{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:52:24Z","timestamp":1781801544669,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.biopha.2017.06.060","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T16:47:10Z","timestamp":1499186830000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Pectolinarigenin from the leaves of Clerodendrum volubile shows potent immunomodulatory activity by inhibiting T \u2212 cell proliferation and modulating respiratory oxidative burst in phagocytes"],"prefix":"10.1016","volume":"93","author":[{"given":"Ochuko L.","family":"Erukainure","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ahmed","family":"Mesaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubunmi","family":"Atolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyu","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika I.","family":"Chukwuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.06.060_bib0005","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/S0074-02762008000600010","article-title":"Evaluation of immunomodulatory and anti-inflammatory effects and phytochemical screening of Alternanthera tenella Colla (Amaranthaceae) aqueous extracts","volume":"103","author":"Biella","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.biopha.2017.06.060_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/181295","article-title":"Flavonoids inhibit the respiratory burst of neutrophils in mammals","author":"Ciz","year":"2012","journal-title":"Oxidat. Med. Cell. Long."},{"issue":"98","key":"10.1016\/j.biopha.2017.06.060_bib0015","article-title":"The oxidative burst reaction inmammalian cells depends on gravity","volume":"11","author":"Adrian","year":"2013","journal-title":"Cell Comm. Signal."},{"issue":"7","key":"10.1016\/j.biopha.2017.06.060_bib0020","first-page":"1113","article-title":"Reactive oxygen species and oxidative burst: roles in stress, senescence and signal transduction in plants","volume":"89","author":"Bhattacharjee","year":"2005","journal-title":"Curr. Sci."},{"key":"10.1016\/j.biopha.2017.06.060_bib0025","doi-asserted-by":"crossref","DOI":"10.3109\/19390211.2013.859213","article-title":"Iridoid glycoside from the leaves of Clerodendrum volubile beauv. shows potent antioxidant activity against oxidative stress in rat brain and hepatic tissues","author":"Erukainure","year":"2014","journal-title":"J Diet. Supp."},{"key":"10.1016\/j.biopha.2017.06.060_bib0030","first-page":"P.5","article-title":"The useful plants of west tropical Africa","author":"Burkill","year":"1985","journal-title":"Kew"},{"key":"10.1016\/j.biopha.2017.06.060_bib0035","doi-asserted-by":"crossref","DOI":"10.1080\/01635581.2016.1156714","article-title":"Dietary fatty acids from leaves of clerodendrum volubile induces cell cycle arrest downregulates matrix metalloproteinase (MMP)-9 expression, and modulates redox status in human Breast cancer","author":"Erukainure","year":"2016","journal-title":"Nutr. Canc."},{"key":"10.1016\/j.biopha.2017.06.060_bib0040","article-title":"Antioxidant and inhibitory properties of Clerodendrum volubile leaf extracts on key enzymes relevant to non-insulin dependent diabetesmellitus and hypertension","author":"Adefegha","year":"2015","journal-title":"J. Taibah Uni. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2017.06.060_bib0045","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4314\/tjpr.v13i2.9","article-title":"Pectolinarigenin \u2212 a flavonoid compound from cirsium japonicum with potential anti-proliferation activity in MCF-7 Breast cancer cell","volume":"13","author":"Lu","year":"2014","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.biopha.2017.06.060_bib0050","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"issue":"2","key":"10.1016\/j.biopha.2017.06.060_bib0055","first-page":"209","article-title":"Clerodendrum and heathcare: an overview \u2212Part II phytochemistry and biotechnology","volume":"1","author":"Shrivastava","year":"2007","journal-title":"Med. Arom. Plant. Sci. Biotech."},{"issue":"2-3","key":"10.1016\/j.biopha.2017.06.060_bib0060","first-page":"149","article-title":"Constituents from the leaves of lantana camara (iv)","volume":"16","author":"Juang","year":"2005","journal-title":"J. Chin. Med."},{"issue":"4","key":"10.1016\/j.biopha.2017.06.060_bib0065","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1248\/bpb.31.760","article-title":"Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-Galactosamine via an antioxidant mechanism","volume":"31","author":"Yoo","year":"2008","journal-title":"Biol. poharm. Bull."},{"key":"10.1016\/j.biopha.2017.06.060_bib0070","doi-asserted-by":"crossref","DOI":"10.5301\/NTM.2014.12285","article-title":"Antioxidant, mitogenic and immuno-modulatory potentials of acacia honey","author":"Aliyu","year":"2014","journal-title":"Nutr. Ther. Metab."},{"key":"10.1016\/j.biopha.2017.06.060_bib0075","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1084\/jem.156.2.492","article-title":"Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding chemiluminescence, and cytolysis","volume":"156","author":"Helfand","year":"1982","journal-title":"J. Exper. Med."},{"key":"10.1016\/j.biopha.2017.06.060_bib0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000019055","article-title":"MHC class II ligation induces CD58 (LFA-3) mediated adhesion in human T cells","volume":"15","author":"Nielsen","year":"1998","journal-title":"Exp. Clin. Immunogenet."},{"key":"10.1016\/j.biopha.2017.06.060_bib0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Method"},{"key":"10.1016\/j.biopha.2017.06.060_bib0090","doi-asserted-by":"crossref","first-page":"W53","DOI":"10.1093\/nar\/gku401","article-title":"ProTox: a web server for the in silico prediction of rodent oral toxicity","volume":"W1","author":"Drwal","year":"2014","journal-title":"Nucl. Acid. Res"},{"key":"10.1016\/j.biopha.2017.06.060_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-030409-101229","article-title":"Innate antifungal immunity: the key role of phagocytes","volume":"29","author":"Brown","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2017.06.060_bib0100","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0031-9422(00)86814-4","article-title":"4\u2019-Methylscutellarein and pectolinarigenin from Clerodendron inerme","volume":"16","author":"Vendantham","year":"1977","journal-title":"Phytochem"},{"issue":"1","key":"10.1016\/j.biopha.2017.06.060_bib0105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1021\/jf00085a054","article-title":"Isolation of rice weevil feeding inhibitors uncinatone and pectolinarigenin from Clerodendron siphonenthus","volume":"37","author":"Pal","year":"1989","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.biopha.2017.06.060_bib0110","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.foodchem.2006.11.054","article-title":"Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review","volume":"104","author":"Tripoli","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2017.06.060_bib0115","first-page":"67","article-title":"Isovitexin from Kigelia pinnata, a potential ecofriendly nematicidal agent","volume":"91","author":"Atolani","year":"2014","journal-title":"Trop. Agric."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.060_bib0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.14720\/aas.2014.104.1.3","article-title":"Nematicidal isochromane glycoside from Kigelia pinnata leaves","volume":"104","author":"Atolani","year":"2014","journal-title":"Acta Agriculturae Slovenica"},{"key":"10.1016\/j.biopha.2017.06.060_bib0125","first-page":"814","article-title":"The influence of bupivacaine on the whole blood chemiluminescence in laboring women\u2014a preliminary report","volume":"83","author":"Hanna","year":"2012","journal-title":"Ginekol. Pols."},{"key":"10.1016\/j.biopha.2017.06.060_bib0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2014.02.007","article-title":"Origin of the phagocytic respiratory burst and its role in gut epithelial phagocytosis in a basal chordate","volume":"70","author":"Yang","year":"2014","journal-title":"Free Rad. Biol. Med."},{"issue":"Supp 10","key":"10.1016\/j.biopha.2017.06.060_bib0135","first-page":"201","article-title":"Role of oxygen in phagocyte microbicidalaction","volume":"102","author":"Allen","year":"1994","journal-title":"Environ. Heal. Persp."},{"issue":"1","key":"10.1016\/j.biopha.2017.06.060_bib0140","doi-asserted-by":"crossref","first-page":"e84353","DOI":"10.1371\/journal.pone.0084353","article-title":"Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection","volume":"9","author":"Kolpen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.06.060_bib0145","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.freeradbiomed.2005.09.017","article-title":"Inhibition of human neutrophil oxidative burst by pyrazolone derivatives","volume":"40","author":"Costa","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2017.06.060_bib0150","series-title":"Immunobiology: The Immune System in Health and Disease","author":"Janeway","year":"2001"},{"key":"10.1016\/j.biopha.2017.06.060_bib0155","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/ar1703","article-title":"The role of the T cell in autoimmune inflammation","volume":"7","author":"Skapenko","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2017.06.060_bib0160","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1189\/jlb.0604358","article-title":"T cell contact-mediated activation of respiratory burst in human polymorphonuclear leukocytes is inhibited by high-density lipoproteins and involves CD18","volume":"77","author":"Cettour-Rose","year":"2005","journal-title":"J. Leukoc. Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217317274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217317274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:24:01Z","timestamp":1766024641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217317274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":32,"alternative-id":["S0753332217317274"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.060","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pectolinarigenin from the leaves of Clerodendrum volubile shows potent immunomodulatory activity by inhibiting T \u2212 cell proliferation and modulating respiratory oxidative burst in phagocytes","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}