{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:06:39Z","timestamp":1776384399881,"version":"3.51.2"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.biopha.2017.07.088","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T08:33:12Z","timestamp":1502181192000},"page":"697-704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["The role and mechanism of cathepsin G in dermatomyositis"],"prefix":"10.1016","volume":"94","author":[{"given":"Siming","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ncl.2014.04.007","article-title":"Idiopathic inflammatory myopathies","volume":"32","author":"Dimachkie","year":"2014","journal-title":"Neurol. Clin."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.088_bib0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrneurol.2011.63","article-title":"Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis","volume":"7","author":"Mammen","year":"2011","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.autrev.2011.05.013","article-title":"Pathogenesis and therapies of immune-mediated myopathies","volume":"11","author":"Dalakas","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.088_bib0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM198602063140601","article-title":"Microvascular deposition of complement membrane attack complex in dermatomyositis","volume":"314","author":"Kissel","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.088_bib0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ana.410270402","article-title":"Microvascular changes in early and advanced dermatomyositis: a quantitative study","volume":"27","author":"Emslie-Smith","year":"1990","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/cei.12194","article-title":"Diagnosis, pathogenesis and treatment of myositis: recent advances","volume":"175","author":"Carstens","year":"2014","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1517\/17530051003713499","article-title":"Pathomechanisms of inflammatory myopathies: recent advances and implications for diagnosis and therapies","volume":"4","author":"Schmidt","year":"2010","journal-title":"Expert Opin. Med. Diagn."},{"issue":"7","key":"10.1016\/j.biopha.2017.07.088_bib0040","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.4049\/jimmunol.0803688","article-title":"T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells","volume":"183","author":"Fasth","year":"2009","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrrheum.2011.39","article-title":"Pathogenesis, classification and treatment of inflammatory myopathies","volume":"7","author":"Zong","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.biopha.2017.07.088_bib0050","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/bj1550273","article-title":"Human cathepsin G. catalytic and immunological properties","volume":"155","author":"Starkey","year":"1976","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.088_bib0055","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.molimm.2009.10.003","article-title":"Cathepsin G: roles in antigen presentation and beyond","volume":"47","author":"Burster","year":"2010","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2017.07.088_bib0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1189\/jlb.69.2.197","article-title":"More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control","volume":"69","author":"Bank","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2017.07.088_bib0065","doi-asserted-by":"crossref","first-page":"459640","DOI":"10.1155\/2014\/459640","article-title":"Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients","volume":"2014","author":"Cohen-Mazor","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.088_bib0070","doi-asserted-by":"crossref","first-page":"e846","DOI":"10.1097\/CCM.0000000000001720","article-title":"Elevated leukocyte azurophilic enzymes in human diabetic ketoacidosis plasma degrade cerebrovascular endothelial junctional proteins","volume":"44","author":"Woo","year":"2016","journal-title":"Crit. Care Med."},{"issue":"11","key":"10.1016\/j.biopha.2017.07.088_bib0075","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/01.ATV.15.11.2037","article-title":"Human endothelial cell damage by neutrophil-derived cathepsin G. Role of cytoskeleton rearrangement and matrix-bound plasminogen activator inhibitor-1","volume":"15","author":"Iacoviello","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0080","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1084\/jem.186.5.739","article-title":"Identification of human neutrophil-derived cathepsin G and azurocidin\/CAP37 as chemoattractants for mononuclear cells and neutrophils","volume":"186","author":"Chertov","year":"1997","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0085","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.4049\/jimmunol.169.3.1467","article-title":"Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4","volume":"169","author":"Vergnolle","year":"2002","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.088_bib0090","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.4049\/jimmunol.163.9.5064","article-title":"Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo","volume":"163","author":"Vergnolle","year":"1999","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.biopha.2017.07.088_bib0095","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.4049\/jimmunol.165.11.6504","article-title":"Delayed onset of inflammation in protease-activated receptor-2-deficient mice","volume":"165","author":"Lindner","year":"2000","journal-title":"J. Immunol."},{"issue":"4\u20136","key":"10.1016\/j.biopha.2017.07.088_bib0100","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00210-007-0194-2","article-title":"Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems","volume":"377","author":"Hansen","year":"2008","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2017.07.088_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2003-0025","article-title":"Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response","volume":"26","author":"Steinhoff","year":"2005","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0110","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/sj.bjp.0702634","article-title":"Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw","volume":"127","author":"Vergnolle","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.088_bib0115","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.169.9.5315","article-title":"Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway","volume":"169","author":"Schmidlin","year":"2002","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.biopha.2017.07.088_bib0120","doi-asserted-by":"crossref","first-page":"5690","DOI":"10.4049\/jimmunol.170.11.5690","article-title":"Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2","volume":"170","author":"Uehara","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.088_bib0125","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.4049\/jimmunol.175.4.2598","article-title":"Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms","volume":"175","author":"Su","year":"2005","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.biopha.2017.07.088_bib0130","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.it.2007.09.001","article-title":"Protease-activated receptors: novel PARtners in innate immunity","volume":"28","author":"Shpacovitch","year":"2007","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2017.07.088_bib0135","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.169.9.5315","article-title":"Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway","volume":"169","author":"Schmidlin","year":"2002","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.biopha.2017.07.088_bib0140","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1096\/fj.02-1112com","article-title":"Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo","volume":"17","author":"Seeliger","year":"2003","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0145","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bjp.0706905","article-title":"Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species","volume":"149","author":"Lim","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2017.07.088_bib0150","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.biopha.2017.07.088_bib0155","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM197502202920807","article-title":"Polymyositis and dermatomyositis (second of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0160","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bjp.0706905","article-title":"Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species","volume":"149","author":"Lim","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.088_bib0165","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/art.10794","article-title":"Interstitial lung disease in polymyositis and dermatomyositis","volume":"47","author":"Marie","year":"2002","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.biopha.2017.07.088_bib0170","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/art.23571","article-title":"Interstitial lung disease in polymyositis and dermatomyositis: longitudinal evaluation by pulmonary function and radiology","volume":"59","author":"Fathi","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.biopha.2017.07.088_bib0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MD.0b013e31819da352","article-title":"Factors associated with underlying malignancy in a retrospective cohort of 121 patients with dermatomyositis","volume":"88","author":"Fardet","year":"2009","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.biopha.2017.07.088_bib0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1254\/jjp.88.77","article-title":"Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear","volume":"88","author":"Kawagoe","year":"2002","journal-title":"Jpn. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2017.07.088_bib0185","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.4049\/jimmunol.165.11.6504","article-title":"Delayed onset of inflammation in protease-activated receptor-2-deficient mice","volume":"165","author":"Lindner","year":"2000","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.088_bib0190","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1189\/jlb.0108001","article-title":"Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity","volume":"83","author":"Shpacovitch","year":"2008","journal-title":"J. Leukoc. Biol."},{"issue":"Pt 7","key":"10.1016\/j.biopha.2017.07.088_bib0195","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1242\/jcs.114.7.1343","article-title":"Rho and Rac but not Cdc42 regulate endothelial cell permeability","volume":"114","author":"Wojciak-Stothard","year":"2001","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.07.088_bib0200","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.RES.87.4.335","article-title":"Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases","volume":"87","author":"van Nieuw Amerongen","year":"2000","journal-title":"Circ. Res."},{"issue":"38","key":"10.1016\/j.biopha.2017.07.088_bib0205","doi-asserted-by":"crossref","first-page":"26815","DOI":"10.1074\/jbc.274.38.26815","article-title":"A rho exchange factor mediates thrombin and Galpha(12)-induced cytoskeletal responses","volume":"274","author":"Majumdar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.07.088_bib0210","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.2741\/3395","article-title":"Endothelial signaling in paracellular and transcellular leukocyte transmigration","volume":"14","author":"Wittchen","year":"2009","journal-title":"Front. Biosci."},{"issue":"6","key":"10.1016\/j.biopha.2017.07.088_bib0215","doi-asserted-by":"crossref","first-page":"e66743","DOI":"10.1371\/journal.pone.0066743","article-title":"Distinctive G protein-dependent signaling by protease-activated receptor 2 (PAR2) in smooth muscle: feedback inhibition of RhoA by cAMP-independent PKA","volume":"8","author":"Sriwai","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2017.07.088_bib0220","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/bi027100x","article-title":"Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells","volume":"42","author":"Greenberg","year":"2003","journal-title":"Biochemistry"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217320863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217320863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:22:30Z","timestamp":1776381750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217320863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":44,"alternative-id":["S0753332217320863"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.07.088","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role and mechanism of cathepsin G in dermatomyositis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.07.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}