{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:30:23Z","timestamp":1771403423214,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"North South University"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biopha.2017.08.113","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T10:46:53Z","timestamp":1505213213000},"page":"513-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["PEG modification of Amorfrutin B from Amorpha fructicosa increases gastric absorption, circulation half-life and glucose uptake by T3T-L1 adipocytes"],"prefix":"10.1016","volume":"95","author":[{"given":"Mehdi Bin","family":"Samad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Nazmul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudipta","family":"Banarjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizanur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabbir","family":"Raihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faika Laz","family":"Banti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sania Sarker","family":"Sayfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M. Nageeb","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farjana","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf Ul","family":"Kabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.A.","family":"Hannan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0005","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.2337\/dc16-1162","article-title":"A contemporary estimate of total mortality and cardiovascular disease risk in young adults with type 1 diabetes: the Pittsburgh epidemiology of diabetes complications study","volume":"39","author":"Miller","year":"2016","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.biopha.2017.08.113_bib0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2337\/diab.23.2.105","article-title":"Morbidity and mortality in diabetics in the Framingham population: sixteen year follow-up study","volume":"23","author":"Garcia","year":"1974","journal-title":"Diabetes"},{"issue":"18","key":"10.1016\/j.biopha.2017.08.113_bib0015","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJM198911023211805","article-title":"Oral hypoglycemic agents","volume":"321","author":"Gerich","year":"1989","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/dmrr.499","article-title":"Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes","volume":"20","author":"Fineman","year":"2004","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2017.08.113_bib0025","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/sj.bjp.0703306","article-title":"Induced desensitization of the insulinotropic effects of antidiabetic drugs: BTS 67 582 and tolbutamide","volume":"130","author":"McClenaghan","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2017.08.113_bib0030","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0006-2952(02)00996-6","article-title":"Desensitization of insulin secretion","volume":"63","author":"Rustenbeck","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0006-2952(00)00579-7","article-title":"Specific desensitization of sulfonylurea-but not imidazoline-induced insulin release after prolonged tolbutamide exposure","volume":"61","author":"McClenaghan","year":"2001","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2017.08.113_bib0040","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2174\/092986706776360860","article-title":"Antidiabetic agents from medicinal plants","volume":"13","author":"Jung","year":"2006","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2017.08.113_bib0045","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-8741(02)00059-4","article-title":"Medicinal plants of India with anti-diabetic potential","volume":"81","author":"Grover","year":"2002","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.08.113_bib0050","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S2221-1691(12)60032-X","article-title":"An overview on antidiabetic medicinal plants having insulin mimetic property","volume":"2","author":"Patel","year":"2012","journal-title":"Asia. Pac. J. Trop. Biomed."},{"issue":"4","key":"10.1016\/j.biopha.2017.08.113_bib0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0031-9422(81)85174-6","article-title":"B, bibenzyl antimicrobial agents from Amorpha fruticosa","volume":"20","author":"Mitscher","year":"1981","journal-title":"Phytochemistry"},{"issue":"19","key":"10.1016\/j.biopha.2017.08.113_bib0060","doi-asserted-by":"crossref","first-page":"7257","DOI":"10.1073\/pnas.1116971109","article-title":"Amorfrutins are potent antidiabetic dietary natural products","volume":"109","author":"Weidner","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0065","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3109\/13880209.2015.1050115","article-title":"quantitative analysis of amorfrutins: novel antidiabetic dietary natural products, by HPLC","volume":"54","author":"Chen","year":"2016","journal-title":"Pharm. Biol."},{"issue":"16","key":"10.1016\/j.biopha.2017.08.113_bib0070","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/jssc.201500224","article-title":"Isolation and purification of prenylated phenolics from Amorpha fruticosa by high-speed counter-current chromatography","volume":"38","author":"Chen","year":"2015","journal-title":"J. Sep. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.08.113_bib0075","first-page":"10670","article-title":"The phytotoxicity and antimicrobial activity of Amorpha fruticosa L: leaves extract","volume":"20","author":"Hovanet","year":"2015","journal-title":"Rom. Biotech. Lett."},{"issue":"8","key":"10.1016\/j.biopha.2017.08.113_bib0080","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00125-013-2920-2","article-title":"Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPAR\u03b3) agonist with potent glucose-lowering properties","volume":"56","author":"Weidner","year":"2013","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.biopha.2017.08.113_bib0085","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s00125-006-0234-3","article-title":"PEGylated glucagon-like peptide-1 displays preserved effects on insulin release in isolated pancreatic islets and improved biological activity in db\/db mice","volume":"49","author":"Lee","year":"2006","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0090","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1016\/j.bcp.2008.03.011","article-title":"C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes","volume":"75","author":"Gault","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.08.113_bib0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/bc049735+","article-title":"Synthesis, characterization, and pharmacokinetic studies of PEGylated glucagon-like peptide-1","volume":"16","author":"Lee","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.biopha.2017.08.113_bib0100","first-page":"004","article-title":"Appliance of PK\/PD modeling in traditional chinese medicine research","volume":"11","author":"Shu","year":"2008","journal-title":"Chin. Pharm. Bull."},{"issue":"23","key":"10.1016\/j.biopha.2017.08.113_bib0105","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1039\/c1an15752c","volume":"136","author":"Wang","year":"2011","journal-title":"Analyst"},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0110","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/S0021-9258(18)89409-1","article-title":"Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes","volume":"260","author":"Frost","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0115","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.amjcard.2004.04.024","article-title":"Safety and compliance with once-daily niacin extended-release\/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) study","volume":"94","author":"Rubenfire","year":"2004","journal-title":"Am. J. cardiol."},{"key":"10.1016\/j.biopha.2017.08.113_bib0120","article-title":"Perception of severity of disease and health locus of control in compliant and noncompliant diabetic patients","author":"Alogna","year":"1980","journal-title":"Am. Diabetes Assoc."},{"issue":"6","key":"10.1016\/j.biopha.2017.08.113_bib0125","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2337\/dc06-2593","article-title":"a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes","volume":"30","author":"Vilsb\u00f8ll","year":"2007","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0130","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1210\/jc.2008-1518","article-title":"Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes","volume":"93","author":"Matthews","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2017.08.113_bib0135","doi-asserted-by":"crossref","first-page":"S279","DOI":"10.2337\/dc11-s231","article-title":"Long-acting glucagon-like peptide 1 receptor agonists","volume":"34","author":"Garber","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2017.08.113_bib0140","unstructured":"Davis FF, Van Es T, Palczuk NC. Non-immunogenic polypeptides. Google Patents; 1979."},{"issue":"1","key":"10.1016\/j.biopha.2017.08.113_bib0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-3659(01)00269-3","article-title":"Drug permeation enhancement via buccal route: possibilities and limitations","volume":"72","author":"\u015eenel","year":"2001","journal-title":"J. Controlled Release"},{"issue":"21","key":"10.1016\/j.biopha.2017.08.113_bib0150","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S1359-6446(05)03575-0","article-title":"PEGylation: successful approach to drug delivery","volume":"10","author":"Veronese","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0155","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrd1033","article-title":"Effect of pegylation on pharmaceuticals","volume":"2","author":"Harris","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0160","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/jps.20024","article-title":"Polyethylene glycol modification of filgrastim results in decreased renal clearance of the protein in rats","volume":"93","author":"Yang","year":"2004","journal-title":"J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0165","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1210\/jcem-57-5-1028","article-title":"Effect of renal function on plasma levels of bone Gla-protein","volume":"57","author":"DELMAS","year":"1983","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.08.113_bib0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.colsurfa.2015.03.006","article-title":"Effects of the PEG molecular weight of a PEG-lipid and cholesterol on PEG chain flexibility on liposome surfaces","volume":"474","author":"Abe","year":"2015","journal-title":"Colloids Surf. Physicochem. Eng. Aspects"},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0175","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.biopha.2017.08.113_bib0180","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ng.443","article-title":"Genetic variant near IRS1 is associated with type 2 diabetes: insulin resistance and hyperinsulinemia","volume":"41","author":"Rung","year":"2009","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0185","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.2337\/diabetes.49.12.2094","article-title":"A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia","volume":"49","author":"Weyer","year":"2000","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0190","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2337\/diab.35.12.1383","article-title":"Metabolic consequences of prolonged hyperinsulinemia in humans: evidence for induction of insulin insensitivity","volume":"35","author":"Marangou","year":"1986","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.biopha.2017.08.113_bib0195","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0026-0495(78)80006-7","article-title":"Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology","volume":"27","author":"Jeanrenaud","year":"1978","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.biopha.2017.08.113_bib0200","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1210\/jc.2003-030087","article-title":"Insulin resistance\/compensatory hyperinsulinemia: essential hypertension, and cardiovascular disease","volume":"88","author":"Reaven","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.biopha.2017.08.113_bib0205","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/0002-8703(91)90434-J","article-title":"Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease","volume":"121","author":"Reaven","year":"1991","journal-title":"Am. Heart J."},{"issue":"6","key":"10.1016\/j.biopha.2017.08.113_bib0210","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0735-1097(02)02982-0","article-title":"Insulin resistance and compensatory hyperinsulinemia","volume":"41","author":"Reaven","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0215","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2337\/diabetes.48.5.1198","article-title":"Control of glucose uptake and release by the liver in vivo","volume":"48","author":"Cherrington","year":"1999","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.biopha.2017.08.113_bib0220","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.1016\/S0021-9258(19)85561-8","article-title":"Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell: apparent translocation of intracellular transport systems to the plasma membrane","volume":"255","author":"Cushman","year":"1980","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2017.08.113_bib0225","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1677\/joe.0.1640187","article-title":"Stimulation of glucose transport by thyroid hormone in 3T3-L1 adipocytes: increased abundance of GLUT1 and GLUT4 glucose transporter proteins","volume":"164","author":"Romero","year":"2000","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0230","doi-asserted-by":"crossref","first-page":"E513","DOI":"10.1152\/ajpendo.00659.2007","article-title":"Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats","volume":"294","author":"Klieverik","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.biopha.2017.08.113_bib0235","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.2337\/db09-0047","article-title":"Dyslipidemia-Induced neuropathy in mice","volume":"58","author":"Vincent","year":"2009","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.biopha.2017.08.113_bib0240","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11892-006-0079-7","article-title":"Lipids and diabetic nephropathy","volume":"6","author":"Rosario","year":"2006","journal-title":"Curr. Diab. Rep."},{"issue":"10","key":"10.1016\/j.biopha.2017.08.113_bib0245","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.CIR.100.10.1134","article-title":"Diabetes and cardiovascular disease","volume":"100","author":"Grundy","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.biopha.2017.08.113_bib0250","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1021\/mp300649z","article-title":"Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles","volume":"10","author":"Yuan","year":"2013","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0255","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jconrel.2006.06.007","article-title":"Improved intestinal delivery of salmon calcitonin by Lys 18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy","volume":"114","author":"Youn","year":"2006","journal-title":"J. Controlled Release"},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0260","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ejpb.2012.04.001","article-title":"Oral administration of paclitaxel with pegylated poly (anhydride) nanoparticles: permeability and pharmacokinetic study","volume":"81","author":"Zabaleta","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"3","key":"10.1016\/j.biopha.2017.08.113_bib0265","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diacare.26.3.881","article-title":"Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients","volume":"26","author":"Monnier","year":"2003","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2017.08.113_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.54.1.1","article-title":"Postprandial hyperglycemia and diabetes complications","volume":"54","author":"Ceriello","year":"2005","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.biopha.2017.08.113_bib0275","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0272-0590(89)90334-5","article-title":"Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats","volume":"13","author":"Kannan","year":"1989","journal-title":"Fundam. Appl. Toxicol."},{"issue":"8P2","key":"10.1016\/j.biopha.2017.08.113_bib0280","doi-asserted-by":"crossref","DOI":"10.1592\/phco.23.9.3S.32886","article-title":"Pegylation: engineering improved biopharmaceuticals for oncology","volume":"23","author":"Molineux","year":"2003","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"issue":"6","key":"10.1016\/j.biopha.2017.08.113_bib0285","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mibio.2003.09.014","article-title":"Determination of lipophilicity and its use as a predictor of blood?brain barrier penetration of molecular imaging agents","volume":"5","author":"Waterhouse","year":"2003","journal-title":"Mol. Imaging Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217337071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217337071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:43:13Z","timestamp":1771400593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217337071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":57,"alternative-id":["S0753332217337071"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.113","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PEG modification of Amorfrutin B from Amorpha fructicosa increases gastric absorption, circulation half-life and glucose uptake by T3T-L1 adipocytes","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}