{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:38:13Z","timestamp":1771403893294,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005742","name":"Universidade Federal de Goi\u00e1s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biopha.2017.08.140","type":"journal-article","created":{"date-parts":[[2017,9,10]],"date-time":"2017-09-10T18:00:27Z","timestamp":1505066427000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acari\u00e7oba) \u2013 Araliaceae"],"prefix":"10.1016","volume":"95","author":[{"given":"Thiago Levi Silva","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Ribeiro de","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stone de","family":"S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Gabriel de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iziara Ferreira","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayane Moreira da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f4nica Vale","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Barreto da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boniek Gontijo","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ricardo","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Realino de","family":"Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.08.140_bib0005","series-title":"Flora de Nicaragua, Helechos","first-page":"110","article-title":"Missouri botanical garden press","author":"Stevens","year":"2001"},{"key":"10.1016\/j.biopha.2017.08.140_bib0010","first-page":"413","article-title":"Atividade alelop\u00e1tica, antioxidante e teor de fen\u00f3is totais de Hydrocotyle bonariensis Lam. (Araliaceae)","volume":"32","author":"Silva","year":"2010","journal-title":"Acta Sci. Technol."},{"key":"10.1016\/j.biopha.2017.08.140_bib0015","series-title":"Plantas medicinais do Brasil: nativas e ex\u00f3ticas","author":"Lorenzi","year":"2002"},{"key":"10.1016\/j.biopha.2017.08.140_bib0020","first-page":"71","article-title":"Estudo farmacogn\u00f3stico de Hydrocotyle bonariensis Lam., adulterante de Centella asi\u00e1tica (L.) urban","volume":"12","author":"Ficher","year":"1994","journal-title":"Lecta Rev. Farm. Biol."},{"key":"10.1016\/j.biopha.2017.08.140_bib0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1590\/S0102-695X2008000300015","article-title":"Caracteriza\u00e7\u00e3o anat\u00f4mica e qu\u00edmica da folha e do sistema radicular de Hydrocotyle umbellata (Apiaceae)","volume":"18","author":"Martins","year":"2008","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.biopha.2017.08.140_bib0030","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/hlca.201100109","article-title":"New triterpenoid and ergostane glycosides from the leaves of Hydrocotyle umbellata L","volume":"94","author":"Sosa","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.biopha.2017.08.140_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1590\/S0102-695X2011005000018","article-title":"Anxiolytic-like and sedative effects of Hydrocotyle umbellata extract in mice","volume":"21","author":"Rocha","year":"2011","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.biopha.2017.08.140_bib0040","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1590\/S0001-37652013000300011","article-title":"Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acari\u00e7oba) in mice","volume":"85","author":"Florentino","year":"2013","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.biopha.2017.08.140_bib0045","first-page":"1246","article-title":"Evaluation of anti-inflammatory activity and total tannin content from the leaves of Bacopa monnieri (Linn.)","volume":"5","author":"Hossain","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.biopha.2017.08.140_bib0050","first-page":"1151","article-title":"NSAID-induced gastrointestinal damage and the 3 design of GI-sparing NSAIDs","volume":"9","author":"Wallace","year":"2008","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.biopha.2017.08.140_bib0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1021\/cen-v079n040.p079","article-title":"Chiral pharmaceuticals","volume":"79","author":"Stinson","year":"2001","journal-title":"Chem. Eng. News"},{"key":"10.1016\/j.biopha.2017.08.140_bib0060","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ptr.5512","article-title":"The effect of verbascoside in neuropathic pain induced by chronic constriction injury in rats","volume":"30","author":"Amin","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.08.140_bib0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. C Struct. Chem."},{"key":"10.1016\/j.biopha.2017.08.140_bib0070","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","article-title":"WinGX and ORTEP for Windows: an update","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.biopha.2017.08.140_bib0075","series-title":"Farmacognosia: da planta ao medicamento","first-page":"229","article-title":"Introdu\u00e7\u00e3o \u00e0 An\u00e1lise Fitoqu\u00edmica","author":"Falkenberg","year":"2010"},{"key":"10.1016\/j.biopha.2017.08.140_bib0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.microc.2016.09.002","article-title":"Determination of podophyllotoxin and related aryltetralin lignans by HPLC\/DAD\/MS from Lamiaceae species","volume":"130","author":"Brand\u00e3o","year":"2016","journal-title":"Microchem. J."},{"key":"10.1016\/j.biopha.2017.08.140_bib0085","series-title":"Plantas Medicinais Arte e Ci\u00eancias","first-page":"129","article-title":"Qu\u00edmica de produtos naturais: m\u00e9todos gerais","author":"Ferri","year":"1996"},{"key":"10.1016\/j.biopha.2017.08.140_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","article-title":"Formalin test in mice, a useful technique for evaluating mild analgesics","volume":"14","author":"Hunskaar","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.biopha.2017.08.140_bib0095","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin induced oedema in hind paw of rats in assay for anti-inflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2017.08.140_bib0100","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/bioinformatics\/16.8.747","article-title":"PASS: predicition of activity spectra for biologically active substances","volume":"8","author":"Lagunin","year":"2000","journal-title":"Bioinformatic"},{"key":"10.1016\/j.biopha.2017.08.140_bib0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ins.2014.08.002","article-title":"A dynamic niching genetic algorithm strategy for docking of highly flexible ligands","volume":"289","author":"Magalh\u00e3es","year":"2014","journal-title":"Inf. Sci."},{"key":"10.1016\/j.biopha.2017.08.140_bib0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2017.08.140_bib0115","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3839\/jksabc.2009.103","article-title":"Suppressive effects of Anthriscus sylvestris constituents on the expression and production of matrix metalloproteinase-9 using luciferase transfected raw 264.7 cell based assay system","volume":"6","author":"Lim","year":"2009","journal-title":"J. Korean Soc. Appl. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.08.140_bib0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/mrc.1260250114","article-title":"Revised assignments of the 13C NMR spectrum of Hibalactone using 2D heteronuclear 1H\/13C correlations","volume":"25","author":"Feliciano","year":"1987","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.biopha.2017.08.140_bib0125","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1021\/acs.biochem.5b00930","article-title":"Identification of the substrate access portal of 5-lipoxygenase","volume":"54","author":"Mitra","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2017.08.140_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0134691","article-title":"Computational structure-based de novo design of hypothetical inhibitors against the anti-inflammatory target COX-2","volume":"10","author":"Dhanjal","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.08.140_bib0135","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1074\/jbc.M009377200","article-title":"Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid","volume":"276","author":"Thuresson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.08.140_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHYT.0000045497.90158.d2","article-title":"Lignans and neolignans as lead compounds","volume":"2","author":"Apers","year":"2003","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.biopha.2017.08.140_bib0145","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.fct.2011.03.001","article-title":"The effect of the dibenzylbutyrolactolic lignin cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster","volume":"49","author":"Rezende","year":"2011","journal-title":"Food Chem Toxicol."},{"key":"10.1016\/j.biopha.2017.08.140_bib0150","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s12272-010-0619-1","article-title":"Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes","volume":"33","author":"Lee","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2017.08.140_bib0155","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.phymed.2016.11.014","article-title":"Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF- \u0138 B signaling","volume":"24","author":"Pham","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.08.140_bib0160","first-page":"1","article-title":"Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. Both In vitro and In vivo","volume":"2012","author":"Chiu","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2017.08.140_bib0165","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11418-015-0913-9","article-title":"Antinociceptive and anti-inflammatory effects of myricetin 3-O-\u03b2-galactoside isolated from Davilla elliptica: involvement of the nitrergic system","volume":"69","author":"Oliveira","year":"2015","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.biopha.2017.08.140_bib0170","first-page":"243","article-title":"Mouse paw edema: a new model for inflammation?","volume":"20","author":"Henriques","year":"1987","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biopha.2017.08.140_bib0175","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Saleh","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2017.08.140_bib0180","series-title":"The Pharmacology of Pain 130","first-page":"1","article-title":"Animal models of analgesia","author":"Tjolsen","year":"1987"},{"key":"10.1016\/j.biopha.2017.08.140_bib0185","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bmcl.2016.11.081","article-title":"In vivo and in silico anti-inflammatory mechanism of action of the semisynthetic (\u2212)-cubebin derivatives (\u2212)-hinokinin and (\u2212)-Obenzylcubebin","volume":"27","author":"Lima","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2017.08.140_bib0190","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jep.2008.03.016","article-title":"Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action","volume":"118","author":"Lima","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.08.140_bib0195","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2174\/0929867311320130013","article-title":"Rationally designed multitarget agents against inflammation and pain","volume":"20","author":"Hwang","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2017.08.140_bib0200","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/fcp.12186","article-title":"Treatment of anxiety and depression: medicinal plants in retrospect","volume":"30","author":"Fajemiroye","year":"2016","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2017.08.140_bib0205","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0024-3205(00)00996-6","article-title":"Effects of melatonin, morphine and diazepam on formalin-induced nociception in mice","volume":"68","author":"Pang","year":"2001","journal-title":"Life Sci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217320139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217320139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:55:10Z","timestamp":1771401310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217320139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":41,"alternative-id":["S0753332217320139"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.140","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acari\u00e7oba) \u2013 Araliaceae","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.08.140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}