article-title":"Nrf2 knockout enhances intestinal tumorigenesis in Apcmin\/+ mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation","volume":"53","author":"Cheung","year":"2014","journal-title":"Molecular Carcinogenesis"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0280","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2010.06.016","article-title":"Caffeic acid phenethyl ester-mediated Nrf2 activation and I\u03baB kinase inhibition are involved in NF\u03baB inhibitory effect: structural analysis for NF\u03baB inhibition","volume":"643","author":"Lee","year":"2010","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.biopha.2017.05.148_bib0285","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress\u2013induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.biopha.2017.05.148_bib0290","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.freeradbiomed.2010.11.026","article-title":"Neuroprotective strategies involving ROS in Alzheimer disease","volume":"51","author":"Dumont","year":"2011","journal-title":"Free Radical Biology and Medicine"},{"issue":"35","key":"10.1016\/j.biopha.2017.05.148_bib0295","doi-asserted-by":"crossref","first-page":"E3669","DOI":"10.1073\/pnas.1405798111","article-title":"Mannan induces ROS-regulated, IL-17A\u2013dependent psoriasis arthritis-like disease in mice","volume":"111","author":"Khmaladze","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"10.1016\/j.biopha.2017.05.148_bib0300","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40139-015-0091-1","article-title":"IL-13 and TGF-\u03b21: Core Mediators of Fibrosis","volume":"3","author":"Borthwick","year":"2015","journal-title":"Current Pathobiology Reports"},{"issue":"1","key":"10.1016\/j.biopha.2017.05.148_bib0305","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-7075-11-2","article-title":"Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2","volume":"11","author":"Chung","year":"2014","journal-title":"Nutrition & Metabolism"},{"key":"10.1016\/j.biopha.2017.05.148_bib0310","first-page":"6","article-title":"Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis","author":"Zhou","year":"2016","journal-title":"Scientific Reports"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217318929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217318929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:25:41Z","timestamp":1766024741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217318929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":62,"alternative-id":["S0753332217318929"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.148","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.05.148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}