{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:12:47Z","timestamp":1790799167394,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000164","name":"Division of Astronomical Sciences","doi-asserted-by":"publisher","award":["02.06.2014"],"award-info":[{"award-number":["02.06.2014"]}],"id":[{"id":"10.13039\/100000164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000164","name":"Division of Astronomical Sciences","doi-asserted-by":"publisher","award":["SB\/YS\/LS-286\/2013"],"award-info":[{"award-number":["SB\/YS\/LS-286\/2013"]}],"id":[{"id":"10.13039\/100000164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.biopha.2017.08.028","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T08:32:38Z","timestamp":1502699558000},"page":"1028-1037","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats"],"prefix":"10.1016","volume":"94","author":[{"given":"Arumugam","family":"Ramakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natesan","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.08.028_bib0005","series-title":"Urea Cycle Disorders Overview, Gene. Rev.","author":"Summar","year":"2005"},{"key":"10.1016\/j.biopha.2017.08.028_bib0010","first-page":"2777","article-title":"Drug formation","author":"Bethesda","year":"2014","journal-title":"Am. Soc. Health Syst. Pharm."},{"key":"10.1016\/j.biopha.2017.08.028_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0065-3101(24)00072-0","article-title":"Urea cycle disorders: diganosis: pathophysiology and therapy","volume":"43","author":"Brusilow","year":"1996","journal-title":"Adv. Pediatr."},{"key":"10.1016\/j.biopha.2017.08.028_bib0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ymgme.2004.11.004","article-title":"Hyperargininemia due to liver arginase deficiency","volume":"84","author":"Crombez","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.biopha.2017.08.028_bib0025","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0006-291X(71)80201-2","article-title":"Enzymatic synthesis of acetylglutamate by mammalian liver preparations and its stimulation by arginine","volume":"44","author":"Shigesada","year":"1971","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.08.028_bib0030","doi-asserted-by":"crossref","first-page":"16950","DOI":"10.1038\/srep16950","article-title":"Structure of human carbamoyl phosphate synthetase: deciphering the on\/off switch of human ureagenesis","volume":"5","author":"De cima","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2017.08.028_bib0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pneurobio.2010.01.012","article-title":"Ammonia metabolism the brain and fatigue; revisiting the link","volume":"91","author":"Wilkinson","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0040","first-page":"175","article-title":"Hepatoprotective effect of Semecarpus anacardiumin rats: a molecular approach","volume":"1","author":"Vijayakumar","year":"2014","journal-title":"Int. J. Adv. Res. Biol. Sci."},{"key":"10.1016\/j.biopha.2017.08.028_bib0045","series-title":"Robbins Pathological Basis of Disease","first-page":"51","author":"Cotran","year":"2001"},{"key":"10.1016\/j.biopha.2017.08.028_bib0050","first-page":"131","article-title":"Oxidative stress and liver disease","volume":"14","author":"Kaplowitz","year":"1996","journal-title":"Prog. Liver Dis."},{"key":"10.1016\/j.biopha.2017.08.028_bib0055","doi-asserted-by":"crossref","first-page":"8115","DOI":"10.1073\/pnas.92.18.8115","article-title":"Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity","volume":"92","author":"Goossens","year":"1995","journal-title":"Proc. Natl. Acad. Sci U. S. A."},{"key":"10.1016\/j.biopha.2017.08.028_bib0060","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1093\/ndt\/gfi155","article-title":"Role of inflammation in diabetic complications","volume":"20","author":"Navarra","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2017.08.028_bib0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0301-472X(02)00777-4","article-title":"NF-kB dependent signalling pathway","volume":"30","author":"Li","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0070","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjp.0704463","article-title":"C. Thi-emermann, Pyrrolidine dithicarbamate attenuates the development of acute and chronic inflammation","volume":"135","author":"Cuzz","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappa B signalling pathways in neurological inflammation: a mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.biopha.2017.08.028_bib0080","first-page":"1","article-title":"IL-6 signal transduction and its physiological roles: the signal orchestration model","volume":"149","author":"Kamimura","year":"2003","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0085","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.8511589","article-title":"IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase","volume":"260","author":"Murakami","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.biopha.2017.08.028_bib0090","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0095","first-page":"1223","article-title":"Comparison of the salivary and the serum nitric oxide levels in chronic and aggressive periodontitis: a biochemical study","volume":"7","author":"Sundar","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.biopha.2017.08.028_bib0100","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1172\/JCI119750","article-title":"Nitric oxide synthesis: which where, how and why?","volume":"100","author":"Michael","year":"1997","journal-title":"J. Clin.. Invest."},{"key":"10.1016\/j.biopha.2017.08.028_bib0105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0197-0186(02)00038-4","article-title":"Nitric oxide in hepatic encephalopathy and hyperammonemia","volume":"41","author":"Rao","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2017.08.028_bib0110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1081\/CBI-120002915","article-title":"Circadian variation of nitric oxide synthase activity in mouse tissue","volume":"19","author":"Tunctan","year":"2002","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.biopha.2017.08.028_bib0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02336140","article-title":"Ammonium acetate inhibits ionotropic receptors and differentially affects metabotropic receptors for glutamate","volume":"97","author":"Lombardi","year":"1994","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.biopha.2017.08.028_bib0120","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","article-title":"Update on used and properties of citrus flavonoids: new findings in anticancer, cardiovascular and anti-inflammatory activity","volume":"56","author":"Benavente-Garcia","year":"2008","journal-title":"J. Agric. Food chem."},{"key":"10.1016\/j.biopha.2017.08.028_bib0125","unstructured":"M. Entezari, F. Ostadzadeh, Antimutagenesis Effect of Naringin International Conference on Biological, Civil and Environmental Engineering, Dubai, (2014) 17\u201319."},{"key":"10.1016\/j.biopha.2017.08.028_bib0130","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1542-3565(04)00461-6","article-title":"Complementary and alternative medicine in gastroenterology: the good, the bad, and the ugly","volume":"2","author":"Keretz","year":"2004","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jacme.2016.08.001","article-title":"Effect of narinigin on ammonium chloride- induced hyperammonemic rats: a dose-dependent study","volume":"6","author":"Ramakrishnan","year":"2016","journal-title":"J. Acute Med."},{"key":"10.1016\/j.biopha.2017.08.028_bib0140","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.biopha.2016.10.080","article-title":"Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity","volume":"84","author":"Ramakrishnan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.08.028_bib0145","first-page":"906","article-title":"Preanalytical increase of ammonia in blood specimens from healthy subjects","volume":"30","author":"Wolheim","year":"1984","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2017.08.028_bib0150","first-page":"159","article-title":"The colorimetric method for the determination of phosphorous","volume":"98","author":"Fiske","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.08.028_bib0155","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.fitote.2012.01.010","article-title":"Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy","volume":"83","author":"Kandhare","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2017.08.028_bib0160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jdiacomp.2012.06.001","article-title":"Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed\/streptozotocin-induced type 2 diabetic rats","volume":"26","author":"Mahmoud","year":"2012","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.biopha.2017.08.028_bib0165","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3109\/0886022X.2016.1163998","article-title":"Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laborate rats: role of FXR and KIM-1","volume":"38","author":"Adil","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.biopha.2017.08.028_bib0170","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.pharep.2014.06.018","article-title":"Chronotherapeutic effect of fisetin on expression of urea cycle enzymes and inflammatory markers in hyperammonaemic rats","volume":"66","author":"Subramanian","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biopha.2017.08.028_bib0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-8993(03)03035-X","article-title":"Sources of oxygen radicals in brain in acute ammonia intoxication in vivo","volume":"981","author":"Kosenko","year":"2003","journal-title":"Brain. Res."},{"key":"10.1016\/j.biopha.2017.08.028_bib0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0301-0082(02)00019-9","article-title":"Neurobiology of ammonia","volume":"67","author":"Felipo","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0185","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10545-005-0303-7","article-title":"Urea cycle defects managements and outcome","volume":"28","author":"Nassogne","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.biopha.2017.08.028_bib0190","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0168-1656(00)00282-0","article-title":"Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr-cells decreases accumulation of ammonium ion in culture media","volume":"81","author":"Park","year":"2000","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0195","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/01.STR.32.8.1750","article-title":"Evolution of cerebral tumor necrosis factor-\u03b1 production during human ischemic stroke","volume":"32","author":"Sairanen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.08.028_bib0200","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00004647-200001000-00009","article-title":"Microglia and macrophages are the major source of tumour necrosis factor in permanent middle cerebral artery occlusion in mice","volume":"20","author":"Gregersen","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.biopha.2017.08.028_bib0205","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4049\/jimmunol.158.1.438","article-title":"Astrocyte- specific but not neuron \u2212specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice","volume":"158","author":"Akassoglou","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00011-004-1337-2","article-title":"The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice","volume":"54","author":"Martin","year":"2005","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.biopha.2017.08.028_bib0215","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1742-2094-7-66","article-title":"Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes","volume":"7","author":"Rao","year":"2010","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.biopha.2017.08.028_bib0220","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2010.03.040","article-title":"Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy","volume":"139","author":"Rodrigo","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2017.08.028_bib0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"E.A. Higgs. Nitric oxide: physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.biopha.2017.08.028_bib0230","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jlb.54.2.171","article-title":"Inflammation, immunoregulation and inducible nitric oxide synthase","volume":"54","author":"Nussler","year":"1993","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2017.08.028_bib0235","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.nbd.2003.08.023","article-title":"Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo","volume":"14","author":"Canales","year":"2003","journal-title":"Neurobiol. Dis."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217329608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217329608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:24:26Z","timestamp":1776381866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217329608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":47,"alternative-id":["S0753332217329608"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.028","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}