{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:07:48Z","timestamp":1780499268126,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010123","name":"Dalian Ocean University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003129","name":"First Affiliated Hospital, Liaoning Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008901","name":"College of Pharmacy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["201601229>"],"award-info":[{"award-number":["201601229>"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biopha.2017.08.064","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T10:45:54Z","timestamp":1505213154000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit\/SCF by activating Sirt1"],"prefix":"10.1016","volume":"95","author":[{"given":"Yi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.08.064_bib0005","first-page":"e287","article-title":"MP 25-07 prostatic inflammation evokes upergulation of neurotrophins in sensory ganglia: possible contribution to dysfunctional voiding","volume":"193","author":"Pradeep","year":"2015","journal-title":"J. Urol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0010","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1464-410X.1984.tb06154.x","article-title":"Urodynamic evaluation of bladder neck obstruction in chronic prostatitis","volume":"56","author":"Murnaghan","year":"1984","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0015","first-page":"215","article-title":"Ambulatory urodynamic monitoring of external urethral sphincter behavior in chronic prostatitis patients","volume":"1","author":"Liao","year":"1999","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.biopha.2017.08.064_bib0020","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1074\/jbc.M114.617886","article-title":"Bhowmick inflammation and pyroptosis mediate muscle expansion in an interleukin-1\u03b2 (IL-1\u03b2)-dependent manner","volume":"290","author":"Haldar","year":"2015","journal-title":"JBC"},{"key":"10.1016\/j.biopha.2017.08.064_bib0025","doi-asserted-by":"crossref","first-page":"F1461","DOI":"10.1152\/ajprenal.00311.2007","article-title":"Greenwood-van Meervel, Beverley: changes in urinary bladder smooth muscle function in response to colonic inflammation","volume":"293","author":"Noronha","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0030","first-page":"260","article-title":"Chronic inflammation in urothelial bladder cancer. virchows arch. 2015;467: 623\u2013633. michaud, dominique S. chronic inflammation and bladder cancer","volume":"25","author":"Nesi","year":"2007","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1182\/blood.V90.1.148.148_148_155","article-title":"Downregulation of c-kit expression in human endothelial cells by inflammatory stimuli","volume":"90","author":"Konig","year":"1996","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.biopha.2017.08.064_bib0040","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-Kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.064_bib0045","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7150\/ijbs.6087","article-title":"The C-kit receptor-mediated signal transduction and tumor-related diseases","volume":"9","author":"Liang","year":"2013","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.biopha.2017.08.064_bib0050","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1007\/s00018-004-4189-6","article-title":"Signal transduction via the stem cell factor receptor\/c-Kit Cell","volume":"61","author":"Ronnstrand","year":"2004","journal-title":"Mol. Life Sci."},{"key":"10.1016\/j.biopha.2017.08.064_bib0055","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ejphar.2005.12.067","article-title":"Stem cell factor and its receptor c-Kit as targets for inflammatory diseases","volume":"533","author":"Reber","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0060","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.2147\/DDDT.S89114","article-title":"Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells","volume":"10","author":"Babaei","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.biopha.2017.08.064_bib0065","first-page":"609","article-title":"CD117 (c-kit) expression in smooth muscle tumor","volume":"116","author":"Wang","year":"2001","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0070","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/modpathol.3880210","article-title":"Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)","volume":"13","author":"Miettinen","year":"2000","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0075","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/jf903210q","article-title":"Regioselective lipase-catalyzed synthesis of 3-o-acyl derivatives of resveratrol and study of their antioxidant properties","volume":"58","author":"Torres","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2017.08.064_bib0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2010.05848.x","article-title":"Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease","volume":"1215","author":"Csiszar","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2017.08.064_bib0085","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vph.2011.11.002","article-title":"Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle","volume":"56","author":"Paffett","year":"2012","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.toxlet.2010.08.010","article-title":"Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation","volume":"199","author":"Zheng","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2017.08.064_bib0095","doi-asserted-by":"crossref","first-page":"G326","DOI":"10.1152\/ajpgi.00083.2011","article-title":"Resveratrol causes cell cycle arrest, decreased collagen synthesis, and apoptosis in rat intestinal smooth muscle cells","volume":"302","author":"Garcia","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pros.22909","article-title":"Protective effect of tadalafil on the functional and structural changes of the rat ventral prostate caused by chronic pelvic ischemia","volume":"75","author":"Zarifpour","year":"2015","journal-title":"Prostate"},{"key":"10.1016\/j.biopha.2017.08.064_bib0105","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.biopha.2017.04.055","article-title":"Therapeutic effect of melittin on a rat model of chronic prostatitis induced by Complete Freund\u2019s Adjuvant","volume":"90","author":"Lin","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.08.064_bib0110","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000438651","article-title":"TGF-b type I receptor kinase inhibitor EW-7197 suppresses cholestatic liver fibrosis by inhibiting HIF1a-induced epithelial mesenchymal transition","volume":"38","author":"Kim","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2017.08.064_bib0115","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1016\/j.jamcollsurg.2005.06.229","article-title":"Mechanisms of statin-mediated smooth muscle cell apoptosis: a role for survivin (SVV)","volume":"201","author":"Wang","year":"2005","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.biopha.2017.08.064_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12935-016-0326-1","article-title":"Survivin a unique target for tumor therapy","volume":"16","author":"Garg","year":"2016","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.biopha.2017.08.064_bib0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1089\/jir.2015.0102","article-title":"Tracheal smooth muscle cells stimulated by stem cell factor-c-Kit coordinate the production of transforming growth factor-\u03b21 and fibroblast growth factor-2 mediated by chemokine (C\u2013C motif) ligand 3","volume":"36","author":"Oliveira","year":"2016","journal-title":"J. Interfer. Cytok. Res."},{"key":"10.1016\/j.biopha.2017.08.064_bib0130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/modpathol.3800318","article-title":"c-kit expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications","volume":"18","author":"Pan","year":"2005","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0135","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1600-0463.2007.apm_629.x","article-title":"Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis","volume":"115","author":"\u00c7omuno\u011flu","year":"2007","journal-title":"Acta Pathol. Microbiol. Et. Immunol. Scandinav."},{"key":"10.1016\/j.biopha.2017.08.064_bib0140","first-page":"1691","article-title":"Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1\/2 phosphorylation","volume":"40","author":"Takeuchi","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0145","first-page":"1691","article-title":"Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1\/2 phosphorylation","volume":"40","author":"Takeuchi","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2017.08.064_bib0150","doi-asserted-by":"crossref","first-page":"e89806","DOI":"10.1371\/journal.pone.0089806","article-title":"Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217318735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217318735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:55:28Z","timestamp":1771401328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217318735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":30,"alternative-id":["S0753332217318735"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.064","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit\/SCF by activating Sirt1","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}