{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:31:00Z","timestamp":1790152260337,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003661","name":"Korea Institute for Advancement of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.biopha.2017.07.026","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T10:01:48Z","timestamp":1500372108000},"page":"1055-1064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Aqueous extract of Codium fragile suppressed inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and carrageenan-induced rats"],"prefix":"10.1016","volume":"93","author":[{"given":"Seul Ah","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Min","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ram","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Suk","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2017.07.026_bib0005","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1039\/b906091j","article-title":"Marine natural products","volume":"27","author":"Blunt","year":"2010","journal-title":"Nat. Prod. Rep."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.026_bib0010","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1021\/jf900820x","article-title":"Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties","volume":"57","author":"Kim","year":"2009","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.026_bib0015","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.3390\/md12094984","article-title":"Overview on biological activities and molecular characteristics of sulfated polysaccharides from marine green algae in recent years","volume":"12","author":"Wang","year":"2014","journal-title":"Mar. Drugs"},{"issue":"3","key":"10.1016\/j.biopha.2017.07.026_bib0020","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3390\/md11030934","article-title":"Evaluation of macroalgae sufated polysaccharides on the Leishmania (L.) amazonensis promasigote","volume":"11","author":"Pires","year":"2013","journal-title":"Mar. Drugs"},{"issue":"10","key":"10.1016\/j.biopha.2017.07.026_bib0025","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.carres.2010.02.026","article-title":"Immnunostimulating effects of a sulfated galactan from Codium fragile","volume":"345","author":"Lee","year":"2010","journal-title":"Carbohydr. Res."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.026_bib0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.apjtm.2016.04.010","article-title":"Methanol extract of Codium fragile inhibits tumor necrosis factor- \u03b1-induced matrix metalloproteinase-9 and invasiveness of MDA-MB-231 cells by suppressing nuclear factor-\u03baB activation","volume":"9","author":"Dilshara","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"14","key":"10.1016\/j.biopha.2017.07.026_bib0035","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.phymed.2010.05.005","article-title":"Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile","volume":"17","author":"Ganesan","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.07.026_bib0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fitote.2013.01.020","article-title":"Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB\/c mice","volume":"86","author":"Lee","year":"2013","journal-title":"Fitoterapia"},{"issue":"4","key":"10.1016\/j.biopha.2017.07.026_bib0045","first-page":"465","article-title":"Anti-inflammatory activities of methanol extracts from various seaweed species","volume":"29","author":"Khan","year":"2008","journal-title":"J. Environ. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.026_bib0050","first-page":"267","article-title":"Anti-inflammatory effects of ethanolic extracts from codium fragile on LPS-stimulated RAW 264.7 macrophages via nuclear factor kappaB inactivation","volume":"14","author":"Yoon","year":"2011","journal-title":"Fish. Aquat. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/jmf.2010.1540","article-title":"Anti-inflammatory effects of methanol extract of Codium fragile in lipopolysaccharide-stimulated RAW264.7 cells","volume":"15","author":"Kang","year":"2012","journal-title":"J. Med. Food"},{"issue":"7203","key":"10.1016\/j.biopha.2017.07.026_bib0060","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00044067-200401000-00002","article-title":"Biological mediators of acute inflammation","volume":"15","author":"Rankin","year":"2004","journal-title":"AACN Clin."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0070","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1373\/clinchem.2007.097360","article-title":"Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction","volume":"54","author":"Packard","year":"2008","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.026_bib0075","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1007\/s10753-013-9703-2","article-title":"Anti-inflammatory activity of baicalein in LPS-stimulated RAW 264.7 macrophages via estrogen receptor and NF-\u03baB-dependent pathways","volume":"36","author":"Fan","year":"2013","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.biopha.2017.07.026_bib0080","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1734-1140(11)70590-4","article-title":"Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-\u03baB activation in LPS-induced RAW 264.7 macrophage cells","volume":"63","author":"Hu","year":"2011","journal-title":"Pharmacol. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.026_bib0085","doi-asserted-by":"crossref","first-page":"C923","DOI":"10.1152\/ajpcell.00417.2003","article-title":"Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-??B signaling pathways in murine RAW 264.7 macrophages","volume":"286","author":"Aga","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2017.07.026_bib0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jneuroim.2012.09.012","article-title":"Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation","volume":"254","author":"Shao","year":"2013","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/gut.52.1.144","article-title":"Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets","volume":"52","author":"Hommes","year":"2003","journal-title":"Gut"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2017.07.026_bib0100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejphar.2008.02.044","article-title":"Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-(B, JNK and p38 MAPK inactivation","volume":"586","author":"Zhou","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.07.026_bib0105","article-title":"Anti-inflammatory effect of Rhapontici Radix ethanol extract via inhibition of NF-kB and MAPK and induction of HO-1 in macrophages","volume":"2016","author":"Jeoun","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"8","key":"10.1016\/j.biopha.2017.07.026_bib0110","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/138955706777934937","article-title":"Naturally occurring NF-kappaB inhibitors","volume":"6","author":"Nam","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"issue":"51","key":"10.1016\/j.biopha.2017.07.026_bib0115","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","article-title":"Introduction to NF-Kb: players, pathways, perspectives","volume":"25","author":"Gilmore","year":"2006","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.biopha.2017.07.026_bib0120","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriaki","year":"2012","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.026_bib0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd1383","article-title":"Inflammatory resolution: new opportunities for drug discovery","volume":"3","author":"Gilroy","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.biopha.2017.07.026_bib0130","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.bcp.2005.07.011","article-title":"6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide-activated murine macrophages","volume":"70","author":"Uto","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.026_bib0135","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1096\/fj.13-247783","article-title":"Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice","volume":"28","author":"Maclntyre","year":"2014","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.026_bib0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/1348-0421.12376","article-title":"A hot water extracts of Aralia cordata activates bone marrow-derived macrophages via a MyD88-dependent pathways and protects mice from bacterial infection","volume":"60","author":"Seo","year":"2016","journal-title":"Microbiol. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.026_bib0145","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jep.2016.07.020","article-title":"In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action","volume":"192","author":"Li","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.07.026_bib0150","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.biopha.2017.07.026_bib0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopha.2016.11.145","article-title":"Aqueous fraction of Alstonia boonei de Wild leaves suppressed inflammatory responses in carrageenan and formaldehyde induced arthritic rats","volume":"86","author":"Akinnawo","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.07.026_bib0160","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1444-2906.2008.01635.x","article-title":"Inhibitory effects of edible marine algae extracts on degranulation of RBL-2H3 cells and mouse eosinophils","volume":"74","author":"Kimiya","year":"2008","journal-title":"Fish. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.026_bib0165","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2567.2004.01984.x","article-title":"Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle","volume":"113","author":"Kolios","year":"2004","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.biopha.2017.07.026_bib0170","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1002\/art.21390","article-title":"Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway","volume":"52","author":"Korotkova","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.biopha.2017.07.026_bib0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10555-010-9227-2","article-title":"Inflammation-mediated promotion of invasion and metastasis","volume":"29","author":"Solinas","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.biopha.2017.07.026_bib0180","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.iy.07.040189.003205","article-title":"The biology of cachectin\/TNF-a primary mediator of the host response","volume":"7","author":"Beutler","year":"1989","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.07.008","article-title":"Regulation of autoimmune inflammation by pro-inflammatory cytokines","volume":"120","author":"Kim","year":"2008","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.026_bib0190","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1349-7006.2006.00197.x","article-title":"Signal transduction of inflammatory cytokines and tumor development","volume":"97","author":"Yoshimura","year":"2006","journal-title":"Cancer Sci."},{"issue":"480\u2013481","key":"10.1016\/j.biopha.2017.07.026_bib0195","first-page":"243","article-title":"Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF- kB activation","volume":"1","author":"Surh","year":"2001","journal-title":"Mutat. Res."},{"issue":"3","key":"10.1016\/j.biopha.2017.07.026_bib0200","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1476-5381.1971.tb07124.x","article-title":"Mediators of the inflammation induced in the rat paw by carrageenan","volume":"42","author":"Crunkhorn","year":"1971","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.07.026_bib0205","article-title":"Anti-inflammatory and anti-arthritic activity of aqueous extract of Rosa centifolia in experimental models in rats","author":"Kumar","year":"2015","journal-title":"Int. J. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0210","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0022-3565(25)28209-X","article-title":"Biphasic development of carrageenan edema in rats","volume":"166","author":"Vinegar","year":"1969","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.026_bib0215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S2221-1691(12)60155-5","article-title":"Analgesic, anti-inflammatory and anti-arthritic activity of Cassia uniflora Mill","volume":"2","author":"Chaudhari","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217322527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217322527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:17:57Z","timestamp":1766024277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217322527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":43,"alternative-id":["S0753332217322527"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.07.026","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aqueous extract of Codium fragile suppressed inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and carrageenan-induced rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}