{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:00:52Z","timestamp":1780354852879,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biopha.2017.09.069","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T23:50:54Z","timestamp":1507765854000},"page":"1868-1875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K\/Akt\/mTOR and Nrf2\/HO-1\/NF-\u03baB pathway in mice"],"prefix":"10.1016","volume":"95","author":[{"given":"Yongming","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfa","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.biopha.2017.09.069_bib0005","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.biocel.2013.08.021","article-title":"ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione","volume":"45","author":"Tan","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.biopha.2017.09.069_bib0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jsps.2012.05.012","article-title":"Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats","volume":"20","author":"Afzal","year":"2012","journal-title":"Saudi Pharm. J."},{"issue":"3","key":"10.1016\/j.biopha.2017.09.069_bib0015","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2017.09.069_bib0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"issue":"1-3","key":"10.1016\/j.biopha.2017.09.069_bib0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2012.07.031","article-title":"N.G., a novel PABA\/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS\/MAPK-dependent mitochondrial pathway","volume":"691","author":"Liu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.069_bib0030","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2013.08.018","article-title":"Thymoquinone inhibits cell proliferation through regulation of G1\/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma","volume":"223","author":"Raghunandhakumar","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2017.09.069_bib0035","first-page":"169","article-title":"The efficacy of Cordyceps militaris capsules in treatment of chronic bronchitis in comparison with Jinshuibao capsules","volume":"13","author":"Gai G-z Jin S-j Wang","year":"2004","journal-title":"Chin. New Drugs J."},{"issue":"6","key":"10.1016\/j.biopha.2017.09.069_bib0040","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/AAC.42.6.1424","article-title":"Antifungal activity of 3'-deoxyadenosine (cordycepin)","volume":"42","author":"Sugar","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.069_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4827(79)90577-9","article-title":"Effects of cordycepin on microtubules of cultured mammalian cells","volume":"118","author":"Deitch","year":"1979","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.09.069_bib0050","first-page":"291","article-title":"Anti-diabetic effects of CCCA, CMKSS, and cordycepin from Cordyceps militaris and the immune responses in streptozotocin-induced diabetic mice","volume":"9","author":"Yun","year":"2003","journal-title":"Nat. Prod. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2017.09.069_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neulet.2011.08.048","article-title":"Cordycepin decreases activity of hippocampal CA1 pyramidal neuron through membrane hyperpolarization","volume":"503","author":"Yao","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"1-3","key":"10.1016\/j.biopha.2017.09.069_bib0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejphar.2011.04.052","article-title":"Cordycepin protects against cerebral ischemia\/reperfusion injury in vivo and in vitro","volume":"664","author":"Cheng","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.biopha.2017.09.069_bib0065","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.intimp.2010.09.011","article-title":"Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells","volume":"10","author":"Jeong","year":"2010","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.09.069_bib0070","first-page":"309","article-title":"Ethanol extract from portulaca oleracea L. attenuated acetaminophen-induced mice liver injury","volume":"7","author":"Liu","year":"2015","journal-title":"Am. J. Transl. Res."},{"issue":"8","key":"10.1016\/j.biopha.2017.09.069_bib0075","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.7314\/APJCP.2015.16.8.3383","article-title":"Portulaca oleracea seed oil exerts cytotoxic effects on human liver cancer (HepG2) and human lung cancer (A-549) cell lines","volume":"16","author":"Al-Sheddi","year":"2015","journal-title":"Asian Pac. J. Cancer Prevent.: APJCP"},{"issue":"2","key":"10.1016\/j.biopha.2017.09.069_bib0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.intimp.2015.04.001","article-title":"Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg\/Th17 balance","volume":"26","author":"Chen","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.09.069_bib0085","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s10620-015-3888-1","article-title":"Interleukin-17A plays a pivotal role in chemically induced hepatocellular carcinoma in mice","volume":"61","author":"Sun","year":"2016","journal-title":"Dig. Dis. Sci."},{"issue":"44","key":"10.1016\/j.biopha.2017.09.069_bib0090","doi-asserted-by":"crossref","first-page":"38192","DOI":"10.1039\/C5RA19841K","article-title":"Protective effect of chrysophanol on LPS\/d-GalN-induced hepatic injury through the RIP140\/NF-[small kappa]B pathway","volume":"6","author":"Jiang","year":"2016","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.biopha.2017.09.069_bib0095","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cbi.2013.10.010","article-title":"Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system","volume":"206","author":"Gupta","year":"2013","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.069_bib0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10753-015-0272-4","article-title":"Protective effect of astragaloside IV against paraquat-Induced lung injury in mice by suppressing rho signaling","volume":"39","author":"Chen","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2017.09.069_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cbi.2015.08.001","article-title":"Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats","volume":"240","author":"Deng","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"24","key":"10.1016\/j.biopha.2017.09.069_bib0110","doi-asserted-by":"crossref","first-page":"20081","DOI":"10.1039\/C5RA21158A","article-title":"Protective effect of trillin against ethanol-induced acute gastric lesions in an animal model","volume":"6","author":"Chen","year":"2016","journal-title":"RSC Adv."},{"issue":"40","key":"10.1016\/j.biopha.2017.09.069_bib0115","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.3748\/wjg.14.6145","article-title":"Diallyl sulfide protects against N-nitrosodiethylamine-induced liver tumorigenesis: role of aldose reductase","volume":"14","author":"Ibrahim","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.09.069_bib0120","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jep.2015.03.068","article-title":"Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3 K\/Akt\/mTOR signaling pathway","volume":"168","author":"Ma","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2017.09.069_bib0125","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10620-015-3751-4","article-title":"Wogonoside shows antifibrotic effects in an experimental regression model of hepatic fibrosis","volume":"60","author":"Wang","year":"2015","journal-title":"Dig. Dis. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2017.09.069_bib0130","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1021\/jm5020023","article-title":"Synthesis and biological evaluation of novel olean-28, 13\u03b2-lactams as potential antiprostate cancer agents","volume":"58","author":"Ai","year":"2015","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2017.09.069_bib0135","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/hep.28357","article-title":"PI3 K\/AKT\/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells","volume":"63","author":"Samarin","year":"2016","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.biopha.2017.09.069_bib0140","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.18632\/oncotarget.3131","article-title":"Inhibition of PI3K\/AKT\/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells","volume":"6","author":"Hambright","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.biopha.2017.09.069_bib0145","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.18632\/aging.100402","article-title":"Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression","volume":"3","author":"Leontieva","year":"2011","journal-title":"Aging"},{"issue":"9","key":"10.1016\/j.biopha.2017.09.069_bib0150","doi-asserted-by":"crossref","first-page":"e75076","DOI":"10.1371\/journal.pone.0075076","article-title":"Insight into the intermolecular recognition mechanism between Keap1 and IKKbeta combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.biopha.2017.09.069_bib0155","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/aps.2015.31","article-title":"The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats","volume":"36","author":"Hua","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.biopha.2017.09.069_bib0160","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s10753-013-9789-6","article-title":"The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1","volume":"37","author":"Seo","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2017.09.069_bib0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cbi.2015.09.010","article-title":"The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state","volume":"243","author":"Jiang","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.biopha.2017.09.069_bib0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.intimp.2015.01.011","article-title":"The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice","volume":"25","author":"Chen","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2017.09.069_bib0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2015.12.007","article-title":"Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho\/ROCK\/NF-kappaB pathway","volume":"103","author":"Zhu","year":"2016","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.biopha.2017.09.069_bib0180","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/18715206113139990078","article-title":"Targeted regulation of PI3 K\/Akt\/mTOR\/NF-kappaB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy","volume":"13","author":"Ahmad","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2017.09.069_bib0185","first-page":"2992","article-title":"M., miR-144 reverses chemoresistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway","volume":"8","author":"Zhou","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2017.09.069_bib0190","article-title":"Hepatic B cell leukemia-3 suppresses chemically-induced hepatocarcinogenesis in mice through altered MAPK and NF-kappaB activation","author":"Gehrke","year":"2016","journal-title":"Oncotarget"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217323004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217323004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:45:11Z","timestamp":1771400711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217323004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":38,"alternative-id":["S0753332217323004"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.09.069","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-hepatocarcinoma effect of cordycepin against NDEA-induced hepatocellular carcinomas via the PI3K\/Akt\/mTOR and Nrf2\/HO-1\/NF-\u03baB pathway in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.09.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}