{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:12:33Z","timestamp":1790187153568,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"SRM University, Chennai"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.biopha.2017.06.035","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T23:30:20Z","timestamp":1497655820000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Antiobesity, antioxidant and hepatoprotective effects of Diallyl trisulphide (DATS) alone or in combination with Orlistat on HFD induced obese rats"],"prefix":"10.1016","volume":"93","author":[{"given":"Sivakumar","family":"Annamalai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Mohanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataraman","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2017.06.035_bib0005","first-page":"269","article-title":"Natural anti-obesity agents","volume":"52","author":"Mohamed","year":"2014","journal-title":"Bull. Fac. Pharm. Cairo Univ."},{"issue":"5","key":"10.1016\/j.biopha.2017.06.035_bib0010","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1242\/dmm.009621","article-title":"Anti-obesity drugs: past, present and future","volume":"5","author":"Rodgers","year":"2012","journal-title":"Dis. Model Mech."},{"issue":"11","key":"10.1016\/j.biopha.2017.06.035_bib0015","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrd2136","article-title":"The obesity pipeline: current strategies in the development of anti-obesity drugs","volume":"5","author":"Cooke","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.035_bib0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4093\/dmj.2012.36.1.13","article-title":"Anti-obesity drugs: a review about their effects and safety","volume":"36","author":"Kang","year":"2012","journal-title":"Diabetes Metab. J."},{"issue":"2","key":"10.1016\/j.biopha.2017.06.035_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-2999(02)01422-X","article-title":"Orlistat: its current status as an anti-obesity drug","volume":"440","author":"Ballinger","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.035_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/clpt.2013.204","article-title":"Antiobesity pharmacotherapy: new drugs and emerging targets","volume":"95","author":"Kim","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2017.06.035_bib0035","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.fct.2011.11.020","article-title":"Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation","volume":"50","author":"Lii","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2017.06.035_bib0040","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/japplphysiol.00672.2012","article-title":"Diallyl trisulfide and diallyl disulfide ameliorate cardiac dysfunction by suppressing apoptotic and enhancing survival pathways in experimental diabetic rats","volume":"114","author":"Huang","year":"2013","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.035_bib0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3892\/ijo.2015.3247","article-title":"Diallyl trisulfide induces apoptosis by suppressing NF-kB signaling through destabilization of TRAF6 in primary effusion lymphoma","volume":"48","author":"Shigemi","year":"2016","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2017.06.035_bib0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00210-014-0959-3","article-title":"Diallyl trisulfide attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic oxidative stress in rats","volume":"387","author":"Zhu","year":"2014","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2017.06.035_bib0055","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1067\/S0022-3476(03)00298-1","article-title":"Orlistat treatment increases fecal bilirubin excretion and decreases plasma bilirubin concentrations in hyperbilirubinemic Gunn rats","volume":"143","author":"Nishioka","year":"2003","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.biopha.2017.06.035_bib0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2005.04.031","article-title":"Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats","volume":"516","author":"Liu","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.035_bib0065","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.06.035_bib0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of superoxide anion radical in the auto-oxidation of pyrogallol and a constituent assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.biopha.2017.06.035_bib0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.06.035_bib0080","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.biopha.2017.06.035_bib0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione: glutathione reductase and glutathione-s-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.06.035_bib0090","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0006-291X(87)91297-6","article-title":"Decreased lipid peroxidation in the rat kidneys during gestation","volume":"145","author":"Devasagayam","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.06.035_bib0095","series-title":"Theory & Practice of Histological Technique","author":"Bancroft","year":"2002"},{"key":"10.1016\/j.biopha.2017.06.035_bib0100","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(07)61721-8","article-title":"Efficacy and safety of weight- loss drug rimonabant: a meta-analysis of randomized trials","volume":"370","author":"Christensen","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2017.06.035_bib0105","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02157708","article-title":"High fat diet and the development of obesity in a albino rats","volume":"15","author":"Masek","year":"1959","journal-title":"Experientia"},{"key":"10.1016\/j.biopha.2017.06.035_bib0110","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/oby.2006.128","article-title":"Weight gain induced by high-fat feeding involves increased liver oxidative stress","volume":"14","author":"Milagro","year":"2006","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2017.06.035_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ctg.2013.11","article-title":"The Effect of high-fat diet-induced pathophysiological changes in the gut on obesity: what should be the ideal treatment?","volume":"4","author":"Lee","year":"2013","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.06.035_bib0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4093\/dmj.2012.36.1.13","article-title":"Anti-obesity drugs: a review about their effects and safety","volume":"36","author":"Kang","year":"2012","journal-title":"Diabetes Metab. J."},{"issue":"4","key":"10.1016\/j.biopha.2017.06.035_bib0125","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.5812\/ijem.6721","article-title":"Macrocytic anemia and thrombocytopenia induced by orlistat","volume":"11","author":"Palacios-Martinez","year":"2013","journal-title":"Int. J. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.035_bib0130","first-page":"15","article-title":"Serum markers of tissue damage and oxidative stress in patients with acute myocardial infarction","volume":"24","author":"Khan","year":"2013","journal-title":"Biomed. Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.06.035_bib0135","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1620\/tjem.206.313","article-title":"Exercise training as an adjunct to orlistat therapy reduces oxidative stress in obese subjects","volume":"206","author":"Ozcelik","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.035_bib0140","first-page":"1","article-title":"Garlic: a review of potential therapeutic effects","volume":"4","author":"Bayan","year":"2014","journal-title":"Avicenna J. Phytomed."},{"issue":"04","key":"10.1016\/j.biopha.2017.06.035_bib0145","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-2006-960119","article-title":"Identification and HPLC quantitation of the sulfides and dialk (en) yl thiosulfinates in commercial garlic products","volume":"57","author":"Lawson","year":"1991","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2017.06.035_bib0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2014.01.010","article-title":"A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment","volume":"725","author":"Liu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.035_bib0155","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-5926-7-6","article-title":"A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: a retrospective study","volume":"7","author":"Kotoh","year":"2008","journal-title":"Comp. Hepatol."},{"key":"10.1016\/j.biopha.2017.06.035_bib0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-290-2_7","article-title":"Detection of necrosis by release of lactate dehydrogenase activity","author":"Chan","year":"2013","journal-title":"Immune Homeost.: Methods Protoc."},{"issue":"5","key":"10.1016\/j.biopha.2017.06.035_bib0165","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.3390\/ijms140510497","article-title":"Obesity-associated oxidative stress: strategies finalized to improve redox state","volume":"14","author":"Savini","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.06.035_bib0170","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1095-6433(03)00114-4","article-title":"Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin","volume":"135","author":"Anwar","year":"2003","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.biopha.2017.06.035_bib0175","first-page":"507","article-title":"Arsenic induced oxidative hematotoxicity in rats and its protection by diallyl trisulfide","volume":"4","author":"Sumedha","year":"2013","journal-title":"Int. J. Biol. Pharmaceut. Res."},{"key":"10.1016\/j.biopha.2017.06.035_bib0180","first-page":"33","article-title":"Antioxidant efficacy of diallyl tri sulfide on arsenic-Induced toxicity in rats: an in vivo and in vitro study","volume":"3","author":"Sumedha","year":"2013","journal-title":"Int. J. Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.06.035_bib0185","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/jn\/134.4.724","article-title":"Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.06.035_bib0190","doi-asserted-by":"crossref","first-page":"f1936","DOI":"10.1136\/bmj.f1936","article-title":"Orlistat and the risk of acute liver injury: self controlled case series study in UK Clinical Practice Research Datalink","volume":"346","author":"Douglas","year":"2013","journal-title":"BMJ"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217311186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217311186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:28:27Z","timestamp":1766024907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217311186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":38,"alternative-id":["S0753332217311186"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.035","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiobesity, antioxidant and hepatoprotective effects of Diallyl trisulphide (DATS) alone or in combination with Orlistat on HFD induced obese rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}