{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:21:18Z","timestamp":1788888078563,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"CONACYT","award":["226454"],"award-info":[{"award-number":["226454"]}]},{"name":"CONACYT","award":["256448"],"award-info":[{"award-number":["256448"]}]},{"name":"CONACYT","award":["INP-NC123280.0"],"award-info":[{"award-number":["INP-NC123280.0"]}]},{"name":"Programa de Becas Posdoctorales de la UNAM, Becaria del Centro Regional de Investigaciones Multidisciplinarias"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.biopha.2017.06.064","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:03:43Z","timestamp":1498316623000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach"],"prefix":"10.1016","volume":"93","author":[{"given":"Gimena","family":"P\u00e9rez-Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe Esther","family":"Angeles-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Argueta-Villamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.06.064_bib0005","series-title":"Depression and Other Common Mental Disorders. Global Health Estimates","author":"World Health Organization WHO","year":"2017"},{"key":"10.1016\/j.biopha.2017.06.064_bib0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1472-8206.1998.tb00967.x","article-title":"Anxiogenic-like effects of Tagetes minuta L. essential oil on T-maze and tonic immobility behaviour in domestic chicks","volume":"12","author":"Marin","year":"1998","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0015","series-title":"Biblioteca Digital de la Medicina Tradicional Mexicana. Tagetes filifolia","author":"Zolla","year":"2017"},{"key":"10.1016\/j.biopha.2017.06.064_bib0020","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jep.2016.01.040","article-title":"Tagetes lucida Cav.: ethobotany, phytochemistry and pharmacology of its tranquilizing properties","volume":"181","author":"P\u00e9rez-Ortega","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0025","first-page":"85","article-title":"Propiedades antif\u00fangicas en especies del g\u00e9nero Tagetes","volume":"34","author":"Barajas-P\u00e9rez","year":"2011","journal-title":"Rev. Mex. Mic."},{"key":"10.1016\/j.biopha.2017.06.064_bib0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.17129\/botsci.388","article-title":"Etnobot\u00e1nica y morfoanatom\u00eda comparada de tres especies de Tagetes que se utilizan en Nicol\u00e1s Romero, Estado de M\u00e9xico","volume":"90","author":"Garc\u00eda-S\u00e1nchez","year":"2012","journal-title":"Bot. Sci."},{"key":"10.1016\/j.biopha.2017.06.064_bib0035","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00436-015-4335-0","article-title":"Evaluation of some aromatic plant extracts for mosquito larvicidal potential against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi","volume":"114","author":"Jayaraman","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biopha.2017.06.064_bib0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S2221-1691(11)60024-5","article-title":"Tagetes erecta Linn. and its mosquitocidal potency against Culex quinquefasciatus","volume":"1","author":"Nikkon","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"e29744","key":"10.1016\/j.biopha.2017.06.064_bib0045","first-page":"20","article-title":"Tagetes erecta, a potential medicinal plant for discovering a new antibacterial agent","volume":"6","author":"Motamedi","year":"2015","journal-title":"Jentashapir J. Health Res."},{"key":"10.1016\/j.biopha.2017.06.064_bib0050","doi-asserted-by":"crossref","first-page":"S488","DOI":"10.12980\/APJTB.4.2014B571","article-title":"Ethnomedicinal plants used for the treatment of cuts and wounds by Kuruma tribes, Wayanadu districts of Kerala, India","volume":"4","author":"Thomas","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2017.06.064_bib0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S2221-1691(14)60235-5","article-title":"Anti-oxidative and anti-inflammatory effects of Tagetes minuta essential oil in activated macrophages","volume":"4","author":"Karimian","year":"2014","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2017.06.064_bib0060","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/ajcn\/71.2.575","article-title":"Carotenoids and colon cancer","volume":"71","author":"Slattery","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2017.06.064_bib0065","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.fct.2006.04.005","article-title":"Antioxidant activity, mutagenicity\/anti-mutagenicity, and clastogenicity\/anti-clastogenicity of lutein from marigold flowers","volume":"44","author":"Wang","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/709628","article-title":"Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity","author":"Jadoon","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.biopha.2017.06.064_bib0075","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1007\/s13197-016-2228-6","article-title":"In vitro antioxidant, anti-diabetic and antilipidemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues","volume":"53","author":"Wang","year":"2016","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0080","series-title":"Plantas Medicinales del Herbario IMSS. Cuadros B\u00e1sicos por Aparatos y Sistemas del Cuerpo Humano","author":"Aguilar","year":"1996"},{"key":"10.1016\/j.biopha.2017.06.064_bib0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-1-60327-114-1_20","article-title":"Marigold regeneration and molecular analysis of carotenogenic genes","volume":"589","author":"Del Villar-Mart\u00ednez","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0090","first-page":"2326","article-title":"Medicinal plants used in various indian traditional customs","volume":"6","author":"Sharma","year":"2016","journal-title":"IJAHM"},{"key":"10.1016\/j.biopha.2017.06.064_bib0095","first-page":"61","article-title":"Religion and Conservation: a review of use and protection of sacred plants and animals in Nepal","volume":"20","author":"Niroula","year":"2015","journal-title":"JIST"},{"key":"10.1016\/j.biopha.2017.06.064_bib0100","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/ptr.2550","article-title":"Studies on the antioxidant and analgesic activities of Aztec marigold (Tagetes erecta) flowers","volume":"22","author":"Bashir","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.06.064_bib0105","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4103\/0253-7613.115026","article-title":"Antidepressant-like action of the hydromethanolic flower extract of Tagetes erecta L. in mice and its possible mechanism of action","volume":"45","author":"Khulbe","year":"2013","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ffj.1360","article-title":"The essential oil of Tagetes erecta L. occurring in Iran","volume":"19","author":"Sefdikon","year":"2004","journal-title":"Flavour Frag. J."},{"key":"10.1016\/j.biopha.2017.06.064_bib0115","first-page":"103","article-title":"Phytochemicals and their biological activities on plants in Tagetes L","volume":"4","author":"Xu","year":"2012","journal-title":"CHM"},{"key":"10.1016\/j.biopha.2017.06.064_bib0120","first-page":"45","article-title":"Marigold a potential ornamental plant drug","volume":"55","author":"Gupta","year":"2012","journal-title":"Hamdard Med."},{"key":"10.1016\/j.biopha.2017.06.064_bib0125","series-title":"Flavonoids of the Sunflower Family (Asteraceae)","author":"Bohm","year":"2001"},{"key":"10.1016\/j.biopha.2017.06.064_bib0130","first-page":"1412","article-title":"Studies on the chemical constituents from the stem and leaves of Tagetes erecta","volume":"33","author":"Zhang","year":"2010","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2017.06.064_bib0135","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jff.2012.05.002","article-title":"Changes in colour antioxidant activities and carotenoids (lycopene, b-carotene, lutein) of marigold flower (Tagetes erecta L.) resulting from different drying processes","volume":"4","author":"Siriamorpun","year":"2012","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2017.06.064_bib0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.fbp.2010.12.004","article-title":"Optimization of extraction parameters of bioactive components from defatted marigold (Tagetes erecta L.) residue using response surface methodology","volume":"90","author":"Gong","year":"2012","journal-title":"Food Bioprod. Process"},{"key":"10.1016\/j.biopha.2017.06.064_bib0145","first-page":"s1","article-title":"Variation in phenolic profile, \u03b2-carotene and flavonoid contents, biological activities of two Tagetes species from Pakistani flora","author":"Ayub","year":"2017","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.biopha.2017.06.064_bib0150","series-title":"Guideline for Testing of Chemicals","author":"OECD","year":"2017"},{"key":"10.1016\/j.biopha.2017.06.064_bib0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF01234480","article-title":"A new approach to practical acute toxicity testing","volume":"54","author":"Lorke","year":"1983","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00404370","article-title":"Exploratory behavior in chronic disulfotan poisoning in mice","volume":"20","author":"Clark","year":"1997","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.biopha.2017.06.064_bib0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effect of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1099-1573(199603)10:2<145::AID-PTR793>3.0.CO;2-W","article-title":"Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties","volume":"10","author":"Hiller","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.06.064_bib0175","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/(SICI)1099-1573(199812)12:8<600::AID-PTR363>3.0.CO;2-N","article-title":"Some pharmacological effects of the ethanol extract of leaves of Annona diversifolia on the central nervous system in mice","volume":"2","author":"Gonz\u00e1lez-Trujano","year":"1998","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.06.064_bib0180","series-title":"Plantas utilizadas en el Estado de Morelos","author":"Monroy-Ortiz","year":"2007"},{"key":"10.1016\/j.biopha.2017.06.064_bib0185","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jep.2012.06.035","article-title":"Medicinal plants used in huasteca potosina Mexico","volume":"143","author":"Alonso-Castro","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0190","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1590\/1516-4446-2013-1139","article-title":"Animal models of anxiety disorders and stress","volume":"35","author":"Campos","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"key":"10.1016\/j.biopha.2017.06.064_bib0195","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jep.2008.04.019","article-title":"Flavonoids from Tilia americana with anxiolytic activity in plus-maze test","volume":"118","author":"Herrera-Ruiz","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2009.09.044","article-title":"HPLC\/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana","volume":"127","author":"Aguirre-Hern\u00e1ndez","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0205","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1055\/s-2007-981593","article-title":"Bioactivity-guided isolation of beta-sitosterol and some fatty acids as active compounds in the anxiolytic and sedative effects of Tilia americana var. mexicana","volume":"73","author":"Aguirre-Hern\u00e1ndez","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2017.06.064_bib0210","doi-asserted-by":"crossref","first-page":"37","DOI":"10.17711\/SM.0185-3325.2015.066","article-title":"Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotoninergic participation","volume":"39","author":"Aguirre-Hern\u00e1ndez","year":"2016","journal-title":"Salud Ment."},{"key":"10.1016\/j.biopha.2017.06.064_bib0215","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1991.tb33838.x","article-title":"Allosteric actions of central nervous system depressants including anesthetics on subtypes of the inhibitory gamma-aminobutyric acid A receptor-chloride channel complex","volume":"625","author":"Olsen","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2017.06.064_bib0220","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.biopsych.2009.03.012","article-title":"Serotonin-1A receptor in anxiety disorders","volume":"66","author":"Akimova","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2017.06.064_bib0225","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jep.2015.01.029","article-title":"Interactions of a standardized flavonoid fraction from Tilia americana with serotoninergic drugs in elevated pluz maze","volume":"164","author":"Nogueron-Merino","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0230","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/FBP.0000000000000290","article-title":"The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala","volume":"28","author":"Hernandez-Leon","year":"2017","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.biopha.2017.06.064_bib0235","doi-asserted-by":"crossref","first-page":"21442","DOI":"10.3390\/molecules191221442","article-title":"Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system","volume":"19","author":"Cassani","year":"2014","journal-title":"Molecules"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217321960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217321960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:23:26Z","timestamp":1766024606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217321960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":47,"alternative-id":["S0753332217321960"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.064","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.06.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}