{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:51:50Z","timestamp":1787961110916,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biopha.2017.09.067","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T17:32:36Z","timestamp":1506015156000},"page":"1461-1468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgf\u03b21 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats"],"prefix":"10.1016","volume":"95","author":[{"given":"Almesh","family":"Kadakol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Goru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajir","family":"Malek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Bhanudas","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2017.09.067_bib0005","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1124\/pr.114.010454","article-title":"International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli","volume":"67","author":"Karnik","year":"2015","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.067_bib0010","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/HJH.0b013e32834d9efe","article-title":"Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors","volume":"30","author":"Karpe","year":"2012","journal-title":"J. Hypertens."},{"issue":"31","key":"10.1016\/j.biopha.2017.09.067_bib0015","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1093\/eurheartj\/eht149","article-title":"Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I","volume":"34","author":"Paneni","year":"2013","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.biopha.2017.09.067_bib0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08037050310001057","article-title":"Angiotensin AT1\/AT2 receptors: regulation, signalling and function","volume":"12","author":"Kaschina","year":"2003","journal-title":"Blood Press."},{"key":"10.1016\/j.biopha.2017.09.067_bib0025","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1097\/01.hjh.0000501055.97675.58","article-title":"Mps 13-09 AT2 receptor stimulation inhibits phosphate-induced vascular calcification","volume":"34","author":"Kukida","year":"2016","journal-title":"J. Hypertens."},{"issue":"6027","key":"10.1016\/j.biopha.2017.09.067_bib0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1192152","article-title":"Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism","volume":"332","author":"Habashi","year":"2011","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biopha.2017.09.067_bib0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1523-1755.2000.00820.x","article-title":"Inhibition of pressure natriuresis in mice lacking the AT 2 receptor","volume":"57","author":"Gross","year":"2000","journal-title":"Kidney Int."},{"issue":"19","key":"10.1016\/j.biopha.2017.09.067_bib0040","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1161\/01.CIR.0000072763.98069.B4","article-title":"Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice","volume":"107","author":"Adachi","year":"2003","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.biopha.2017.09.067_bib0045","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1161\/hc4601.099401","article-title":"Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT2 receptor","volume":"104","author":"Brede","year":"2001","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.biopha.2017.09.067_bib0050","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2005.08.006","article-title":"Activation of AP-1 through reactive oxygen species by angiotensin II in rat cardiomyocytes","volume":"39","author":"Wu","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2017.09.067_bib0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biochi.2016.09.016","article-title":"H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats","volume":"131","author":"Pandey","year":"2016","journal-title":"Biochimie"},{"issue":"21","key":"10.1016\/j.biopha.2017.09.067_bib0060","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1042\/BCJ20160595","article-title":"H2BK120 mono-ubiquitination modulate SET7\/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis","volume":"473","author":"Goru","year":"2016","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.biopha.2017.09.067_bib0065","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.celrep.2012.11.011","article-title":"Deubiquitinases as a signaling target of oxidative stress","volume":"2","author":"Cotto-Rios","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2017.09.067_bib0070","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.biopha.2016.10.072","article-title":"Esculetin A phytochemical endeavor fortifying effect against non-communicable diseases","volume":"84","author":"Kadakol","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.09.067_bib0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jff.2015.05.017","article-title":"Esculetin reverses histone H2A\/H2B ubiquitination H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy","volume":"17","author":"Kadakol","year":"2015","journal-title":"J. Funct. Food"},{"key":"10.1016\/j.biopha.2017.09.067_bib0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jff.2017.05.051","article-title":"Esculetin ameliorates insulin resistance and type 2 diabetic nephropathy through reversal of histone H3 acetylation and H2A lysine 119 monoubiquitination","volume":"35","author":"Kadakol","year":"2017","journal-title":"J. Funct. Foods"},{"issue":"2","key":"10.1016\/j.biopha.2017.09.067_bib0085","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbrc.2015.04.036","article-title":"Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia","volume":"461","author":"Kadakol","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.09.067_bib0090","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jff.2015.05.017","article-title":"Esculetin reverses histone H2A\/H2B ubiquitination H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy","volume":"17","author":"Kadakol","year":"2015","journal-title":"J. Funct. Foods"},{"issue":"2","key":"10.1016\/j.biopha.2017.09.067_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.atherosclerosis.2013.07.003","article-title":"Epigenetic signatures and vascular risk in type 2 diabetes: a clinical perspective","volume":"230","author":"Paneni","year":"2013","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.biopha.2017.09.067_bib0100","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.067_bib0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/157016111201140327155551","article-title":"Epigenetics in vascular disease?therapeutic potential of new agents","volume":"12","author":"Xu","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2017.09.067_bib0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11357-016-9943-9","article-title":"IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis","volume":"38","author":"Tarantini","year":"2016","journal-title":"AGE"},{"issue":"26","key":"10.1016\/j.biopha.2017.09.067_bib0115","doi-asserted-by":"crossref","first-page":"24824","DOI":"10.1074\/jbc.M502115200","article-title":"The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code","volume":"280","author":"Fish","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2017.09.067_bib0120","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbagrm.2014.06.004","article-title":"Epigenetic regulation of smooth muscle cell plasticity","volume":"1849","author":"Liu","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Gene Regul. Mech."},{"key":"10.1016\/j.biopha.2017.09.067_bib0125","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ejphar.2015.09.035","article-title":"Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis","volume":"765","author":"Kadakol","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.09.067_bib0130","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1038\/sj.ki.4490561","article-title":"Factors involved in the effects of losartan on endothelialdysfunction induced by aging in SHR","volume":"54","author":"Maeso","year":"1998","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.biopha.2017.09.067_bib0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20060342","article-title":"Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology","volume":"112","author":"Higuchi","year":"2007","journal-title":"Clin. Sci."},{"issue":"7010","key":"10.1016\/j.biopha.2017.09.067_bib0140","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature02985","article-title":"Role of histone H2A ubiquitination in Polycomb silencing","volume":"431","author":"Wang","year":"2004","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.biopha.2017.09.067_bib0145","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.molmet.2014.08.002","article-title":"The Polycomb protein, Bmi1, regulates insulin sensitivity","volume":"3","author":"Cannon","year":"2014","journal-title":"Mol. metab."},{"key":"10.1016\/j.biopha.2017.09.067_bib0150","doi-asserted-by":"crossref","first-page":"20894","DOI":"10.1038\/srep20894","article-title":"Overexpression of RNF2 is an independent predictor of outcome in patients with urothelial carcinoma of the bladder undergoing radical cystectomy","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.067_bib0155","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1210\/en.2014-1381","article-title":"AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-\u03b21 expression in male rat glomerular mesangial cells","volume":"156","author":"Huang","year":"2014","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.biopha.2017.09.067_bib0160","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.freeradbiomed.2012.07.020","article-title":"The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals","volume":"53","author":"Chervona","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2017.09.067_bib0165","doi-asserted-by":"crossref","first-page":"24108","DOI":"10.1038\/srep24108","article-title":"Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis","volume":"6","author":"Karnewar","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2017.09.067_bib0170","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1039\/C4MB00636D","article-title":"Multi-spectroscopic and molecular modelling studies on the interaction of esculetin with calf thymus DNA","volume":"11","author":"Sarwar","year":"2015","journal-title":"Mol. Biosyst."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217331621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217331621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:01:24Z","timestamp":1771401684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217331621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":34,"alternative-id":["S0753332217331621"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.09.067","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgf\u03b21 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.09.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}